Primary hypertrophic osteoarthropathy (pachydermoperiostosis). Report of 2 familial cases and literature review
Osteoartropatía hipertrófica primaria (paquidermoperiostosis). Aportación de 2 casos familiares y revisión de la literatura
Norberto Gómez Rodríguez
, Jesús Ibáñez Ruán, Marisol González Pérez
Corresponding author
Servicio de Reumatología, Hospital POVISA, Vigo, Pontevedra, Spain
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Report of 2 familial cases and literature review" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "259" "paginaFinal" => "263" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Norberto Gómez Rodríguez, Jesús Ibáñez Ruán, Marisol González Pérez" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Norberto" "apellidos" => "Gómez Rodríguez" "email" => array:1 [ 0 => "ngomez@povisa.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Jesús" "apellidos" => "Ibáñez Ruán" ] 2 => array:2 [ "nombre" => "Marisol" "apellidos" => "González Pérez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Reumatología, Hospital POVISA, Vigo, Pontevedra, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Osteoartropatía hipertrófica primaria (paquidermoperiostosis). Aportación de 2 casos familiares y revisión de la literatura" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-12-07" "fechaAceptado" => "2009-01-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112241" "palabras" => array:6 [ 0 => "Primary hypertrophic osteoarthropathy" 1 => "Pachydermoperiostosis" 2 => "Arthritis" 3 => "Hypertrophic gastritis" 4 => "Digital clubbing" 5 => "Bisphosphonates" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112240" "palabras" => array:6 [ 0 => "Osteoartropatía hipertrófica primaria" 1 => "Paquidermoperiostosis" 2 => "Artritis" 3 => "Gastritis hipertrófica" 4 => "Dedos en palillo de tambor" 5 => "Bisfosfonatos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The primary hypertrophic osteoarthropathy (pachydermoperiostosis) is a hereditary disease characterized by skin thickening (pachydermia), finger clubbing, and proliferation of periosteum (periostitis) with subperiosteal new bone formation. We describe the cases of 2 brothers of 30 and 24 years, who consulted due to bone pain, arthralgia, and oligoarthritis. Pachydermia, hyperhidrosis, seborrhea, digital clubbing, periostosis, and non-inflammatory effusions of the knees. The first had been diagnosed with juvenile idiopathic arthritis at age 15, while the youngest also presented with a thoracic scoliosis, hypertrophic gastritis, iron deficiency anemia, and glucose intolerance by pancreatic endocrine dysfunction. In both patients, symptoms were controlled satisfactorily with etoricoxib (90<span class="elsevierStyleHsp" style=""></span>mg/day) and risedronate (35<span class="elsevierStyleHsp" style=""></span>mg/week).</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La osteoartropatía hipertrófica primaria (paquidermoperiostosis) es una enfermedad hereditaria caracterizada por engrosamiento cutáneo (paquidermia), dedos en palillo de tambor y proliferación perióstica (periostosis) con neoformación ósea subcortical. Describimos los casos de 2 hermanos de 30 y 24 años, que consultaron por dolores óseos, artralgias y oligoartritis. En ambos casos se objetivó paquidermia, hiperhidrosis, seborrea, hipocratismo digital, periostosis y derrame articular en las rodillas de características no inflamatorias. El primero había sido diagnosticado de artritis idiopática juvenil a los 15 años, mientras que el más joven también presentaba una escoliosis dorsal, gastritis hipertrófica, anemia ferropénica crónica e intolerancia a la glucosa por disfunción endocrina pancreática. Los síntomas se controlaron satisfactoriamente en ambos enfermos con etoricoxib (90<span class="elsevierStyleHsp" style=""></span>mg/día) y risedronato (35<span class="elsevierStyleHsp" style=""></span>mg/ semana).