array:22 [
  "pii" => "S2173574309701091"
  "issn" => "21735743"
  "doi" => "10.1016/S2173-5743(09)70109-1"
  "estado" => "S300"
  "fechaPublicacion" => "2009-07-01"
  "aid" => "70109"
  "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2009"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "edi"
  "cita" => "Reumatol Clin. 2009;5:143-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1586
    "formatos" => array:3 [
      "EPUB" => 46
      "HTML" => 1046
      "PDF" => 494
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574309701108"
    "issn" => "21735743"
    "doi" => "10.1016/S2173-5743(09)70110-8"
    "estado" => "S300"
    "fechaPublicacion" => "2009-07-01"
    "aid" => "70110"
    "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2009;5:147-52"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1820
      "formatos" => array:3 [
        "EPUB" => 43
        "HTML" => 1101
        "PDF" => 676
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Treating severe systemic lupus erythematosus with rituximab. An open study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "147"
          "paginaFinal" => "152"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tratamiento del lupus eritematoso severo con rituximab. Un estudio abierto"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Carlos Abud-Mendoza, Ricardo Moreno-Valdés, Enrique Cuevas-Orta, Antonio Borjas, Francisco Aranda, Fedra Irazoque, Lilia Andrade, M. Vigna-Pérez, R. González-Amaro"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Abud-Mendoza"
            ]
            1 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Moreno-Valdés"
            ]
            2 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "Cuevas-Orta"
            ]
            3 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "Borjas"
            ]
            4 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Aranda"
            ]
            5 => array:2 [
              "nombre" => "Fedra"
              "apellidos" => "Irazoque"
            ]
            6 => array:2 [
              "nombre" => "Lilia"
              "apellidos" => "Andrade"
            ]
            7 => array:2 [
              "nombre" => "M."
              "apellidos" => "Vigna-Pérez"
            ]
            8 => array:2 [
              "nombre" => "R."
              "apellidos" => "González-Amaro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574309701108?idApp=UINPBA00004M"
    "url" => "/21735743/0000000500000004/v1_201305061557/S2173574309701108/v1_201305061557/en/main.assets"
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "Cytokine biomarkers and the promise of personalized therapy in rheumatoid arthritis"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "143"
        "paginaFinal" => "146"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "John M. Davis, Eric L. Matteson"
        "autores" => array:2 [
          0 => array:3 [
            "nombre" => "John M."
            "apellidos" => "Davis"
            "sufijo" => "III"
          ]
          1 => array:4 [
            "nombre" => "Eric L."
            "apellidos" => "Matteson"
            "email" => array:1 [
              0 => "Matteson.eric@mayo.edu"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Division of Rheumatology&#44; Mayo Clinic College of Medicine&#44; Rochester&#44; Minnesota&#44; USA"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Citocinas biomarcadoras y la promesa de un tratamiento personalizado en artritis reumatoide"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolving concepts of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;S&#46; Firestein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nature01661"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2003"
                        "volumen" => "423"
                        "paginaInicial" => "356"
                        "paginaFinal" => "361"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12748655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The need for prognosticators in rheumatoid arthritis&#46; Biological and clinical markers&#58; where are we now&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;S&#46; Smolen"
                            1 => "D&#46; Aletaha"
                            2 => "J&#46; Grisar"
                            3 => "K&#46; Redlich"
                            4 => "G&#46; Steiner"
                            5 => "O&#46; Wagner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar2418"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2008"
                        "volumen" => "10"
                        "paginaInicial" => "208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18557991"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New therapies for treatment of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;S&#46; Smolen"
                            1 => "D&#46; Aletaha"
                            2 => "M&#46; Koeller"
                            3 => "M&#46;H&#46; Weisman"
                            4 => "P&#46; Emery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(07)60784-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2007"
                        "volumen" => "370"
                        "paginaInicial" => "1861"
                        "paginaFinal" => "1874"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17570481"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46; de Jager"
                            1 => "B&#46;J&#46; Prakken"
                            2 => "J&#46;W&#46; Bijlsma"
                            3 => "W&#46; Kuis"
                            4 => "G&#46;T&#46; Rijkers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jim.2005.03.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol Methods"
                        "fecha" => "2005"
                        "volumen" => "300"
                        "paginaInicial" => "124"
                        "paginaFinal" => "135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15896801"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteomic analysis of secreted proteins in early rheumatoid arthritis&#58; anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Hueber"
                            1 => "B&#46;H&#46; Tomooka"
