array:22 [
  "pii" => "S2173574308701746"
  "issn" => "21735743"
  "doi" => "10.1016/S2173-5743(08)70174-6"
  "estado" => "S300"
  "fechaPublicacion" => "2008-07-01"
  "aid" => "70174"
  "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "edi"
  "cita" => "Reumatol Clin. 2008;4:129-31"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1689
    "formatos" => array:3 [
      "EPUB" => 37
      "HTML" => 1038
      "PDF" => 614
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574308701758"
    "issn" => "21735743"
    "doi" => "10.1016/S2173-5743(08)70175-8"
    "estado" => "S300"
    "fechaPublicacion" => "2008-07-01"
    "aid" => "70175"
    "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2008;4:132-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1848
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 1211
        "PDF" => 593
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Susceptibility of the Spanish Population to Adverse Effects by Sulfasalazine: Systematic Review"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "132"
          "paginaFinal" => "135"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Susceptibilidad de la población española a los efectos adversos por sulfasalazina: revisión sistemática"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Cayetano Alegre de Miquel, Carlos Santos Ramírez, Mireia Barceló Bru"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Cayetano"
              "apellidos" => "Alegre de Miquel"
            ]
            1 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Santos Ramírez"
            ]
            2 => array:2 [
              "nombre" => "Mireia"
              "apellidos" => "Barceló Bru"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574308701758?idApp=UINPBA00004M"
    "url" => "/21735743/0000000400000004/v1_201305061547/S2173574308701758/v1_201305061547/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Animal Models in Rheumatoid Arthritis"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "129"
        "paginaFinal" => "131"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mònica Gumà Uriel"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "Mònica Gumà"
            "apellidos" => "Uriel"
            "email" => array:1 [
              0 => "mguma@ucsd.edu"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Laboratory of Gene Regulation and Signal Transduction&#44; Department of Pharmacology&#44; School of Medicine&#44; University of California&#44; San Diego&#44; USA"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Laboratory of Gene Regulation and Signal Transduction&#44; Department of Pharmacology&#44; School of Medicine&#44; University of California&#44; San Diego&#44; 9500 Gilman Drive&#44; La Jolla&#44; CA 92093-0723&#44; USA"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2008-04-14"
    "fechaAceptado" => "2008-04-16"
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:26 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Animal models of rheumatoid arthritis and their relevance to human disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Kannan"
                            1 => "R&#46;A&#46; Ortmann"
                            2 => "D&#46; Kimpel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.pathophys.2005.07.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pathophysiology"
                        "fecha" => "2005"
                        "volumen" => "12"
                        "paginaInicial" => "167"
                        "paginaFinal" => "181"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16171986"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rodent models of arthritis&#58; relevance for human disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;O&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "1998"
                        "volumen" => "114"
                        "paginaInicial" => "330"
                        "paginaFinal" => "332"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9844039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Animal models of arthritis caused by systemic alteration of the immune system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Sakaguchi"
                            1 => "N&#46; Sakaguchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.coi.2005.09.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Immunol"
                        "fecha" => "2005"
                        "volumen" => "17"
                        "paginaInicial" => "589"
                        "paginaFinal" => "594"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16214319"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagen-induced arthritis as a model for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;O&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1385/1-59259-771-8:207"
                      "Revista" => array:6 [
                        "tituloSerie" => "Methods Mol Med"
                        "fecha" => "2004"
                        "volumen" => "98"
                        "paginaInicial" => "207"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15064442"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibody-induced arthritis&#58; disease mechanisms and genes involved at the effector phase of arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;S&#46; Nandakumar"
                            1 => "R&#46; Holmdahl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar2089"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2006"
                        "volumen" => "8"
                        "paginaInicial" => "223"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17254316"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The KRN mouse model of inflammatory arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Kyburz"
