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Vol. 14. Num. 4.July - August 2018
Pages 181-250
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Vol. 14. Num. 4.July - August 2018
Pages 181-250
Case report
DOI: 10.1016/j.reumae.2016.10.011
Anti-MDA5 dermatomyositis mimicking psoriatic arthritis
Dermatomiositis con anticuerpos anti-MDA5 simulando una artritis psoriásica
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Iván Cabezas-Rodrígueza,
Corresponding author
icaro231@gmail.com

Corresponding author.
, Isla Morante-Boladoa, Anahy Brandy-Garcíaa, Rubèc)n Queiro-Silvaa, Lourdes Mozob, Francisco Javier Ballina-Garcíaa
a Servicio de Reumatología, Hospital Universitario Central de Asturias, Oviedo, Spain
b Servicio de Inmunología, Hospital Universitario Central de Asturias, Oviedo, Spain
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Abstract

Dermatomyositis causes inflammation and damage of muscle and skin, and sometimes involves internal organs, especially lung parenchyma. Patients with dermatomyositis still represent a diagnostic challenge because of the rarity of this disease and the lack of specificity of some of its cutaneous manifestations. Herein, we describe the case of a patient with dermatomyositis, initially diagnosed as psoriatic arthritis, in which the performance of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was decisive to establish a definitive diagnosis.

Keywords:
Dermatomyositis
Melanoma differentiation-associated protein gene 5
Psoriatic arthritis
Resumen

La dermatomiositis causa inflamación y daño del músculo y la piel, y en ocasiones afecta a órganos internos, especialmente el parèc)nquima pulmonar. Los pacientes con dermatomiositis representan todavía un reto diagnóstico debido a la rareza de esta enfermedad y la falta de especificidad de algunas de sus manifestaciones cutáneas. Describimos el caso de una paciente con dermatomiositis, inicialmente diagnosticada de artritis psoriásica, en la que la determinación de anticuerpos anti-MDA5 fue decisiva para establecer un diagnóstico definitivo.

Palabras clave:
Dermatomiositis
Proteína asociada a la diferenciación del melanoma 5
Artritis psoriásica

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