Interleukin 6 in the Physiopathology of Rheumatoid Arthritis
La interleucina 6 en la fisiopatología de la artrirtis reumatoide
José Luis Pablos Álvarez
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Servicio de Reumatología y Unidad de Investigación, Hospital 12 de Octubre, Madrid, Spain
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"identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Reumatología y Unidad de Investigación, Hospital 12 de Octubre, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La interleucina 6 en la fisiopatología de la artrirtis reumatoide" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-09-17" "fechaAceptado" => "2008-10-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec111992" "palabras" => array:6 [ 0 => "Interleukin 6" 1 => "Cytokines" 2 => "Rheumatoid arthritis" 3 => "Physiopathology" 4 => "Therapy" 5 => "Tocilizumab" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111993" "palabras" => array:6 [ 0 => "Interleucina 6" 1 => "Citocinas" 2 => "Artritis reumatoide" 3 => "Fisiopatología" 4 => "Terapia" 5 => "Tocilizumab" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Interleukin (IL) 6 was identified in 1986 as a factor produced by T lymphocytes, that mediates growth and immunoglobulin synthesis on B lymphocytes. IL-6 is a member of a large cytokine family sharing a gp130 membrane receptor. This receptor mediates specific Jak/STAT3 activation, which induces widespread expression of pro-inflammatory and immunoregulatory genes. IL-6 mediates potent systemic responses, in organs distant from its local inflammatory sources, in a prominent fashion compared to other cytokines. Most specific effects involve hematopoiesis and hepatic acute phase reactants synthesis. IL-6 became a rheumatoid arthritis (RA) target due to its pro-inflammatory and joint destructive potential, as well as its participation in T and B immunoregulation. The therapeutic success of tocilizumab has confirmed IL-6 as an RA target.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Although additional studies on the participation of IL-6 in RA physiopathology are needed, a number of indirect data point to a relevant position in this setting.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La interleucina (IL) 6 fue identificada en 1986 como un factor producido por los linfocitos T, con efectos estimuladores del crecimiento y síntesis de inmunoglobulinas en los linfocitos B. Pertenece a una amplia familia de citocinas que comparten el receptor de membrana gp130, mediador de una señal específica de activación del sistema Jak/STAT3 con amplios efectos en la expresión de genes proinflamatorios e inmunorreguladores.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">De forma más prominente que otras citocinas, la IL-6 media potentes acciones sistémicas en órganos distantes de su origen local inflamatorio. Las más específicas afectan a la hematopoyesis y la síntesis hepática de reactantes de fase aguda. Su potencial actividad proinflamatoria y de destrucción articular, junto con su implicación en la inmunorregulación T y B, la convirtió en una diana terapéutica atractiva, confirmada por el éxito de su antagonista tocilizumab en la artritis reumatoide (AR).</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Aunque son necesarios estudios más amplios sobre la participación de la IL-6 en la fisiopatología de la AR, numerosos datos indirectos permiten situarla en una posición muy relevante.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-6: from basic science to medicine. 40 years in immunology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 12 | 19 |
| 2024 October | 36 | 45 | 81 |
| 2024 September | 43 | 16 | 59 |
| 2024 August | 60 | 37 | 97 |
| 2024 July | 36 | 35 | 71 |
| 2024 June | 48 | 44 | 92 |
| 2024 May | 45 | 28 | 73 |
| 2024 April | 37 | 24 | 61 |
| 2024 March | 40 | 29 | 69 |
| 2024 February | 40 | 19 | 59 |
| 2024 January | 36 | 29 | 65 |
| 2023 December | 31 | 29 | 60 |
| 2023 November | 34 | 19 | 53 |
| 2023 October | 26 | 34 | 60 |
| 2023 September | 30 | 40 | 70 |
| 2023 August | 27 | 12 | 39 |
| 2023 July | 17 | 26 | 43 |
| 2023 June | 25 | 27 | 52 |
| 2023 May | 27 | 14 | 41 |
| 2023 April | 21 | 9 | 30 |
| 2023 March | 25 | 33 | 58 |
| 2023 February | 34 | 27 | 61 |
| 2023 January | 32 | 28 | 60 |