                            1 => "M&#46; Corr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00281-003-0131-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Springer Semin Immunopathol"
                        "fecha" => "2003"
                        "volumen" => "25"
                        "paginaInicial" => "79"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12904893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The TNF-alpha transgenic mouse model of inflammatory arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Li"
                            1 => "E&#46;M&#46; Schwarz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00281-003-0125-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Springer Semin Immunopathol"
                        "fecha" => "2003"
                        "volumen" => "25"
                        "paginaInicial" => "19"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12904889"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Niki"
                            1 => "H&#46; Yamada"
                            2 => "S&#46; Seki"
                            3 => "T&#46; Kikuchi"
                            4 => "H&#46; Takaishi"
                            5 => "Y&#46; Toyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI11530"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2001"
                        "volumen" => "107"
                        "paginaInicial" => "1127"
                        "paginaFinal" => "1135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11342576"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The usefulness and the limitations of animal models in identifying targets for therapy in arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;H&#46; Wooley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.berh.2003.09.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Best Pract Res Clin Rheumatol"
                        "fecha" => "2004"
                        "volumen" => "18"
                        "paginaInicial" => "47"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15123037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluating the validity of animal models for research into therapies for immune-based disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;A&#46; &#8216;t Hart"
                            1 => "S&#46; Amor"
                            2 => "M&#46; Jonker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1359-6446(04)03112-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Discov Today"
                        "fecha" => "2004"
                        "volumen" => "9"
                        "paginaInicial" => "517"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15183159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Considerations for the sensible use of rodent models of inflammatory disease in predicting efficacy of new biological therapeutics in the clinic"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;A&#46; Arnett"
                            1 => "J&#46;L&#46; Viney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.addr.2007.06.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Drug Deliv Rev"
                        "fecha" => "2007"
                        "volumen" => "59"
                        "paginaInicial" => "1084"
                        "paginaFinal" => "1092"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17804112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utility of animal models for identification of potential therapeutics for Rheumatoid Arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Hegen"
                            1 => "J&#46;C&#46; Keith Jr&#46;"
                            2 => "M&#46; Collins"
                            3 => "C&#46;L&#46; Nickerson-Nutter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Ann Rheum Dis&#46;"
                        "fecha" => "2007"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arguments for IL-1 as a target in chronic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;B&#46; van der Berg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2000"
                        "volumen" => "59"
                        "numero" => "Suppl I"
                        "paginaInicial" => "i81"
                        "paginaFinal" => "i84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11053095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Horneff"
                            1 => "G&#46;R&#46; Burmester"
                            2 => "F&#46; Emmrich"
                            3 => "J&#46;R&#46; Kalden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1991"
                        "volumen" => "34"
                        "paginaInicial" => "129"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1994909"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibody therapy for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;C&#46; Taylor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Pharmacol"
                        "fecha" => "2003"
                        "volumen" => "3"
                        "paginaInicial" => "323"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12810200"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;O&#46; Williams"
                            1 => "M&#46; Feldmann"
                            2 => "R&#46;N&#46; Maini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1992"
                        "volumen" => "89"
                        "paginaInicial" => "9784"
                        "paginaFinal" => "9788"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1409699"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor necrosis factor inhibitors for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;L&#46; Scott"
                            1 => "G&#46;H&#46; Kingsley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMct055183"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2006"
