Systematic Review: Is There Contraindication to the Concomitant Use of Non-Steroidal Anti-Inflammatory Drugs and Steroids?
Revisión sistemática: ¿hay alguna razón para contraindicar el uso concominante de antiinflamatorios no esteroideos y esteroideos?
Estíbaliz Loza
Corresponding author
eloza.hcsc@salud.madrid.org
Correspondence: Hospital Clínico San Carlos. Prof. Martín Lagos, s/n. 28015 Madrid. España.
Correspondence: Hospital Clínico San Carlos. Prof. Martín Lagos, s/n. 28015 Madrid. España.
Servicio de Reumatología, Hospital Clínico San Carlos, Madrid, Spain
Read
4246
Timeswas read the article
1995
Total PDF
2251
Total HTML
Share statistics
array:23 [ "pii" => "S2173574308701941" "issn" => "21735743" "doi" => "10.1016/S2173-5743(08)70194-1" "estado" => "S300" "fechaPublicacion" => "2008-11-01" "aid" => "70194" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2008;4:220-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 804 "formatos" => array:3 [ "EPUB" => 49 "HTML" => 543 "PDF" => 212 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173574308701953" "issn" => "21735743" "doi" => "10.1016/S2173-5743(08)70195-3" "estado" => "S300" "fechaPublicacion" => "2008-11-01" "aid" => "70195" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2008;4:228-31" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2303 "formatos" => array:3 [ "EPUB" => 39 "HTML" => 1694 "PDF" => 570 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Clinical Role for the Professional Nurse in Rheumatology" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "228" "paginaFinal" => "231" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Implicación clínica del profesional de enfermería en la consulta de reumatología" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Amelia Carbonell Jordá, Mauricio Mínguez Veja, Gaspar Panadero Tendero, Pilar Bernabeu Gonzálvez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Amelia" "apellidos" => "Carbonell Jordá" ] 1 => array:2 [ "nombre" => "Mauricio" "apellidos" => "Mínguez Veja" ] 2 => array:2 [ "nombre" => "Gaspar" "apellidos" => "Panadero Tendero" ] 3 => array:2 [ "nombre" => "Pilar" "apellidos" => "Bernabeu Gonzálvez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574308701953?idApp=UINPBA00004M" "url" => "/21735743/0000000400000006/v1_201305061550/S2173574308701953/v1_201305061550/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S217357430870193X" "issn" => "21735743" "doi" => "10.1016/S2173-5743(08)70193-X" "estado" => "S300" "fechaPublicacion" => "2008-11-01" "aid" => "70193" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Reumatol Clin. 2008;4:217-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1548 "formatos" => array:3 [ "EPUB" => 42 "HTML" => 1035 "PDF" => 471 ] ] "en" => array:7 [ "idiomaDefecto" => true "titulo" => "Diagnosis and Prevention of Tuberculosis in Patients With Inflammatory Rheumatic Disease, Is There Anything New?" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "217" "paginaFinal" => "219" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Miguel Santín" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Miguel" "apellidos" => "Santín" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357430870193X?idApp=UINPBA00004M" "url" => "/21735743/0000000400000006/v1_201305061550/S217357430870193X/v1_201305061550/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "titulo" => "Systematic Review: Is There Contraindication to the Concomitant Use of Non-Steroidal Anti-Inflammatory Drugs and Steroids?" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "220" "paginaFinal" => "227" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Estíbaliz Loza" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Estíbaliz" "apellidos" => "Loza" "email" => array:1 [ 0 => "eloza.hcsc@salud.madrid.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Reumatología, Hospital Clínico San Carlos, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Hospital Clínico San Carlos. Prof. Martín Lagos, s/n. 28015 Madrid. España." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Revisión sistemática: ¿hay alguna razón para contraindicar el uso concominante de antiinflamatorios no esteroideos y esteroideos?" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-02-15" "fechaAceptado" => "2008-06-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111932" "palabras" => array:3 [ 0 => "Non-steroidal anti-inflammatory drugs" 1 => "Steroids" 2 => "Safety" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111933" "palabras" => array:3 [ 0 => "Antiinflamatorios no esteroideos" 1 => "Esteroides" 2 => "Seguridad" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the safety of combining non-steroidal anti-inflammatory drugs (NSAID) and steroids.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A systematic review following a sensitive search strategy was performed. All articles published in MEDLINE (since 1961), EMBASE (since 1961), and Cochrane Library, up to December 2007 were examined. Selection criteria: the population (subjects with musculoskeletal diseases on steroids), the intervention (concomitant use of NSAID), and outcomes related to drugs safety (gastrointestinal, renal, and cardiovascular toxicity). Titles and abstracts of retrieved articles meeting inclusion criteria from the search were reviewed. Only randomized controlled trials (RCT) or high quality cohort studies with a control group were included.