NeuroBehçet: a case
Neurobehçet: a propósito de un caso
Germán Latorre González
, Ana Belén Escribano Gascón, Carlos López de Silanes de Miguel, Rocío García Cobos, Luis Ignacio Casanova Peño, Teresa Lapeña Montero
Corresponding author
Hospital Clínico San Carlos, Madrid, Spain
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"autoresLista" => "Germán Latorre González, Ana Belén Escribano Gascón, Carlos López de Silanes de Miguel, Rocío García Cobos, Luis Ignacio Casanova Peño, Teresa Lapeña Montero" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Germán Latorre" "apellidos" => "González" "email" => array:1 [ 0 => "ger.latorre@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Ana Belén" "apellidos" => "Escribano Gascón" ] 2 => array:2 [ "nombre" => "Carlos López de" "apellidos" => "Silanes de Miguel" ] 3 => array:2 [ "nombre" => "Rocío García" "apellidos" => "Cobos" ] 4 => array:2 [ "nombre" => "Luis Ignacio" "apellidos" => "Casanova Peño" ] 5 => array:2 [ "nombre" => "Teresa Lapeña" "apellidos" => "Montero" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Hospital Clínico San Carlos, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Neurobehçet: a propósito de un caso" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-02-07" "fechaAceptado" => "2008-06-02" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112137" "palabras" => array:3 [ 0 => "Behçet's disease" 1 => "NeuroBehçet" 2 => "Neurological alterations" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112138" "palabras" => array:3 [ 0 => "Enfermedad de Behçet" 1 => "Neurobehçet" 2 => "Afectación neurológica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Behçet's disease is an inflammatory systemic disorder, with oral and genital ulcers, as well as ophthalmologic and cutaneous disturbances. Five percent of the patients have neurological alterations. We present a case of neuroBehçet with a rare neurological involvement.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A 28-years-old male patient with recurrent oral and genital ulcer history and folliculitis presents 48 h progressive fever, headache, nausea, right sixth cranial nerve palsy, and right upper limb paresis. The CSF showed lymphocyte pleocytosis and high proteinorrachia, so antibiotic treatment was initiated. Cerebral MR found hyperintense enhancing lesions in the brainstem and left transverse sinus thrombosis. Patient improved with endovenous corticosteroids and was discharged asymptomatic.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Neurological involvement in Behçet's disease is rare and moreover the coexistence of parenchymatous and non-parenchymatous alterations in the same patient. It normally has a good response to immunosuppressant treatment.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La enfermedad de Behçet es un trastorno inflamatorio sistémico, caracterizado por aftosis orogenital así como por alteraciones oftalmológicas y cutáneas. Un 5% de los pacientes presenta manifestaciones neurológicas. Se presenta un caso de neurobehçet con participación neurológica inhabitual.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Varón de 28 años con antecedente de aftas orales y genitales recurrentes e historia de foliculitis, que acudió por cuadro de 48 h de fiebre, cefalea, náuseas, paresia del sexto par craneal y del miembro superior derecho. El análisis del líquido cefalorraquídeo reveló pleocitosis linfocitaria con hiperproteinorraquia, se inició tratamiento antibiótico de amplio espectro. Se realizó resonancia magnética cerebral, que mostró lesiones hiperintensas de predominio troncoencefálico con realce tras infusión de gadolinio y trombosis del seno transverso izquierdo. El paciente mejoró progresivamente con tratamiento intravenoso con corticoides hasta quedar asintomático.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La afectación neurológica en la enfermedad de Behçet es infrecuente y más aún la coexistencia de lesiones intraparenquimatosas y extraparenquimatosas. Habitualmente, presenta buena respuesta al tratamiento inmunosupresor.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2023 February | 18 | 35 | 53 |
