Correspondence: Unidad de Reumatología. Hospital Universitario Vall d'Hebron. Pg. de la Vall d’Hebron, 119-129. 08035 Barcelona. España.
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Hospital Universitario Vall d'Hebron. Pg. de la Vall d’Hebron, 119-129. 08035 Barcelona. España." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Susceptibilidad de la población española a los efectos adversos por sulfasalazina: revisión sistemática" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-02-25" "fechaAceptado" => "2008-05-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111861" "palabras" => array:3 [ 0 => "Sulfasalazine" 1 => "Adverse effects" 2 => "Slow acetylation" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111860" "palabras" => array:3 [ 0 => "Sulfasalazina" 1 => "Efectos adversos" 2 => "Acetilación lenta" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical experience raises suspicion that the Spanish population could suffer higher rates of side effects of sulfasalazine (SSZ) therapy. We conducted a systematic review of existing literature to analyze the susceptibility to developing adverse events produced by SSZ in the Spanish population.</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A literature search was conducted in EMBASE, IBECS, and MEDLINE from 1973 to March 2007. The items sought were those describing adverse effects, both in text and tables, and reasons for withdrawal, the population under study and discussion of differences in side effects of the different treatment groups.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Of the 106 retrieved articles, 36 were selected for review and detailed analysis. 34 articles were selected from MEDLINE and EMBASE and 2 from IBECS. We did not find any study that showed that the Spanish population was more susceptible to SSZ.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The adverse effects of SSZ vary with the pattern of acetylation. Thus, in slow-acetylators, depending on the dosage of SSZ, the side effects increase significantly. In the Spanish population slow-acetylators prevalence is higher than in other ethnic groups. Therefore, one could infer that the incidence of adverse side effects by SSZ could be higher in the Spanish population than in others different ethnic groups. We found no evidence that the Spanish population was more likely to suffer adverse effects by SSZ than other ethnic groups.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La experiencia clínica hace sospechar que la población española pudiera sufrir más efectos adversos por la sulfasalazina (SSZ). Se realizó una revisión sistemática de la literatura existente con el objetivo de analizar la susceptibilidad a desarrollar eventos adversos producidos por la SSZ en la población española.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se definió una estrategia de búsqueda bibliográfica sensible en EMBASE, IBECS y MEDLINE desde 1973 hasta marzo de 2007. En los artículos seleccionados se buscó la descripción de los efectos adversos, tanto en el texto como en las tablas, así como los motivos de retirada, la población estudiada y la discusión sobre la opinión de las diferencias en los efectos adversos de los diferentes grupos de tratamiento.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">De un total de 106 artículos rescatados se seleccionaron 36 para realizar un análisis detallado de los 34 artículos seleccionados en MEDLINE y EMBASE y de los 2 de IBECS. No se encontró ningún estudio que evidencie que la población española sea más susceptible a los efectos adversos por SSZ.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los efectos adversos por SSZ varían según el patrón de acetilación. En la población española la prevalencia de acetiladores lentos es mayor que en otros grupos étnicos; por tanto, cabría inferir que la incidencia de efectos adversos secundarios a la SSZ podría ser mayor en la población española que en otros grupos. No encontramos evidencia en la literatura de que la población española sea más susceptible a los efectos adversos por la SSZ.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.F. 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Year/Month | Html | Total | |
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2024 November | 12 | 17 | 29 |
2024 October | 41 | 38 | 79 |
2024 September | 56 | 22 | 78 |
2024 August | 46 | 39 | 85 |
2024 July | 38 | 29 | 67 |
