Assessing the efficacy of non-arthroscopic joint lavage in patients with osteoarthritis of the knee
Valoracioón de la eficacia del lavado articular no artroscópico en pacientes con artrosis de rodilla
Gabriel Frías, Pilar Font, Elisa Muñoz-Gomariz, Miguel A. Caracuel, Alejandro Escudero, Maria C. Castro, Eduardo Collantes-Estévez
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Servicio de Reumatología, Hospital Universitario Reina Sofía, Córdoba, Spain
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Caracuel, Alejandro Escudero, Maria C. Castro, Eduardo Collantes-Estévez" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Gabriel" "apellidos" => "Frías" ] 1 => array:2 [ "nombre" => "Pilar" "apellidos" => "Font" ] 2 => array:2 [ "nombre" => "Elisa" "apellidos" => "Muñoz-Gomariz" ] 3 => array:2 [ "nombre" => "Miguel A." "apellidos" => "Caracuel" ] 4 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Escudero" ] 5 => array:2 [ "nombre" => "Maria C." "apellidos" => "Castro" ] 6 => array:4 [ "nombre" => "Eduardo" "apellidos" => "Collantes-Estévez" "email" => array:1 [ 0 => "eduardo.collantes.sspa@juntadeandalucia.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Reina Sofía, Córdoba, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Valoracioón de la eficacia del lavado articular no artroscópico en pacientes con artrosis de rodilla" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-06-21" "fechaAceptado" => "2008-10-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112166" "palabras" => array:4 [ 0 => "Joint Lavage" 1 => "Osteoarthritis" 2 => "Knee" 3 => "NSAIDs" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112167" "palabras" => array:4 [ 0 => "Lavado articular" 1 => "Osteoartrosis" 2 => "Rodilla" 3 => "AINE" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate the efficacy of joint lavage in patients with osteoarthritis of the knee.</p> <span class="elsevierStyleSectionTitle">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We conducted an open prospective study involving 111 patients of whom 77% were females. The patients’ age range was 43–81 years and the average age 64 (8.7) years. All patients had gonarthrosis as diagnosed according to the (ACR) American College of Rheumatology criteria (Kellgren radiographic grades II and III). Patients were randomly distributed between 2 treatment groups: a) joint lavage without nonsteroidal anti-inflammatory drugs (NAJL, n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>57), and b) non-steroidal anti-inflammatory drugs alone (NSAIDs, n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>54). Evaluations were done at baseline and 1, 3, and 6 months after enrollment. Clinical and demographic variables, and WOMAC index scores, were recorded and patient improvement was determined by following the OARSI guidelines. Statistical analyses included c2, analysis of covariance (baseline WOMAC) with one between-subject factor (treatment). Post-hoc comparisons were made with Sidak's adjustment.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The respective improvement rates as measured by the OARSI index for the patients in the JL and NSAIDs groups were 50.9% and 31.5% at 1 month; 55.4% and 38.9% at 3 months; and 63.2% and 64.8% at 6 months. The patients in both groups were seen to improve from the first month (P=.038). At the end of the 6-month follow-up period, the WOMAC score had decreased significantly in both groups (P<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.000), with no significant differences between them.