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Vol. 1. Núm. 2.
Páginas 121-128 (Julio - Agosto 2005)
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Vol. 1. Núm. 2.
Páginas 121-128 (Julio - Agosto 2005)
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The gut: beyond immunology
El intestino: más allá de la inmunología
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Y. Richaud-Patin, E. Soto-Vega, L. Llorente
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lllyrp@quetzal.innsz.mx

Correspondene: Dr. L. Llorente. Departamento de Inmunología y Reumatología. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Vasco de Quiroga, 15. Tlalpán. 14000 México DF. México.
Departamento de Inmunología y Reumatología. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. México DF. México
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The immune system is characterized by the ability to distinguish self from non-self. The intestinal immune system bears this latter property but, furthermore, it must discriminate among nutritious and beneficial substances from toxic or harmful ones. Considering that the gut has to be colonized by commensal bacteria participating in digestion as well as in the control of pathogen microorganisms, it is not surprising that mucosal surfaces are the largest and probably the most exquisitely specialized immune system's compartment. This means that not only innate and adaptive immunity are present, but further, particular structures, cells, and mechanisms such as physical barrriers, epithelia, Peyer's patches, M cells among others, which together are involved in the dynamic control of the homeostasis between gut and its flora. The present review deals with some popular conceptions about the digestive system with particular emphasis on the gut's immunology.

Key words:
Mucosol immunity
Gut
Commensal flora
Yoghurt

El sistema inmunitario se caracteriza principalmente por la capacidad de distinguir lo propio de lo extraño. En el intestino, el sistema inmunitario no sólo comparte esta propiedad, sino que es, además, apto para seleccionar los componentes nutritivos y/o benéficos de aquellos ue pueden ser nocivos. Si se considera que el intestino es colonizado por bacterias comensales que contribuyen a a digestión y al control del crecimiento de microorganismos patógenos, no es sorprendente que sea la superficie mucosa el más extenso y, acaso, el más sofisticado de los compartimientos del sistema inmunitario. Así, las respuestas innata y adaptativa se suman a estructuras, células y mecanismos exquisitamente especializados, tales como el epitelio intestinal, las placas de Peyer, las células M, entre otros, que en conjunto son responsables del control dinámico de la homeostasis entre el intestino y su flora. La presente revisión versa sobre algunos conceptos populares sobre el aparato digestivo y hace hincapié en el papel del intestino como órgano inmunitario.

