Clinical Cases
Acute Leukemia in Children Erroneously Diagnosed as Idiopathic Juvenile Arthritis
Leucemia aguda en niños con diagnóstico erróneo de artritis idiopática juvenil
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Rodríguez" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Natalí" "apellidos" => "Serra-Bonett" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Yusmary" "apellidos" => "Guzmán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ernesto" "apellidos" => "Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Alberto" "apellidos" => "Millán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:4 [ "nombre" => "Martín A." "apellidos" => "Rodríguez" "email" => array:1 [ 0 => "martinalbertove@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Pediatría, Hospital Universitario de Caracas, Caracas, Venezuela" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Hospital Universitario de Caracas. Caracas. Apartado 47365. Caracas 1010. Venezuela." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Leucemia aguda en niños con diagnóstico erróneo de artritis idiopática juvenil" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111765" "palabras" => array:3 [ 0 => "Acute leukemia" 1 => "Juvenile arthritis" 2 => "Osteolysis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111766" "palabras" => array:3 [ 0 => "Leucemia" 1 => "Artritis juvenil" 2 => "Osteólisis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We here present 3 Venezuelan children with acute leukemia, initially diagnosed as idiopathic juvenile arthritis because of the occurrence of pain and joint swelling at the onset of disease. Joint pain was aggravated at night and the arthritis showed a migratory pattern, mainly affecting large joints in an asymmetrical fashion. One patient presented with persistent unilateral sacroiliac pain leading to a wrong diagnosis of spondyloarthritis. The elevation of acute phase reactants, disproportionate to the extent of joint disease, and marked elevation of serum lactate dehydrogenase, as well as characteristic radiological changes allowed the correct diagnosis in all cases. This combination of clinical manifestations, clinical laboratory findings, and joint and bone imaging should prompt the clinician to an early diagnosis of acute leukemia in children with arthritis.</p>" ] "es" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se presentan 3 niños venezolanos con leucemia aguda cuya enfermedad se inició con dolor e inflamación articular, inicialmente se les diagnosticó artritis idiopática juvenil. El cuadro clínico se caracterizó por artritis migratoria de grandes articulaciones, dolor óseo metafisario de predominio nocturno, aumento de los reactantes de fase aguda desproporcionado para el número de articulaciones afectadas y elevación de la lactatodeshidrogenasa. Un paciente presentó dolor sacroilíaco persistente que condujo al diagnóstico incorrecto de espondiloartritis. Los hallazgos radiológicos predominantes fueron osteopenia, osteólisis y presencia de bandas radiotransparentes metafisarias. Esta combinación de manifestaciones clínicas, hallazgos de laboratorio y cambios radiológicos debe hacer sospechar una enfermedad mieloproliferativa en niños con inflamación articular.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2014 September | 9 | 53 | 62 |
| 2014 August | 12 | 50 | 62 |
| 2014 July | 18 | 78 | 96 |
| 2014 June | 30 | 48 | 78 |
| 2014 May | 33 | 32 | 65 |
| 2014 April | 23 | 40 | 63 |
| 2014 March | 33 | 39 | 72 |
| 2014 February | 21 | 39 | 60 |
| 2014 January | 26 | 27 | 53 |
| 2013 December | 20 | 32 | 52 |
| 2013 November | 16 | 28 | 44 |
| 2013 October | 26 | 33 | 59 |
| 2013 September | 29 | 45 | 74 |
| 2013 August | 23 | 38 | 61 |
| 2013 July | 20 | 40 | 60 |
| 2013 June | 17 | 32 | 49 |
| 2013 May | 90 | 29 | 119 |
| 2013 April | 20 | 18 | 38 |
| 2013 March | 21 | 31 | 52 |
| 2013 February | 26 | 15 | 41 |
| 2013 January | 29 | 16 | 45 |
| 2012 December | 22 | 4 | 26 |
| 2012 November | 3 | 15 | 18 |
| 2012 October | 8 | 10 | 18 |
| 2012 September | 8 | 7 | 15 |
| 2012 June | 2 | 0 | 2 |
| 2012 April | 6 | 0 | 6 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 3 | 0 | 3 |
| 2012 January | 2 | 0 | 2 |
| 2011 December | 3 | 0 | 3 |
| 2011 November | 5 | 0 | 5 |
| 2011 October | 4 | 0 | 4 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 2 | 0 | 2 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 March | 2 | 0 | 2 |
| 2011 February | 4 | 0 | 4 |
| 2011 January | 4 | 0 | 4 |
| 2010 December | 3 | 0 | 3 |
| 2010 November | 10 | 0 | 10 |
| 2010 October | 5 | 0 | 5 |
| 2010 September | 2 | 0 | 2 |
| 2010 August | 6 | 0 | 6 |
| 2010 July | 5 | 0 | 5 |
| 2010 May | 11 | 0 | 11 |
| 2010 April | 7 | 0 | 7 |
| 2010 March | 6 | 0 | 6 |
| 2010 February | 6 | 0 | 6 |
| 2010 January | 13 | 0 | 13 |
| 2009 December | 16 | 0 | 16 |
| 2009 November | 2 | 0 | 2 |
| 2009 October | 7 | 0 | 7 |
| 2009 September | 6 | 0 | 6 |
| 2009 August | 9 | 0 | 9 |
| 2009 July | 5 | 0 | 5 |
| 2009 June | 10 | 0 | 10 |
| 2009 May | 7 | 0 | 7 |
| 2009 April | 13 | 0 | 13 |
| 2009 March | 9 | 0 | 9 |
Show all
