Characteristics of Paget's disease in Spain. Data from the National Paget's Register
Características de la enfermedad ósea de Paget en España. Datos del Registro Nacional de Paget
Javier del Pino-Montesa, M. Jesús García de Yébenes Prousb,
, Antonio Torrijos Eslavac, Antonio Morales Pigad, Jordi Carbonell Abellóe, Jordi Farrerons Minguelaf, Jesús Garrido Garcíab, Milena Gobbo Montoyab, Manuel Rodríguez Pérezg, Jesús Tornero Molinah, Nuria Guañabens Gayi, Loreto Carmonab, the Register working Group (list in the Appendix)
Corresponding author
a Sección de Reumatologia, Hospital Universitario de Salamanca, RETICEF, Salamanca, Spain
b Unidad de Investigación de la Fundación Española de Reumatología, Madrid, Spain
c Servicio de Reumatología, Hospital La Paz, Madrid, Spain
d Ministerio de Sanidad y Consumo, Madrid, Spain
e Servicio de Reumatología, Instituto Municipal de Asistencia Sanitaria, Barcelona, Spain
f Servicio de Medicina Interna, Hospital de la Santa Creu i San Pau, Barcelona, Spain
g Servicio de Reumatología, Hospital Regional Universitario Carlos Haya, Málaga, Spain
h Servicio de Reumatología, Hospital General, Guadalajara, Castilla-La Mancha, Spain
i Servicio de Reumatología, Hospital Clinic i Provincial, Barcelona, Spain
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Datos del Registro Nacional de Paget" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-04-30" "fechaAceptado" => "2008-11-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112082" "palabras" => array:3 [ 0 => "Paget disease" 1 => "National registry" 2 => "Characteristics of patients" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112081" "palabras" => array:3 [ 0 => "Enfermedad de Paget" 1 => "Registro nacional" 2 => "Características de los sujetos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical and epidemiological characteristics of patients included in the National Register of Paget's disease.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A Register of patients with Paget disease (PD), radiologically confirmed, and pertaining to 25 hospitals was analyzed. Clinical and epidemiological data were collected, including age, sex, date, and presentations at time of diagnosis, treatment, quality of life (QL) (EuroQol 5D) and perceived health, environmental factors (profession, history of measles, contact with animals, dairy consumption, housing conditions, place of birth and address) and family history (PD history, origin of the ancestors, number of children). We conducted a statistical description of the data.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The register included 602 patients with an average age of 62 (11) years and a predominance of male (55%). Of the patients included, 79% showed symptoms at the time of diagnosis, mainly pain (83%); 82% had received treatment, mainly bisphosphonates (47% more than one drug). Despite treatment, a significant proportion had limitations in their QL, especially related to pain (64%), mobility (47%), and anxiety/depression (33%). Most of the patients had been exposed to situations which were considered as risk factors. Of the patients included, 14% had family history of PD and 1.5% had children with PD. The ancestors of the familial cases came more frequently from Ávila, Salamanca, La Coruña, and Málaga.