                        "volumen" => "355"
                        "paginaInicial" => "704"
                        "paginaFinal" => "712"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16914706"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagen-induced arthritis in the BB rat"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;B&#46; Knoerzer"
                            1 => "R&#46;W&#46; Karr"
                            2 => "B&#46;D&#46; Schwartz"
                            3 => "L&#46;J&#46; Mengle-Gaw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Prevention of disease by treatment with CTLA-4- Ig&#46; J Clin Invest"
                        "fecha" => "1995"
                        "volumen" => "96"
                        "paginaInicial" => "987"
                        "paginaFinal" => "993"
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674901483473"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept&#58; twelve-month results of a phase iib&#44; double-blind&#44; randomized&#44; placebocontrolled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Kremer"
                            1 => "M&#46; Dougados"
                            2 => "P&#46; Emery"
                            3 => "P&#46; Durez"
                            4 => "J&#46; Sibilia"
                            5 => "W&#46; Shergy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.21201"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "2263"
                        "paginaFinal" => "2271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16052582"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "B-cell depletion inhibits arthritis in a collagen-induced arthritis &#40;CIA&#41; model&#44; but does not adversely affect humoral responses in a respiratory syncytial virus &#40;RSV&#41; vaccination model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Dunussi-Joannopoulos"
                            1 => "G&#46;E&#46; Hancock"
                            2 => "A&#46; Kunz"
                            3 => "M&#46; Hegen"
                            4 => "X&#46;X&#46; Zhou"
                            5 => "B&#46;J&#46; Sheppard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2004-11-4547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2005"
                        "volumen" => "106"
                        "paginaInicial" => "2235"
                        "paginaFinal" => "2243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15947095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Edwards"
                            1 => "L&#46; Szczepanski"
                            2 => "J&#46; Szechinski"
                            3 => "A&#46; Filipowicz-Sosnowska"
                            4 => "P&#46; Emery"
                            5 => "D&#46;R&#46; Close"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa032534"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "2572"
                        "paginaFinal" => "2581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15201414"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin 6 is required for the development of collagen-induced arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Alonzi"
                            1 => "E&#46; Fattori"
                            2 => "D&#46; Lazzaro"
                            3 => "P&#46; Costa"
                            4 => "L&#46; Probert"
                            5 => "G&#46; Kollias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1998"
                        "volumen" => "187"
                        "paginaInicial" => "461"
                        "paginaFinal" => "468"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9463396"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist&#44; tocilizumab&#44; in European patients with rheumatoid arthritis who had an incomplete response to methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;N&#46; Maini"
                            1 => "P&#46;C&#46; Taylor"
                            2 => "J&#46; Szechinski"
                            3 => "K&#46; Pavelka"
                            4 => "J&#46; Br&#246;ll"
                            5 => "G&#46; Balint"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.22033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2006"
                        "volumen" => "54"
                        "paginaInicial" => "2817"
                        "paginaFinal" => "2829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16947782"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of rheumatoid arthritis with humanized anti-interleukin- 6 receptor antibody&#58; a multicenter&#44; double-blind&#44; placebo-controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Nishimoto"
                            1 => "K&#46; Yoshizaki"
                            2 => "N&#46; Miyasaka"
                            3 => "K&#46; Yamamoto"
                            4 => "S&#46; Kawai"
                            5 => "T&#46; Takeuchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.20303"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "50"
                        "paginaInicial" => "1761"
                        "paginaFinal" => "1769"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15188351"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Pine"
                            1 => "B&#46; Chang"
                            2 => "N&#46; Schoettler"
                            3 => "M&#46;L&#46; Banquerigo"
                            4 => "S&#46; Wang"
                            5 => "A&#46; Lau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clim.2007.03.543"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Immunol"
                        "fecha" => "2007"
                        "volumen" => "124"