| 2023 January | 14 | 25 | 39 |
| 2022 December | 22 | 46 | 68 |
| 2022 November | 23 | 24 | 47 |
| 2022 October | 19 | 23 | 42 |
| 2022 September | 20 | 34 | 54 |
| 2022 August | 29 | 56 | 85 |
| 2022 July | 18 | 44 | 62 |
| 2022 June | 18 | 28 | 46 |
| 2022 May | 25 | 46 | 71 |
| 2022 April | 29 | 56 | 85 |
| 2022 March | 19 | 45 | 64 |
| 2022 February | 23 | 40 | 63 |
| 2022 January | 12 | 40 | 52 |
| 2021 December | 18 | 37 | 55 |
| 2021 November | 27 | 56 | 83 |
| 2021 October | 36 | 53 | 89 |
| 2021 September | 26 | 54 | 80 |
| 2021 August | 25 | 42 | 67 |
| 2021 July | 21 | 35 | 56 |
| 2021 June | 29 | 56 | 85 |
| 2021 May | 24 | 35 | 59 |
| 2021 April | 46 | 90 | 136 |
| 2021 March | 28 | 25 | 53 |
| 2021 February | 29 | 17 | 46 |
| 2021 January | 30 | 23 | 53 |
| 2020 December | 23 | 17 | 40 |
| 2020 November | 19 | 31 | 50 |
| 2020 October | 21 | 22 | 43 |
| 2020 September | 22 | 23 | 45 |
| 2020 August | 18 | 15 | 33 |
| 2020 July | 11 | 10 | 21 |
| 2020 June | 20 | 16 | 36 |
| 2020 May | 22 | 19 | 41 |
| 2020 April | 32 | 13 | 45 |
| 2020 March | 19 | 8 | 27 |
| 2020 February | 1 | 0 | 1 |
| 2019 September | 1 | 0 | 1 |
| 2019 February | 1 | 0 | 1 |
| 2018 May | 2 | 1 | 3 |
| 2018 April | 30 | 13 | 43 |
| 2018 March | 27 | 15 | 42 |
| 2018 February | 16 | 1 | 17 |
| 2018 January | 16 | 5 | 21 |
| 2017 December | 24 | 5 | 29 |
| 2017 November | 23 | 7 | 30 |
| 2017 October | 13 | 5 | 18 |
| 2017 September | 20 | 2 | 22 |
| 2017 August | 14 | 10 | 24 |
| 2017 July | 17 | 5 | 22 |
| 2017 June | 29 | 8 | 37 |
| 2017 May | 29 | 11 | 40 |
| 2017 April | 28 | 2 | 30 |
| 2017 March | 28 | 4 | 32 |
| 2017 February | 6 | 7 | 13 |
| 2017 January | 12 | 1 | 13 |
| 2016 December | 55 | 10 | 65 |
| 2016 November | 34 | 2 | 36 |
| 2016 October | 65 | 14 | 79 |
| 2016 September | 42 | 3 | 45 |
| 2016 August | 26 | 4 | 30 |
| 2016 July | 19 | 10 | 29 |
| 2016 May | 2 | 14 | 16 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 1 | 0 | 1 |
| 2015 September | 2 | 0 | 2 |
| 2015 August | 3 | 0 | 3 |
| 2015 July | 17 | 4 | 21 |
| 2015 June | 13 | 17 | 30 |
| 2015 May | 34 | 11 | 45 |
| 2015 April | 20 | 13 | 33 |
| 2015 March | 14 | 18 | 32 |
| 2015 February | 12 | 16 | 28 |
| 2015 January | 10 | 16 | 26 |
| 2014 December | 18 | 11 | 29 |
| 2014 November | 16 | 10 | 26 |
| 2014 October | 13 | 15 | 28 |
| 2014 September | 10 | 13 | 23 |
| 2014 August | 18 | 14 | 32 |
| 2014 July | 18 | 13 | 31 |
| 2014 June | 34 | 14 | 48 |
| 2014 May | 34 | 13 | 47 |
| 2014 April | 28 | 7 | 35 |
| 2014 March | 44 | 13 | 57 |
| 2014 February | 32 | 12 | 44 |
| 2014 January | 33 | 10 | 43 |
| 2013 December | 24 | 5 | 29 |
| 2013 November | 29 | 7 | 36 |
| 2013 October | 40 | 19 | 59 |
| 2013 September | 34 | 13 | 47 |
| 2013 August | 21 | 8 | 29 |
| 2013 July | 22 | 8 | 30 |
| 2013 June | 26 | 8 | 34 |
| 2013 May | 18 | 4 | 22 |
| 2013 April | 17 | 11 | 28 |
| 2013 March | 21 | 8 | 29 |
| 2013 February | 23 | 11 | 34 |
| 2013 January | 17 | 7 | 24 |
| 2012 December | 15 | 10 | 25 |
| 2012 November | 10 | 13 | 23 |
| 2012 October | 7 | 4 | 11 |
| 2012 September | 9 | 4 | 13 |
| 2012 June | 3 | 0 | 3 |
| 2012 May | 1 | 0 | 1 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 7 | 0 | 7 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 2 | 0 | 2 |
| 2011 November | 3 | 0 | 3 |
| 2011 October | 4 | 0 | 4 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 1 | 0 | 1 |
| 2011 April | 1 | 0 | 1 |
| 2011 March | 4 | 0 | 4 |
| 2011 February | 8 | 0 | 8 |
| 2011 January | 17 | 0 | 17 |
| 2010 December | 7 | 0 | 7 |
| 2010 November | 4 | 0 | 4 |
| 2010 October | 9 | 0 | 9 |
| 2010 July | 6 | 0 | 6 |
| 2010 May | 2 | 0 | 2 |
| 2010 April | 4 | 0 | 4 |
| 2010 March | 4 | 0 | 4 |
| 2010 February | 12 | 0 | 12 |
| 2010 January | 2 | 0 | 2 |
| 2009 December | 15 | 0 | 15 |
| 2009 November | 16 | 0 | 16 |
Show all
