The Therapeutic Blockade of TNF Reduces Serum Levels of Interleukin 15 in Patients With Rheumatoid Arthritis
El bloqueo terapéutico del factor de necrosis tumoral disminuye la concentración sérica de interleucina 15 en pacientes con artritis reumatoide
Read
4514
Timeswas read the article
2144
Total PDF
2370
Total HTML
Share statistics
array:23 [ "pii" => "S2173574309700838" "issn" => "21735743" "doi" => "10.1016/S2173-5743(09)70083-8" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70083" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2009;5:23-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1752 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 1221 "PDF" => 487 ] ] "itemSiguiente" => array:18 [ "pii" => "S217357430970084X" "issn" => "21735743" "doi" => "10.1016/S2173-5743(09)70084-X" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70084" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Reumatol Clin. 2009;5:28-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 576 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 410 "PDF" => 123 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Efficacy of Rituximab Combined With Wyclophosphamide in a Patient With Systemic Lupus Erythematosus and Peritoneal Vasculitis Refractory to Conventional Inmunosupressive Therapy" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "28" "paginaFinal" => "30" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia de rituximab combinado con ciclofosfamida en una paciente con lupus eritematoso sistémico y vasculitis peritoneal resistente a tratamiento inmunosupresor convencional" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rocío Garrido Rasco, Francisco José García Hernández, Rocío González León, María Jesús Castillo Palma, Celia Ocaña Medina, Julio Sánchez Román" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Rocío" "apellidos" => "Garrido Rasco" ] 1 => array:2 [ "nombre" => "Francisco José" "apellidos" => "García Hernández" ] 2 => array:2 [ "nombre" => "Rocío" "apellidos" => "González León" ] 3 => array:2 [ "nombre" => "María Jesús" "apellidos" => "Castillo Palma" ] 4 => array:2 [ "nombre" => "Celia" "apellidos" => "Ocaña Medina" ] 5 => array:2 [ "nombre" => "Julio" "apellidos" => "Sánchez Román" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357430970084X?idApp=UINPBA00004M" "url" => "/21735743/0000000500000001/v1_201305061551/S217357430970084X/v1_201305061551/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173574309700826" "issn" => "21735743" "doi" => "10.1016/S2173-5743(09)70082-6" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70082" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2009;5:18-22" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3021 "formatos" => array:3 [ "EPUB" => 45 "HTML" => 1777 "PDF" => 1199 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Polyarticular Septic Arthritis: Analysis of 19 Cases" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "18" "paginaFinal" => "22" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Artritis séptica politópica: análisis de 19 casos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lourdes Mateo Soria, Alejandro Olivé Marqués, Elisabet García Casares, Emma García Melchor, Susana Holgado Pérez, Xavier Tena Marsà" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Lourdes" "apellidos" => "Mateo Soria" ] 1 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Olivé Marqués" ] 2 => array:2 [ "nombre" => "Elisabet" "apellidos" => "García Casares" ] 3 => array:2 [ "nombre" => "Emma" "apellidos" => "García Melchor" ] 4 => array:2 [ "nombre" => "Susana" "apellidos" => "Holgado Pérez" ] 5 => array:2 [ "nombre" => "Xavier" "apellidos" => "Tena Marsà" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574309700826?idApp=UINPBA00004M" "url" => "/21735743/0000000500000001/v1_201305061551/S2173574309700826/v1_201305061551/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "titulo" => "The Therapeutic Blockade of TNF Reduces Serum Levels of Interleukin 15 in Patients With Rheumatoid Arthritis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "23" "paginaFinal" => "27" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Isidoro González-Álvaro, Ana M. Ortiz, Eva G. Tomero, Alejandro Balsa, Javier Orte, Pedro Sabando Suárez, Rosario García-Vicuña" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Isidoro" "apellidos" => "González-Álvaro" "email" => array:1 [ 0 => "isidoro.ga@ser.