| 2022 December | 38 | 34 | 72 |
| 2022 November | 31 | 26 | 57 |
| 2022 October | 22 | 36 | 58 |
| 2022 September | 21 | 28 | 49 |
| 2022 August | 23 | 50 | 73 |
| 2022 July | 19 | 44 | 63 |
| 2022 June | 23 | 34 | 57 |
| 2022 May | 25 | 44 | 69 |
| 2022 April | 26 | 45 | 71 |
| 2022 March | 42 | 49 | 91 |
| 2022 February | 24 | 35 | 59 |
| 2022 January | 22 | 37 | 59 |
| 2021 December | 28 | 43 | 71 |
| 2021 November | 28 | 39 | 67 |
| 2021 October | 25 | 51 | 76 |
| 2021 September | 24 | 40 | 64 |
| 2021 August | 15 | 37 | 52 |
| 2021 July | 11 | 35 | 46 |
| 2021 June | 16 | 45 | 61 |
| 2021 May | 24 | 38 | 62 |
| 2021 April | 49 | 82 | 131 |
| 2021 March | 43 | 29 | 72 |
| 2021 February | 48 | 36 | 84 |
| 2021 January | 19 | 14 | 33 |
| 2020 December | 28 | 23 | 51 |
| 2020 November | 23 | 30 | 53 |
| 2020 October | 10 | 24 | 34 |
| 2020 September | 71 | 20 | 91 |
| 2020 August | 91 | 18 | 109 |
| 2020 July | 80 | 15 | 95 |
| 2020 June | 43 | 27 | 70 |
| 2020 May | 24 | 35 | 59 |
| 2020 April | 23 | 24 | 47 |
| 2020 March | 10 | 9 | 19 |
| 2020 February | 5 | 0 | 5 |
| 2019 December | 4 | 0 | 4 |
| 2019 July | 2 | 0 | 2 |
| 2019 June | 1 | 0 | 1 |
| 2019 April | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 2 | 0 | 2 |
| 2018 December | 2 | 0 | 2 |
| 2018 May | 4 | 3 | 7 |
| 2018 April | 16 | 8 | 24 |
| 2018 March | 19 | 12 | 31 |
| 2018 February | 14 | 5 | 19 |
| 2018 January | 10 | 4 | 14 |
| 2017 December | 10 | 6 | 16 |
| 2017 November | 14 | 6 | 20 |
| 2017 October | 9 | 9 | 18 |
| 2017 September | 10 | 3 | 13 |
| 2017 August | 10 | 8 | 18 |
| 2017 July | 8 | 7 | 15 |
| 2017 June | 22 | 5 | 27 |
| 2017 May | 21 | 16 | 37 |
| 2017 April | 14 | 5 | 19 |
| 2017 March | 14 | 2 | 16 |
| 2017 February | 9 | 7 | 16 |
| 2017 January | 13 | 5 | 18 |
| 2016 December | 35 | 17 | 52 |
| 2016 November | 23 | 2 | 25 |
| 2016 October | 34 | 7 | 41 |
| 2016 September | 21 | 7 | 28 |
| 2016 August | 14 | 4 | 18 |
| 2016 July | 12 | 3 | 15 |
| 2016 January | 3 | 0 | 3 |
| 2015 December | 2 | 0 | 2 |
| 2015 September | 1 | 0 | 1 |
| 2015 July | 15 | 4 | 19 |
| 2015 June | 11 | 14 | 25 |
| 2015 May | 32 | 22 | 54 |
| 2015 April | 25 | 28 | 53 |
| 2015 March | 16 | 17 | 33 |
| 2015 February | 10 | 13 | 23 |
| 2015 January | 17 | 13 | 30 |
| 2014 December | 25 | 15 | 40 |
| 2014 November | 19 | 17 | 36 |
| 2014 October | 13 | 17 | 30 |
| 2014 September | 12 | 13 | 25 |
| 2014 August | 20 | 22 | 42 |
| 2014 July | 19 | 25 | 44 |
| 2014 June | 24 | 28 | 52 |
| 2014 May | 28 | 28 | 56 |
| 2014 April | 31 | 18 | 49 |
| 2014 March | 44 | 23 | 67 |
| 2014 February | 30 | 20 | 50 |
| 2014 January | 28 | 28 | 56 |
| 2013 December | 18 | 26 | 44 |
| 2013 November | 20 | 17 | 37 |
| 2013 October | 33 | 13 | 46 |
| 2013 September | 27 | 25 | 52 |
| 2013 August | 23 | 18 | 41 |
| 2013 July | 44 | 17 | 61 |
| 2013 June | 22 | 21 | 43 |
| 2013 May | 12 | 21 | 33 |
| 2013 April | 22 | 16 | 38 |
| 2013 March | 24 | 26 | 50 |
| 2013 February | 24 | 16 | 40 |
| 2013 January | 23 | 20 | 43 |
| 2012 December | 21 | 20 | 41 |
| 2012 November | 13 | 32 | 45 |
| 2012 October | 9 | 16 | 25 |
| 2012 September | 7 | 9 | 16 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 2 | 0 | 2 |
| 2012 May | 3 | 0 | 3 |
| 2012 April | 8 | 0 | 8 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 3 | 0 | 3 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 5 | 0 | 5 |
| 2011 November | 10 | 0 | 10 |
| 2011 October | 3 | 0 | 3 |
| 2011 September | 2 | 0 | 2 |
| 2011 August | 3 | 0 | 3 |
| 2011 July | 4 | 0 | 4 |
| 2011 June | 5 | 0 | 5 |
| 2011 May | 3 | 0 | 3 |
| 2011 April | 1 | 0 | 1 |
| 2011 March | 12 | 0 | 12 |
| 2011 February | 5 | 0 | 5 |
| 2011 January | 7 | 0 | 7 |
| 2010 December | 5 | 0 | 5 |
| 2010 November | 4 | 0 | 4 |
| 2010 October | 12 | 0 | 12 |
| 2010 September | 12 | 0 | 12 |
| 2010 August | 5 | 0 | 5 |
| 2010 July | 11 | 0 | 11 |
| 2010 June | 7 | 0 | 7 |
| 2010 May | 12 | 0 | 12 |
| 2010 April | 17 | 0 | 17 |
| 2010 March | 24 | 0 | 24 |
| 2010 February | 9 | 0 | 9 |
| 2010 January | 9 | 0 | 9 |
| 2009 December | 9 | 0 | 9 |
| 2009 November | 18 | 0 | 18 |
| 2009 October | 10 | 0 | 10 |
| 2009 September | 4 | 0 | 4 |
| 2009 August | 11 | 0 | 11 |
| 2009 July | 14 | 0 | 14 |
| 2009 June | 37 | 0 | 37 |
| 2009 May | 8 | 0 | 8 |
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