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Vol. 3. Issue 5.
Pages 237-240 (September - October 2007)
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Vol. 3. Issue 5.
Pages 237-240 (September - October 2007)
Caso clínico
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Artritis séptica por Bacteroides fragilis en paciente con linfoma no hodgkiniano y enfermedad mixta del tejido conectivo
Septic arthritis due to Bacteroides fragilis in a patient with non-Hodgkin lymphoma and mixed connective tissue disease
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Mario Luis Cousseaua,
Corresponding author
mlcousseau@yahoo.com.ar

Correspondencia: Dr. M.L. Cousseau. Policlínica Privada Paz. 7000 Tandil. Buenos Aires. Argentina.
, Jorge Gentileb, Roxana Pérezc
a Servicio de Reumatología. Policlínica Privada Paz. Tandil. Buenos Aires. Argentina
b Servicio de Infectología. Sanatorio Tandil. Tandil. Buenos Aires. Argentina
c Laboratorio de Bioquímica. Sanatorio Tandil. Tandil. Buenos Aires. Argentina
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Presentamos una paciente de 53 años de edad con enfermedad mixta del tejido conectivo que desarrolló un linfoma no hodgkiniano de alto grado de malignidad y 2 años más tarde, un cuadro de absceso inguinal izquierdo, luego tenosinovitis supurada de tobillo izquierdo y, finalmente, artritis séptica del hombro derecho y tenosinovitis supurada del tercer dedo de la mano derecha. Se logró aislar Bacteroides fragilis en líquido sinovial del hombro, en hemocultivos y en punta de catéter central intravenoso. El foco infeccioso primario se presume que haya sido intraabdominal, y el catéter central en permanencia, el factor de mantenimiento de la infección crónica. Utilizamos un tratamiento empírico secuencial de ampicilina/sulbactam y clindamicina intravenosos y más tarde metronidazol por vía oral hasta la cura definitiva de la infección. La artritis séptica por Bacteroides fragilis es una entidad rara que ocurre principalmente en pacientes inmunodeficientes, tal como refleja este caso.

Palabras clave:
Artritis séptica
Bacteroides fragilis
Linfoma no hodgkiniano

We present a 53 year old woman with pre-existing mixed collagen tissue disease who developped highly-malignant non-Hodgkin lymphoma and 2 years later had left groin abscess, then septic tenosynovitis of the left ankle, septic artrhritis of the right shoulder and purulent tenosynovitis of the right hand. Bacteroides fragilis was identified in synovial fluid drawn from the right shoulder, in blood cultures and in culture of a central venous catheter tip. The primary infection site is presumed to have been the abdominal cavity, and the presence of an indwelling central venous catheter the reason for recurrence of infection. We treated her empyrically with intravenous ampicillin/sulbactam and clindamycine then oral metronidazol until definite resolution of the infection. Septic artrhritis due to Bacteroides fragilis is a rare entity mainly occurring in immunocompromised patients, as shown in this case.

Key words:
Septic arthritis
Bacteroides fragilis
Non-Hodgkin lymphoma
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Bibliografía
[1.]
D.L. Goldenberg.
Artritis bacteriana. Kelley's Reumatología.
6.a ed., Marban Editores, (2003),
[2.]
C.J. Kaandorp, H.J. Dinant, M.A. Van de Laar, H.J. Moens, A.P. Prins, B.A. Dijkmans.
Incidence and sources of native and prosthetic joint infection: a community based prospective survey.
Ann Rheum Dis, 56 (1997), pp. 470-475
[3.]
M.J. Ryan, R. Kavanagh, P.G. Wall, B.L. Hazleman.
Bacterial joint infections in England and Wales: analysis of bacterial isolates over a four year period.
Br J Rheumatol, 36 (1997), pp. 370-373
[4.]
D.S. Morgan, D. Fisher, A. Merianos, B.J. Currie.
An 18 year clinical review of septic arthritis from tropical Australia.
Epidemiol Infect, 117 (1996), pp. 423-428
[5.]
L. Le Dantec, F. Maury, R.M. Flipo, S. Laskri, B. Cortet, B. Duquesnoy, et al.
Peripheral pyogenic arthritis. A study of one hundred seventy-nine cases.
Rev Rhum Engl Ed, 63 (1996), pp. 103-110
[6.]
A. Borer, G. Weber, K. Riesenberg, F. Schlaffer, J. Horowitz.
Septic arthritis due to Bacteroides fragilis after pilonidal sinus resection in a patient with rheumatoid arthritis.
Clinical Reumatology, 16 (1997), pp. 632-634
[7.]
J.M. Nolla, C. Gomez-Vaquero, J. Fiter, L. Mateo, X. Juanola, J. Rodriguez-Moreno, et al.
Pyarthrosis in patients with rheumatoid arthritis: a detailed analysis of 10 cases and literature review.
Semin Arthritis Rheum, 30 (2000), pp. 121-126
[8.]
J.J. Alegre-Sancho, X. Juanola, F.J. Narvaez, D. Roig-Escofet.
Septic arthritis due to Prevotella bivia in a patient with rheumatoid arthritis.
Joint Bone Spine, 67 (2000), pp. 228-229
[9.]
P.D. Sonsale, M.R. Philipson, J. Bowskill.
Septic arthritis of the knee due to Fusobacterium necrophorum.
J Clin Microbiol, 42 (2004), pp. 3369-3370
[10.]
M. Roche, E. Smyth.
A case of septic arthritis due to infection with Gemella morbillorum.
J Infect, 51 (2005), pp. e187-e189
[11.]
I. Brook, E. Frazier.
Anaerobic osteomyelitis and arthritis in a military hospital: a 10-year experience.
Am J Med, 94 (1993), pp. 21-28
[12.]
P. Rosenkranz, M.M. Ledermann, K.V. Gopalakrishna, J. Ellner.
Septic arthritis caused by Bacteroides fragilis.
Rev Infect Dis, 12 (1990), pp. 20-30
[13.]
K. Konstantopoulos, A. Avlami, K. Demarongona, G. Sideris, L. Rekoumi, J. Stefanou, et al.
Bacteroides fragilis arthritis in a sickle cell-thalassaemia patient.
Scand J Infect Dis, 26 (1994), pp. 495-497
[14.]
M. Merle-Melet, D. Mainard, D. Regent, C. Dopff, J.N. Tamisier, P. Ross, et al.
An unusual case of hip septic arthritis due to Bacteroides fragilis in an alcoholic patient.
Infection, 22 (1994), pp. 353-355
[15.]
SM. Finegold.
Anaerobic bacteria: general concepts.
Principles and practice of infectious diseases, 5.ª ed., pp. 2519-2527
[16.]
D.M. Citron, P.C. Appelbaum.
How far should a clinical laboratory go in identifying anaerobic isolates, and who should pay?.
Clin Infect Dis, 16 (1993), pp. S435-S438
[17.]
M. Studahl, B. Bergman, P. Kalebo, J. Lindberg.
Septic arthritis of the knee: a 10-year review and long-term follow-up using a new scoring system.
Scand J Infect Dis, 26 (1994), pp. 85-93
Copyright © 2007. Elsevier España S.L Barcelona
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