Treatment of Lupus Nephritis
Tratamiento de la nefritis lúpica
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Ginzler" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Lucía Silva" "apellidos" => "Fernández" "email" => array:1 [ 0 => "luciasilvaf@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "José Luis" "apellidos" => "Andréu Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ellen M." "apellidos" => "Ginzler" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología, Complexo Hospitalario de Pontevedra, Pontevedra, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Puerta de Hierro, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Rheumatology Division, SUNY Downstate Medical Center, New Yot, NY, USA" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento de la nefritis lúpica" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111873" "palabras" => array:4 [ 0 => "Lupus nephritis" 1 => "Mycophenolate mofetil" 2 => "Cyclophosphamide" 3 => "Systemic lupus erythematosus" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111872" "palabras" => array:4 [ 0 => "Nefritis lúpica" 1 => "Micofenolato mofetilo" 2 => "Ciclofosfamida" 3 => "Lupus eritematoso sistémico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lupus nephritis is a relevant source of morbidity and mortality in patients with systemic lupus erythematosus. The standard therapy of remission induction in severe lupus nephritis is based on the use of monthly intravenous cyclophosphamide. Recent data have established that the maintenance of remission in lupus nephritis can be achieved with azathioprine or mycophenolate mofetil, with less adverse effects than quarterly intravenous cyclophosphamide. In recent years, a number of controlled randomized clinical trials have been published, opening new therapeutic options in the induction of remission in lupus nephritis, such as less aggressive regimens of intravenous cyclophosphamide or mycophenolate mofetil. Further studies are needed for establishing the optimal therapy of lupus nephritis patients.</p>" ] "es" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La nefritis lúpica es una causa importante de morbilidad y mortalidad en los pacientes con lupus eritematoso sistémico. El tratamiento convencional de inducción de remisión en la nefritis lúpica grave se basa en la utilización de ciclofosfamida intravenosa mensual. Datos recientes han puesto de manifiesto que el mantenimiento de remisión de la nefritis lúpica se consigue con un menor número de efectos secundarios utilizando azatioprina o micofenolato, frente a la administración trimestral de ciclofosfamida intravenosa. En los últimos años se han publicado ensayos clínicos controlados y aleatorizados que plantean nuevas modalidades terapéuticas en la inducción de remisión en la nefritis lúpica, como son la utilización de pautas menos agresivas de ciclofosfamida intravenosa o el uso de micofenolato mofetilo. Se necesitan más estudios para establecer el tratamiento óptimo de los pacientes con nefritis lúpica grave.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:96 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology and estimated population burden of selected autoinmune diseases in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.L. Jacobson" 1 => "S.J. Gange" 2 => "N.R. Rose" 3 => "N.M. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 19 | 25 |
| 2024 October | 44 | 36 | 80 |
| 2024 September | 45 | 21 | 66 |
| 2024 August | 49 | 44 | 93 |
| 2024 July | 42 | 36 | 78 |
| 2024 June | 48 | 56 | 104 |
| 2024 May | 41 | 47 | 88 |
| 2024 April | 51 | 23 | 74 |
| 2024 March | 55 | 35 | 90 |
| 2024 February | 50 | 32 | 82 |
| 2024 January | 41 | 39 | 80 |
| 2023 December | 27 | 39 | 66 |
| 2023 November | 46 | 38 | 84 |
| 2023 October | 45 | 45 | 90 |
| 2023 September | 46 | 77 | 123 |
| 2023 August | 30 | 31 | 61 |
| 2023 July | 48 | 38 | 86 |
| 2023 June | 49 | 26 | 75 |
| 2023 May | 39 | 15 | 54 |
| 2023 April | 22 | 12 | 34 |
| 2023 March | 35 | 37 | 72 |
| 2023 February | 21 | 48 | 69 |
| 2023 January | 28 | 26 | 54 |
| 2022 December | 26 | 48 | 74 |
| 2022 November | 26 | 27 | 53 |
| 2022 October | 23 | 30 | 53 |
| 2022 September | 27 | 50 | 77 |
| 2022 August | 30 | 51 | 81 |
| 2022 July | 21 | 48 | 69 |