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The pain and the limitation of mobility decrease the QL of patients with PD despite treatment. Frequently, patients have a history of exposure to risk factors</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Describir las características clínicas y epidemiológicas de los sujetos incluidos en el Registro Nacional de Paget.</p> <span class="elsevierStyleSectionTitle">Sujetos y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Registro de pacientes con enfermedad ósea de Paget (EOP), confirmada radiológicamente, de 25 centros participantes. Se recogieron datos clinicoepidemiológicos (edad, sexo, fecha y manifestaciones al diagnóstico y tratamientos), calidad de vida (CV) (cuestionario EuroQol de 5 dimensiones), estado de salud, factores ambientales (profesión, antecedentes de sarampión, contacto con animales, consumo de lácteos, condiciones de la vivienda, lugar de nacimiento y domicilio) y familiares (historia de EOP, procedencia de los ascendientes y número de hijos). Se realizó una descripción estadística de los datos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El registro incluyó a 602 sujetos con edad media de 62 (11) años con predominio de varones (55%). El 79% de los sujetos presentaba síntomas en el momento del diagnóstico, fundamentalmente dolor (83%). El 82% de los sujetos había recibido tratamiento, principalmente bisfosfonatos, con más de un fármaco en el 47% de los casos. A pesar del tratamiento, una proporción importante tenía limitación de la CV, especialmente relacionada con dolor (64%), movilidad (47%) y ansiedad junto con malestar (33%). La mayor parte de los sujetos habían estado expuestos a situaciones que se consideran factores de riesgo. El 14% de los sujetos tenía historia familiar de EOP y el 1,5% de los sujetos tenía hijos con EOP. Los ascendientes de los casos familiares procedían con más frecuencia de Ávila, Salamanca, Málaga y La Coruña.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El dolor y la limitación de la movilidad disminuyen la CV del sujeto con EOP a pesar del tratamiento. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 18 | 28 |
| 2024 October | 36 | 54 | 90 |
| 2024 September | 38 | 30 | 68 |
| 2024 August | 50 | 36 | 86 |
| 2024 July | 28 | 38 | 66 |
| 2024 June | 34 | 30 | 64 |
| 2024 May | 33 | 30 | 63 |
| 2024 April | 20 | 21 | 41 |
| 2024 March | 23 | 40 | 63 |
| 2024 February | 23 | 26 | 49 |
| 2024 January | 14 | 29 | 43 |
| 2023 December | 24 | 63 | 87 |
| 2023 November | 21 | 52 | 73 |
| 2023 October | 16 | 35 | 51 |
| 2023 September | 42 | 40 | 82 |
| 2023 August | 17 | 9 | 26 |
| 2023 July | 12 | 22 | 34 |
| 2023 June | 15 | 20 | 35 |
| 2023 May | 13 | 6 | 19 |
| 2023 April | 12 | 11 | 23 |
| 2023 March | 26 | 26 | 52 |
| 2023 February | 21 | 29 | 50 |
| 2023 January | 14 | 18 | 32 |
| 2022 December | 23 | 36 | 59 |
| 2022 November | 26 | 26 | 52 |
| 2022 October | 19 | 23 | 42 |
| 2022 September | 14 | 30 | 44 |
| 2022 August | 28 | 46 | 74 |
| 2022 July | 26 | 58 | 84 |
| 2022 June | 18 | 41 | 59 |
| 2022 May | 24 | 47 | 71 |
| 2022 April | 19 | 48 | 67 |
| 2022 March | 26 | 48 | 74 |
| 2022 February | 17 | 38 | 55 |
| 2022 January | 17 | 37 | 54 |
| 2021 December | 19 | 47 | 66 |
| 2021 November | 20 | 51 | 71 |
| 2021 October | 17 | 59 | 76 |
