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            2 => "Slow acetylation"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical experience raises suspicion that the Spanish population could suffer higher rates of side effects of sulfasalazine &#40;SSZ&#41; therapy&#46; We conducted a systematic review of existing literature to analyze the susceptibility to developing adverse events produced by SSZ in the Spanish population&#46;</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A literature search was conducted in EMBASE&#44; IBECS&#44; and MEDLINE from 1973 to March 2007&#46; The items sought were those describing adverse effects&#44; both in text and tables&#44; and reasons for withdrawal&#44; the population under study and discussion of differences in side effects of the different treatment groups&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Of the 106 retrieved articles&#44; 36 were selected for review and detailed analysis&#46; 34 articles were selected from MEDLINE and EMBASE and 2 from IBECS&#46; We did not find any study that showed that the Spanish population was more susceptible to SSZ&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The adverse effects of SSZ vary with the pattern of acetylation&#46; Thus&#44; in slow-acetylators&#44; depending on the dosage of SSZ&#44; the side effects increase significantly&#46; In the Spanish population slow-acetylators prevalence is higher than in other ethnic groups&#46; Therefore&#44; one could infer that the incidence of adverse side effects by SSZ could be higher in the Spanish population than in others different ethnic groups&#46; We found no evidence that the Spanish population was more likely to suffer adverse effects by SSZ than other ethnic groups&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La experiencia cl&#237;nica hace sospechar que la poblaci&#243;n espa&#241;ola pudiera sufrir m&#225;s efectos adversos por la sulfasalazina &#40;SSZ&#41;&#46; Se realiz&#243; una revisi&#243;n sistem&#225;tica de la literatura existente con el objetivo de analizar la susceptibilidad a desarrollar eventos adversos producidos por la SSZ en la poblaci&#243;n espa&#241;ola&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se defini&#243; una estrategia de b&#250;squeda bibliogr&#225;fica sensible en EMBASE&#44; IBECS y MEDLINE desde 1973 hasta marzo de 2007&#46; En los art&#237;culos seleccionados se busc&#243; la descripci&#243;n de los efectos adversos&#44; tanto en el texto como en las tablas&#44; as&#237; como los motivos de retirada&#44; la poblaci&#243;n estudiada y la discusi&#243;n sobre la opini&#243;n de las diferencias en los efectos adversos de los diferentes grupos de tratamiento&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">De un total de 106 art&#237;culos rescatados se seleccionaron 36 para realizar un an&#225;lisis detallado de los 34 art&#237;culos seleccionados en MEDLINE y EMBASE y de los 2 de IBECS&#46; No se encontr&#243; ning&#250;n estudio que evidencie que la poblaci&#243;n espa&#241;ola sea m&#225;s susceptible a los efectos adversos por SSZ&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los efectos adversos por SSZ var&#237;an seg&#250;n el patr&#243;n de acetilaci&#243;n&#46; En la poblaci&#243;n espa&#241;ola la prevalencia de acetiladores lentos es mayor que en otros grupos &#233;tnicos&#59; por tanto&#44; cabr&#237;a inferir que la incidencia de efectos adversos secundarios a la SSZ podr&#237;a ser mayor en la poblaci&#243;n espa&#241;ola que en otros grupos&#46; No encontramos evidencia en la literatura de que la poblaci&#243;n espa&#241;ola sea m&#225;s susceptible a los efectos adversos por la SSZ&#46;</p>"
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Susceptibility of the Spanish Population to Adverse Effects by Sulfasalazine: Systematic Review
Susceptibilidad de la población española a los efectos adversos por sulfasalazina: revisión sistemática
Cayetano Alegre de Miquel
Corresponding author
calegre@vhebron.net

Correspondence: Unidad de Reumatología. Hospital Universitario Vall d'Hebron. Pg. de la Vall d’Hebron, 119-129. 08035 Barcelona. España.
