Reumatología Clínica (English Edition) Reumatología Clínica (English Edition)
Case Report
Scleroderma “en coup de sabre” With Epilepsy and Uveitis Successfully Treated With Tocilizumab
La esclerodermia «en coup de sabre» con epilepsia y uveítis se trata con éxito con tocilizumab
Maria Osminina, , Nathalia Geppe, Elena Afonina
Department of Pediatrics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Received 14 December 2017, Accepted 03 May 2018
Abstract

Case history of a small girl outlet with epilepsy, followed by scleroderma skin damage and uveitis, neurovasculitis with white matter foci in brain on the side of skin lesion in two months, immunologic disease activity. Resistance to conventional immunosuppressive therapy forced us to initiate the treatment with tocilizumab. It was well tolerated and led to significant improvement of brain, ocular and skin manifestations.

Resumen

Historia de la enfermedad de una niña con epilepsia, así como las lesiones cutáneas de la esclerodermia y la uveítis, la neurovasculitis con materia blanca se centra en el cerebro en el lado de la lesión de la piel en 2 meses, la actividad de las enfermedades inmunológicas. La resistencia a la terapia inmunosupresora tradicional nos hizo comenzar el tratamiento con tocilizumab. Fue bien tolerado y condujo a una mejoría significativa en las manifestaciones cerebrales, oculares y de la piel.

Keywords
Scleroderma “en coup de sabre” with neurovasculitis, Epilepsy and uveitis, Tocilizumab treatment
Palabras clave
Esclerodermia «en coup de sabre» con neurovasculitis, Epilepsia y uveítis, Tratamiento con tocilizumab

Article

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