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Ana M." "apellidos" => "Ortiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Eva G." "apellidos" => "Tomero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Alejandro" "apellidos" => "Balsa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Javier" "apellidos" => "Orte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Pedro" "apellidos" => "Sabando Suárez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Rosario" "apellidos" => "García-Vicuña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El bloqueo terapéutico del factor de necrosis tumoral disminuye la concentración sérica de interleucina 15 en pacientes con artritis reumatoide" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-03-12" "fechaAceptado" => "2008-06-02" "PalabrasClave" => array:1 [ "en" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec111977" "palabras" => array:4 [ 0 => "Rheumatoid Arthritis" 1 => "Cytokines" 2 => "TNF antagonists" 3 => "IL-15" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec111978" "palabras" => array:4 [ 0 => "Rheumatoid arthritis" 1 => "Cytokines" 2 => "TNF antagonists" 3 => "IL-15" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the effect of the TNF blocking agents (aTNF) on the serum levels of interleukin 15 (IL- 15). To determine whether baseline IL-15 serum levels or their response to aTNF therapy can predict the TNF antagonist's clinical response to this treatment.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We studied 75 patients suffering from rheumatoid arthritis that were selected to start aTNF therapy. Serum samples were obtained at baseline visit and after 3 months of aTNF treatment. Measurement of IL-15 serum concentration was performed through immune-enzyme assay. We collected the clinical and analytical parameters needed to calculate DAS28 both at baseline and final visit, as well as sociodemographic variables and other such as rheumatoid factor, previous disease modifying antirheumatic drugs (DMARD), etc. We defined remission as a DAS28 <2.6 and clinical response when the decrease in DAS28 value was higher than 1.2.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">There was a significant correlation between IL-15 serum level and the number of previous DMARD. We also detected a significant decrease in the concentration of serum IL-15 after 3 months of treatment with aTNF. However, neither the baseline IL-15 serum level nor the decrease in the concentration of IL-15 was associated with a specific pattern of response to aTNF.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Our data seem to support previous in vitro findings suggesting that TNF is involved in the regulation of IL-15 expression. Nevertheless, the measurement of IL-15 serum levels does not seem to be a useful tool to select those patients that should be treated with aTNF therapy.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analizar el efecto de la terapia con agentes inhibidores del factor de necrosis tumoral (TNF) en la concentración sérica de interleucina 15 (IL-15) y determinar si los valores basales de ésta o su variación con el tratamiento predicen la respuesta clínica a los anti-TNF.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se estudió a 75 pacientes con artritis reumatoide que iban a iniciar tratamiento con anti-TNF. Se recogieron muestras de suero previas y a los 3 meses de tratamiento. La concentración de IL-15 se cuantificó mediante enzimoinmunoanálisis. Tanto en la visita basal como en la final se recogieron parámetros clínicos y analíticos que permitieran calcular el DAS28. También se recogieron variables sociodemográficas y otras relacionadas con la enfermedad, como factor reumatoide, número de fármacos previos, etc. Se definió remisión como un DAS28 < 2,6 y respuesta clínica relevante, como una disminución del DAS28 > 1,2.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La concentración de IL-15 se relacionó de forma significativa con un mayor uso de fármacos modificadores de la enfermedad durante el seguimiento de los pacientes. También se observó una disminución significativa de la IL-15 a los 3 meses de tratamiento con anti-TNF. Sin embargo, los valores basales de IL-15 y su disminución con el tratamiento no se relacionaron con la respuesta a los anti-TNF o la consecución de remisión clínica.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Nuestros datos parecen confirmar los obtenidos in vitro, que indican que el TNF está implicado en la modulación de la expresión de IL-15. No obstante, la medición de la concentración sérica de IL-15 no parece ser de utilidad para seleccionar a los pacientes candidatos a terapia anti-TNF.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-15: a new cytokine target for the treatment of inflammatory diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.B. McInnes" 1 => "J.A. Gracie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.coph.2004.04.003" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pharmacol" "fecha" => "2004" "volumen" => "4" "paginaInicial" => "392" "paginaFinal" => "397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15251134" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.A. Waldmann" 1 => "Y. Tagaya" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.immunol.17.1.19" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Immunol" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "19" "paginaFinal" => "49" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10358752" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O.J. Cordero" 1 => "F.J. Salgado" 2 => "A. Mera-Varela" 3 => "M. Nogueira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "2001" "volumen" => "21" "paginaInicial" => "69" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11732862" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased serum levels of interleukin-15 in rheumatoid arthritis with long- term disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I. Gonzalez-Alvaro" 1 => "A.M. Ortiz" 2 => "R. Garcia-Vicuna" 3 => "A. Balsa" 4 => "D. Pascual-Salcedo" 5 => "A. Laffon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "639" "paginaFinal" => "642" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14611115" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I.B. McInnes" 1 => "B.P. Leung" 2 => "R.D. Sturrock" 3 => "M. Field" 4 => "F.Y. Liew" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "1997" "volumen" => "3" "paginaInicial" => "189" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9018238" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CD69 expression on lymphocytes and interleukin- 15 levels in synovial fluids from different inflammatory arthropathies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Ortiz" 1 => "A. Laffon" 2 => "I. Gonzalez-Alvaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "2002" "volumen" => "21" "paginaInicial" => "182" "paginaFinal" => "188" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11958434" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-15 and interferon-gamma participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Gonzalez-Alvaro" 1 => "C. Dominguez-Jimenez" 2 => "A.M. Ortiz" 3 => "V. Nunez-Gonzalez" 4 => "P. Roda- Navarro" 5 => "E. Fernandez-Ruiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/ar1955" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2006" "volumen" => "8" "paginaInicial" => "R88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16684368" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.E. Miranda-Carus" 1 => "A. Balsa" 2 => "M. Benito-Miguel" 3 => "C. Perez de Ayala" 4 => "E. Martin-Mola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "2004" "volumen" => "173" "paginaInicial" => "1463" "paginaFinal" => "1476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15240743" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.C. Arnett" 1 => "S.M. Edworthy" 2 => "D.A. Bloch" 3 => "D.J. McShane" 4 => "J.F. Fries" 5 => "N.S. Cooper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1988" "volumen" => "31" "paginaInicial" => "315" "paginaFinal" => "324" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3358796" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.L. Prevoo" 1 => "M.A. van’t Hof" 2 => "H.H. Kuper" 3 => "M.A. van Leeuwen" 4 => "L.B. van de Putte" 5 => "P.L. van Riel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1995" "volumen" => "38" "paginaInicial" => "44" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7818570" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Generalized linear models and extensions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Hardin" 1 => "J. Hilbe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "2. a ed" "fecha" => "2007" "editorial" => "Stata Press" "editorialLocalizacion" => "College Station" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/Internacional