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Of a total of 4164 references retrieved, 42 were analyzed in detail, and 10 were finally included, 6 RCT and 4 prospective cohort studies, which included more than 20 000 patients.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The use of NSAID and low dose of steroids in patients with musculoskeletal diseases does not seem to increase the risk of gastrointestinal adverse events.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analizar la seguridad del uso concomitante de antiinflamatorios no esteroideos (AINE) con esteroides en pacientes con enfermedad reumática.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Revisión sistemática. Se definió una estrategia de búsqueda bibliográfica sensible en MEDLINE (desde 1961), EMBASE (desde 1980) y Cochrane Library hasta diciembre del 2007, definiendo la población (sujetos con enfermedad reumática en tratamiento con esteroides) y la intervención (tratamiento concomitante con AINE) y definiendo como resultados variables de seguridad (toxicidad gastrointestinal, renal y cardiovascular). Se seleccionaron ensayos clínicos y estudios de cohortes de calidad.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se recuperaron 4.164 estudios, de los que 42 se analizaron en detalle; finalmente se incluyeron 10 en los análisis, 6 de los cuales fueron ensayos clínicos y 4, estudios de cohortes prospectivos, que incluyeron a más de 20.000 pacientes.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El uso concomitante de AINE y esteroides a dosis bajas en pacientes con enfermedad reumática no parece que incremente el riesgo de eventos adversos gastrointestinales.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:47 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Advances in the adverse effects of NSAIDs in the gastrointestinal tract]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Lanas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gastroenterol Hepatol" "fecha" => "2006" "volumen" => "29" "paginaInicial" => "16" "paginaFinal" => "22" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.E. Gabriel" 1 => "L. Jaakkimainen" 2 => "C. Bombardier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1991" "volumen" => "115" "paginaInicial" => "787" "paginaFinal" => "796" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1834002" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.A. Garcia Rodriguez" 1 => "S. Hernandez-Diaz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Artritis Res" "fecha" => "2001" "volumen" => "3" "paginaInicial" => "98" "paginaFinal" => "101" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessing the quality of reports of randomized clinical trials: is blinding necessary?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.R. Jadad" 1 => "R.A. Moore" 2 => "D. Carroll" 3 => "C. Jenkinson" 4 => "D.J. Reynolds" 5 => "D.J. Gavaghan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Control Clin Trials" "fecha" => "1996" "volumen" => "17" "paginaInicial" => "1" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8721797" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.L. Goldstein" 1 => "P. Correa" 2 => "W.W. Zhao" 3 => "A.M. Burr" 4 => "R.C. Hubbard" 5 => "K.M. Verburg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1572-0241.2001.03740.x" "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2001" "volumen" => "96" "paginaInicial" => "1019" "paginaFinal" => "1027" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11316141" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dexamethasone and dexamethasone-aspirin in the treatment of chronic rheumatoid arthritis. A controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Jick" 1 => "R.S. Pinals" 2 => "R. Ullian" 3 => "D. Slone" 4 => "H. Muench" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1965" "volumen" => "2" "paginaInicial" => "1203" "paginaFinal" => "1205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2903419" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Laine" 1 => "C. Bombardier" 2 => "C.J. Hawkey" 3 => "B. Davis" 4 => "D. Shapiro" 5 => "C. Brett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "2002" "volumen" => "123" "paginaInicial" => "1006" "paginaFinal" => "1012" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12360461" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Laine" 1 => "L.G. Connors" 2 => "A. Reicin" 3 => "C.J. Hawkey" 4 => "R. Burgos-Vargas" 5 => "T.J. Schnitzer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/gast.2003.50054" "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "288" "paginaFinal" => "292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12557133" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroid sparing activity of tenidap in patients with polymyalgia rheumatica: a multicenter double