                        "paginaInicial" => "244"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17537677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mitogen activated protein kinase inhibitors&#58; where are we now and where are we going&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;E&#46; Sweeney"
                            1 => "G&#46;S&#46; Firestein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2006.058388"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2006"
                        "volumen" => "65"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "iii83"
                        "paginaFinal" => "iii88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17038480"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000400000004/v1_201305061547/S2173574308701746/v1_201305061547/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "17335"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000400000004/v1_201305061547/S2173574308701746/v1_201305061547/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574308701746?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Animal Models in Rheumatoid Arthritis
Mònica Gumà Uriel
Corresponding author
mguma@ucsd.edu

Correspondence: Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, USA
Read
4887
Times
was read the article
2670
Total PDF
2217
Total HTML
Share statistics
 array:22 [
  "pii" => "S2173574308701746"
  "issn" => "21735743"
  "doi" => "10.1016/S2173-5743(08)70174-6"
  "estado" => "S300"
  "fechaPublicacion" => "2008-07-01"
  "aid" => "70174"
  "copyright" => "Sociedad Espa&#241;ola de Reumatolog&#237;a and Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "edi"
  "cita" => "Reumatol Clin. 2008;4:129-31"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1689
    "formatos" => array:3 [
      "EPUB" => 37
      "HTML" => 1038
      "PDF" => 614
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574308701758"
    "issn" => "21735743"
    "doi" => "10.1016/S2173-5743(08)70175-8"
    "estado" => "S300"
    "fechaPublicacion" => "2008-07-01"
    "aid" => "70175"
    "copyright" => "Sociedad Espa&#241;ola de Reumatolog&#237;a and Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2008;4:132-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1848
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 1211
        "PDF" => 593
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Susceptibility of the Spanish Population to Adverse Effects by Sulfasalazine&#58; Systematic Review"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "132"
          "paginaFinal" => "135"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Susceptibilidad de la poblaci&#243;n espa&#241;ola a los efectos adversos por sulfasalazina&#58; revisi&#243;n sistem&#225;tica"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Cayetano Alegre de Miquel, Carlos Santos Ram&#237;rez, Mireia Barcel&#243; Bru"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Cayetano"
              "apellidos" => "Alegre de Miquel"
            ]
            1 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Santos Ram&#237;rez"
            ]
            2 => array:2 [
              "nombre" => "Mireia"
              "apellidos" => "Barcel&#243; Bru"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574308701758?idApp=UINPBA00004M"
    "url" => "/21735743/0000000400000004/v1_201305061547/S2173574308701758/v1_201305061547/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Animal Models in Rheumatoid Arthritis"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "129"
        "paginaFinal" => "131"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#242;nica Gum&#224; Uriel"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "M&#242;nica Gum&#224;"
            "apellidos" => "Uriel"
            "email" => array:1 [
              0 => "mguma&#64;ucsd&#46;edu"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Laboratory of Gene Regulation and Signal Transduction&#44; Department of Pharmacology&#44; School of Medicine&#44; University of California&#44; San Diego&#44; USA"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Laboratory of Gene Regulation and Signal Transduction&#44; Department of Pharmacology&#44; School of Medicine&#44; University of California&#44; San Diego&#44; 9500 Gilman Drive&#44; La Jolla&#44; CA 92093-0723&#44; USA"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2008-04-14"
    "fechaAceptado" => "2008-04-16"
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:26 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Animal models of rheumatoid arthritis and their relevance to human disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Kannan"
                            1 => "R&#46;A&#46; Ortmann"
                            2 => "D&#46; Kimpel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.pathophys.2005.07.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pathophysiology"
                        "fecha" => "2005"
                        "volumen" => "12"
                        "paginaInicial" => "167"
                        "paginaFinal" => "181"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16171986"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rodent models of arthritis&#58; relevance for human disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;O&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "1998"
                        "volumen" => "114"
                        "paginaInicial" => "330"
                        "paginaFinal" => "332"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9844039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Animal models of arthritis caused by systemic alteration of the immune system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Sakaguchi"
                            1 => "N&#46; Sakaguchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.coi.2005.09.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Immunol"