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Six months after treatment, joint lavage proved as effective as NSAIDs in patients with gonarthrosis, so it constitutes an effective therapeutic choice in those cases where NSAIDs are contraindicated.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este trabajo fue evaluar la eficacia del lavado articular (LA) en pacientes con osteoartrosis de rodilla.</p> <span class="elsevierStyleSectionTitle">Diseño</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se realizó un estudio abierto prospectivo en el que se incluyeron 111 pacientes, de los que el 77% eran mujeres. El rango de edad fue de 43 a 81 años y la media de edad de 64<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>8,7 años. Todos los pacientes tenían diagnóstico de artrosis según los criterios del American College of Rheumatology (ACR), con grado radiológico II y III de la escala radiológica de Kellgren. Los pacientes se aleatorizaron en 2 grupos de tratamiento: a) LA sin antiinflamatorios no esteroideos (AINE) (LA, n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>57) y b) AINE solos (AINE, n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>54). Las evaluaciones se realizaron de forma basal, al mes, a los 3 meses y a los 6 meses de haberse realizado el tratamiento. Se recogieron variables clínicas y demográficas, así como el índice de WOMAC (Western Ontario and McMaster University). La mejoría de los pacientes se valoró según los criterios de la (Osteoarthritis Research Society International [OARSI] Investigación de la Osteoartritis). El análisis estadístico incluyó el test de c2, y el analisis de covarianza (WOMAC basal) con un factor entre sujetos (tratamiento). Las comparaciones post hoc se realizaron con ajuste de Sidak.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El grado de mejoría según los criterios de la OARSI para los pacientes del grupo LA y del grupo AINE fue, respectivamente: 50,9 y 31,5% al mes; 55,4 y 38,9% a los 3 meses, y 63,2 y 64,8% a los 6 meses. Los pacientes en ambos grupos mejoraron desde el primer mes (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,038). Al final de los 6 meses del seguimiento, el WOMAC había descendido significativamente en ambos grupos (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,000), sin que hubiera diferencias significativas entre ellos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A los 6 meses del tratamiento, el LA es tan eficaz como los AINE en pacientes con gonartrosis, por lo que es una alternativa terapeútica eficaz en los pacientes en los que los AINE están contraindicados.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 13 | 17 |
| 2024 October | 35 | 44 | 79 |
| 2024 September | 38 | 26 | 64 |
| 2024 August | 39 | 38 | 77 |
| 2024 July | 23 | 32 | 55 |
| 2024 June | 32 | 36 | 68 |
| 2024 May | 25 | 38 | 63 |
| 2024 April | 24 | 24 | 48 |
| 2024 March | 43 | 39 | 82 |
| 2024 February | 24 | 26 | 50 |
| 2024 January | 16 | 25 | 41 |
| 2023 December | 14 | 35 | 49 |
| 2023 November | 16 | 34 | 50 |
| 2023 October | 19 | 41 | 60 |
| 2023 September | 30 | 32 | 62 |
| 2023 August | 8 | 13 | 21 |
| 2023 July | 20 | 55 | 75 |
| 2023 June | 19 | 20 | 39 |
| 2023 May | 11 | 3 | 14 |
| 2023 April | 11 | 14 | 25 |
| 2023 March | 32 | 25 | 57 |
| 2023 February | 22 | 36 | 58 |
| 2023 January | 19 | 29 | 48 |
| 2022 December | 20 | 35 | 55 |
| 2022 November | 26 | 25 | 51 |
| 2022 October | 17 | 29 | 46 |
| 2022 September | 21 | 37 | 58 |
| 2022 August | 17 | 58 | 75 |
| 2022 July | 25 | 58 | 83 |
