Inhibition of interleukin 6, a new therapeutic option in rheumatoid arthritis
La inhibición de la interleucina-6, una nueva opción terapéutica en la artritis reumatoide
Ricardo Blanco Alonso
, Mario Agudo Bilbao
Corresponding author
Servicio de Reumatología, Hospital Universitario Marqués de Valdecilla, Santander, Spain
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In Japan it is already under use for Castleman's disease, rheumatoid arthritis (RA), and juvenile idiopathic arthritis. The clinical development outside Japan is very extensive and has shown efficacy in possible RA scenarios; early RA (part of the AMBITION study), established, MTX-resistant RA (OPTION) and RA resistant to other DMARD (TOWARD), and anti-TNF-α resistant RA (RADIATE). Both monotherapy with TCZ (AMBITION) and associated to other background drugs. Radiological efficacy has also been proven (LITHE). So TCZ is probably the biologic therapy with the most extensive clinical development before marketing in the western hemisphere. In this review we will specifically deal with clinical and radiological efficacy, as wel as its safety profile.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Tocilizumab (TCZ) es un anticuerpo monoclonal humanizado dirigido contra el receptor de la interleucina-6 (IL-6) desarrollado entre la farmacéutica japonesa Chugai y la suiza Roche. En Japón tiene ya indicación para la enfermedad de Castleman, artritis reumatoide (AR) y artritis idiopática juvenil. El desarrollo clínico fuera de Japón es muy extenso y ha demostrado eficacia en los escenarios posibles de la AR, AR precoz (parte del estudio AMBITION), AR establecida refractaria a metotrexato (OPTION) y a otros fármacos modificadores de enfermedad (TOWARD) y AR refractaria a anti-TNF-α (RADIATE), tanto con TCZ en monoterapia (estudio AMBITION) como asociado a fármacos de fondo. También se ha comprobado la eficacia radiológica (LITHE). En consecuencia el TCZ es probablemente el fármaco biológico con el desarrollo clínico más extenso habiéndose aprobado su comercialización por la agencia europea del medicamento con las siguientes indicaciones: TCZ en combinación con MTX está indicado para el tratamiento de la AR activa de moderada a grave en pacientes adultos que han presentado una respuesta inadecuada o fueron intolerantes a terapia previa con uno o más FAMEs o antagonistas del TNF. En estos pacientes TCZ puede ser administrado en monoterapia, en caso de intolerancia a MTX, o cuando el tratamiento prolongado con MTX es inapropiado. En esta revisión nos centraremos especialmente en la eficacia clínica, radiológica, así como en el perfil de seguridad</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
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| 2024 November | 5 | 24 | 29 |
| 2024 October | 27 | 36 | 63 |
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| 2024 April | 28 | 15 | 43 |
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| 2024 February | 27 | 27 | 54 |
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| 2023 December | 18 | 30 | 48 |
| 2023 November | 23 | 36 | 59 |
| 2023 October | 22 | 31 | 53 |
| 2023 September | 27 | 36 | 63 |
| 2023 August | 20 | 13 | 33 |
| 2023 July | 21 | 24 | 45 |
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| 2023 May | 14 | 8 | 22 |
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| 2023 March | 28 | 33 | 61 |
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| 2020 February | 2 | 0 | 2 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 3 | 3 | 6 |
| 2018 April | 9 | 12 | 21 |
| 2018 March | 20 | 14 | 34 |
| 2018 February | 12 | 4 | 16 |
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| 2017 December | 13 | 8 | 21 |
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| 2017 September | 12 | 8 | 20 |
| 2017 August | 10 | 6 | 16 |
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| 2017 June | 23 | 7 | 30 |
| 2017 May | 22 | 14 | 36 |
| 2017 April | 14 | 9 | 23 |
| 2017 March | 11 | 17 | 28 |
| 2017 February | 10 | 7 | 17 |
| 2017 January | 9 | 8 | 17 |
| 2016 December | 33 | 18 | 51 |
| 2016 November | 15 | 7 | 22 |
| 2016 October | 29 | 16 | 45 |
| 2016 September | 18 | 3 | 21 |
| 2016 August | 17 | 4 | 21 |
| 2016 July | 11 | 9 | 20 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 September | 1 | 0 | 1 |
| 2015 July | 18 | 3 | 21 |
| 2015 June | 19 | 21 | 40 |
| 2015 May | 27 | 20 | 47 |
| 2015 April | 26 | 23 | 49 |
| 2015 March | 18 | 25 | 43 |
| 2015 February | 12 | 11 | 23 |
| 2015 January | 16 | 22 | 38 |
| 2014 December | 20 | 28 | 48 |
| 2014 November | 12 | 28 | 40 |
| 2014 October | 13 | 28 | 41 |
| 2014 September | 12 | 18 | 30 |
| 2014 August | 17 | 32 | 49 |
| 2014 July | 17 | 24 | 41 |
| 2014 June | 28 | 24 | 52 |
| 2014 May | 33 | 18 | 51 |
| 2014 April | 34 | 10 | 44 |
| 2014 March | 41 | 19 | 60 |
| 2014 February | 44 | 14 | 58 |
| 2014 January | 34 | 16 | 50 |
| 2013 December | 22 | 11 | 33 |
| 2013 November | 25 | 22 | 47 |
| 2013 October | 34 | 11 | 45 |
| 2013 September | 31 | 19 | 50 |
| 2013 August | 21 | 19 | 40 |
| 2013 July | 21 | 14 | 35 |
| 2013 June | 24 | 12 | 36 |
| 2013 May | 21 | 14 | 35 |
| 2013 April | 22 | 21 | 43 |
| 2013 March | 23 | 12 | 35 |
| 2013 February | 28 | 9 | 37 |
| 2013 January | 19 | 10 | 29 |
| 2012 December | 21 | 15 | 36 |
| 2012 November | 6 | 17 | 23 |
| 2012 October | 2 | 15 | 17 |
| 2012 September | 4 | 5 | 9 |
| 2012 May | 2 | 0 | 2 |
| 2012 April | 2 | 0 | 2 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 4 | 0 | 4 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 3 | 0 | 3 |
| 2011 November | 4 | 0 | 4 |
| 2011 October | 5 | 0 | 5 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 1 | 0 | 1 |
| 2011 June | 4 | 0 | 4 |
| 2011 May | 1 | 0 | 1 |
| 2011 March | 3 | 0 | 3 |
| 2011 February | 8 | 0 | 8 |
| 2011 January | 12 | 0 | 12 |
| 2010 December | 9 | 0 | 9 |
| 2010 November | 5 | 0 | 5 |
| 2010 October | 7 | 0 | 7 |
| 2010 September | 10 | 0 | 10 |
| 2010 August | 3 | 0 | 3 |
| 2010 July | 4 | 0 | 4 |
| 2010 June | 7 | 0 | 7 |
| 2010 May | 8 | 0 | 8 |
| 2010 April | 12 | 0 | 12 |
| 2010 March | 5 | 0 | 5 |
| 2010 February | 8 | 0 | 8 |
| 2010 January | 6 | 0 | 6 |
| 2009 December | 16 | 0 | 16 |
| 2009 November | 18 | 0 | 18 |
Show all