Palabras clave:
Inmunidad de mucosas
Intestino
Flora comensales
Yogur
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Bibliografía
[1.]
J. Madara.
Regulation of movement of solutes across tight junctions.
Annu Rev Physiol, 60 (1998), pp. 143-159
[2.]
J.P. Kraehenbuhl, M.R. Neutra.
Epithelial M cells: differentiation and function.
Annu Rev Cell Dev Biol, 16 (2000), pp. 301-332
[3.]
S. Kemeis, A. Bogdanova, J.P. Kraehenbuhl, E. Pringault.
Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transports bacteria.
Science, 277 (1997), pp. 949-952
[4.]
N. Debard, F. Sierro, J. Browning, J.P. Krahenbuhl.
Effect of mature lymphocytes and lymphotoxin on the development of the follicule-associated epithelium and M cells in mouse Peyer's patches.
Gastroenterology, 120 (2001), pp. 1173-1182
[5.]
A.M. Mowat.
Anatomical basis of tolerance and immunity to intestinal antigens.
Nature Rev Immunol, 3 (2003), pp. 331-341
[6.]
E.C. Butcher, M. Williams, K. Yougman, L. Rott, M. Briskin.
Lymphocyte trafficking and regional immunity.
Adv Immunol, 72 (1999), pp. 209-253
[7.]
A. Iwasaki, B.L. Kelsall.
Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin-10 nd the differentiation of T-helper type 2 cells.
J Exp Med, 190 (1999), pp. 229-239
[8.]
D.N. Cook, D.M. Posser, R. Forster, J. Zhang, N.A. Kuklin, S.J. Abbondanzo, et al.
CCR6 mediates dendritic cell localization lymphocyte homeostasis, and immune responses in the mucosal tissue.
Immunity, 12 (2000), pp. 495-503
[9.]
B.B. Cazac, J. Roes.
TGF-β receptors control B cell responsiveness and induction of IgA in vivo.
Immunity, 13 (2001), pp. 443-451
[10.]
F.W. Van Ginkel, S.M. Wahl, J.F. Keamey, M.N. Kweon, K. Fujihashi, P.D. Burrows, et al.
Partial IgA-deficiency with increased Th2-type cytokines in TGF-β1 knockout mice.
J Immunol, 163 (1999), pp. 1951-1957
[11.]
T.T. MacDonald.
The mucosal Immune system.
Parasite Immunol, 25 (2003), pp. 235-246
[12.]
J. Braunstein, L. Qiao, F. Autschbach, G. Schumann, S. Meuer.
T cells of the human intestinal lamina propria are high producers of interleukin-10.
Gut, 41 (1997), pp. 215-220
[13.]
M. Carol, A. Lambretchts, A. Van Gossum, M. Libin, M. Goldman, F. Mascart-Lemone.
Spontaneous secretion of interferon γ and inteleukin-4 by human intraephitelial and lamina propria gut lymphocytes.
Gut, 42 (1998), pp. 643-649
[14.]
S.D. Hurst, C.J. Cooper, S.M. Sitterding, J. Choi, R.L. Jump, A.D. Levine, et al.
The differentiated state of intestinal lamina propria CD4+ T cells results in altered cytokine production, activation threshold and costimulatory requirements.
J Immunol, 163 (1999), pp. 5937-5945
[15.]
A. Hayday, R. Tigelaar.
Immunoregulation in the tissues by γδ T cells.
Nature Rev Immunol, 3 (2003), pp. 233-242
[16.]
M. Allez, L. Mayer.
Regulatory T cells: peace keepers in the gut.
Inflam Bowel Dis, 10 (2004), pp. 666-676
[17.]
S.R. Targan, R.L. Demm, M. Liu, S. Wang, A. Nel.
Definition of a lamina propria T-cell responsive state. Enhanced cytokine responsiveness of T cell stimulated through the CD2 pathway.
J Immunol, 154 (1995), pp. 664-675
[18.]
H.L. Schieferdecker, R. Ullrich, H. Hirseland, M. Zeitz.
T cell differentiation antigens on lymphocytes in the human intestinal lamina propria.
J Immunol, 148 (1992), pp. 2816-2822
[19.]
R.L. Mosley, M. Whetsell, J.R. Klein.
Proliferative properties of murine intestinal intraepithelial lymphocytes (IEL): IEL expressing TCR alpha beta or TCR tau delta are largely unresponsive to proliferative signals mediated via conventional stimulation of the CD3-TCR complex.
Int Immunol, 3 (1991), pp. 563-569
[20.]
A. Hayday, E. Theodoris, E. Ramsburg, J. Shires.
Intraepithelial lymphocytes: exploring the third way in immunology.
Nature Immunol, 2 (2001), pp. 997-1003
[21.]
M.R. Neutra, A. Frey, J.P. Kraehenbuhl.
Epithelial M cells: gateways for mucosal infection and immunization.
Cell, 86 (1996), pp. 345-348
[22.]
R.D. Newberry, W.F. Stenson, R.G. Lorenz.
Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen.
Nature Med, 5 (1999), pp. 900-906
[23.]
R.D. Mewberry, J.S. McDonough, W.F. Stenson, R.G. Lorenz.
Spontaneous and continuos cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: directing the tone of the intestinal immune response.
J Immunol, 166 (2001), pp. 4465-4472
[24.]
C. Nagler-Anderson.
Man the barrier! Strategic defenses in the intestinal mucosa.
Nature Rev Immunol, 1 (2001), pp. 59-67
[25.]
W.L. Beatty, P.J. Sansonetti.
Role of lipopolysaccharide in signaling to subepithelial polymorphonuclear leukocytes.
Infect Immunol, 65 (1997), pp. 4395-4404
[26.]
E. Breese, C.P. Braegger, C.J. Corrigan, J.A. Walker-Smith, T.T. MacDonald.
Interleukin-2 and interferon-gamma secreting T cells in normal and diseased human intestinal mucosa.
Immunology, 78 (1993), pp. 127-131
[27.]
R.B. Sartor.
Cytokines in intestinal inflammation: pathophysiological and clinical considerations.
Gastroenterology, 106 (1994), pp. 533-539
[28.]
L.V. Hooper, T.S. Stappenbeck, C.V. Hong, J.I. Gordon.
Angiogenins: a new class of microbicidal proteins involved in innate immunity.
Nature Immunol, 4 (2003), pp. 269-273
[29.]
P.J. Sansonetti.
War and peace at mucosal surfaces.
Nature Rev Immunol, 4 (2004), pp. 953-964
[30.]
M. Wills-Karp, J. Santeliz, C.L. Karp.
The germless theory of allergic disease: revisiting the hygiene hypothesis.
Nature Rev Immunol, 1 (2001), pp. 69-75
[31.]
L. Steidler, W. Hans, L. Schotte, S. Neirynck, F. Obermeier, W. Falk, et al.
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.
Science, 289 (2002), pp. 1352-1354
[32.]
M.E.H. Bashir, P. Andersen, I.J. Fuss, H.N. Shi, C. Nagler-Anderson.
An enteric helminth infection protects against an allergic response to dietary antigen.
J Immunol, 169 (2002), pp. 3284-3292
[33.]
M. Simmaco, M.L. Mangoni, A. Boman, D. Barra, H.G. Boman.
Experimental infections of Rana esculenta with Aeromonas hydrophila: a molecular mechanism for the control of the normal flora.
Scand J Immunol, 48 (1998), pp. 357-363
[34.]
J. Klein.
Batrachomyomachia: Frogs 1, Mice 0.
Scand J Immunol, 49 (1999), pp. 11-13
[35.]
C. Combes.
Les associations du vivant: L‘art d’être parasite.
Flammarion, (2001),
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