                            2 => "X&#46; Zhao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2006.054924"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2007"
                        "volumen" => "66"
                        "paginaInicial" => "712"
                        "paginaFinal" => "719"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16901957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between serum RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Boiardi"
                            1 => "P&#46; Macchioni"
                            2 => "R&#46; Meliconi"
                            3 => "L&#46; Pulsatelli"
                            4 => "A&#46; Facchini"
                            5 => "C&#46; Salvarani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "1999"
                        "volumen" => "17"
                        "paginaInicial" => "419"
                        "paginaFinal" => "425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10464551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A high serum level of eotaxin &#40;CCL 11&#41; is associated with less radiographic progression in early rheumatoid arthritis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;W&#46; Syversen"
                            1 => "G&#46;L&#46; Goll"
                            2 => "E&#46;A&#46; Haavardsholm"
                            3 => "P&#46; Boyesen"
                            4 => "T&#46; Lea"
                            5 => "T&#46;K&#46; Kvien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar2381"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2008"
                        "volumen" => "10"
                        "paginaInicial" => "R28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18312691"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Protein biochip array technology for cytokine profiling predicts etanercept responsiveness in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Fabre"
                            1 => "A&#46;M&#46; Dupuy"
                            2 => "N&#46; Dossat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2249.2008.03691.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "2008"
                        "volumen" => "153"
                        "paginaInicial" => "188"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18549443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;A&#46; Hitchon"
                            1 => "P&#46; Alex"
                            2 => "L&#46;B&#46; Erdile"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2004"
                        "volumen" => "31"
                        "paginaInicial" => "2336"
                        "paginaFinal" => "2346"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15570632"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potential novel biomarkers of disease activity in rheumatoid arthritis patients&#58; CXCL13&#44; CCL23&#44; transforming growth factor alpha&#44; tumor necrosis factor receptor superfamily member 9&#44; and macrophage colonystimulating factor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "I&#46; Rioja"
                            1 => "F&#46;J&#46; Hughes"
                            2 => "C&#46;H&#46; Sharp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.23667"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "2257"
                        "paginaFinal" => "2267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18668547"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum Cytokine Levels Determined by Multiplex Assays and Clinical Characteristics in Patients with Rheumatoid Arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Davis"
                            1 => "K&#46;L&#46; Knutson"
                            2 => "M&#46;A&#46; Strausbauch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2007"
                        "volumen" => "56"
                        "paginaInicial" => "S270"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reduction of serum interleukin 7 levels upon methotrexate therapy in early rheumatoid arthritis correlates with disease suppression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;A&#46; van Roon"
                            1 => "K&#46; Jacobs"
                            2 => "S&#46; Verstappen"
                            3 => "J&#46; Bijlsma"
                            4 => "F&#46; Lafeber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2007.081059"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2008"
                        "volumen" => "67"
                        "paginaInicial" => "1054"
                        "paginaFinal" => "1055"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18556451"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistence of interleukin 7 activity and levels on tumour necrosis factor alpha blockade in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; van Roon"
                            1 => "S&#46;A&#46; Hartgring"
                            2 => "M&#46; Wenting-van Wijk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2006.062547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2007"
                        "volumen" => "66"
                        "paginaInicial" => "664"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17185327"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint cytokine quantification in two rodent arthritis models&#58; kinetics of expression&#44; correlation of mRNA and protein levels and response to prednisolone treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Rioja"
                            1 => "K&#46;A&#46; Bush"
                            2 => "J&#46;B&#46; Buckton"
                            3 => "M&#46;C&#46; Dickson"
                            4 => "P&#46;F&#46; Life"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2249.2004.02499.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "2004"
                        "volumen" => "137"
                        "paginaInicial" => "65"
                        "paginaFinal" => "73"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15196245"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "www&#46;personalizedmedicinecoalition&#46;org"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacogenomic considerations for immunosuppressive therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Yagil"
