Reumatología Clínica (English Edition) Reumatología Clínica (English Edition)
Brief Report
Elderly-onset Sarcoidosis: A Single Center Comparative Study
Estudio comparativo entre la sarcoidosis de inicio en la edad adulta y en la tercera edad. Análisis de 131 casos
Senol Kobaka,, , Fidan Yildizb, Huseyin Semizc, Mehmet Ormand
a Istinye University Faculty of Medicine, LIV Hospital, Department of Rheumatology, Turkey
b Medicalpark Hospital, Department of Chest Diseases, Turkey
c Ege University Faculty of Medicine, Department of Internal Medicine, Turkey
d Ege University Faculty of Medicine, Department of Statistics, Turkey
Received 22 March 2018, Accepted 19 June 2018
Abstract
Objectives

Sarcoidosis rarely affect patients older than 65 years old. The purpose of this study is to compare and evaluate the demographic, clinical and laboratory features of elderly-onset (EOS) and young-onset sarcoidosis (YOS) patients.

Methods

One hundred and thirty one patients diagnosed with sarcoidosis according to clinical, radiologic and histopathological evaluation were included in this study. The patients with initial symptoms started after age 65 were accepted as EOS.

Results

Twenty (15.3%) of 131 patients were diagnosed as EOS, and 111 (84.7%) patients were evaluated as YOS. Fifteen of 20 EOS patients were female and 5 of them were male. Average duration of the disease was determined as 38.4 months for YOS and 22.5 months for EOS (p=0.556). Delay of the diagnosis was 12 months for YOS while it was 3 months for EOS (p=0.001). Higher rates of fatique, comorbid diseases and more hydroxychloroquine (HQ) use were detected in EOS patients comparing to YOS (p=0.010, p=0.003 and p=0.039 respectively).

Conclusions

EOS patients are characterized with higher rates of fatique and comorbid diseases, less inflammatory sign and delayed diagnosis, and less DMARDs use.

Resumen
Objetivos

La sarcoidosis raramente afecta a mayores de 65 años. Este estudio se diseñó para evaluar las características demográficas, clínicas y de laboratorio de pacientes diagnosticados de sarcoidosis en la tercera edad, comparados con sarcoidosis de inicio en la edad adulta.

Pacientes y métodos

Ciento treinta y un pacientes fueron diagnosticados de sarcoidosis de acuerdo con la evaluación clínica, radiológica e histopatológica.

Resultados

Veinte pacientes (15,3%) fueron diagnosticados de sarcoidosis en la tercera edad y 111 pacientes (84,7%) fueron diagnosticados en la edad adulta. Quince de los 20 pacientes diagnosticados en la tercera edad eran mujeres y 5 varones. La duración media de la enfermedad fue de 38,4 meses para los pacientes menores de 65 años y de 22,5 meses para los mayores de 65 años. El retraso diagnóstico fue de 12 meses para los primeros y 22,5 meses para los segundos (p=0,001, p=0,010 y p=0,003, p=0,039, respectivamente).

Conclusiones

Los pacientes con sarcoidosis de inicio en la tercera edad se caracterizan por mayor incidencia de fatiga y de comorbilidades, menos clínica inflamatoria, menor uso de FAME y mayor retraso diagnóstico.

Keywords
Sarcoidosis, Elderly-onset, Features
Palabras clave
Sarcoidosis, Inicio de edad avanzada, Características

Article

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