Review
Extrahepatic manifestations in patients with chronic infections due to the hepatitis C virus
Manifestaciones extrahepáticas en pacientes con infección crónica por el virus de la hepatitis C
Manuel Ramos-Casals
Laboratory of Autoimmune Disease Josep Font, IDIBAPS, Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Spain
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The hepatitis C virus (HCV), a linear, singlestranded RNA virus, identified in 1989, is recognized as one of the viruses most often associated with autoimmune features. The association between HCV and SAD has generated growing interest in recent years. The extrahepatic manifestations often observed in patients with chronic HCV infection (both clinical and immunological) may lead to the fulfillment of the current classification criteria for some SAD.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Existe una estrecha relación entre los procesos autoinmunitarios y las infecciones virales, un hecho que ha originado que se propusiera diversos virus como posibles agentes etiológicos o desencadenantes de las enfermedades autoinmunitarias sistémicas (EAS). El virus de la hepatitis C (VHC) es un virus ARN de cadena única identificado en 1989, y que en la actualidad se considera uno de los agentes virales más relacionados con el desarrollo de manifestaciones autoinmunitarias. La relación del VHC con las diversas EAS ha generado un interés creciente en los últimos años, ya que las manifestaciones extrahepáticas, que a menudo presentan los pacientes con infección crónica por el VHC (tanto clínicas como inmunológicas), pueden ocasionar el cumplimiento de los criterios clasificatorios vigentes de diversas EAS.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2015 April | 22 | 25 | 47 |
| 2015 March | 15 | 27 | 42 |
| 2015 February | 18 | 15 | 33 |
| 2015 January | 16 | 26 | 42 |
| 2014 December | 26 | 20 | 46 |
| 2014 November | 13 | 30 | 43 |
| 2014 October | 24 | 21 | 45 |
| 2014 September | 24 | 13 | 37 |
| 2014 August | 23 | 30 | 53 |
| 2014 July | 18 | 16 | 34 |
| 2014 June | 33 | 22 | 55 |
| 2014 May | 26 | 21 | 47 |
| 2014 April | 42 | 8 | 50 |
| 2014 March | 45 | 19 | 64 |
| 2014 February | 40 | 16 | 56 |
| 2014 January | 38 | 19 | 57 |
| 2013 December | 35 | 16 | 51 |
| 2013 November | 25 | 16 | 41 |
| 2013 October | 33 | 13 | 46 |
| 2013 September | 28 | 20 | 48 |
| 2013 August | 24 | 3 | 27 |
| 2013 July | 34 | 10 | 44 |
| 2013 June | 22 | 10 | 32 |
| 2013 May | 18 | 5 | 23 |
| 2013 April | 21 | 5 | 26 |
| 2013 March | 27 | 7 | 34 |
| 2013 February | 19 | 5 | 24 |
| 2013 January | 15 | 7 | 22 |
| 2012 December | 19 | 7 | 26 |
| 2012 November | 4 | 12 | 16 |
| 2012 October | 2 | 2 | 4 |
| 2012 September | 3 | 2 | 5 |
| 2012 June | 1 | 0 | 1 |
| 2012 April | 3 | 0 | 3 |
| 2012 March | 4 | 0 | 4 |
| 2012 February | 1 | 0 | 1 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 3 | 0 | 3 |
| 2011 November | 7 | 0 | 7 |
| 2011 October | 3 | 0 | 3 |
| 2011 June | 3 | 0 | 3 |
| 2011 May | 2 | 0 | 2 |
| 2011 March | 5 | 0 | 5 |
| 2011 February | 4 | 0 | 4 |
| 2011 January | 1 | 0 | 1 |
| 2010 December | 4 | 0 | 4 |
| 2010 November | 1 | 0 | 1 |
| 2010 October | 2 | 0 | 2 |
| 2010 September | 4 | 0 | 4 |
| 2010 August | 3 | 0 | 3 |
| 2010 July | 3 | 0 | 3 |
| 2010 May | 6 | 0 | 6 |
| 2010 April | 12 | 0 | 12 |
| 2010 March | 13 | 0 | 13 |
| 2010 February | 8 | 0 | 8 |
| 2010 January | 1 | 0 | 1 |
| 2009 December | 5 | 0 | 5 |
| 2009 November | 8 | 0 | 8 |
| 2009 October | 22 | 0 | 22 |
| 2009 September | 15 | 0 | 15 |
| 2009 August | 21 | 0 | 21 |
Show all