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:52 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The clinical spectrum of pachydermoperiostosis (primary hypertrophic osteoarthropathy)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 16 | 21 |
| 2024 October | 44 | 91 | 135 |
| 2024 September | 77 | 50 | 127 |
| 2024 August | 84 | 55 | 139 |
| 2024 July | 54 | 54 | 108 |
| 2024 June | 114 | 70 | 184 |
| 2024 May | 98 | 53 | 151 |
| 2024 April | 108 | 47 | 155 |
| 2024 March | 71 | 54 | 125 |
| 2024 February | 68 | 61 | 129 |
| 2024 January | 62 | 49 | 111 |
| 2023 December | 65 | 58 | 123 |
| 2023 November | 73 | 70 | 143 |
| 2023 October | 53 | 46 | 99 |
| 2023 September | 105 | 63 | 168 |
| 2023 August | 75 | 21 | 96 |
| 2023 July | 74 | 50 | 124 |
| 2023 June | 78 | 50 | 128 |
| 2023 May | 66 | 25 | 91 |
| 2023 April | 39 | 16 | 55 |
| 2023 March | 66 | 51 | 117 |
| 2023 February | 45 | 37 | 82 |
| 2023 January | 31 | 27 | 58 |
| 2022 December | 48 | 56 | 104 |
| 2022 November | 48 | 38 | 86 |
| 2022 October | 59 | 51 | 110 |
| 2022 September | 49 | 49 | 98 |
| 2022 August | 48 | 53 | 101 |
| 2022 July | 43 | 67 | 110 |
| 2022 June | 26 | 54 | 80 |
| 2022 May | 47 | 61 | 108 |
| 2022 April | 35 | 59 | 94 |
| 2022 March | 28 | 65 | 93 |
| 2022 February | 31 | 49 | 80 |
| 2022 January | 32 | 68 | 100 |
| 2021 December | 33 | 59 | 92 |
| 2021 November | 31 | 47 | 78 |
| 2021 October | 37 | 56 | 93 |
| 2021 September | 26 | 54 | 80 |
| 2021 August | 30 | 51 | 81 |
| 2021 July | 19 | 35 | 54 |
| 2021 June | 34 | 61 | 95 |
| 2021 May | 26 | 46 | 72 |
| 2021 April | 73 | 88 | 161 |
| 2021 March | 87 | 47 | 134 |
| 2021 February | 48 | 32 | 80 |
| 2021 January | 44 | 20 | 64 |
| 2020 December | 40 | 25 | 65 |
| 2020 November | 44 | 23 | 67 |
| 2020 October | 34 | 28 | 62 |
| 2020 September | 42 | 36 | 78 |
| 2020 August | 28 | 18 | 46 |
| 2020 July | 30 | 19 | 49 |
| 2020 June | 33 | 16 | 49 |
| 2020 May | 32 | 24 | 56 |
| 2020 April | 27 | 16 | 43 |
| 2020 March | 12 | 11 | 23 |
| 2020 February | 2 | 0 | 2 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 2 | 0 | 2 |
| 2019 November | 1 | 0 | 1 |
| 2019 September | 7 | 0 | 7 |
| 2019 June | 2 | 0 | 2 |
| 2019 May | 2 | 0 | 2 |
| 2019 April | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2019 February | 1 | 0 | 1 |
| 2019 January | 3 | 0 | 3 |
| 2018 December | 2 | 0 | 2 |
| 2018 May | 4 | 2 | 6 |
| 2018 April | 26 | 11 | 37 |
| 2018 March | 16 | 17 | 33 |
| 2018 February | 17 | 8 | 25 |
| 2018 January | 19 | 8 | 27 |
| 2017 December | 15 | 10 | 25 |
| 2017 November | 20 | 11 | 31 |
| 2017 October | 20 | 16 | 36 |
| 2017 September | 35 | 25 | 60 |
| 2017 August | 32 | 35 | 67 |
| 2017 July | 29 | 16 | 45 |
| 2017 June | 22 | 32 | 54 |
| 2017 May | 25 | 19 | 44 |
| 2017 April | 21 | 23 | 44 |
| 2017 March | 16 | 17 | 33 |
| 2017 February | 9 | 19 | 28 |
| 2017 January | 24 | 9 | 33 |
| 2016 December | 68 | 22 | 90 |
| 2016 November | 24 | 23 | 47 |
| 2016 October | 52 | 27 | 79 |
| 2016 September | 60 | 25 | 85 |
| 2016 August | 50 | 26 | 76 |
| 2016 July | 23 | 20 | 43 |
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