Original article
Churg-Strauss Vasculitis. Description of 9 cases
Vasculitis de Jacob Churg y Lotte Strauss. