Drugs employed during pregnancy and contraceptive methods in rheumatic disease. New evidence
Fármacos durante el embarazo y métodos contraceptivos en enfermedades reumáticas. Nuevas aportaciones
Xavier Juanola Roura
, Valeria Ríos Rodríguez, Diana de la Fuente de Dios
Corresponding author
Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
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New evidence" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "43" "paginaFinal" => "48" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Xavier Juanola Roura, Valeria Ríos Rodríguez, Diana de la Fuente de Dios" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Xavier" "apellidos" => "Juanola Roura" "email" => array:2 [ 0 => "x.juanola@bellvitgehospital.cat" 1 => "xjuanola@comb.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Valeria" "apellidos" => "Ríos Rodríguez" ] 2 => array:2 [ "nombre" => "Diana" "apellidos" => "de la Fuente de Dios" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fármacos durante el embarazo y métodos contraceptivos en enfermedades reumáticas. Nuevas aportaciones" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-12-16" "fechaAceptado" => "2009-01-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112325" "palabras" => array:4 [ 0 => "Drugs" 1 => "Pregnancy" 2 => "Lupus" 3 => "Contraception" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112324" "palabras" => array:4 [ 0 => "Fármacos" 1 => "Embarazo" 2 => "Lupus" 3 => "Contracepción" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Voluntary birth control, the ability to identify the best moment for becoming pregnant depending on disease activity, and the need to avoid conception during the administration of teratogenic drugs are the main reasons for the use of contraceptive methods among women with rheumatic diseases.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This article reviews the risks that antirheumatic drugs represent during conception, pregnancy and lactation and the contraceptive methods that are currently available to patients. Hormonal therapy has developed considerably and can further our understanding of safety aspects, especially for systemic lupus erythematosus patients. Recently the methods of administration have evolved, and now include transdermal and intravaginal routes, a progesterone-releasing intrauterine device, and an extended-cycle oral contraceptive.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Rheumatologists work increasingly in conjunction with patients to assist in choices regarding contraceptive methods and pregnancy planning. Each decision should be individualized according to the personal preference and the stage of reproductive life.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El control voluntario de la natalidad, el hecho de poder establecer el mejor momento de la gestación en función de la actividad de la enfermedad y la necesidad de evitar el embarazo debido a la indicación de fármacos potencialmente teratógenos constituyen las razones principales para la utilización de métodos contraceptivos en pacientes afectas de enfermedades reumáticas.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En este artículo se revisan los posibles riesgos durante el embarazo de las medicaciones utilizadas en reumatología y los diversos métodos contraceptivos disponibles actualmente. En los últimos años se ha producido un mejor conocimiento de la seguridad de los métodos contraceptivos hormonales con datos especialmente relevantes de su utilización en pacientes con lupus eritematoso sistémico. La evolución de la contracepción hormonal con nuevas vías de administración, como la transdérmica, la intravaginal y los dispositivos intrauterinos o los implantes liberadores de progestágenos, han significado avances evidentes en este campo.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La implicación del reumatólogo, como responsable de la atención de estos pacientes, es requerida con mayor frecuencia y el conocimiento de todos los métodos disponibles, con todas sus ventajas, desventajas y efectos adversos ayudará a facilitar información para que la pareja pueda escoger en cada caso la mejor opción.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:45 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 10 | 15 |
| 2024 October | 25 | 46 | 71 |
| 2024 September | 21 | 18 | 39 |