blind randomized placebo controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.H. Littman" 1 => "D. Bjarnason" 2 => "G. Bryant" 3 => "J. Engelbrecht" 4 => "M. Cohen" 5 => "L. Mertz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1995" "volumen" => "22" "paginaInicial" => "1097" "paginaFinal" => "1103" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7674236" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progression of radiographic joint erosion during low dose corticosteroid treatment of rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.E. Paulus" 1 => "D. Di Primeo" 2 => "M. Sanda" 3 => "J.M. Lynch" 4 => "B.A. Schwartz" 5 => "J.T. Sharp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2000" "volumen" => "27" "paginaInicial" => "1632" "paginaFinal" => "1637" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10914843" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of low-dose aspirin on the decreased risk of development of dyspepsia and gastrointestinal ulcers associated to cyclooxygenase-2 selective inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Benito-Garcia" 1 => "K. Michaud" 2 => "F. Wolfe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2007" "volumen" => "34" "paginaInicial" => "1765" "paginaFinal" => "1769" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17611980" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors in the duration and discontinuation of treatment with nonsteroidal anti-inflammatory medications" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.F. Fries" 1 => "P.W. Spitz" 2 => "D.A. Bloch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Ther" "fecha" => "1991" "volumen" => "13" "paginaInicial" => "51" "paginaFinal" => "62" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adverse outcomes of antiinflammatory therapy among patients with polymyalgia rheumatica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.E. Gabriel" 1 => "J. Sunku" 2 => "C. Salvarani" 3 => "W.M. O’Fallon" 4 => "G.G. Hunder" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(199710)40:10<1873::AID-ART22>3.0.CO;2-V" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1997" "volumen" => "40" "paginaInicial" => "1873" "paginaFinal" => "1878" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9336424" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The comparative risk and predictors of adverse gastrointestinal events in rheumatoid arthritis and osteoarthritis: a prospective 13 year study of 2131 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Wolfe" 1 => "D.J. Hawley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2000" "volumen" => "27" "paginaInicial" => "1668" "paginaFinal" => "1673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10914849" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroids and risk of upper gastrointestinal complications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Hernandez-Diaz" 1 => "L.A. Rodriguez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "2001" "volumen" => "153" "paginaInicial" => "1089" "paginaFinal" => "1093" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11390328" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective, randomized trial of oral piroxicam in the prophylaxis of postoperative cystoid macular edema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.B. Abelson" 1 => "L.M. Smith" 2 => "L.D. Ormerod" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Ocul Pharmacol" "fecha" => "1989" "volumen" => "5" "paginaInicial" => "147" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2666532" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beta-cyclodextrin-piroxicam in the treatment of rheumatic diseases: a prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "U. Ambanelli" 1 => "A. Nervetti" 2 => "B. Colombo" 3 => "G. Cherie-Ligniere" 4 => "I. Gualdi" 5 => "R. Marcolongo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Drug Development" "fecha" => "1991" "volumen" => "4" "paginaInicial" => "55" "paginaFinal" => "66" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors of oesophagitis in arthritic patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Avidan" 1 => "A. Sonnenberg" 2 => "T.G. Schnell" 3 => "E. Budiman-Mak" 4 => "S. Sontag" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Gastroenterol Hepatol" "fecha" => "2001" "volumen" => "13" "paginaInicial" => "1095" "paginaFinal" => "1099" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11564962" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacokinetic interactions between zileuton and prednisone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.M. Awni" 1 => "J.H. Cavanaugh" 2 => "T.B. Tzeng" 3 => "G. Witt" 4 => "G.R. Granneman" 5 => "L.M. Dube" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacokinet" "fecha" => "1995" "volumen" => "29" "paginaInicial" => "105" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8620666" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Naproxen: corticosteroid-sparing effect in rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.J. Badia Flores" 1 => "S. Valdez