                            1 => "C&#46; Yagil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1517/phgs.4.3.309.22690"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacogenomics"
                        "fecha" => "2003"
                        "volumen" => "4"
                        "paginaInicial" => "309"
                        "paginaFinal" => "319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12718721"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46;G&#46; Faag"
                            1 => "G&#46;G&#46; Teng"
                            2 => "N&#46;M&#46; Patker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Rheum &#40;Arthritis Care Res&#41;"
                        "fecha" => "2008"
                        "volumen" => "59"
                        "paginaInicial" => "762"
                        "paginaFinal" => "784"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New drugs for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;J&#46; Olsen"
                            1 => "T&#46;M&#46; Stein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra032906"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "2167"
                        "paginaFinal" => "2179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15152062"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Ranganthan"
                            1 => "S&#46; Eisen"
                            2 => "W&#46; Yokoyama"
                            3 => "H&#46; McLeod"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2003"
                        "volumen" => "62"
                        "paginaInicial" => "4"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12480661"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TPMT testing in rheumatology&#58; Any better than routine monitoring&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Payne"
                            1 => "W&#46; Newman"
                            2 => "E&#46; Fargher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/kel427"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatology"
                        "fecha" => "2007"
                        "volumen" => "46"
                        "paginaInicial" => "727"
                        "paginaFinal" => "729"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17255139"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "www&#46;fda&#46;gov&#92;dde&#92;genomics"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacogenetics of immunosuppression&#58; Progress&#44; pitfalls&#44; and promises"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Cattaneo"
                            1 => "S&#46; Baldelli"
                            2 => "N&#46; Perico"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Transplantation"
                        "fecha" => "2008"
                        "volumen" => "8"
                        "paginaInicial" => "1374"
                        "paginaFinal" => "1383"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pretreatment cytokine profiles of peripheral blood mononuclear cells and serum from patients with rheumatoid arthritis in different American College of Rheumatology response groups to methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Seitz"
                            1 => "M&#46; Zwicker"
                            2 => "P&#46;M&#46; Villiger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "28"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12508386"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biomarkers of inflammation in patients with unclassified polyarthritis and early rheumatoid arthritis&#46; Relationship to disease activity and radiographic outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;S&#46; Knudsen"
                            1 => "M&#46; Klarlund"
                            2 => "H&#46; Skjodt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2008"
                        "volumen" => "35"
                        "paginaInicial" => "1277"
                        "paginaFinal" => "1287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18597410"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000500000004/v1_201305061557/S2173574309701091/v1_201305061557/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "17335"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000500000004/v1_201305061557/S2173574309701091/v1_201305061557/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574309701091?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Cytokine biomarkers and the promise of personalized therapy in rheumatoid arthritis
Citocinas biomarcadoras y la promesa de un tratamiento personalizado en artritis reumatoide
John M. Davis III, Eric L. Matteson
Corresponding author
Matteson.eric@mayo.edu

Corresponding author.
Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Read
4399
Times
was read the article
2262
Total PDF
2137
Total HTML
Share statistics
 array:22 [
  "pii" => "S2173574309701091"
  "issn" => "21735743"
  "doi" => "10.1016/S2173-5743(09)70109-1"
  "estado" => "S300"
  "fechaPublicacion" => "2009-07-01"
  "aid" => "70109"
  "copyright" => "Sociedad Espa&#241;ola de Reumatolog&#237;a and Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2009"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "edi"
  "cita" => "Reumatol Clin. 2009;5:143-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1586
    "formatos" => array:3 [
      "EPUB" => 46
      "HTML" => 1046
      "PDF" => 494
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574309701108"
    "issn" => "21735743"
    "doi" => "10.1016/S2173-5743(09)70110-8"
    "estado" => "S300"
    "fechaPublicacion" => "2009-07-01"
    "aid" => "70110"
    "copyright" => "Sociedad Espa&#241;ola de Reumatolog&#237;a and Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2009;5:147-52"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1820
      "formatos" => array:3 [
        "EPUB" => 43
        "HTML" => 1101
        "PDF" => 676
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Treating severe systemic lupus erythematosus with rituximab&#46; An open study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "147"
