Gene polymorphisms and pharmacogenetics in rheumatoid arthritis

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Blanco" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Rego-Pérez" ] 1 => array:2 [ "nombre" => "Mercedes" "apellidos" => "Fernández-Moreno" ] 2 => array:2 [ "nombre" => "Vanessa" "apellidos" => "Carreira-García" ] 3 => array:4 [ "nombre" => "Francisco J." "apellidos" => "Blanco" "email" => array:1 [ 0 => "fblagar@canalejo.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "¿" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Investigación del Envejecimiento Osteoarticular, Laboratorio de Investigación, INIBIC, División de Reumatología, A Coruña, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Polimorfismos genéticos y farmacogenética en la artritis reumatoide" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-10-06" "fechaAceptado" => "2008-12-04" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112254" "palabras" => array:7 [ 0 => "Pharmacogenetics" 1 => "Pharmacogenomics" 2 => "Rheumatoid arthritis" 3 => "Tumor necrosis factor" 4 => "Interleukin-1" 5 => "Cytokines" 6 => "Gene polymorphisms" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112255" "palabras" => array:7 [ 0 => "Farmacogenética" 1 => "Farmacogenómica" 2 => "Artritis reumatoide" 3 => "Factor de necrosis tumoral" 4 => "Interleucina-1" 5 => "Citocinas" 6 => "Polimorfismos genéticos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Rheumatoid arthritis (RA) is a systemic, chronic, and inflammatory disease of unknown aetiology with a genetic predisposition. The advent of new biological agents, as well as the more traditional diseasemodifying anti rheumatic drugs, has resulted in highly efficient therapies for reducing the symptoms and signs of RA; however, not all patients show the same level of response regarding disease progression to these therapies. These variations suggest that RA patients may have different genetic regulatory mechanisms. The extensive polymorphisms revealed in non-coding gene-regulatory regions in the immune system, as well as genetic variations in drug-metabolizing enzymes, suggest that this type of variation is of functional and evolutionary importance and may provide clues for developing new therapeutic strategies. Pharmacogenetics is a rapidly advancing area of research that holds the promise that therapies will soon be tailored to an individual patient's genetic profile.Chronic and severe forms of gout are frequently wrongly evaluated from the clinical standpoint." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La artritis reumatoide (AR) es una enfermedad inflamatoria, sistémica y crónica de etiología desconocida y con predisposición genética. La llegada de los nuevos agentes biológicos, así como los ya conocidos fármacos antirreumáticos modificadores de la enfermedad, condujeron a una eficacia elevada en los tratamientos de la AR. Sin embargo, no todos los sujetos muestran el mismo grado de progresión de la enfermedad como respuesta a estos tratamientos. Estas variaciones demuestran que los sujetos con AR deben tener diferentes mecanismos de regulación génica. Los polimorfismos detectados en las regiones reguladoras no codificantes del sistema inmune y las variaciones genéticas de las enzimas que metabolizan los fármacos demuestran que este tipo de variaciones tiene una importancia funcional y evolutiva elevada, lo que proporciona nuevas pistas para el desarrollo de nuevas estrategias terapéuticas. La farmacogenética es un campo que avanza rápidamente y promete el desarrollo de tratamientos adaptados al perfil genético del sujeto en un futuro cercano." ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:110 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Polimorfismos genéticos y farmacogenética en la artritis reumatoide

Ignacio Rego-Pérez, Mercedes Fernández-Moreno, Vanessa Carreira-García, Francisco J. Blanco

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fblagar@canalejo.org

Corresponding author.

Unidad de Investigación del Envejecimiento Osteoarticular, Laboratorio de Investigación, INIBIC, División de Reumatología, A Coruña, Spain

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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; is a systemic&#44; chronic&#44; and inflammatory disease of unknown aetiology with a genetic predisposition&#46; The advent of new biological agents&#44; as well as the more traditional diseasemodifying anti rheumatic drugs&#44; has resulted in highly efficient therapies for reducing the symptoms and signs of RA&#59; however&#44; not all patients show the same level of response regarding disease progression to these therapies&#46; These variations suggest that RA patients may have different genetic regulatory mechanisms&#46; The extensive polymorphisms revealed in non-coding gene-regulatory regions in the immune system&#44; as well as genetic variations in drug-metabolizing enzymes&#44; suggest that this type of variation is of functional and evolutionary importance and may provide clues for developing new therapeutic strategies&#46; Pharmacogenetics is a rapidly advancing area of research that holds the promise that therapies will soon be tailored to an individual patient&#39;s genetic profile&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Chronic and severe forms of gout are frequently wrongly evaluated from the clinical standpoint&#46;</p>"
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        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La artritis reumatoide &#40;AR&#41; es una enfermedad inflamatoria&#44; sist&#233;mica y cr&#243;nica de etiolog&#237;a desconocida y con predisposici&#243;n gen&#233;tica&#46; La llegada de los nuevos agentes biol&#243;gicos&#44; as&#237; como los ya conocidos f&#225;rmacos antirreum&#225;ticos modificadores de la enfermedad&#44; condujeron a una eficacia elevada en los tratamientos de la AR&#46; Sin embargo&#44; no todos los sujetos muestran el mismo grado de progresi&#243;n de la enfermedad como respuesta a estos tratamientos&#46; Estas variaciones demuestran que los sujetos con AR deben tener diferentes mecanismos de regulaci&#243;n g&#233;nica&#46; Los polimorfismos detectados en las regiones reguladoras no codificantes del sistema inmune y las variaciones gen&#233;ticas de las enzimas que metabolizan los f&#225;rmacos demuestran que este tipo de variaciones tiene una importancia funcional y evolutiva elevada&#44; lo que proporciona nuevas pistas para el desarrollo de nuevas estrategias terap&#233;uticas&#46; La farmacogen&#233;tica es un campo que avanza r&#225;pidamente y promete el desarrollo de tratamientos adaptados al perfil gen&#233;tico del sujeto en un futuro cercano&#46;</p>"
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Article information

