Reumatología Clínica (English Edition) Reumatología Clínica (English Edition)
Case Report
Scleroderma “en coup de sabre” With Epilepsy and Uveitis Successfully Treated With Tocilizumab
La esclerodermia «en coup de sabre» con epilepsia y uveítis se trata con éxito con tocilizumab
Maria Osminina, , Nathalia Geppe, Elena Afonina
Department of Pediatrics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Received 14 December 2017, Accepted 03 May 2018

Case history of a small girl outlet with epilepsy, followed by scleroderma skin damage and uveitis, neurovasculitis with white matter foci in brain on the side of skin lesion in two months, immunologic disease activity. Resistance to conventional immunosuppressive therapy forced us to initiate the treatment with tocilizumab. It was well tolerated and led to significant improvement of brain, ocular and skin manifestations.


Historia de la enfermedad de una niña con epilepsia, así como las lesiones cutáneas de la esclerodermia y la uveítis, la neurovasculitis con materia blanca se centra en el cerebro en el lado de la lesión de la piel en 2 meses, la actividad de las enfermedades inmunológicas. La resistencia a la terapia inmunosupresora tradicional nos hizo comenzar el tratamiento con tocilizumab. Fue bien tolerado y condujo a una mejoría significativa en las manifestaciones cerebrales, oculares y de la piel.

Scleroderma “en coup de sabre” with neurovasculitis, Epilepsy and uveitis, Tocilizumab treatment
Palabras clave
Esclerodermia «en coup de sabre» con neurovasculitis, Epilepsia y uveítis, Tratamiento con tocilizumab


To access the full text of the publication Reumatología Clínica (English Edition) you have to be a subscriber or else to be a member of the Colegio Mexicano de Reumatología (CMR) or a member of the Sociedad Española de Reumatología (SER)

  • If you are member of CMR or SER:
    • Please go to the member area of SER SER or CMR and click on the Journal link.
  • If you are a subscriber:
    You can recover your password on "I Forgot my Password"
Cookies Policy
To improve our services and products, we use cookies (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.