Reumatología Clínica (English Edition) Reumatología Clínica (English Edition)
Reumatol Clin 2018;14:211-4 - Vol. 14 Num.4 DOI: 10.1016/j.reumae.2018.01.001
Review Article
HPV Vaccination Syndrome: A Clinical Mirage, or a New Tragic Fibromyalgia Model
Síndrome posvacunal VPH. ¿Un espejismo clínico, o un nuevo modelo trágico de fibromialgia?
Manuel Martínez-Lavín
Departamento de Reumatología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Received 15 November 2017, Accepted 31 January 2018

Independent investigators have described the onset of a chronic painful dysautonomic syndrome soon after human papillomavirus (HPV) vaccination. The veracity of this syndrome is hotly debated. Many of the reported post-HPV vaccination cases fulfil fibromyalgia diagnostic criteria.

This article discusses the arguments favoring the existence of a syndrome associated to HPV vaccination. We propose that fibromyalgia dysautonomic-neuropathic model could help in the diagnostic and therapeutic process in those patients in whom the onset of a painful chronic illness began after HPV immunization. On the other hand, if its veracity is corroborated, HPV vaccination syndrome may become a new tragic fibromyalgia model.


Investigadores independientes han descrito la emergencia de un síndrome doloroso-disautonómico crónico enseguida de la vacunación contra el virus del papiloma humano (VPH). La veracidad de este síndrome es objeto de un encendido debate. Muchos de los casos reportados cumplen los criterios diagnósticos de fibromialgia.

Este artículo discute los argumentos a favor de la existencia de este nuevo síndrome. Propone que el modelo neuropático-disautonómico de la fibromialgia podría ayudar en el proceso diagnóstico y terapéutico de los casos que presentan un padecimiento doloroso crónico después de haber sido inmunizados frente al VPH. Por otro lado, de corroborarse su veracidad, el síndrome posvacunal VPH se erigiría como un nuevo modelo trágico e indeseado de fibromialgia.

HPV vaccine, Fibromyalgia, Small fiber neuropathy, Dysautonomia, Chronic fatigue syndrome, HPV vaccination syndrome
Palabras clave
Vacuna del papiloma, Fibromialgia, Neuropatía de fibras pequeñas, Disautonomía, Síndrome de fatiga crónica, Síndrome posvacunal de VPH


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Reumatol Clin 2018;14:211-4 - Vol. 14 Num.4 DOI: 10.1016/j.reumae.2018.01.001
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