, Carlos Santos Ramírez, Mireia Barceló Bru
Unidad de Reumatología, Hospital Universitario Vall d’Hebron, Barcelona, Spain
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        "autoresLista" => "Cayetano Alegre de Miquel, Carlos Santos Ram&#237;rez, Mireia Barcel&#243; Bru"
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            "nombre" => "Cayetano"
            "apellidos" => "Alegre de Miquel"
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Susceptibilidad de la poblaci&#243;n espa&#241;ola a los efectos adversos por sulfasalazina&#58; revisi&#243;n sistem&#225;tica"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2008-02-25"
    "fechaAceptado" => "2008-05-05"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec111861"
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            0 => "Sulfasalazine"
            1 => "Adverse effects"
            2 => "Slow acetylation"
          ]
        ]
      ]
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            0 => "Sulfasalazina"
            1 => "Efectos adversos"
            2 => "Acetilaci&#243;n lenta"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical experience raises suspicion that the Spanish population could suffer higher rates of side effects of sulfasalazine &#40;SSZ&#41; therapy&#46; We conducted a systematic review of existing literature to analyze the susceptibility to developing adverse events produced by SSZ in the Spanish population&#46;</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A literature search was conducted in EMBASE&#44; IBECS&#44; and MEDLINE from 1973 to March 2007&#46; The items sought were those describing adverse effects&#44; both in text and tables&#44; and reasons for withdrawal&#44; the population under study and discussion of differences in side effects of the different treatment groups&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Of the 106 retrieved articles&#44; 36 were selected for review and detailed analysis&#46; 34 articles were selected from MEDLINE and EMBASE and 2 from IBECS&#46; We did not find any study that showed that the Spanish population was more susceptible to SSZ&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The adverse effects of SSZ vary with the pattern of acetylation&#46; Thus&#44; in slow-acetylators&#44; depending on the dosage of SSZ&#44; the side effects increase significantly&#46; In the Spanish population slow-acetylators prevalence is higher than in other ethnic groups&#46; Therefore&#44; one could infer that the incidence of adverse side effects by SSZ could be higher in the Spanish population than in others different ethnic groups&#46; We found no evidence that the Spanish population was more likely to suffer adverse effects by SSZ than other ethnic groups&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La experiencia cl&#237;nica hace sospechar que la poblaci&#243;n espa&#241;ola pudiera sufrir m&#225;s efectos adversos por la sulfasalazina &#40;SSZ&#41;&#46; Se realiz&#243; una revisi&#243;n sistem&#225;tica de la literatura existente con el objetivo de analizar la susceptibilidad a desarrollar eventos adversos producidos por la SSZ en la poblaci&#243;n espa&#241;ola&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se defini&#243; una estrategia de b&#250;squeda bibliogr&#225;fica sensible en EMBASE&#44; IBECS y MEDLINE desde 1973 hasta marzo de 2007&#46; En los art&#237;culos seleccionados se busc&#243; la descripci&#243;n de los efectos adversos&#44; tanto en el texto como en las tablas&#44; as&#237; como los motivos de retirada&#44; la poblaci&#243;n estudiada y la discusi&#243;n sobre la opini&#243;n de las diferencias en los efectos adversos de los diferentes grupos de tratamiento&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">De un total de 106 art&#237;culos rescatados se seleccionaron 36 para realizar un an&#225;lisis detallado de los 34 art&#237;culos seleccionados en MEDLINE y EMBASE y de los 2 de IBECS&#46; No se encontr&#243; ning&#250;n estudio que evidencie que la poblaci&#243;n espa&#241;ola sea m&#225;s susceptible a los efectos adversos por SSZ&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los efectos adversos por SSZ var&#237;an seg&#250;n el patr&#243;n de acetilaci&#243;n&#46; En la poblaci&#243;n espa&#241;ola la prevalencia de acetiladores lentos es mayor que en otros grupos &#233;tnicos&#59; por tanto&#44; cabr&#237;a inferir que la incidencia de efectos adversos secundarios a la SSZ podr&#237;a ser mayor en la poblaci&#243;n espa&#241;ola que en otros grupos&#46; No encontramos evidencia en la literatura de que la poblaci&#243;n espa&#241;ola sea m&#225;s susceptible a los efectos adversos por la SSZ&#46;</p>"
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ISSN: 21735743
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