          "paginaFinal" => "152"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tratamiento del lupus eritematoso severo con rituximab&#46; Un estudio abierto"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Carlos Abud-Mendoza, Ricardo Moreno-Vald&#233;s, Enrique Cuevas-Orta, Antonio Borjas, Francisco Aranda, Fedra Irazoque, Lilia Andrade, M&#46; Vigna-P&#233;rez, R&#46; Gonz&#225;lez-Amaro"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Abud-Mendoza"
            ]
            1 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Moreno-Vald&#233;s"
            ]
            2 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "Cuevas-Orta"
            ]
            3 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "Borjas"
            ]
            4 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Aranda"
            ]
            5 => array:2 [
              "nombre" => "Fedra"
              "apellidos" => "Irazoque"
            ]
            6 => array:2 [
              "nombre" => "Lilia"
              "apellidos" => "Andrade"
            ]
            7 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Vigna-P&#233;rez"
            ]
            8 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Gonz&#225;lez-Amaro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574309701108?idApp=UINPBA00004M"
    "url" => "/21735743/0000000500000004/v1_201305061557/S2173574309701108/v1_201305061557/en/main.assets"
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "Cytokine biomarkers and the promise of personalized therapy in rheumatoid arthritis"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "143"
        "paginaFinal" => "146"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "John M&#46; Davis, Eric L&#46; Matteson"
        "autores" => array:2 [
          0 => array:3 [
            "nombre" => "John M&#46;"
            "apellidos" => "Davis"
            "sufijo" => "III"
          ]
          1 => array:4 [
            "nombre" => "Eric L&#46;"
            "apellidos" => "Matteson"
            "email" => array:1 [
              0 => "Matteson&#46;eric&#64;mayo&#46;edu"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Division of Rheumatology&#44; Mayo Clinic College of Medicine&#44; Rochester&#44; Minnesota&#44; USA"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Citocinas biomarcadoras y la promesa de un tratamiento personalizado en artritis reumatoide"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolving concepts of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;S&#46; Firestein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nature01661"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2003"
                        "volumen" => "423"
                        "paginaInicial" => "356"
                        "paginaFinal" => "361"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12748655"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The need for prognosticators in rheumatoid arthritis&#46; Biological and clinical markers&#58; where are we now&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;S&#46; Smolen"
                            1 => "D&#46; Aletaha"
                            2 => "J&#46; Grisar"
                            3 => "K&#46; Redlich"
                            4 => "G&#46; Steiner"
                            5 => "O&#46; Wagner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar2418"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2008"
                        "volumen" => "10"
                        "paginaInicial" => "208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18557991"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New therapies for treatment of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;S&#46; Smolen"
                            1 => "D&#46; Aletaha"
                            2 => "M&#46; Koeller"
                            3 => "M&#46;H&#46; Weisman"
                            4 => "P&#46; Emery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(07)60784-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2007"
                        "volumen" => "370"
                        "paginaInicial" => "1861"
                        "paginaFinal" => "1874"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17570481"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46; de Jager"
                            1 => "B&#46;J&#46; Prakken"
                            2 => "J&#46;W&#46; Bijlsma"
                            3 => "W&#46; Kuis"
                            4 => "G&#46;T&#46; Rijkers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jim.2005.03.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol Methods"
                        "fecha" => "2005"
                        "volumen" => "300"
                        "paginaInicial" => "124"
                        "paginaFinal" => "135"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15896801"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteomic analysis of secreted proteins in early rheumatoid arthritis&#58; anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Hueber"
                            1 => "B&#46;H&#46; Tomooka"
                            2 => "X&#46; Zhao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2006.054924"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2007"
                        "volumen" => "66"
                        "paginaInicial" => "712"
                        "paginaFinal" => "719"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16901957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between serum RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Boiardi"
                            1 => "P&#46; Macchioni"
                            2 => "R&#46; Meliconi"
                            3 => "L&#46; Pulsatelli"
                            4 => "A&#46; Facchini"
                            5 => "C&#46; Salvarani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "1999"
                        "volumen" => "17"
                        "paginaInicial" => "419"
                        "paginaFinal" => "425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10464551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A high serum level of eotaxin &#40;CCL 11&#41; is associated with less radiographic progression in early rheumatoid arthritis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;W&#46; Syversen"
                            1 => "G&#46;L&#46; Goll"
                            2 => "E&#46;A&#46; Haavardsholm"