                        "fecha" => "2005"
                        "volumen" => "17"
                        "paginaInicial" => "589"
                        "paginaFinal" => "594"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16214319"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagen-induced arthritis as a model for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;O&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1385/1-59259-771-8:207"
                      "Revista" => array:6 [
                        "tituloSerie" => "Methods Mol Med"
                        "fecha" => "2004"
                        "volumen" => "98"
                        "paginaInicial" => "207"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15064442"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibody-induced arthritis&#58; disease mechanisms and genes involved at the effector phase of arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;S&#46; Nandakumar"
                            1 => "R&#46; Holmdahl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar2089"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2006"
                        "volumen" => "8"
                        "paginaInicial" => "223"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17254316"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The KRN mouse model of inflammatory arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Kyburz"
                            1 => "M&#46; Corr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00281-003-0131-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Springer Semin Immunopathol"
                        "fecha" => "2003"
                        "volumen" => "25"
                        "paginaInicial" => "79"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12904893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The TNF-alpha transgenic mouse model of inflammatory arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Li"
                            1 => "E&#46;M&#46; Schwarz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00281-003-0125-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Springer Semin Immunopathol"
                        "fecha" => "2003"
                        "volumen" => "25"
                        "paginaInicial" => "19"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12904889"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Niki"
                            1 => "H&#46; Yamada"
                            2 => "S&#46; Seki"
                            3 => "T&#46; Kikuchi"
                            4 => "H&#46; Takaishi"
                            5 => "Y&#46; Toyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI11530"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "2001"
                        "volumen" => "107"
                        "paginaInicial" => "1127"
                        "paginaFinal" => "1135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11342576"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The usefulness and the limitations of animal models in identifying targets for therapy in arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;H&#46; Wooley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.berh.2003.09.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Best Pract Res Clin Rheumatol"
                        "fecha" => "2004"
                        "volumen" => "18"
                        "paginaInicial" => "47"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15123037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluating the validity of animal models for research into therapies for immune-based disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;A&#46; &#8216;t Hart"
                            1 => "S&#46; Amor"
                            2 => "M&#46; Jonker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1359-6446(04)03112-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Discov Today"
                        "fecha" => "2004"
                        "volumen" => "9"
                        "paginaInicial" => "517"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15183159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Considerations for the sensible use of rodent models of inflammatory disease in predicting efficacy of new biological therapeutics in the clinic"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;A&#46; Arnett"
                            1 => "J&#46;L&#46; Viney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.addr.2007.06.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Drug Deliv Rev"
                        "fecha" => "2007"
                        "volumen" => "59"
                        "paginaInicial" => "1084"
                        "paginaFinal" => "1092"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17804112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utility of animal models for identification of potential therapeutics for Rheumatoid Arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Hegen"
                            1 => "J&#46;C&#46; Keith Jr&#46;"
                            2 => "M&#46; Collins"
                            3 => "C&#46;L&#46; Nickerson-Nutter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Ann Rheum Dis&#46;"
                        "fecha" => "2007"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arguments for IL-1 as a target in chronic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;B&#46; van der Berg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2000"
                        "volumen" => "59"
                        "numero" => "Suppl I"
                        "paginaInicial" => "i81"
                        "paginaFinal" => "i84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11053095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Horneff"
