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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine damage presence and predictors factors for its appearance in a cohort of Cuban patients with systemic lupus erythematosus &#40;SLE&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective cohort study included 80 patients presenting with SLE seen in Rheumatology Service of &#8220;Hermanos Ameijeiras&#8221; Clinical Surgical Hospital in Havana City&#44; Cuba&#46; Damage was assessed using The Systemic Lupus International Collaborating Clinics&#47;American College of Rheumatology &#40;ACR&#41; Damage Index &#40;SLIC&#47;ACR&#41;&#44; a tool approved for damage measurement&#46; Damage presence was related to initial disease features to diagnose this condition&#44; to sociodemographic elements&#44; to treatments used&#44; and to the disease course time&#46; Statistical analysis had two variants&#58; the univariate and multivariate type using Chi2 and statistical significance was established in <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We found that 39 patients &#40;48&#46;8&#37;&#41; had some degree of damage&#46; More involved domains were the musculoskeletal &#40;18&#46;8&#37;&#41;&#44; neuropsychiatric&#44; and skin&#44; 16&#46;3&#37;&#44; pulmonary and ocular&#44; present in 15&#37; of cases&#46; In the multivariate analysis&#44; damage was associated with the use of higher than 30<span class="elsevierStyleHsp" style=""></span>mg&#47;day Prednisone doses for more of 4 weeks &#40;OR&#61;54&#46;68&#44; CI 95&#37;&#61;3&#46;56&#8211;97&#46;45&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; presence of leukopenia &#40;RO&#61;18&#46;73&#44; CI 95&#37;&#61;2&#46;74&#8211;62&#46;23 m <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;004&#41;&#44; and time course of disease &#40;OR&#61;1&#46;02&#44; CI 95&#37;&#61;1&#46;00 2&#8211;1&#46;09&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;006&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Damage was practically present in half of the study patients&#44; the most involved domain was the musculoskeletal&#44; and use of higher than 30<span class="elsevierStyleHsp" style=""></span>mg prednisone doses were the factor most associated with the presence of damage&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Determinar la presencia de da&#241;o y factores predictores de su aparici&#243;n en una cohorte de pacientes cubanos con lupus eritematoso sist&#233;mico &#40;LES&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio de cohorte retrospectivo que incluy&#243; a 80 pacientes con LES atendidos en el Servicio de Reumatolog&#237;a del Hospital Hermanos Ameijeiras en la ciudad de La Habana&#44; Cuba&#46; El da&#241;o fue determinado aplicando el Systemic Lupus International Collaborating Clinics&#47;American College of Rheumatology &#40;SLICC&#47;ACR&#41; Damage Index&#46; La presencia de da&#241;o se relacion&#243; con las caracter&#237;sticas iniciales de la enfermedad al diagn&#243;stico&#44; con elementos sociodemogr&#225;ficos&#44; con los tratamientos utilizados y con el tiempo de evoluci&#243;n de la enfermedad&#46; El an&#225;lisis estad&#237;stico incluy&#243; estudios univariante y multivariado&#44; y se utiliz&#243; el test de Chi-cuadrado &#40;la significaci&#243;n estad&#237;stica se fij&#243; en p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Encontramos que 39 pacientes &#40;48&#44;8&#37;&#41; ten&#237;an alg&#250;n grado de da&#241;o&#46; Los dominios m&#225;s afectados fueron el m&#250;sculo esquel&#233;tico &#40;18&#44;8&#37;&#41;&#44; el neuropsiqui&#225;trico y la piel&#44; ambos con un 16&#44;3&#37;&#46; En el an&#225;lisis multivariado el da&#241;o se asoci&#243; con la utilizaci&#243;n de dosis de prednisona mayores de 30<span class="elsevierStyleHsp" style=""></span>mg diarios por m&#225;s de cuatro semanas &#40;OR &#61; 54&#44;68&#59; IC 95&#37;&#58; 3&#44;56&#8211;97&#44;45&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; presencia de leucopenia &#40;OR &#61; 18&#44;73&#59; IC 95&#37;&#58; 2&#44;74&#8211;62&#44;23&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41; y el tiempo mayor de evoluci&#243;n de la enfermedad &#40;OR &#61; 1&#44;02&#59; IC 95&#37;&#58;1&#44;002&#8211;1&#44;09&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El da&#241;o estuvo presente pr&#225;cticamente en la mitad de los pacientes estudiados&#44; el dominio m&#225;s afectado fue el musculoesquel&#233;tico y la utilizaci&#243;n de dosis mayores a 30<span class="elsevierStyleHsp" style=""></span>mg de prednisona fue el factor m&#225;s asociado con la presencia de da&#241;o&#46;</p>"
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Damage in Cuban patients with systemic lupus erythematosus. Relation with disease features
Daño en pacientes cubanos con lupus eritematoso sistémico. Relación con características de la enfermedad
Miguel Estévez del Toro
Corresponding author
mestevez@infomed.sld.cu

Corresponding author.