                            3 => "P&#46; Boyesen"
                            4 => "T&#46; Lea"
                            5 => "T&#46;K&#46; Kvien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar2381"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2008"
                        "volumen" => "10"
                        "paginaInicial" => "R28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18312691"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Protein biochip array technology for cytokine profiling predicts etanercept responsiveness in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Fabre"
                            1 => "A&#46;M&#46; Dupuy"
                            2 => "N&#46; Dossat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2249.2008.03691.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "2008"
                        "volumen" => "153"
                        "paginaInicial" => "188"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18549443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;A&#46; Hitchon"
                            1 => "P&#46; Alex"
                            2 => "L&#46;B&#46; Erdile"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2004"
                        "volumen" => "31"
                        "paginaInicial" => "2336"
                        "paginaFinal" => "2346"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15570632"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potential novel biomarkers of disease activity in rheumatoid arthritis patients&#58; CXCL13&#44; CCL23&#44; transforming growth factor alpha&#44; tumor necrosis factor receptor superfamily member 9&#44; and macrophage colonystimulating factor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "I&#46; Rioja"
                            1 => "F&#46;J&#46; Hughes"
                            2 => "C&#46;H&#46; Sharp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.23667"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "2257"
                        "paginaFinal" => "2267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18668547"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum Cytokine Levels Determined by Multiplex Assays and Clinical Characteristics in Patients with Rheumatoid Arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Davis"
                            1 => "K&#46;L&#46; Knutson"
                            2 => "M&#46;A&#46; Strausbauch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2007"
                        "volumen" => "56"
                        "paginaInicial" => "S270"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reduction of serum interleukin 7 levels upon methotrexate therapy in early rheumatoid arthritis correlates with disease suppression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;A&#46; van Roon"
                            1 => "K&#46; Jacobs"
                            2 => "S&#46; Verstappen"
                            3 => "J&#46; Bijlsma"
                            4 => "F&#46; Lafeber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2007.081059"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2008"
                        "volumen" => "67"
                        "paginaInicial" => "1054"
                        "paginaFinal" => "1055"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18556451"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistence of interleukin 7 activity and levels on tumour necrosis factor alpha blockade in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; van Roon"
                            1 => "S&#46;A&#46; Hartgring"
                            2 => "M&#46; Wenting-van Wijk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2006.062547"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2007"
                        "volumen" => "66"
                        "paginaInicial" => "664"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17185327"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint cytokine quantification in two rodent arthritis models&#58; kinetics of expression&#44; correlation of mRNA and protein levels and response to prednisolone treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Rioja"
                            1 => "K&#46;A&#46; Bush"
                            2 => "J&#46;B&#46; Buckton"
                            3 => "M&#46;C&#46; Dickson"
                            4 => "P&#46;F&#46; Life"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2249.2004.02499.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Immunol"
                        "fecha" => "2004"
                        "volumen" => "137"
                        "paginaInicial" => "65"
                        "paginaFinal" => "73"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15196245"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "www&#46;personalizedmedicinecoalition&#46;org"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacogenomic considerations for immunosuppressive therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Yagil"
                            1 => "C&#46; Yagil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1517/phgs.4.3.309.22690"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacogenomics"
                        "fecha" => "2003"
                        "volumen" => "4"
                        "paginaInicial" => "309"
                        "paginaFinal" => "319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12718721"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46;G&#46; Faag"
                            1 => "G&#46;G&#46; Teng"
                            2 => "N&#46;M&#46; Patker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Rheum &#40;Arthritis Care Res&#41;"
                        "fecha" => "2008"
                        "volumen" => "59"
                        "paginaInicial" => "762"
                        "paginaFinal" => "784"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New drugs for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;J&#46; Olsen"
                            1 => "T&#46;M&#46; Stein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra032906"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "2167"
                        "paginaFinal" => "2179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15152062"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Ranganthan"
                            1 => "S&#46; Eisen"
                            2 => "W&#46; Yokoyama"
                            3 => "H&#46; McLeod"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2003"
                        "volumen" => "62"
                        "paginaInicial" => "4"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12480661"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TPMT testing in rheumatology&#58; Any better than routine monitoring&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Payne"
                            1 => "W&#46; Newman"
                            2 => "E&#46; Fargher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/kel427"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatology"
                        "fecha" => "2007"
                        "volumen" => "46"
                        "paginaInicial" => "727"
                        "paginaFinal" => "729"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17255139"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "www&#46;fda&#46;gov&#92;dde&#92;genomics"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacogenetics of immunosuppression&#58; Progress&#44; pitfalls&#44; and promises"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Cattaneo"
                            1 => "S&#46; Baldelli"
                            2 => "N&#46; Perico"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Transplantation"
                        "fecha" => "2008"
                        "volumen" => "8"
                        "paginaInicial" => "1374"
                        "paginaFinal" => "1383"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pretreatment cytokine profiles of peripheral blood mononuclear cells and serum from patients with rheumatoid arthritis in different American College of Rheumatology response groups to methotrexate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Seitz"
                            1 => "M&#46; Zwicker"
                            2 => "P&#46;M&#46; Villiger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "28"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12508386"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biomarkers of inflammation in patients with unclassified polyarthritis and early rheumatoid arthritis&#46; Relationship to disease activity and radiographic outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;S&#46; Knudsen"
                            1 => "M&#46; Klarlund"
                            2 => "H&#46; Skjodt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2008"
                        "volumen" => "35"
                        "paginaInicial" => "1277"
                        "paginaFinal" => "1287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18597410"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000500000004/v1_201305061557/S2173574309701091/v1_201305061557/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "17335"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000500000004/v1_201305061557/S2173574309701091/v1_201305061557/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574309701091?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 6 9 15
2024 October 16 56 72
2024 September 20 26 46
2024 August 30 44 74
2024 July 18 35 53
2024 June 27 35 62
2024 May 23 29 52
2024 April 17 24 41
2024 March 22 34 56
2024 February 23 22 45
2024 January 13 23 36
2023 December 24 32 56
2023 November 24 19 43
2023 October 17 24 41
2023 September 27 28 55
2023 August 16 23 39
2023 July 14 21 35
2023 June 15 18 33
2023 May 11 15 26
2023 April 8 7 15
2023 March 16 27 43
2023 February 16 30 46
2023 January 16 30 46
2022 December 21 39 60
2022 November 17 33 50
2022 October 15 30 45
2022 September 19 38 57
2022 August 23 42 65
2022 July 15 46 61
2022 June 15 27 42
2022 May 16 37 53
2022 April 18 38 56
2022 March 16 32 48
2022 February 16 26 42
2022 January 21 31 52
2021 December 16 31 47
2021 November 22 50 72
2021 October 30 43 73
2021 September 23 41 64
2021 August 20 39 59
2021 July 22 40 62
2021 June 18 41 59
2021 May 19 26 45
2021 April 26 95 121
2021 March 56 42 98
2021 February 27 34 61
2021 January 13 23 36
2020 December 13 15 28
2020 November 25 30 55
2020 October 18 21 39
2020 September 21 29 50
2020 August 12 17 29
2020 July 17 22 39
2020 June 16 24 40
2020 May 17 34 51
2020 April 16 29 45
2020 March 13 12 25
2020 February 1 0 1
2019 July 1 0 1
2019 April 1 0 1
2018 December 2 0 2
2018 May 2 1 3
2018 April 24 11 35
2018 March 16 13 29
2018 February 10 6 16
2018 January 15 4 19
2017 December 10 8 18
2017 November 18 9 27
2017 October 12 7 19
2017 September 7 9 16
2017 August 9 7 16
2017 July 14 10 24
2017 June 20 6 26
2017 May 19 12 31
2017 April 12 4 16
2017 March 10 32 42
2017 February 5 3 8
2017 January 13 2 15
2016 December 35 14 49
2016 November 16 2 18
2016 October 25 10 35
2016 September 30 9 39
2016 August 23 11 34
2016 July 13 9 22
2016 June 0 10 10
2016 April 4 0 4
2016 January 2 0 2
2015 December 2 0 2
2015 November 2 0 2
2015 October 2 0 2
2015 September 1 0 1
2015 August 1 0 1
2015 July 21 4 25
2015 June 40 11 51
2015 May 34 20 54
2015 April 21 15 36
2015 March 21 7 28
2015 February 21 8 29
2015 January 13 9 22
2014 December 28 13 41
2014 November 17 9 26
2014 October 16 9 25
2014 September 25 12 37
2014 August 16 13 29
2014 July 20 8 28
2014 June 24 7 31
2014 May 25 11 36
2014 April 26 6 32
2014 March 28 15 43
2014 February 26 12 38
2014 January 21 9 30
2013 December 15 5 20
2013 November 16 3 19
2013 October 17 12 29
2013 September 18 8 26
2013 August 13 8 21
2013 July 14 5 19
2013 June 10 3 13
2013 May 11 6 17
2013 April 11 7 18
2013 March 8 8 16
2013 February 12 7 19
2013 January 7 2 9
2012 December 6 4 10
2012 November 9 5 14
2012 October 3 2 5
2012 September 9 2 11
2012 June 1 0 1
2012 March 2 0 2
2012 February 1 0 1
2012 January 2 0 2
2011 December 1 0 1
2011 November 1 0 1
2011 October 2 0 2
2011 June 2 0 2
2011 May 1 0 1
2011 February 2 0 2
2011 January 1 0 1
2010 December 2 0 2
2010 November 1 0 1
2010 October 2 0 2
2010 September 1 0 1
2010 July 2 0 2
2010 June 1 0 1
2010 April 2 0 2
2010 March 1 0 1
2010 February 3 0 3
2010 January 5 0 5
2009 December 5 0 5
2009 November 6 0 6
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?