Correlation Between Cytokines and Anxious-Depressive Symptoms in Patients With Fibromyalgia
Correlación entre citocinas y síntomas ansiosodepresivos en pacientes con fibromialgia
José-Raúl García-Lozanoa,
, Carmen Capilla-Sevillab, Olga García-Lópezb, Isabel Moreno-Gallegoc
Corresponding author
jraul.garcia.sspa@juntadeandalucia.es
Correspondence: Servicio de Inmunología. Hospital Universitario Virgen del Rocío. Avda. Manuel Siurot, s/n. 41013 Sevilla. España.
Correspondence: Servicio de Inmunología. Hospital Universitario Virgen del Rocío. Avda. Manuel Siurot, s/n. 41013 Sevilla. España.
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Hospital Universitario Virgen del Rocío. Avda. Manuel Siurot, s/n. 41013 Sevilla. España." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Correlación entre citocinas y síntomas ansiosodepresivos en pacientes con fibromialgia" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-03-10" "fechaAceptado" => "2008-04-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111864" "palabras" => array:3 [ 0 => "Cytokines" 1 => "Fibromyalgia" 2 => "Pain" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111863" "palabras" => array:3 [ 0 => "Citocinas" 1 => "Fibromialgia" 2 => "Dolor" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To establish the influence of cytokines on anxious-depressive manifestations in fibromyalgia (FM) patients.</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The study comprised 56 women (50.5 [7.8] years) with FM and 32 healthy female controls (39.65 [9.24] years). Psychiatric symptoms were analyzed using the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS), while pain was assessed by means of a Visual Analog Scale (VAS). Proinflammatory cytokines IL-6, IL-8, IL-10, and TNFα were assayed in serum using the Luminex-xMAP method. The statistical analysis was carried out using the SSPS statistical package.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">IL-8 values were significantly lower (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.013) in patients than in controls. No differences were observed among IL-6, IL-10, and TNFα levels. When comparing cytokine levels with patient age, we observed a significant reduction in IL-6, IL-8, and TNFα in older patients. The values of these cytokines showed no relationship to the anxious-depressive symptoms.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In our series no differences in serum cytokines were seen between patients with FM and controls, with the exception of a reduction in IL-8 among patients with FM, and which could be attributed to the older age of these patients.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Determinar la influencia de las citocinas en las manifestaciones ansioso-depresivas de pacientes con fibromialgia.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En el estudio se incluyó a 56 mujeres con fibromialgia (50,5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>7,8 años) y 32 mujeres sanas como controles (39,65<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>9,24 años). Los síntomas psiquiátricos fueron analizados con la Hamilton Depression Rating Scale (HDRS) y la Hamilton Anxiety Rating Scale (HARS), mientras que el dolor fue valorado por medio de una escala visual analógica. Las concentraciones de citocinas proinflamatorias de interleucina (IL)-6, IL-8, IL-10 y factor de necrosis tumoral alfa (TNFα) se midieron en suero mediante Luminex-xMAP. El análisis estadístico se realizó con el programa estadístico SSPS.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Las concentraciones de IL-8 fueron estadísticamente más bajas en pacientes que en controles (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,013). No se observaron diferencias con respecto a las concentraciones de IL-6, IL-10 y TNFα. Al comparar los valores de citocinas con la edad de los pacientes, se observó una reducción significativa de IL-6, IL-8 y TNFα en los pacientes de mayor edad. No se observó relación entre los valores de estas citocinas y los síntomas ansioso-depresivos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En nuestra serie no hay diferencias en las concentraciones séricas de citocinas entre pacientes con fibromialgia y controles, con la excepción de una reducción de IL-8 en los pacientes con fibromialgia que podría ser debida a la mayor edad de los pacientes con respecto a los controles.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 18 | 23 |
| 2024 October | 18 | 34 | 52 |
| 2024 September | 32 | 20 | 52 |
| 2024 August | 33 | 36 | 69 |
| 2024 July | 28 | 36 | 64 |
| 2024 June | 23 | 39 | 62 |
| 2024 May | 23 | 29 | 52 |