Rojas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pharmacol" "fecha" => "1975" "volumen" => "15" "paginaInicial" => "373" "paginaFinal" => "377" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1092731" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Naproxen in rheumatoid arthritis. A controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.E. Bowers" 1 => "H.R. Dyer" 2 => "W.M. Fosdick" 3 => "K.E. Keller" 4 => "A.L. Rosenberg" 5 => "P. Sussman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1975" "volumen" => "83" "paginaInicial" => "470" "paginaFinal" => "475" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1101758" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Double-blind multicentre, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis patients under basic steroid treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.B. del Campo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Rheumatol Inflamm" "fecha" => "1981" "volumen" => "4" "paginaInicial" => "135" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7042357" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Naproxen: Corticosteroid sparing effect in rheumatoid arthritis]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.B. Flores" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol" "fecha" => "1973" "volumen" => "2" "paginaInicial" => "127" "paginaFinal" => "131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4769065" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polyarticular corticosteroid injection versus systemic administration in treatment of rheumatoid arthritis patients: a randomized controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Furtado" 1 => "L.M. Oliveira" 2 => "J. Natour" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2005" "volumen" => "32" "paginaInicial" => "1691" "paginaFinal" => "1698" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16142862" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastrointestinal prophylactic therapy among patients with arthritis treated by rheumatology specialists" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.B. Garcia" 1 => "K. Michaud" 2 => "F. Wolfe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2006" "volumen" => "33" "paginaInicial" => "779" "paginaFinal" => "784" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16511939" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of the anti-inflammatory agent tenidap on the pharmacokinetics and pharmacodynamics of prednisolone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Garg" 1 => "R. Blum" 2 => "K.D. Wilner" 3 => "W.J. Jusko" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pharmacol" "fecha" => "1992" "volumen" => "32" "paginaInicial" => "222" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1564126" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of systemic lupus erythematosus (SLE) with piroxicam (Hotemin-Egis)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Gergely" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ther Hung" "fecha" => "1989" "volumen" => "37" "paginaInicial" => "83" "paginaFinal" => "85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2686085" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prescription rheumatology practices among mexican specialists" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.V. Goycochea-Robles" 1 => "C.A. Arce-Salinas" 2 => "S. Guzman-Vazquez" 3 => "M. Cardiel-Rios" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arcmed.2006.11.008" "Revista" => array:6 [ "tituloSerie" => "Arch Med Res" "fecha" => "2007" "volumen" => "38" "paginaInicial" => "354" "paginaFinal" => "359" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17350489" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systematic review of randomised controlled trials of interventions for painful shoulder: selection criteria, outcome assessment, and efficacy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Green" 1 => "R. Buchbinder" 2 => "R. Glazier" 3 => "A. Forbes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1998" "volumen" => "316" "paginaInicial" => "354" "paginaFinal" => "360" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9487172" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GI risk factors and use of GI protective agents among patients receiving nonsteroidal antiinflammatory drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.L. Harris" 1 => "D.W. Raisch" 2 => "U. Abhyankar" 3 => "S. Marfatia" 4 => "H.M. Campbell" 5 => "M.R. Sather" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1345/aph.1H183" "Revista" => array:6 [ "tituloSerie" => "Ann Pharmacother" "fecha" => "2006" "volumen" => "40" "paginaInicial" => "1924" "paginaFinal" => "1931" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17047140" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequent prescribing of drugs with potential gastrointestinal toxicity among continuous users of non-steroidal anti-inflammatory drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Helin-Salmivaara" 1 => "R. Huupponen" 2 => "A. Virtanen" 3 => "J. Lammela" 4 => "T. Klaukka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00228-005-0949-y" "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Pharmacol" "fecha" => "2005" "volumen" => "61" "paginaInicial" => "425" "paginaFinal" => "431" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15952021" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Which patients taking non-aspirin non-steroidal anti-inflammatory drugs bleed? A case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Hochain" 1 => "I. Berkelmans" 2 => "P. Czernichow" 3 => "C. Duhamel" 4 => "J. Tranvouez" 5 => "E. Lerebours" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Gastroenterol Hepatol" "fecha" => "1995" "volumen" => "7" "paginaInicial" => "419" "paginaFinal" => "426" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7614104" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Holvoet" 1 => "L. Terriere" 2 => "W. van Hee" 3 => "L. Verbist" 4 => "E. Fierens" 5 => "M.L. Hautekeete" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gut" "fecha" => "1991" "volumen" => "32" "paginaInicial" => "730" "paginaFinal" => "734" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1855677" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Huerta" 1 => "J. Castellsague" 2 => "C. Varas-Lorenzo" 3 => "L.A. Garcia Rodriguez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.ajkd.2004.12.005" "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "2005" "volumen" => "45" "paginaInicial" => "531" "paginaFinal" => "539" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15754275" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroid-sparing action of flurbiprofen: use of an additional parameter of joint scans with 99m technetium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V.R. Joshi" 1 => "R.D. Lele" 2 => "A.R. Virani" 3 => "H.K. Nagarwala" 4 => "P.K. Pispati" 5 => "M.M. Desai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1185/03007997709108975" "Revista" => array:6 [ "tituloSerie" => "Curr Med Res Opin" "fecha" => "1977" "volumen" => "5" "paginaInicial" => "43" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/334473" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Longitudinal study of rheumatoid arthritis patients discloses sustained elevated serum levels of soluble cd106 (v-cam)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.N. Kolopp-Sarda" 1 => "F. Guillemin" 2 => "I. Chary-Valckenaere" 3 => "M.C. Bene" 4 => "J. Pourel" 5 => "G.C. Faure" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "165" "paginaFinal" => "170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11326478" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The EuroHeart Failure Survey programme-a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Komajda" 1 => "F. Follath" 2 => "K. Swedberg" 3 => "J. Cleland" 4 => "J.C. Aguilar" 5 => "A. Cohen-Solal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2003" "volumen" => "24" "paginaInicial" => "464" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12633547" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of nabumetone in the treatment of active adult rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.G. Lanier" 1 => "R.A. Turner Jr." 2 => "R.L. Collins" 3 => "R.G. Senter Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1987" "volumen" => "83" "paginaInicial" => "40" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3318427" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increasing dose of naproxen in rheumatoid arthritis: use with and without corticosteroids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Luftschein" 1 => "H. Bienenstock" 2 => "J.C. Varady" 3 => "F.W. Stitt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1979" "volumen" => "6" "paginaInicial" => "397" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/392094" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Gastroduodenal lesions in rheumatoid arthritis. Evaluation and treatment]" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.O. Martinez" 1 => "H. Casas" 2 => "P.A. Mazure" 3 => "H. Leczycki" 4 => "J.N. Cosen" 5 => "L. Canievsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Gastroenterol Latinoam" "fecha" => "1988" "volumen" => "18" "paginaInicial" => "87" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3075109" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The influence of antirheumatic drugs on the occurrence of peptic ulcers. A controlled study of patients with chronic rheumatic diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Martio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol" "fecha" => "1980" "volumen" => "9" "paginaInicial" => "55" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6990480" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "NSAID's – a double-edged sword" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. McNeil" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hosp Pharm" "fecha" => "1993" "volumen" => "28" "paginaInicial" => "50" "paginaFinal" => "55" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Double blind evaluation of the long-term effects of etodolac versus ibuprofen