ISSN: 21735743
Original language: English

DOI:10.1016/S2173-5743(09)70135-2

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Year/Month	Html	Pdf	Total

2024 November	6	17	23
2024 October	33	35	68
2024 September	41	14	55
2024 August	52	30	82
2024 July	36	35	71
2024 June	42	34	76
2024 May	53	37	90
2024 April	41	33	74
2024 March	38	38	76
2024 February	32	33	65
2024 January	32	29	61
2023 December	22	29	51
2023 November	23	20	43
2023 October	34	42	76
2023 September	30	32	62
2023 August	20	16	36
2023 July	27	23	50
2023 June	22	21	43
2023 May	24	23	47
2023 April	20	6	26
2023 March	19	34	53
2023 February	27	33	60
2023 January	18	20	38
2022 December	34	43	77
2022 November	36	34	70
2022 October	31	36	67
2022 September	24	39	63
2022 August	26	53	79
2022 July	31	59	90
2022 June	27	33	60
2022 May	27	65	92
2022 April	22	66	88
2022 March	36	42	78
2022 February	31	48	79
2022 January	24	61	85
2021 December	27	49	76
2021 November	33	53	86
2021 October	43	51	94
2021 September	34	56	90
2021 August	24	46	70
2021 July	29	44	73
2021 June	33	56	89
2021 May	60	40	100
2021 April	70	65	135
2021 March	57	32	89
2021 February	71	29	100
2021 January	36	23	59
2020 December	36	27	63
2020 November	29	16	45
2020 October	20	19	39
2020 September	34	19	53
2020 August	14	19	33
2020 July	27	19	46
2020 June	26	42	68
2020 May	19	25	44
2020 April	25	21	46
2020 March	17	9	26
2020 February	1	0	1
2020 January	4	0	4
2019 October	1	0	1
2019 September	4	0	4
2019 June	2	0	2
2019 March	2	0	2
2019 February	1	0	1
2019 January	1	0	1
2018 December	1	0	1
2018 May	3	1	4
2018 April	16	17	33
2018 March	18	18	36
2018 February	14	6	20
2018 January	9	7	16
2017 December	14	8	22
2017 November	14	7	21
2017 October	17	8	25
2017 September	14	5	19
2017 August	9	15	24
2017 July	16	15	31
2017 June	25	9	34
2017 May	34	10	44
2017 April	12	6	18
2017 March	10	33	43
2017 February	1	1	2
2017 January	14	4	18
2016 December	32	10	42
2016 November	17	4	21
2016 October	36	6	42
2016 September	27	11	38
2016 August	25	8	33
2016 July	20	8	28
2016 June	0	7	7
2016 May	0	10	10
2016 April	2	9	11
2016 March	0	7	7
2016 February	0	15	15
2016 January	2	23	25
2015 December	4	0	4
2015 September	1	0	1
2015 August	2	0	2
2015 July	17	5	22
2015 June	32	22	54
2015 May	38	41	79
2015 April	25	33	58
2015 March	41	16	57
2015 February	47	31	78
2015 January	38	11	49
2014 December	26	21	47
2014 November	12	14	26
2014 October	20	14	34
2014 September	12	24	36
2014 August	15	20	35
2014 July	19	28	47
2014 June	43	26	69
2014 May	64	29	93
2014 April	39	19	58
2014 March	35	26	61
2014 February	36	17	53
2014 January	26	17	43
2013 December	25	13	38
2013 November	27	14	41
2013 October	36	10	46
2013 September	31	16	47
2013 August	27	13	40
2013 July	35	13	48
2013 June	28	17	45
2013 May	23	19	42
2013 April	34	17	51
2013 March	31	22	53
2013 February	33	8	41
2013 January	31	13	44
2012 December	18	9	27
2012 November	8	7	15
2012 October	3	17	20
2012 September	6	3	9
2012 May	1	0	1
2012 April	3	0	3
2012 March	5	0	5
2012 February	1	0	1
2012 January	4	0	4
2011 December	2	0	2
2011 November	4	0	4
2011 October	3	0	3
2011 September	1	0	1
2011 May	3	0	3
2011 April	1	0	1
2011 March	6	0	6
2011 February	2	0	2
2011 January	7	0	7
2010 December	5	0	5
2010 November	2	0	2
2010 October	8	0	8
2010 September	2	0	2
2010 August	5	0	5
2010 July	5	0	5
2010 June	8	0	8
2010 May	7	0	7
2010 April	17	0	17
2010 March	4	0	4

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