                            1 => "G&#46;R&#46; Burmester"
                            2 => "F&#46; Emmrich"
                            3 => "J&#46;R&#46; Kalden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1991"
                        "volumen" => "34"
                        "paginaInicial" => "129"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1994909"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibody therapy for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;C&#46; Taylor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Pharmacol"
                        "fecha" => "2003"
                        "volumen" => "3"
                        "paginaInicial" => "323"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12810200"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;O&#46; Williams"
                            1 => "M&#46; Feldmann"
                            2 => "R&#46;N&#46; Maini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1992"
                        "volumen" => "89"
                        "paginaInicial" => "9784"
                        "paginaFinal" => "9788"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1409699"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor necrosis factor inhibitors for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;L&#46; Scott"
                            1 => "G&#46;H&#46; Kingsley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMct055183"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2006"
                        "volumen" => "355"
                        "paginaInicial" => "704"
                        "paginaFinal" => "712"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16914706"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagen-induced arthritis in the BB rat"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;B&#46; Knoerzer"
                            1 => "R&#46;W&#46; Karr"
                            2 => "B&#46;D&#46; Schwartz"
                            3 => "L&#46;J&#46; Mengle-Gaw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Prevention of disease by treatment with CTLA-4- Ig&#46; J Clin Invest"
                        "fecha" => "1995"
                        "volumen" => "96"
                        "paginaInicial" => "987"
                        "paginaFinal" => "993"
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674901483473"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept&#58; twelve-month results of a phase iib&#44; double-blind&#44; randomized&#44; placebocontrolled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Kremer"
                            1 => "M&#46; Dougados"
                            2 => "P&#46; Emery"
                            3 => "P&#46; Durez"
                            4 => "J&#46; Sibilia"
                            5 => "W&#46; Shergy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.21201"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "2263"
                        "paginaFinal" => "2271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16052582"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "B-cell depletion inhibits arthritis in a collagen-induced arthritis &#40;CIA&#41; model&#44; but does not adversely affect humoral responses in a respiratory syncytial virus &#40;RSV&#41; vaccination model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Dunussi-Joannopoulos"
                            1 => "G&#46;E&#46; Hancock"
                            2 => "A&#46; Kunz"
                            3 => "M&#46; Hegen"
                            4 => "X&#46;X&#46; Zhou"
                            5 => "B&#46;J&#46; Sheppard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2004-11-4547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2005"
                        "volumen" => "106"
                        "paginaInicial" => "2235"
                        "paginaFinal" => "2243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15947095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Edwards"
                            1 => "L&#46; Szczepanski"
                            2 => "J&#46; Szechinski"
                            3 => "A&#46; Filipowicz-Sosnowska"
                            4 => "P&#46; Emery"
                            5 => "D&#46;R&#46; Close"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa032534"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "2572"
                        "paginaFinal" => "2581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15201414"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin 6 is required for the development of collagen-induced arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Alonzi"
                            1 => "E&#46; Fattori"
                            2 => "D&#46; Lazzaro"
                            3 => "P&#46; Costa"
                            4 => "L&#46; Probert"
                            5 => "G&#46; Kollias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "1998"
                        "volumen" => "187"
                        "paginaInicial" => "461"
                        "paginaFinal" => "468"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9463396"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist&#44; tocilizumab&#44; in European patients with rheumatoid arthritis who had an incomplete response to methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;N&#46; Maini"
                            1 => "P&#46;C&#46; Taylor"
                            2 => "J&#46; Szechinski"
                            3 => "K&#46; Pavelka"
                            4 => "J&#46; Br&#246;ll"
                            5 => "G&#46; Balint"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.22033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2006"
