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Vol. 4. Issue 1.
Pages 37-39 (January - February 2008)
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Vol. 4. Issue 1.
Pages 37-39 (January - February 2008)
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Chondrocalcinosis and Hypomagnesemia: Clinical and Radiological Progression
Condrocalcinosis e hipomagnesemia: evolución clinicorradiológica
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José González Domíngueza,
Corresponding author
jose.gonzalez.dominguez.sspa@juntadeandalucia.es

Correspondence: Servicio de Reumatología. Hospital Clínico San Cecilio. Avda. Dr. Oloriz, 16. 18012 Granada. España.
, Alejandro Escudero Contrerasb, Verónica Pérez Guijob, Francisco Ginés Martínez Sánchezb, Miguel Ángel Caracuel Ruizb, Eduardo Collantes Estévezb
a Servicio de Reumatología, Hospital Clínico San Cecilio, Granada, Spain
b Sergicio de Reumatología, Hospital Universitario Reina Sofía, Córdoba, Spain
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Hypomagnesemia is a rare secondary metabolic disorder associated with calcium pyrophosphate dihydrate cristal deposition disease in joint structures and may cause asymptomatic chondrocalcinosis (linear calcification of cartilage), pseudogout, and chronic arthropathy.

We report 2 young men with relapsing acute knee monoarthritis with chondrocalcinosis and hypomagnesemia. After follow-up clinical and radiological events at least for 5 years and treatment with magnesium lactate, these patients have not shown new pseudogout attacks. We discuss knee radiological evolution in both patients, outstanding major knee radiological deterioration in the patient with early symptoms and a familial chondrocalcinosis association, in spite of clinical asymptomatic status.

Key words:
Chondrocalcinosis
Hypomagnesemia
Calcium pyrophosphate

Entre las causas secundarias infrecuentes de la enfermedad por depósitos de cristales de pirofosfato cálcico se incluye la hipomagnesemia.

Se presentan 2 casos de pacientes jóvenes con ataques repetidos de monoartritis en rodillas con condrocalcinosis articular e hipomagnesemia. Tras seguimiento clinicorradiológico y tratamiento con lactato de magnesio durante al menos 5 años, los pacientes no han presentado nuevos ataques de seudogota en rodillas. Se discute la evolución clinicorradiológica de las rodillas afectadas en ambos pacientes; destaca el mayor deterioro radiológico en sus rodillas del paciente con inicio más precoz y antecedentes familiares de condrocalcinosis articular, a pesar de seguir clínicamente asintomático.

Palabras clave:
Condrocalcinosis
Hipomagnesemia
Pirofosfato cálcico
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Copyright © 2008. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
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