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Vol. 14. Num. 4.July - August 2018
Pages 181-250
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Vol. 14. Num. 4.July - August 2018
Pages 181-250
Original Article
DOI: 10.1016/j.reumae.2016.11.010
Long-term Changes in the Quality of Life of Patients With Rheumatoid Arthritis Treated With Biological Therapies
Evolución a largo plazo de la calidad de vida en pacientes con artritis reumatoide tratados con terapias biológicas
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Luis Ortega-Valína,
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lortegav@saludcastillayleon.es

Corresponding author.
, Isabel Mayorga-Bajoa, Carolina Prieto-Fernándeza, Javier del Pozo-Ruizb, Esperanza Gutiérrez-Gutiérreza, Trinidad Pérez-Sandovalc
a Servicio de Farmacia, Complejo Asistencial Universitario de León, León, Spain
b Servicio de Farmacia, Hospital San Juan de Dios, León, Spain
c Servicio de Reumatología, Complejo Asistencial Universitario de León, León, Spain
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Tables (4)
Table 1. Sociodemographic Characteristics of the Patients.
Table 2. Values (Mean and Standard Deviation) of the Overall Results and Broken Down by Item in the Quality of Life in Rheumatoid Arthritis Scale in E1, E2 and E3, and P Value Upon Comparing E1 and E2 and E2 and E3.
Table 3. Dropouts Throughout the Study and Causes.
Table 4. Overall Results of the Health-related Quality of Life Questionnaire Broken Down by Item (Mean±Standard Deviation) in Cross-sectional Studies Utilizing the Quality of Life in Rheumatoid Arthritis Scale.
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Abstract
Objective

To analyze the changes in health-related quality of life (HRQoL) of patients with rheumatoid arthritis (RA) treated with biological therapies.

Method

Observational prospective study performed from October 2006 to May 2011. The inclusion criteria were adult patients, diagnosed with RA, treated for at least one year with anti-tumor necrosis factor therapy (infliximab or etanercept), who had not received other biological treatments previously. A total of 41 patients who completed the study undertook the specific and validated questionnaire QoL-RA Scale 3 times: E1 (September 2006–February 2007), E2 (April 2008–January 2009) and E3 (July 2010–May 2011). Data analysis was conducted using Epi-Info version 3.3 2004 for Windows® and Excel 2007; mean comparisons were evaluated by Student's t-test and the relationship between the 3 outcomes for each patient by lineal regression.

Results

Overall results show a downward trend which was not statistically significant: 7.09 (standard deviation [SD]=1.15) in E1; 6.90 (SD=1.60) in E2; and 6.52 (SD=1.59) in E3. Items with higher scores were those related to psychosocial aspects (help from family, interaction with family and friends), whereas the physical dimension was valued more poorly (physical ability, arthritis pain, arthritis). Between E2 and E3 there was a significant increase in help from family (P=.0008), whereas level of tension (P=.0119) and mood (P=.0451) decreased significantly.

Conclusions

In all, HRQoL reported by patients is good and has remained unchanged after approximately 6 years of study. The stability of HRQoL is probably partly attributable to treatment.

Keywords:
Rheumatoid arthritis
Quality of life
Infliximab
Etanercept
Biological therapy
Resumen
Objetivo

Analizar la evolución a largo plazo de la calidad de vida relacionada con la salud (CVRS) en pacientes con artritis reumatoide (AR) tratados con terapias biológicas.

Método

Estudio observacional prospectivo realizado entre octubre de 2006 y mayo de 2011. Se seleccionó a pacientes mayores de edad, diagnosticados de AR, tratados durante al menos un año con anti-TNF (infliximab o etanercept) y que no hubieran recibido otros tratamientos biológicos previos. Completaron el estudio 41 pacientes, cumplimentando el cuestionario específico validado QOL-AR en 3ocasiones: E1 (entre septiembre de 2006 y febrero de 2007), E2 (entre abril de 2008 y enero de 2009) y E3 (entre julio de 2010 y mayo de 2011). Los datos se analizaron con Epi-Info versión 3.3-2004 para Windows ® y Excel 2007; la comparación de las medias con la prueba t de Student y la relación entre valores de un mismo paciente, mediante regresión lineal.

Resultados

Resultados globales: tendencia descendente no estadísticamente significativa: 7,09±1,15 en E1; 6,90±1,60 en E2 y 6,52±1,59 en E3. Los ítems con mayor puntuación fueron los relacionados con aspectos psicosociales (ayuda familiar, interacción con familia y amigos). La dimensión física fue la peor valorada (habilidad física, dolor artrítico, artritis). Entre E2 y E3 aumentó significativamente la valoración de la ayuda familiar (p=0,0008) y disminuyeron significativamente tensión nerviosa (p=0,0119) y estado de ánimo (p=0,0451).

Conclusiones

La CVRS de los pacientes es buena y se ha mantenido prácticamente invariable tras unos 6años de estudio. Es probable que parte de la estabilidad en la CVRS sea atribuible al tratamiento.

Palabras clave:
Artritis reumatoide
Calidad de vida
Infliximab
Etanercept
Terapia biológica

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