, Araceli Chico Capote, Rafael Hechavarría, Rosa Jiménez Paneque, Elena Kokuina
Servicio de Reumatología, Hospital Hermanos Ameijeiras, Havana City, Cuba
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine damage presence and predictors factors for its appearance in a cohort of Cuban patients with systemic lupus erythematosus &#40;SLE&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective cohort study included 80 patients presenting with SLE seen in Rheumatology Service of &#8220;Hermanos Ameijeiras&#8221; Clinical Surgical Hospital in Havana City&#44; Cuba&#46; Damage was assessed using The Systemic Lupus International Collaborating Clinics&#47;American College of Rheumatology &#40;ACR&#41; Damage Index &#40;SLIC&#47;ACR&#41;&#44; a tool approved for damage measurement&#46; Damage presence was related to initial disease features to diagnose this condition&#44; to sociodemographic elements&#44; to treatments used&#44; and to the disease course time&#46; Statistical analysis had two variants&#58; the univariate and multivariate type using Chi2 and statistical significance was established in <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We found that 39 patients &#40;48&#46;8&#37;&#41; had some degree of damage&#46; More involved domains were the musculoskeletal &#40;18&#46;8&#37;&#41;&#44; neuropsychiatric&#44; and skin&#44; 16&#46;3&#37;&#44; pulmonary and ocular&#44; present in 15&#37; of cases&#46; In the multivariate analysis&#44; damage was associated with the use of higher than 30<span class="elsevierStyleHsp" style=""></span>mg&#47;day Prednisone doses for more of 4 weeks &#40;OR&#61;54&#46;68&#44; CI 95&#37;&#61;3&#46;56&#8211;97&#46;45&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#44; presence of leukopenia &#40;RO&#61;18&#46;73&#44; CI 95&#37;&#61;2&#46;74&#8211;62&#46;23 m <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;004&#41;&#44; and time course of disease &#40;OR&#61;1&#46;02&#44; CI 95&#37;&#61;1&#46;00 2&#8211;1&#46;09&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;006&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Damage was practically present in half of the study patients&#44; the most involved domain was the musculoskeletal&#44; and use of higher than 30<span class="elsevierStyleHsp" style=""></span>mg prednisone doses were the factor most associated with the presence of damage&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Determinar la presencia de da&#241;o y factores predictores de su aparici&#243;n en una cohorte de pacientes cubanos con lupus eritematoso sist&#233;mico &#40;LES&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio de cohorte retrospectivo que incluy&#243; a 80 pacientes con LES atendidos en el Servicio de Reumatolog&#237;a del Hospital Hermanos Ameijeiras en la ciudad de La Habana&#44; Cuba&#46; El da&#241;o fue determinado aplicando el Systemic Lupus International Collaborating Clinics&#47;American College of Rheumatology &#40;SLICC&#47;ACR&#41; Damage Index&#46; La presencia de da&#241;o se relacion&#243; con las caracter&#237;sticas iniciales de la enfermedad al diagn&#243;stico&#44; con elementos sociodemogr&#225;ficos&#44; con los tratamientos utilizados y con el tiempo de evoluci&#243;n de la enfermedad&#46; El an&#225;lisis estad&#237;stico incluy&#243; estudios univariante y multivariado&#44; y se utiliz&#243; el test de Chi-cuadrado &#40;la significaci&#243;n estad&#237;stica se fij&#243; en p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Encontramos que 39 pacientes &#40;48&#44;8&#37;&#41; ten&#237;an alg&#250;n grado de da&#241;o&#46; Los dominios m&#225;s afectados fueron el m&#250;sculo esquel&#233;tico &#40;18&#44;8&#37;&#41;&#44; el neuropsiqui&#225;trico y la piel&#44; ambos con un 16&#44;3&#37;&#46; En el an&#225;lisis multivariado el da&#241;o se asoci&#243; con la utilizaci&#243;n de dosis de prednisona mayores de 30<span class="elsevierStyleHsp" style=""></span>mg diarios por m&#225;s de cuatro semanas &#40;OR &#61; 54&#44;68&#59; IC 95&#37;&#58; 3&#44;56&#8211;97&#44;45&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; presencia de leucopenia &#40;OR &#61; 18&#44;73&#59; IC 95&#37;&#58; 2&#44;74&#8211;62&#44;23&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41; y el tiempo mayor de evoluci&#243;n de la enfermedad &#40;OR &#61; 1&#44;02&#59; IC 95&#37;&#58;1&#44;002&#8211;1&#44;09&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El da&#241;o estuvo presente pr&#225;cticamente en la mitad de los pacientes estudiados&#44; el dominio m&#225;s afectado fue el musculoesquel&#233;tico y la utilizaci&#243;n de dosis mayores a 30<span class="elsevierStyleHsp" style=""></span>mg de prednisona fue el factor m&#225;s asociado con la presencia de da&#241;o&#46;</p>"
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