Reumatología Clínica (English Edition) Reumatología Clínica (English Edition)
Case report
Anti-MDA5 dermatomyositis mimicking psoriatic arthritis
Dermatomiositis con anticuerpos anti-MDA5 simulando una artritis psoriásica
Iván Cabezas-Rodrígueza,, , Isla Morante-Boladoa, Anahy Brandy-Garcíaa, Rubén Queiro-Silvaa, Lourdes Mozob, Francisco Javier Ballina-Garcíaa
a Servicio de Reumatología, Hospital Universitario Central de Asturias, Oviedo, Spain
b Servicio de Inmunología, Hospital Universitario Central de Asturias, Oviedo, Spain
Received 05 September 2016, Accepted 28 October 2016
Abstract

Dermatomyositis causes inflammation and damage of muscle and skin, and sometimes involves internal organs, especially lung parenchyma. Patients with dermatomyositis still represent a diagnostic challenge because of the rarity of this disease and the lack of specificity of some of its cutaneous manifestations. Herein, we describe the case of a patient with dermatomyositis, initially diagnosed as psoriatic arthritis, in which the performance of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was decisive to establish a definitive diagnosis.

Resumen

La dermatomiositis causa inflamación y daño del músculo y la piel, y en ocasiones afecta a órganos internos, especialmente el parénquima pulmonar. Los pacientes con dermatomiositis representan todavía un reto diagnóstico debido a la rareza de esta enfermedad y la falta de especificidad de algunas de sus manifestaciones cutáneas. Describimos el caso de una paciente con dermatomiositis, inicialmente diagnosticada de artritis psoriásica, en la que la determinación de anticuerpos anti-MDA5 fue decisiva para establecer un diagnóstico definitivo.

Keywords
Dermatomyositis, Melanoma differentiation-associated protein gene 5, Psoriatic arthritis
Palabras clave
Dermatomiositis, Proteína asociada a la diferenciación del melanoma 5, Artritis psoriásica

Article

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