| 2022 June | 28 | 37 | 65 |
| 2022 May | 33 | 58 | 91 |
| 2022 April | 48 | 59 | 107 |
| 2022 March | 45 | 64 | 109 |
| 2022 February | 53 | 38 | 91 |
| 2022 January | 29 | 43 | 72 |
| 2021 December | 32 | 49 | 81 |
| 2021 November | 26 | 55 | 81 |
| 2021 October | 42 | 62 | 104 |
| 2021 September | 36 | 43 | 79 |
| 2021 August | 29 | 46 | 75 |
| 2021 July | 25 | 39 | 64 |
| 2021 June | 31 | 50 | 81 |
| 2021 May | 43 | 49 | 92 |
| 2021 April | 97 | 102 | 199 |
| 2021 March | 47 | 32 | 79 |
| 2021 February | 52 | 38 | 90 |
| 2021 January | 36 | 28 | 64 |
| 2020 December | 33 | 26 | 59 |
| 2020 November | 28 | 21 | 49 |
| 2020 October | 26 | 13 | 39 |
| 2020 September | 25 | 20 | 45 |
| 2020 August | 28 | 12 | 40 |
| 2020 July | 18 | 18 | 36 |
| 2020 June | 32 | 18 | 50 |
| 2020 May | 32 | 15 | 47 |
| 2020 April | 20 | 11 | 31 |
| 2020 March | 9 | 8 | 17 |
| 2020 February | 5 | 0 | 5 |
| 2019 December | 4 | 0 | 4 |
| 2019 September | 1 | 0 | 1 |
| 2019 July | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 February | 1 | 0 | 1 |
| 2018 December | 2 | 0 | 2 |
| 2018 May | 3 | 1 | 4 |
| 2018 April | 26 | 10 | 36 |
| 2018 March | 15 | 12 | 27 |
| 2018 February | 17 | 7 | 24 |
| 2018 January | 12 | 6 | 18 |
| 2017 December | 14 | 7 | 21 |
| 2017 November | 16 | 8 | 24 |
| 2017 October | 26 | 15 | 41 |
| 2017 September | 15 | 10 | 25 |
| 2017 August | 11 | 11 | 22 |
| 2017 July | 10 | 10 | 20 |
| 2017 June | 22 | 7 | 29 |
| 2017 May | 27 | 10 | 37 |
| 2017 April | 19 | 7 | 26 |
| 2017 March | 12 | 13 | 25 |
| 2017 February | 6 | 3 | 9 |
| 2017 January | 12 | 5 | 17 |
| 2016 December | 21 | 21 | 42 |
| 2016 November | 7 | 8 | 15 |
| 2016 October | 22 | 8 | 30 |
| 2016 September | 14 | 5 | 19 |
| 2016 August | 17 | 5 | 22 |
| 2016 July | 10 | 8 | 18 |
| 2016 February | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 November | 1 | 0 | 1 |
| 2015 October | 1 | 0 | 1 |
| 2015 August | 1 | 0 | 1 |
| 2015 July | 20 | 6 | 26 |
| 2015 June | 19 | 116 | 135 |
| 2015 May | 30 | 127 | 157 |
| 2015 April | 21 | 192 | 213 |
| 2015 March | 32 | 181 | 213 |
| 2015 February | 18 | 165 | 183 |
| 2015 January | 30 | 149 | 179 |
| 2014 December | 26 | 141 | 167 |
| 2014 November | 15 | 116 | 131 |
| 2014 October | 29 | 111 | 140 |
| 2014 September | 17 | 68 | 85 |
| 2014 August | 14 | 93 | 107 |
| 2014 July | 19 | 77 | 96 |
| 2014 June | 45 | 73 | 118 |
| 2014 May | 56 | 34 | 90 |
| 2014 April | 58 | 46 | 104 |
| 2014 March | 43 | 46 | 89 |
| 2014 February | 29 | 38 | 67 |
| 2014 January | 28 | 45 | 73 |
| 2013 December | 32 | 28 | 60 |
| 2013 November | 26 | 52 | 78 |
| 2013 October | 38 | 41 | 79 |
| 2013 September | 36 | 48 | 84 |
| 2013 August | 24 | 31 | 55 |
| 2013 July | 45 | 26 | 71 |
| 2013 June | 26 | 27 | 53 |
| 2013 May | 21 | 20 | 41 |
| 2013 April | 30 | 23 | 53 |
| 2013 March | 24 | 30 | 54 |
| 2013 February | 24 | 14 | 38 |
| 2013 January | 23 | 35 | 58 |
| 2012 December | 19 | 25 | 44 |
| 2012 November | 14 | 23 | 37 |
| 2012 October | 12 | 17 | 29 |
| 2012 September | 5 | 10 | 15 |
| 2012 July | 4 | 0 | 4 |
| 2012 June | 9 | 0 | 9 |
| 2012 May | 18 | 0 | 18 |
| 2012 April | 6 | 0 | 6 |
| 2012 March | 7 | 0 | 7 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 2 | 0 | 2 |
| 2011 December | 7 | 0 | 7 |
| 2011 November | 5 | 0 | 5 |
| 2011 October | 3 | 0 | 3 |
| 2011 September | 3 | 0 | 3 |
| 2011 August | 1 | 0 | 1 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 5 | 0 | 5 |
| 2011 April | 3 | 0 | 3 |
| 2011 March | 9 | 0 | 9 |
| 2011 February | 14 | 0 | 14 |
| 2011 January | 18 | 0 | 18 |
| 2010 December | 3 | 0 | 3 |
| 2010 November | 10 | 0 | 10 |
| 2010 October | 11 | 0 | 11 |
| 2010 September | 13 | 0 | 13 |
| 2010 August | 5 | 0 | 5 |
| 2010 July | 11 | 0 | 11 |
| 2010 June | 1 | 0 | 1 |
| 2010 May | 7 | 0 | 7 |
| 2010 April | 8 | 0 | 8 |
| 2010 March | 6 | 0 | 6 |
| 2010 February | 23 | 0 | 23 |
| 2010 January | 11 | 0 | 11 |
| 2009 December | 8 | 0 | 8 |
| 2009 November | 32 | 0 | 32 |
| 2009 October | 18 | 0 | 18 |
| 2009 September | 16 | 0 | 16 |
| 2009 August | 9 | 0 | 9 |
| 2009 July | 7 | 0 | 7 |
| 2009 June | 12 | 0 | 12 |
| 2009 May | 10 | 0 | 10 |
| 2009 April | 29 | 0 | 29 |
| 2009 March | 17 | 0 | 17 |
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