League Against Rheumatism Criteria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.M. van Gestel" 1 => "M.L. Prevoo" 2 => "M.A. van’t Hof" 3 => "M.H. van Rijswijk" 4 => "L.B. van de Putte" 5 => "P.L. van Riel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1996" "volumen" => "39" "paginaInicial" => "34" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8546736" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rheumatoid arthritis in Spain: occurrence of extra-articular manifestations and estimates of disease severity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Carmona" 1 => "I. Gonzalez-Alvaro" 2 => "A. Balsa" 3 => "M. Angel Belmonte" 4 => "X. Tena" 5 => "R. Sanmarti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2003" "volumen" => "62" "paginaInicial" => "897" "paginaFinal" => "900" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12922967" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TNF-alpha modulates cytokine and cytokine receptors in C2C12 myotubes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Alvarez" 1 => "L.S. Quinn" 2 => "S. Busquets" 3 => "F.J. Lopez-Soriano" 4 => "J.M. Argiles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Lett" "fecha" => "2002" "volumen" => "175" "paginaInicial" => "181" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11741746" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermal fibroblasts sustain proliferation of activated T cells via membrane-bound interleukin- 15 upon long-term stimulation with tumor necrosis factor-alpha" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Rappl" 1 => "A. Kapsokefalou" 2 => "C. Heuser" 3 => "M. Rossler" 4 => "S. Ugurel" 5 => "W. Tilgen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2001.00239.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2001" "volumen" => "116" "paginaInicial" => "102" "paginaFinal" => "109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11168804" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Induction of IL-15 mRNA and protein in A549 cells by pro-inflammatory cytokines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Stoeck" 1 => "W. Kromer" 2 => "V. Gekeler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0171-2985(98)80060-0" "Revista" => array:6 [ "tituloSerie" => "Immunobiology" "fecha" => "1998" "volumen" => "199" "paginaInicial" => "14" "paginaFinal" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9717664" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased IL-15 production of muscle cells in polymyositis and dermatomyositis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Sugiura" 1 => "M. Harigai" 2 => "Y. Kawaguchi" 3 => "K. Takagi" 4 => "C. Fukasawa" 5 => "S. Ohsako-Higami" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Immunol" "fecha" => "2002" "volumen" => "14" "paginaInicial" => "917" "paginaFinal" => "924" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12147628" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y. Tagaya" 1 => "R.N. Bamford" 2 => "A.P. DeFilippis" 3 => "T.A. Waldmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Immunity" "fecha" => "1996" "volumen" => "4" "paginaInicial" => "329" "paginaFinal" => "336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8612127" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Variations in the drug treatment of rheumatoid arthritis in Spain]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Gonzalez-Alvaro" 1 => "C. Hernandez-Garcia" 2 => "V. Villaverde Garcia" 3 => "E. Vargas" 4 => "A.M. Ortiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2002" "volumen" => "118" "paginaInicial" => "771" "paginaFinal" => "776" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000500000001/v1_201305061551/S2173574309700838/v1_201305061551/en/main.assets" "Apartado" => array:4 [ "identificador" => "17338" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original Article" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000500000001/v1_201305061551/S2173574309700838/v1_201305061551/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574309700838?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 11 | 15 |
| 2024 October | 20 | 35 | 55 |
| 2024 September | 15 | 17 | 32 |
| 2024 August | 40 | 35 | 75 |
| 2024 July | 21 | 43 | 64 |
| 2024 June | 37 | 30 | 67 |
| 2024 May | 31 | 24 | 55 |
| 2024 April | 26 | 19 | 45 |
| 2024 March | 20 | 42 | 62 |
| 2024 February | 19 | 24 | 43 |
| 2024 January | 16 | 21 | 37 |