in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.H. Neustadt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1997" "volumen" => "47" "numero" => "Suppl" "paginaInicial" => "17" "paginaFinal" => "22" ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patient retention and hand-wrist radiograph progression of rheumatoid arthritis during a 3-year prospective study that prohibited disease modifying antirheumatic drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.E. Paulus" 1 => "D. Di Primeo" 2 => "J.T. Sharp" 3 => "H.K. Genant" 4 => "B.N. Weissman" 5 => "M.H. Weisman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2004" "volumen" => "31" "paginaInicial" => "470" "paginaFinal" => "481" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14994390" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tolfenamic acid in the treatment of rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Rejholec" 1 => "H. Vapaatalo" 2 => "O. Tokola" 3 => "G. Gothoni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol" "fecha" => "1979" "volumen" => "24" "numero" => "Suppl" "paginaInicial" => "9" "paginaFinal" => "12" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ileum-targeted steroid therapy in rheumatoid arthritis: doubleblind, placebo-controlled trial of controlled-release budesonide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Sheldon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00296-002-0278-8" "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "154" "paginaFinal" => "158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12856138" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-steroidal anti-inflammatory analgesics and oral corticosteroids in rheumatoid arthritis: do we need both?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Tougas" 1 => "C. Saldanha" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "1987" "volumen" => "5" "paginaInicial" => "89" "paginaFinal" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3297447" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000400000006/v1_201305061550/S2173574308701941/v1_201305061550/en/main.assets" "Apartado" => array:4 [ "identificador" => "17338" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original Article" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000400000006/v1_201305061550/S2173574308701941/v1_201305061550/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574308701941?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 11 | 19 |
| 2024 October | 94 | 53 | 147 |
| 2024 September | 53 | 32 | 85 |
| 2024 August | 43 | 32 | 75 |
| 2024 July | 40 | 40 | 80 |
| 2024 June | 50 | 31 | 81 |
| 2024 May | 36 | 35 | 71 |
| 2024 April | 38 | 30 | 68 |
| 2024 March | 48 | 33 | 81 |
| 2024 February | 32 | 27 | 59 |
| 2024 January | 30 | 24 | 54 |
| 2023 December | 33 | 27 | 60 |
| 2023 November | 27 | 20 | 47 |
| 2023 October | 25 | 33 | 58 |
| 2023 September | 39 | 42 | 81 |
| 2023 August | 17 | 15 | 32 |
| 2023 July | 26 | 28 | 54 |
| 2023 June | 26 | 20 | 46 |
| 2023 May | 22 | 13 | 35 |
| 2023 April | 16 | 14 | 30 |
| 2023 March | 19 | 14 | 33 |
| 2023 February | 21 | 25 | 46 |
| 2023 January | 24 | 24 | 48 |
| 2022 December | 42 | 46 | 88 |
| 2022 November | 47 | 37 | 84 |
| 2022 October | 39 | 36 | 75 |
| 2022 September | 22 | 34 | 56 |
| 2022 August | 25 | 46 | 71 |
| 2022 July | 23 | 46 | 69 |
| 2022 June | 24 | 32 | 56 |
| 2022 May | 24 | 54 | 78 |
| 2022 April | 25 | 49 | 74 |
| 2022 March | 22 | 46 | 68 |
| 2022 February | 18 | 38 | 56 |
| 2022 January | 17 | 46 | 63 |
| 2021 December | 29 | 39 | 68 |
| 2021 November | 26 | 48 | 74 |
| 2021 October | 24 | 49 | 73 |
| 2021 September | 21 | 41 | 62 |
| 2021 August | 24 | 39 | 63 |
| 2021 July | 11 | 27 | 38 |
| 2021 June | 26 | 39 | 65 |
| 2021 May | 24 | 36 | 60 |
| 2021 April | 47 | 58 | 105 |
| 2021 March | 58 | 28 | 86 |
| 2021 February | 29 | 26 | 55 |
| 2021 January | 23 | 24 | 47 |
| 2020 December | 23 | 24 | 47 |
| 2020 November | 27 | 27 | 54 |
| 2020 October | 19 | 17 | 36 |
| 2020 September | 34 | 24 | 58 |
| 2020 August | 17 | 19 | 36 |
| 2020 July | 22 | 22 | 44 |
| 2020 June | 42 | 11 | 53 |
| 2020 May | 33 | 23 | 56 |
| 2020 April | 27 | 22 | 49 |
| 2020 March | 22 | 7 | 29 |
| 2020 February | 6 | 0 | 6 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 August | 1 | 0 | 1 |
| 2019 July | 1 | 0 | 1 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 4 | 0 | 4 |
| 2019 January | 1 | 0 | 1 |
| 2018 December | 4 | 0 | 4 |
| 2018 May | 5 | 3 | 8 |
| 2018 April | 17 | 11 | 28 |
| 2018 March | 18 | 15 | 33 |
| 2018 February | 15 | 9 | 24 |
| 2018 January | 8 | 6 | 14 |
| 2017 December | 12 | 4 | 16 |
| 2017 November | 8 | 7 | 15 |
| 2017 October | 25 | 6 | 31 |
| 2017 September | 12 | 8 | 20 |
| 2017 August | 12 | 6 | 18 |
| 2017 July | 12 | 9 | 21 |
| 2017 June | 31 | 26 | 57 |
| 2017 May | 30 | 23 | 53 |
| 2017 April | 18 | 6 | 24 |
| 2017 March | 15 | 22 | 37 |
| 2017 February | 5 | 4 | 9 |
| 2017 January | 17 | 4 | 21 |
| 2016 December | 64 | 12 | 76 |
| 2016 November | 49 | 7 | 56 |
| 2016 October | 52 | 7 | 59 |
| 2016 September | 40 | 4 | 44 |
| 2016 August | 30 | 7 | 37 |
| 2016 July | 24 | 6 | 30 |
Show all