                        "volumen" => "54"
                        "paginaInicial" => "2817"
                        "paginaFinal" => "2829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16947782"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of rheumatoid arthritis with humanized anti-interleukin- 6 receptor antibody&#58; a multicenter&#44; double-blind&#44; placebo-controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Nishimoto"
                            1 => "K&#46; Yoshizaki"
                            2 => "N&#46; Miyasaka"
                            3 => "K&#46; Yamamoto"
                            4 => "S&#46; Kawai"
                            5 => "T&#46; Takeuchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.20303"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "50"
                        "paginaInicial" => "1761"
                        "paginaFinal" => "1769"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15188351"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Pine"
                            1 => "B&#46; Chang"
                            2 => "N&#46; Schoettler"
                            3 => "M&#46;L&#46; Banquerigo"
                            4 => "S&#46; Wang"
                            5 => "A&#46; Lau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clim.2007.03.543"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Immunol"
                        "fecha" => "2007"
                        "volumen" => "124"
                        "paginaInicial" => "244"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17537677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mitogen activated protein kinase inhibitors&#58; where are we now and where are we going&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;E&#46; Sweeney"
                            1 => "G&#46;S&#46; Firestein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2006.058388"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2006"
                        "volumen" => "65"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "iii83"
                        "paginaFinal" => "iii88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17038480"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000400000004/v1_201305061547/S2173574308701746/v1_201305061547/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "17335"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000400000004/v1_201305061547/S2173574308701746/v1_201305061547/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574308701746?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 9 13
2024 October 21 47 68
2024 September 25 43 68
2024 August 37 52 89
2024 July 26 41 67
2024 June 29 45 74
2024 May 38 52 90
2024 April 26 44 70
2024 March 33 43 76
2024 February 20 42 62
2024 January 16 37 53
2023 December 13 48 61
2023 November 14 41 55
2023 October 23 73 96
2023 September 20 57 77
2023 August 14 26 40
2023 July 18 34 52
2023 June 10 23 33
2023 May 14 11 25
2023 April 12 19 31
2023 March 19 31 50
2023 February 16 37 53
2023 January 21 45 66
2022 December 19 31 50
2022 November 14 29 43
2022 October 25 37 62
2022 September 40 35 75
2022 August 20 47 67
2022 July 24 49 73
2022 June 15 42 57
2022 May 19 43 62
2022 April 24 44 68
2022 March 20 44 64
2022 February 17 39 56
2022 January 16 38 54
2021 December 20 40 60
2021 November 38 39 77
2021 October 31 35 66
2021 September 22 45 67
2021 August 38 46 84
2021 July 12 29 41
2021 June 23 47 70
2021 May 16 30 46
2021 April 48 72 120
2021 March 19 40 59
2021 February 24 29 53
2021 January 15 21 36
2020 December 18 30 48
2020 November 14 24 38
2020 October 17 11 28
2020 September 15 19 34
2020 August 16 21 37
2020 July 13 23 36
2020 June 12 21 33
2020 May 19 27 46
2020 April 14 17 31
2020 March 8 12 20
2020 February 6 0 6
2020 January 1 0 1
2019 October 1 0 1
2019 September 3 0 3
2019 August 3 0 3
2019 July 4 0 4
2019 June 1 0 1
2019 May 3 0 3
2019 April 4 0 4
2019 March 3 0 3
2019 February 1 0 1
2018 December 1 0 1
2018 May 5 2 7
2018 April 22 15 37
2018 March 17 16 33
2018 February 13 10 23
2018 January 6 10 16
2017 December 16 10 26
2017 November 10 15 25
2017 October 17 15 32
2017 September 7 17 24
2017 August 17 25 42
2017 July 15 18 33
2017 June 20 34 54
2017 May 12 27 39
2017 April 10 21 31
2017 March 12 34 46
2017 February 7 17 24
2017 January 15 13 28
2016 December 26 22 48
2016 November 25 15 40
2016 October 26 13 39
2016 September 28 15 43
2016 August 27 14 41
2016 July 22 20 42
2016 April 1 0 1
2016 February 1 0 1
2015 December 2 0 2
2015 August 6 0 6
2015 July 6 5 11
2015 June 18 3 21
2015 May 14 7 21
2015 April 18 8 26
2015 March 7 3 10
2015 February 9 7 16
2015 January 9 7 16
2014 December 17 12 29
2014 November 11 7 18
2014 October 9 6 15
2014 September 7 7 14
2014 August 14 12 26
2014 July 12 8 20
2014 June 25 8 33
2014 May 31 6 37
2014 April 23 4 27
2014 March 29 13 42
2014 February 14 3 17
2014 January 16 9 25
2013 December 24 5 29
2013 November 20 6 26
2013 October 32 10 42
2013 September 30 9 39
2013 August 21 7 28
2013 July 16 8 24
2013 June 13 4 17
2013 May 25 4 29
2013 April 15 5 20
2013 March 10 6 16
2013 February 14 4 18
2013 January 8 2 10
2012 December 15 2 17
2012 November 7 3 10
2012 October 2 3 5
2012 September 9 3 12
2012 June 1 0 1
2012 April 2 0 2
2012 February 2 0 2
2012 January 1 0 1
2011 December 3 0 3
2011 November 1 0 1
2011 October 2 0 2
2011 June 3 0 3
2011 March 1 0 1
2011 February 3 0 3
2011 January 1 0 1
2010 December 2 0 2
2010 November 2 0 2
2010 October 1 0 1
2010 August 11 0 11
2010 July 1 0 1
2010 June 1 0 1
2010 May 4 0 4
2010 April 1 0 1
2010 January 2 0 2
2009 December 2 0 2
2009 November 2 0 2
2009 October 2 0 2
2009 September 1 0 1
2009 August 4 0 4
2009 July 1 0 1
2009 June 8 0 8
2009 May 2 0 2
2009 April 7 0 7
2009 March 3 0 3
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?