| 2024 April | 23 | 23 | 46 |
| 2024 March | 26 | 34 | 60 |
| 2024 February | 24 | 23 | 47 |
| 2024 January | 16 | 22 | 38 |
| 2023 December | 15 | 34 | 49 |
| 2023 November | 16 | 26 | 42 |
| 2023 October | 26 | 43 | 69 |
| 2023 September | 21 | 39 | 60 |
| 2023 August | 19 | 15 | 34 |
| 2023 July | 26 | 25 | 51 |
| 2023 June | 15 | 20 | 35 |
| 2023 May | 17 | 9 | 26 |
| 2023 April | 16 | 12 | 28 |
| 2023 March | 20 | 27 | 47 |
| 2023 February | 32 | 28 | 60 |
| 2023 January | 25 | 18 | 43 |
| 2022 December | 35 | 41 | 76 |
| 2022 November | 46 | 35 | 81 |
| 2022 October | 34 | 29 | 63 |
| 2022 September | 22 | 25 | 47 |
| 2022 August | 19 | 51 | 70 |
| 2022 July | 24 | 49 | 73 |
| 2022 June | 18 | 29 | 47 |
| 2022 May | 18 | 39 | 57 |
| 2022 April | 23 | 43 | 66 |
| 2022 March | 22 | 41 | 63 |
| 2022 February | 20 | 35 | 55 |
| 2022 January | 24 | 26 | 50 |
| 2021 December | 16 | 44 | 60 |
| 2021 November | 31 | 45 | 76 |
| 2021 October | 27 | 49 | 76 |
| 2021 September | 24 | 43 | 67 |
| 2021 August | 17 | 48 | 65 |
| 2021 July | 26 | 36 | 62 |
| 2021 June | 15 | 56 | 71 |
| 2021 May | 18 | 37 | 55 |
| 2021 April | 27 | 65 | 92 |
| 2021 March | 26 | 27 | 53 |
| 2021 February | 20 | 25 | 45 |
| 2021 January | 19 | 23 | 42 |
| 2020 December | 13 | 14 | 27 |
| 2020 November | 23 | 20 | 43 |
| 2020 October | 10 | 3 | 13 |
| 2020 September | 14 | 15 | 29 |
| 2020 August | 14 | 12 | 26 |
| 2020 July | 14 | 10 | 24 |
| 2020 June | 14 | 10 | 24 |
| 2020 May | 19 | 15 | 34 |
| 2020 April | 11 | 16 | 27 |
| 2020 March | 7 | 10 | 17 |
| 2020 February | 5 | 0 | 5 |
| 2019 August | 1 | 0 | 1 |
| 2019 April | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2018 December | 1 | 0 | 1 |
| 2018 May | 7 | 1 | 8 |
| 2018 April | 28 | 9 | 37 |
| 2018 March | 21 | 11 | 32 |
| 2018 February | 35 | 8 | 43 |
| 2018 January | 13 | 5 | 18 |
| 2017 December | 25 | 5 | 30 |
| 2017 November | 17 | 6 | 23 |
| 2017 October | 13 | 3 | 16 |
| 2017 September | 10 | 4 | 14 |
| 2017 August | 9 | 5 | 14 |
| 2017 July | 11 | 7 | 18 |
| 2017 June | 17 | 4 | 21 |
| 2017 May | 16 | 7 | 23 |
| 2017 April | 14 | 19 | 33 |
| 2017 March | 19 | 23 | 42 |
| 2017 February | 6 | 1 | 7 |
| 2017 January | 12 | 1 | 13 |
| 2016 December | 29 | 7 | 36 |
| 2016 November | 13 | 3 | 16 |
| 2016 October | 24 | 9 | 33 |
| 2016 September | 33 | 6 | 39 |
| 2016 August | 20 | 3 | 23 |
| 2016 July | 9 | 3 | 12 |
| 2016 March | 1 | 0 | 1 |
| 2015 December | 4 | 0 | 4 |
| 2015 November | 1 | 0 | 1 |
| 2015 October | 1 | 0 | 1 |
| 2015 July | 8 | 6 | 14 |
| 2015 June | 20 | 15 | 35 |
| 2015 May | 23 | 17 | 40 |
| 2015 April | 21 | 11 | 32 |
| 2015 March | 15 | 3 | 18 |
| 2015 February | 12 | 13 | 25 |
| 2015 January | 8 | 18 | 26 |
| 2014 December | 19 | 10 | 29 |
| 2014 November | 8 | 18 | 26 |
| 2014 October | 12 | 10 | 22 |
| 2014 September | 10 | 9 | 19 |
| 2014 August | 15 | 14 | 29 |
| 2014 July | 12 | 16 | 28 |
| 2014 June | 33 | 10 | 43 |
| 2014 May | 28 | 13 | 41 |
| 2014 April | 27 | 14 | 41 |
| 2014 March | 34 | 24 | 58 |
| 2014 February | 34 | 9 | 43 |
| 2014 January | 27 | 10 | 37 |
| 2013 December | 27 | 6 | 33 |
| 2013 November | 12 | 7 | 19 |
| 2013 October | 30 | 13 | 43 |
| 2013 September | 29 | 15 | 44 |
| 2013 August | 31 | 9 | 40 |
| 2013 July | 14 | 10 | 24 |
| 2013 June | 16 | 5 | 21 |
| 2013 May | 20 | 12 | 32 |
| 2013 April | 19 | 12 | 31 |
| 2013 March | 15 | 12 | 27 |
| 2013 February | 18 | 7 | 25 |
| 2013 January | 20 | 6 | 26 |
| 2012 December | 19 | 8 | 27 |
| 2012 November | 13 | 6 | 19 |
| 2012 October | 13 | 7 | 20 |
| 2012 September | 7 | 2 | 9 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 1 | 0 | 1 |
| 2012 May | 3 | 0 | 3 |
| 2012 April | 5 | 0 | 5 |
| 2012 March | 4 | 0 | 4 |
| 2012 February | 1 | 0 | 1 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 4 | 0 | 4 |
| 2011 November | 9 | 0 | 9 |
| 2011 October | 1 | 0 | 1 |
| 2011 September | 1 | 0 | 1 |
| 2011 June | 3 | 0 | 3 |
| 2011 March | 5 | 0 | 5 |
| 2011 February | 4 | 0 | 4 |
| 2011 January | 4 | 0 | 4 |
| 2010 December | 4 | 0 | 4 |
| 2010 November | 1 | 0 | 1 |
| 2010 October | 6 | 0 | 6 |
| 2010 September | 3 | 0 | 3 |
| 2010 August | 4 | 0 | 4 |
| 2010 July | 2 | 0 | 2 |
| 2010 June | 1 | 0 | 1 |
| 2010 May | 4 | 0 | 4 |
| 2010 April | 4 | 0 | 4 |
| 2010 March | 3 | 0 | 3 |
| 2010 February | 2 | 0 | 2 |
| 2010 January | 5 | 0 | 5 |
| 2009 December | 4 | 0 | 4 |
| 2009 November | 8 | 0 | 8 |
| 2009 October | 8 | 0 | 8 |
| 2009 September | 9 | 0 | 9 |
| 2009 August | 7 | 0 | 7 |
| 2009 July | 9 | 0 | 9 |
| 2009 June | 17 | 0 | 17 |
| 2009 May | 9 | 0 | 9 |
| 2009 April | 25 | 0 | 25 |
| 2009 March | 15 | 0 | 15 |
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