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Vol. 17. Issue 3.
Pages 170-174 (March 2021)
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Vol. 17. Issue 3.
Pages 170-174 (March 2021)
Review Article
DOI: 10.1016/j.reumae.2020.03.002
Efficacy of belimumab in Primary Sjögren's syndrome: A systematic review
Eficacia del belimumab en el síndrome de Sjögren primario: una revisión sistemática
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Noelia Álvarez-Rivasa,?
Corresponding author
nalvriv@gmail.com

Corresponding author.
, Hye Sang-Parkb, Petra Díaz del Campoc, Mónica Fernández-Castrod, Hector Corominasb, José Luis Andreue, Victoria Navarro-Compánf
a Rheumatology Department. Hospital Universitario San Agustín, Avilés, Spain
b Rheumatology Division, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain
c Research Unit, Spanish Society of Rheumatology, Madrid, Spain
d Rheumatology Department. Hospital Universitario Infanta Sofia, Madrid, Spain
e Rheumatology Department, Hospital Universitario Puerta del Hierro Majadahonda, Majadahonda, Spain
f Rheumatology Department, IdiPaz, Hospital Universitario La Paz, Madrid, Spain
Article information
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Table 1. Table of evidence of studies: design and outcomes.
Table 2. Baseline characteristics of patients included in the selected studies.
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Abstract
Objective

To evaluate the efficacy and safety of belimumab in patients with Primary Sjögren's syndrome (pSS).

Methods

The search included manuscripts assessing the efficacy or safety of belimumab in patients with pSS (American-European Consensus Criteria 2002) published between 2004 and 2017 in MEDLINE, EMBASE or Cochrane databases. Two reviewers independently selected the articles, extracted data and evaluated the quality of the evidence following Scottish Intercollegiate Guidelines Network (SIGN) recommendation grades.

Results

Out of 135 citations, only 3 articles were included. All of them publishing results from the same study at different time points including 28 patients. At week 28 improvement was reported for visual analogue scale (VAS) dryness score and glandular manifestations in 37% and 77% of patients, respectively, which persisted at week 52 (W52). Belimumab was well tolerated and safely administered.

Conclusion

Published evidence to determine the efficacy of belimumab in pSS is limited. Belimumab seems to be effective to reduce systemic activity, parotid enlargement, lymphadenopathies, articular manifestation and B cell biomarkers.

Keywords:
Primary Sjögren's syndrome
B-cell targeted therapy
Belimumab
Systematic review
Resumen
Objetivo

Evaluar la eficacia y la seguridad de belimumab en pacientes con síndrome de Sjögren primario (SSp).

Métodos

La búsqueda incluyó manuscritos que evaluaban la eficacia o seguridad de belimumab en pacientes con SSp (Criterios Europeo-Americanos del 2002) publicados entre 2004 y 2007 en MEDLINE, EMBASE o Cochrane database. Dos revisores independientes seleccionaron los artículos, extrajeron los datos y evaluaron la calidad de la evidencia según los grados de recomendación de la Scottish Intercollegiate Guidelines Network (SIGN).

Resultados

De 135 artículos se incluyeron 3. Todos publicaban resultados del mismo estudio en diferentes momentos, incluyéndose 28 pacientes. En la semana 28 presentaban una mejoría en la puntuación de sequedad en la escala analógica visual (VAS) y en las manifestaciones glandulares un 37 y 77% de los pacientes, respectivamente, que persistieron en la 52. La administración de belimumab fue segura y bien tolerada.

Conclusión

Belimumab parece ser efectivo para reducir la actividad sistémica, el aumento parotídeo, las linfadenopatías, las manifestaciones articulares y los biomarcadores de células B, aunque con evidencia limitada.

Palabras clave:
Síndrome de Sjögren primario
Terapia dirigida frente a células B
Belimumab
Revisión sistemática

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