Reumatología Clínica (English Edition) Reumatología Clínica (English Edition)
Reumatol Clin 2017;13:301-2 - Vol. 13 Num.5 DOI: 10.1016/j.reumae.2016.05.008
Images in Clinical Rheumatology
Painful Subcutaneous Nodule
Nódulo subcutáneo doloroso
Jorge Santos-Juanesa,, , Cristina Galachea, Veronica Blancob
a Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
b Servicio de Radiodiagnóstico, Hospital Lozano Blesa, Zaragoza, Spain
Received 13 April 2016, Accepted 05 May 2016

The patient was a 57-year-old woman who practiced hiking, and had no history of disease. She presented with a subcutaneous lesion measuring 5mm in the fifth toe of her left foot that she had detected 12 weeks earlier. The lesion was intensely painful and had undergone no changes. Plain radiography of the foot revealed the presence of a small calcification on the lateral border of the distal phalanx of the fifth toe on left foot (Fig. 1). Analyses included inflammatory markers, calcium, phosphorus and uric acid, which were all normal. The pain disappeared after extirpation (Fig. 2). In 20 months of follow-up, it has not reappeared.

Fig. 1.

Plain radiography shows a small calcification in a lateral region of the distal phalanx of the fifth toe.

Fig. 2.

Abundant psammoma bodies and proliferation of fusiform mononuclear cells (H&E 100×). (A) Presence of spherical calcifications (arrows) and multinuclear giant cells (arrowhead) (H&E 200×). (B) CD68 immunostaining reveals the presence of disseminated mononuclear cells surrounding the calcifications and multinuclear giant cells (arrowhead) (CD68 200×).

The diagnosis was tenosynovitis with psammomatous calcification. Although it can be considered part of the spectrum of tumor lesions with calcification, its clinical and histological features indicate that it is a distinct entity. It is very seldom observed, and rarely reported in the medical literature.1–4 It can be described clinically as a single subcutaneous nodule or mass that is most frequently located in the acral regions of the extremities, predominantly in adult women. The patients mentioned a history of repeated injuries associated with their occupation or related to sports.2 The lesions were situated in tendon or in peritendinous soft tissue. From the histological point of view, they were found to be a proliferation composed of histiocytes and (myo) fibroblasts, and the presence of numerous psammoma bodies.

The differential diagnosis should include a variety of neoplastic and nonneoplastic processes of the distal extremities accompanied by calcifications: gout, pseudogout, calcifying aponeurotic fibroma, giant cell tumor of the tendon sheath, synovial sarcoma and parosteal osteochondromatous proliferation.1–4 The addition of tenosynovitis with psammomatous calcification to the differential diagnosis of painful acral lesions is important, and will make it possible to avoid confusing them with other neoplastic or nonneoplastic diseases in which calcifications are present.

Ethical DisclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that they have followed the protocols of their work center on the publication of patient data.

Right to privacy and informed consent

The authors declare that no patient data appear in this article.


The authors have received no funding for performing this project.

Conflicts of Interest

The authors declare they have no conflicts of interest.

M.B. Gravanis,E.F. Gaffney
Idiopathic calcifying tenosynovitis. Histopathologic features and possible pathogenesis
Am J Surg Pathol, 7 (1983), pp. 357-361
W. Shon,A.L. Folpe
Tenosynovitis with psammomatous calcification: a poorly recognized pseudotumor related to repetitive tendinous injury
Am J Surg Pathol, 34 (2010), pp. 892-895
M. Kawata,K. Seki,T. Miura
Tenosynovitis with psammomatous calcification arising from the volar plate of the proximal interphalangeal joint of the finger
Pathol Int, 64 (2014), pp. 539-541
T. Robb,K. Oliver,G.M. Strutton,M. McAuliffe
Tenosynovitis with psammomatous calcification of the knee

Please cite this article as: Santos-Juanes J, Galache C, Blanco V. Nódulo subcutáneo doloroso. Reumatol Clin. 2017;13:301–302.

Corresponding author. (Jorge Santos-Juanes
Copyright © 2016. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
Reumatol Clin 2017;13:301-2 - Vol. 13 Num.5 DOI: 10.1016/j.reumae.2016.05.008