| 2021 September | 20 | 66 | 86 |
| 2021 August | 19 | 44 | 63 |
| 2021 July | 12 | 31 | 43 |
| 2021 June | 19 | 47 | 66 |
| 2021 May | 13 | 36 | 49 |
| 2021 April | 39 | 89 | 128 |
| 2021 March | 34 | 20 | 54 |
| 2021 February | 20 | 17 | 37 |
| 2021 January | 19 | 25 | 44 |
| 2020 December | 8 | 16 | 24 |
| 2020 November | 15 | 23 | 38 |
| 2020 October | 12 | 13 | 25 |
| 2020 September | 14 | 19 | 33 |
| 2020 August | 16 | 14 | 30 |
| 2020 July | 12 | 14 | 26 |
| 2020 June | 21 | 12 | 33 |
| 2020 May | 19 | 19 | 38 |
| 2020 April | 18 | 13 | 31 |
| 2020 March | 14 | 11 | 25 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 2 | 1 | 3 |
| 2018 April | 34 | 12 | 46 |
| 2018 March | 28 | 11 | 39 |
| 2018 February | 54 | 4 | 58 |
| 2018 January | 10 | 5 | 15 |
| 2017 December | 45 | 6 | 51 |
| 2017 November | 9 | 4 | 13 |
| 2017 October | 7 | 4 | 11 |
| 2017 September | 14 | 7 | 21 |
| 2017 August | 9 | 7 | 16 |
| 2017 July | 12 | 8 | 20 |
| 2017 June | 28 | 9 | 37 |
| 2017 May | 22 | 10 | 32 |
| 2017 April | 18 | 3 | 21 |
| 2017 March | 10 | 15 | 25 |
| 2017 February | 6 | 2 | 8 |
| 2017 January | 10 | 2 | 12 |
| 2016 December | 35 | 11 | 46 |
| 2016 November | 24 | 3 | 27 |
| 2016 October | 31 | 6 | 37 |
| 2016 September | 21 | 4 | 25 |
| 2016 August | 15 | 3 | 18 |
| 2016 July | 14 | 2 | 16 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 1 | 0 | 1 |
| 2015 September | 3 | 0 | 3 |
| 2015 August | 1 | 0 | 1 |
| 2015 July | 12 | 3 | 15 |
| 2015 June | 18 | 7 | 25 |
| 2015 May | 27 | 16 | 43 |
| 2015 April | 24 | 7 | 31 |
| 2015 March | 15 | 6 | 21 |
| 2015 February | 15 | 8 | 23 |
| 2015 January | 13 | 10 | 23 |
| 2014 December | 21 | 16 | 37 |
| 2014 November | 13 | 10 | 23 |
| 2014 October | 15 | 10 | 25 |
| 2014 September | 12 | 14 | 26 |
| 2014 August | 20 | 12 | 32 |
| 2014 July | 18 | 11 | 29 |
| 2014 June | 30 | 11 | 41 |
| 2014 May | 26 | 14 | 40 |
| 2014 April | 22 | 13 | 35 |
| 2014 March | 45 | 14 | 59 |
| 2014 February | 25 | 13 | 38 |
| 2014 January | 21 | 9 | 30 |
| 2013 December | 28 | 10 | 38 |
| 2013 November | 12 | 6 | 18 |
| 2013 October | 28 | 16 | 44 |
| 2013 September | 29 | 12 | 41 |
| 2013 August | 17 | 17 | 34 |
| 2013 July | 31 | 7 | 38 |
| 2013 June | 24 | 6 | 30 |
| 2013 May | 22 | 3 | 25 |
| 2013 April | 13 | 10 | 23 |
| 2013 March | 17 | 13 | 30 |
| 2013 February | 18 | 6 | 24 |
| 2013 January | 15 | 6 | 21 |
| 2012 December | 12 | 9 | 21 |
| 2012 November | 8 | 5 | 13 |
| 2012 October | 2 | 4 | 6 |
| 2012 September | 5 | 17 | 22 |
| 2012 June | 1 | 0 | 1 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 1 | 0 | 1 |
| 2012 January | 5 | 0 | 5 |
| 2011 December | 3 | 0 | 3 |
| 2011 November | 9 | 0 | 9 |
| 2011 October | 2 | 0 | 2 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 1 | 0 | 1 |
| 2011 June | 4 | 0 | 4 |
| 2011 April | 2 | 0 | 2 |
| 2011 February | 7 | 0 | 7 |
| 2011 January | 8 | 0 | 8 |
| 2010 December | 4 | 0 | 4 |
| 2010 November | 7 | 0 | 7 |
| 2010 October | 2 | 0 | 2 |
| 2010 September | 14 | 0 | 14 |
| 2010 August | 4 | 0 | 4 |
| 2010 July | 4 | 0 | 4 |
| 2010 June | 1 | 0 | 1 |
| 2010 May | 2 | 0 | 2 |
| 2010 April | 5 | 0 | 5 |
| 2010 March | 4 | 0 | 4 |
| 2010 February | 2 | 0 | 2 |
| 2010 January | 4 | 0 | 4 |
| 2009 December | 19 | 0 | 19 |
| 2009 November | 17 | 0 | 17 |
Show all