| 2022 June | 15 | 39 | 54 |
| 2022 May | 17 | 54 | 71 |
| 2022 April | 18 | 60 | 78 |
| 2022 March | 35 | 48 | 83 |
| 2022 February | 21 | 30 | 51 |
| 2022 January | 16 | 41 | 57 |
| 2021 December | 16 | 49 | 65 |
| 2021 November | 21 | 45 | 66 |
| 2021 October | 35 | 67 | 102 |
| 2021 September | 27 | 52 | 79 |
| 2021 August | 30 | 59 | 89 |
| 2021 July | 36 | 38 | 74 |
| 2021 June | 29 | 53 | 82 |
| 2021 May | 38 | 43 | 81 |
| 2021 April | 66 | 81 | 147 |
| 2021 March | 47 | 34 | 81 |
| 2021 February | 29 | 19 | 48 |
| 2021 January | 21 | 21 | 42 |
| 2020 December | 22 | 25 | 47 |
| 2020 November | 27 | 20 | 47 |
| 2020 October | 35 | 21 | 56 |
| 2020 September | 24 | 35 | 59 |
| 2020 August | 19 | 28 | 47 |
| 2020 July | 27 | 22 | 49 |
| 2020 June | 19 | 26 | 45 |
| 2020 May | 27 | 20 | 47 |
| 2020 April | 21 | 16 | 37 |
| 2020 March | 14 | 4 | 18 |
| 2020 February | 1 | 0 | 1 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 17 | 7 | 24 |
| 2018 March | 26 | 13 | 39 |
| 2018 February | 14 | 10 | 24 |
| 2018 January | 8 | 5 | 13 |
| 2017 December | 11 | 5 | 16 |
| 2017 November | 11 | 5 | 16 |
| 2017 October | 12 | 5 | 17 |
| 2017 September | 12 | 2 | 14 |
| 2017 August | 10 | 6 | 16 |
| 2017 July | 8 | 8 | 16 |
| 2017 June | 23 | 12 | 35 |
| 2017 May | 25 | 7 | 32 |
| 2017 April | 19 | 5 | 24 |
| 2017 March | 9 | 3 | 12 |
| 2017 February | 8 | 4 | 12 |
| 2017 January | 13 | 1 | 14 |
| 2016 December | 34 | 8 | 42 |
| 2016 November | 17 | 2 | 19 |
| 2016 October | 28 | 5 | 33 |
| 2016 September | 29 | 5 | 34 |
| 2016 August | 23 | 8 | 31 |
| 2016 July | 16 | 7 | 23 |
| 2016 February | 2 | 9 | 11 |
| 2016 January | 4 | 0 | 4 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 3 | 0 | 3 |
| 2015 August | 2 | 0 | 2 |
| 2015 July | 7 | 4 | 11 |
| 2015 June | 18 | 8 | 26 |
| 2015 May | 23 | 7 | 30 |
| 2015 April | 26 | 9 | 35 |
| 2015 March | 18 | 1 | 19 |
| 2015 February | 21 | 6 | 27 |
| 2015 January | 15 | 11 | 26 |
| 2014 December | 21 | 12 | 33 |
| 2014 November | 14 | 9 | 23 |
| 2014 October | 14 | 13 | 27 |
| 2014 September | 15 | 6 | 21 |
| 2014 August | 19 | 12 | 31 |
| 2014 July | 22 | 14 | 36 |
| 2014 June | 34 | 8 | 42 |
| 2014 May | 23 | 14 | 37 |
| 2014 April | 29 | 10 | 39 |
| 2014 March | 36 | 16 | 52 |
| 2014 February | 21 | 12 | 33 |
| 2014 January | 27 | 23 | 50 |
| 2013 December | 21 | 8 | 29 |
| 2013 November | 17 | 15 | 32 |
| 2013 October | 28 | 13 | 41 |
| 2013 September | 33 | 16 | 49 |
| 2013 August | 17 | 8 | 25 |
| 2013 July | 35 | 7 | 42 |
| 2013 June | 23 | 14 | 37 |
| 2013 May | 24 | 15 | 39 |
| 2013 April | 17 | 7 | 24 |
| 2013 March | 21 | 5 | 26 |
| 2013 February | 11 | 9 | 20 |
| 2013 January | 13 | 7 | 20 |
| 2012 December | 13 | 5 | 18 |
| 2012 November | 3 | 4 | 7 |
| 2012 October | 2 | 2 | 4 |
| 2012 September | 4 | 1 | 5 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 2 | 0 | 2 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 5 | 0 | 5 |
| 2011 November | 5 | 0 | 5 |
| 2011 October | 1 | 0 | 1 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 1 | 0 | 1 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 5 | 0 | 5 |
| 2011 March | 5 | 0 | 5 |
| 2011 February | 6 | 0 | 6 |
| 2011 January | 4 | 0 | 4 |
| 2010 December | 8 | 0 | 8 |
| 2010 November | 2 | 0 | 2 |
| 2010 October | 3 | 0 | 3 |
| 2010 September | 7 | 0 | 7 |
| 2010 July | 2 | 0 | 2 |
| 2010 June | 1 | 0 | 1 |
| 2010 May | 7 | 0 | 7 |
| 2010 April | 17 | 0 | 17 |
| 2010 March | 12 | 0 | 12 |
| 2010 February | 12 | 0 | 12 |
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