Response to rituximab in a patient with Wegener's granulomatosis refractory to conventional therapies
Respuesta a rituximab en un paciente con granulomatosis de Wegener refractaria a terapia convencional
Inmaculada Macías Fernández
Sección de Reumatología, Hospital Universitario Puerta del Mar, Cádiz, Spain
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The patient received treatment with rituximab in 4 doses with clinical and radiographic improvement.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso de un paciente con granulomatosis de Wegener asociada a anticuerpos antiproteinasa 3 que tuvo mejoría inicial con dosis altas de glucocorticoides y ciclofosfamida, pero que posteriormente a una recaída no respondió a los mismos medicamentos, ni a metotrexate ni a zatioprina. Por tal motivo, recibió tratamiento con rituximab en 4 dosis, además de glucocorticoides, obteniendo mejoría del cuadro tanto clínica como radiográficamente.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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