2024 June | 50 | 43 | 93 |
2024 May | 75 | 37 | 112 |
2024 April | 54 | 19 | 73 |
2024 March | 84 | 34 | 118 |
2024 February | 83 | 24 | 107 |
2024 January | 90 | 24 | 114 |
2023 December | 93 | 23 | 116 |
2023 November | 100 | 25 | 125 |
2023 October | 63 | 34 | 97 |
2023 September | 67 | 29 | 96 |
2023 August | 73 | 18 | 91 |
2023 July | 59 | 29 | 88 |
2023 June | 68 | 18 | 86 |
2023 May | 59 | 9 | 68 |
2023 April | 46 | 9 | 55 |
2023 March | 60 | 29 | 89 |
2023 February | 43 | 27 | 70 |
2023 January | 47 | 20 | 67 |
2022 December | 53 | 29 | 82 |
2022 November | 37 | 35 | 72 |
2022 October | 50 | 20 | 70 |
2022 September | 36 | 26 | 62 |
2022 August | 48 | 51 | 99 |
2022 July | 34 | 37 | 71 |
2022 June | 24 | 31 | 55 |
2022 May | 26 | 48 | 74 |
2022 April | 29 | 46 | 75 |
2022 March | 25 | 54 | 79 |
2022 February | 28 | 26 | 54 |
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2021 December | 26 | 42 | 68 |
2021 November | 34 | 42 | 76 |
2021 October | 34 | 55 | 89 |
2021 September | 31 | 46 | 77 |
2021 August | 19 | 37 | 56 |
2021 July | 14 | 20 | 34 |
2021 June | 22 | 46 | 68 |
2021 May | 29 | 40 | 69 |
2021 April | 53 | 57 | 110 |
2021 March | 39 | 31 | 70 |
2021 February | 16 | 21 | 37 |
2021 January | 11 | 17 | 28 |
2020 December | 23 | 22 | 45 |
2020 November | 19 | 20 | 39 |
2020 October | 11 | 4 | 15 |
2020 September | 18 | 20 | 38 |
2020 August | 13 | 14 | 27 |
2020 July | 19 | 10 | 29 |
2020 June | 19 | 18 | 37 |
2020 May | 24 | 19 | 43 |
2020 April | 15 | 10 | 25 |
2020 March | 11 | 11 | 22 |
2020 February | 4 | 0 | 4 |
2019 August | 1 | 0 | 1 |
2019 July | 1 | 0 | 1 |
2019 March | 3 | 0 | 3 |
2018 December | 1 | 0 | 1 |
2018 May | 4 | 3 | 7 |
2018 April | 31 | 11 | 42 |
2018 March | 6 | 14 | 20 |
2018 February | 11 | 6 | 17 |
2018 January | 10 | 7 | 17 |
2017 December | 10 | 5 | 15 |
2017 November | 7 | 5 | 12 |
2017 October | 13 | 11 | 24 |
2017 September | 11 | 3 | 14 |
2017 August | 10 | 13 | 23 |
2017 July | 8 | 3 | 11 |
2017 June | 19 | 11 | 30 |
2017 May | 21 | 11 | 32 |
2017 April | 11 | 8 | 19 |
2017 March | 19 | 8 | 27 |
2017 February | 5 | 11 | 16 |
2017 January | 11 | 4 | 15 |
2016 December | 31 | 11 | 42 |
2016 November | 14 | 2 | 16 |
2016 October | 21 | 15 | 36 |
2016 September | 23 | 10 | 33 |
2016 August | 23 | 6 | 29 |
2016 July | 19 | 6 | 25 |
2016 April | 2 | 0 | 2 |
2016 February | 1 | 0 | 1 |
2015 December | 3 | 0 | 3 |
2015 October | 2 | 0 | 2 |
2015 August | 6 | 0 | 6 |
2015 July | 12 | 6 | 18 |
2015 June | 12 | 14 | 26 |
2015 May | 31 | 13 | 44 |
2015 April | 19 | 7 | 26 |
2015 March | 11 | 6 | 17 |
2015 February | 10 | 8 | 18 |
2015 January | 13 | 10 | 23 |
2014 December | 16 | 11 | 27 |
2014 November | 14 | 8 | 22 |
2014 October | 8 | 10 | 18 |
2014 September | 10 | 8 | 18 |
2014 August | 13 | 17 | 30 |
2014 July | 15 | 15 | 30 |
2014 June | 30 | 17 | 47 |
2014 May | 23 | 15 | 38 |
2014 April | 27 | 8 | 35 |
2014 March | 29 | 17 | 46 |
2014 February | 25 | 13 | 38 |
2014 January | 27 | 14 | 41 |
2013 December | 27 | 11 | 38 |
2013 November | 12 | 16 | 28 |
2013 October | 25 | 15 | 40 |
2013 September | 27 | 15 | 42 |
2013 August | 12 | 21 | 33 |
2013 July | 19 | 12 | 31 |
2013 June | 19 | 20 | 39 |
2013 May | 28 | 8 | 36 |
2013 April | 25 | 10 | 35 |
2013 March | 14 | 14 | 28 |
2013 February | 11 | 9 | 20 |
2013 January | 22 | 10 | 32 |
2012 December | 15 | 7 | 22 |
2012 November | 4 | 13 | 17 |
2012 October | 6 | 8 | 14 |
2012 September | 8 | 3 | 11 |
2012 June | 2 | 0 | 2 |
2012 May | 1 | 0 | 1 |
2012 April | 2 | 0 | 2 |
2012 March | 3 | 0 | 3 |
2012 February | 2 | 0 | 2 |
2012 January | 3 | 0 | 3 |
2011 December | 6 | 0 | 6 |
2011 November | 4 | 0 | 4 |
2011 October | 3 | 0 | 3 |
2011 August | 1 | 0 | 1 |
2011 July | 1 | 0 | 1 |
2011 June | 3 | 0 | 3 |
2011 May | 1 | 0 | 1 |
2011 March | 3 | 0 | 3 |
2011 February | 6 | 0 | 6 |
2011 January | 9 | 0 | 9 |
2010 December | 8 | 0 | 8 |
2010 November | 4 | 0 | 4 |
2010 October | 7 | 0 | 7 |
2010 September | 5 | 0 | 5 |
2010 August | 2 | 0 | 2 |
2010 July | 1 | 0 | 1 |
2010 June | 3 | 0 | 3 |
2010 May | 4 | 0 | 4 |
2010 April | 7 | 0 | 7 |
2010 March | 3 | 0 | 3 |
2010 February | 3 | 0 | 3 |
2010 January | 4 | 0 | 4 |
2009 December | 4 | 0 | 4 |
2009 November | 28 | 0 | 28 |
2009 October | 17 | 0 | 17 |
2009 September | 5 | 0 | 5 |
2009 August | 13 | 0 | 13 |
2009 July | 4 | 0 | 4 |
2009 June | 7 | 0 | 7 |
2009 May | 8 | 0 | 8 |
2009 April | 25 | 0 | 25 |
2009 March | 22 | 0 | 22 |