| 2023 December | 18 | 26 | 44 |
| 2023 November | 18 | 18 | 36 |
| 2023 October | 22 | 32 | 54 |
| 2023 September | 28 | 43 | 71 |
| 2023 August | 14 | 13 | 27 |
| 2023 July | 11 | 20 | 31 |
| 2023 June | 11 | 16 | 27 |
| 2023 May | 11 | 16 | 27 |
| 2023 April | 14 | 12 | 26 |
| 2023 March | 21 | 27 | 48 |
| 2023 February | 14 | 22 | 36 |
| 2023 January | 30 | 21 | 51 |
| 2022 December | 18 | 31 | 49 |
| 2022 November | 22 | 26 | 48 |
| 2022 October | 15 | 24 | 39 |
| 2022 September | 19 | 34 | 53 |
| 2022 August | 17 | 49 | 66 |
| 2022 July | 20 | 45 | 65 |
| 2022 June | 20 | 40 | 60 |
| 2022 May | 17 | 44 | 61 |
| 2022 April | 22 | 50 | 72 |
| 2022 March | 22 | 44 | 66 |
| 2022 February | 24 | 43 | 67 |
| 2022 January | 16 | 60 | 76 |
| 2021 December | 14 | 40 | 54 |
| 2021 November | 21 | 43 | 64 |
| 2021 October | 21 | 44 | 65 |
| 2021 September | 24 | 43 | 67 |
| 2021 August | 19 | 38 | 57 |
| 2021 July | 14 | 30 | 44 |
| 2021 June | 25 | 41 | 66 |
| 2021 May | 13 | 39 | 52 |
| 2021 April | 32 | 67 | 99 |
| 2021 March | 42 | 21 | 63 |
| 2021 February | 27 | 20 | 47 |
| 2021 January | 14 | 10 | 24 |
| 2020 December | 24 | 18 | 42 |
| 2020 November | 19 | 18 | 37 |
| 2020 October | 17 | 16 | 33 |
| 2020 September | 22 | 19 | 41 |
| 2020 August | 18 | 18 | 36 |
| 2020 July | 14 | 22 | 36 |
| 2020 June | 25 | 14 | 39 |
| 2020 May | 25 | 15 | 40 |
| 2020 April | 15 | 17 | 32 |
| 2020 March | 6 | 7 | 13 |
| 2020 February | 6 | 0 | 6 |
| 2019 December | 4 | 0 | 4 |
| 2019 July | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2018 December | 1 | 0 | 1 |
| 2018 May | 6 | 2 | 8 |
| 2018 April | 24 | 7 | 31 |
| 2018 March | 33 | 10 | 43 |
| 2018 February | 19 | 4 | 23 |
| 2018 January | 9 | 4 | 13 |
| 2017 December | 12 | 8 | 20 |
| 2017 November | 7 | 5 | 12 |
| 2017 October | 11 | 6 | 17 |
| 2017 September | 8 | 5 | 13 |
| 2017 August | 9 | 6 | 15 |
| 2017 July | 11 | 9 | 20 |
| 2017 June | 22 | 6 | 28 |
| 2017 May | 17 | 10 | 27 |
| 2017 April | 10 | 45 | 55 |
| 2017 March | 16 | 8 | 24 |
| 2017 February | 9 | 1 | 10 |
| 2017 January | 15 | 6 | 21 |
| 2016 December | 35 | 8 | 43 |
| 2016 November | 6 | 2 | 8 |
| 2016 October | 22 | 7 | 29 |
| 2016 September | 13 | 2 | 15 |
| 2016 August | 15 | 4 | 19 |
| 2016 July | 6 | 4 | 10 |
| 2016 May | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 September | 3 | 0 | 3 |
| 2015 August | 1 | 0 | 1 |
| 2015 July | 14 | 4 | 18 |
| 2015 June | 19 | 6 | 25 |
| 2015 May | 27 | 9 | 36 |
| 2015 April | 21 | 9 | 30 |
| 2015 March | 18 | 4 | 22 |
| 2015 February | 15 | 6 | 21 |
| 2015 January | 12 | 7 | 19 |
| 2014 December | 16 | 12 | 28 |
| 2014 November | 12 | 11 | 23 |
| 2014 October | 14 | 9 | 23 |
| 2014 September | 7 | 6 | 13 |
| 2014 August | 13 | 12 | 25 |
| 2014 July | 21 | 11 | 32 |
| 2014 June | 28 | 10 | 38 |
| 2014 May | 25 | 10 | 35 |
| 2014 April | 25 | 5 | 30 |
| 2014 March | 27 | 20 | 47 |
| 2014 February | 28 | 22 | 50 |
| 2014 January | 22 | 11 | 33 |
| 2013 December | 25 | 11 | 36 |
| 2013 November | 18 | 10 | 28 |
| 2013 October | 28 | 15 | 43 |
| 2013 September | 26 | 15 | 41 |
| 2013 August | 25 | 7 | 32 |
| 2013 July | 28 | 7 | 35 |
| 2013 June | 17 | 9 | 26 |
| 2013 May | 19 | 8 | 27 |
| 2013 April | 20 | 11 | 31 |
| 2013 March | 22 | 4 | 26 |
| 2013 February | 20 | 6 | 26 |
| 2013 January | 21 | 4 | 25 |
| 2012 December | 15 | 9 | 24 |
| 2012 November | 13 | 11 | 24 |
| 2012 October | 7 | 3 | 10 |
| 2012 September | 10 | 4 | 14 |
| 2012 June | 2 | 0 | 2 |
| 2012 May | 1 | 0 | 1 |
| 2012 April | 3 | 0 | 3 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 3 | 0 | 3 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 3 | 0 | 3 |
| 2011 November | 8 | 0 | 8 |
| 2011 October | 1 | 0 | 1 |
| 2011 September | 2 | 0 | 2 |
| 2011 August | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 1 | 0 | 1 |
| 2011 March | 2 | 0 | 2 |
| 2011 February | 6 | 0 | 6 |
| 2011 January | 2 | 0 | 2 |
| 2010 December | 6 | 0 | 6 |
| 2010 November | 3 | 0 | 3 |
| 2010 October | 4 | 0 | 4 |
| 2010 September | 2 | 0 | 2 |
| 2010 July | 6 | 0 | 6 |
| 2010 June | 3 | 0 | 3 |
| 2010 May | 2 | 0 | 2 |
| 2010 April | 4 | 0 | 4 |
| 2010 March | 6 | 0 | 6 |
| 2010 February | 5 | 0 | 5 |
| 2010 January | 7 | 0 | 7 |
| 2009 December | 12 | 0 | 12 |
| 2009 November | 5 | 0 | 5 |
| 2009 October | 14 | 0 | 14 |
| 2009 September | 4 | 0 | 4 |
| 2009 August | 9 | 0 | 9 |
| 2009 July | 12 | 0 | 12 |
| 2009 June | 38 | 0 | 38 |
| 2009 May | 6 | 0 | 6 |
Show all