| 2024 August | 39 | 37 | 76 |
| 2024 July | 27 | 39 | 66 |
| 2024 June | 31 | 33 | 64 |
| 2024 May | 39 | 28 | 67 |
| 2024 April | 30 | 25 | 55 |
| 2024 March | 29 | 35 | 64 |
| 2024 February | 35 | 26 | 61 |
| 2024 January | 26 | 24 | 50 |
| 2023 December | 24 | 32 | 56 |
| 2023 November | 21 | 19 | 40 |
| 2023 October | 27 | 35 | 62 |
| 2023 September | 29 | 45 | 74 |
| 2023 August | 22 | 12 | 34 |
| 2023 July | 28 | 30 | 58 |
| 2023 June | 21 | 20 | 41 |
| 2023 May | 24 | 13 | 37 |
| 2023 April | 15 | 16 | 31 |
| 2023 March | 14 | 26 | 40 |
| 2023 February | 25 | 26 | 51 |
| 2023 January | 32 | 41 | 73 |
| 2022 December | 26 | 32 | 58 |
| 2022 November | 22 | 17 | 39 |
| 2022 October | 26 | 30 | 56 |
| 2022 September | 24 | 29 | 53 |
| 2022 August | 28 | 47 | 75 |
| 2022 July | 27 | 49 | 76 |
| 2022 June | 27 | 35 | 62 |
| 2022 May | 26 | 58 | 84 |
| 2022 April | 27 | 40 | 67 |
| 2022 March | 25 | 45 | 70 |
| 2022 February | 17 | 42 | 59 |
| 2022 January | 18 | 39 | 57 |
| 2021 December | 13 | 43 | 56 |
| 2021 November | 19 | 49 | 68 |
| 2021 October | 25 | 51 | 76 |
| 2021 September | 24 | 50 | 74 |
| 2021 August | 21 | 56 | 77 |
| 2021 July | 16 | 45 | 61 |
| 2021 June | 28 | 54 | 82 |
| 2021 May | 22 | 45 | 67 |
| 2021 April | 41 | 76 | 117 |
| 2021 March | 46 | 32 | 78 |
| 2021 February | 36 | 21 | 57 |
| 2021 January | 17 | 22 | 39 |
| 2020 December | 29 | 29 | 58 |
| 2020 November | 26 | 17 | 43 |
| 2020 October | 24 | 23 | 47 |
| 2020 September | 25 | 18 | 43 |
| 2020 August | 16 | 26 | 42 |
| 2020 July | 11 | 17 | 28 |
| 2020 June | 29 | 20 | 49 |
| 2020 May | 44 | 13 | 57 |
| 2020 April | 26 | 22 | 48 |
| 2020 March | 24 | 12 | 36 |
| 2020 January | 10 | 0 | 10 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 2 | 0 | 2 |
| 2018 December | 2 | 0 | 2 |
| 2018 May | 3 | 1 | 4 |
| 2018 April | 22 | 14 | 36 |
| 2018 March | 29 | 20 | 49 |
| 2018 February | 20 | 9 | 29 |
| 2018 January | 15 | 7 | 22 |
| 2017 December | 14 | 12 | 26 |
| 2017 November | 14 | 12 | 26 |
| 2017 October | 19 | 7 | 26 |
| 2017 September | 14 | 10 | 24 |
| 2017 August | 7 | 10 | 17 |
| 2017 July | 11 | 20 | 31 |
| 2017 June | 32 | 18 | 50 |
| 2017 May | 28 | 19 | 47 |
| 2017 April | 30 | 8 | 38 |
| 2017 March | 29 | 12 | 41 |
| 2017 February | 12 | 6 | 18 |
| 2017 January | 17 | 9 | 26 |
| 2016 December | 58 | 15 | 73 |
| 2016 November | 38 | 8 | 46 |
| 2016 October | 62 | 13 | 75 |
| 2016 September | 46 | 11 | 57 |
| 2016 August | 25 | 4 | 29 |
| 2016 July | 28 | 10 | 38 |
| 2016 February | 2 | 0 | 2 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 3 | 0 | 3 |
| 2015 September | 1 | 0 | 1 |
| 2015 August | 3 | 0 | 3 |
| 2015 July | 14 | 7 | 21 |
| 2015 June | 25 | 13 | 38 |
| 2015 May | 35 | 24 | 59 |
| 2015 April | 19 | 22 | 41 |
| 2015 March | 11 | 8 | 19 |
| 2015 February | 19 | 16 | 35 |
| 2015 January | 7 | 21 | 28 |
| 2014 December | 22 | 13 | 35 |
| 2014 November | 13 | 11 | 24 |
| 2014 October | 16 | 15 | 31 |
| 2014 September | 13 | 11 | 24 |
| 2014 August | 16 | 16 | 32 |
| 2014 July | 17 | 17 | 34 |
| 2014 June | 46 | 10 | 56 |
| 2014 May | 30 | 14 | 44 |
| 2014 April | 32 | 12 | 44 |
| 2014 March | 37 | 14 | 51 |
| 2014 February | 22 | 15 | 37 |
| 2014 January | 20 | 18 | 38 |
| 2013 December | 22 | 12 | 34 |
| 2013 November | 21 | 8 | 29 |
| 2013 October | 41 | 16 | 57 |
| 2013 September | 39 | 13 | 52 |
| 2013 August | 23 | 8 | 31 |
| 2013 July | 28 | 6 | 34 |
| 2013 June | 20 | 11 | 31 |
| 2013 May | 18 | 16 | 34 |
| 2013 April | 27 | 26 | 53 |
| 2013 March | 15 | 15 | 30 |
| 2013 February | 17 | 8 | 25 |
| 2013 January | 19 | 14 | 33 |
| 2012 December | 17 | 11 | 28 |
| 2012 November | 12 | 8 | 20 |
| 2012 October | 7 | 1 | 8 |
| 2012 September | 6 | 3 | 9 |
| 2012 June | 5 | 0 | 5 |
| 2012 April | 3 | 0 | 3 |
| 2012 March | 4 | 0 | 4 |
| 2012 February | 4 | 0 | 4 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 2 | 0 | 2 |
| 2011 November | 5 | 0 | 5 |
| 2011 October | 6 | 0 | 6 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 4 | 0 | 4 |
| 2011 March | 2 | 0 | 2 |
| 2011 February | 4 | 0 | 4 |
| 2011 January | 5 | 0 | 5 |
| 2010 December | 14 | 0 | 14 |
| 2010 November | 1 | 0 | 1 |
| 2010 October | 10 | 0 | 10 |
| 2010 September | 5 | 0 | 5 |
| 2010 August | 12 | 0 | 12 |
| 2010 July | 12 | 0 | 12 |
| 2010 June | 9 | 0 | 9 |
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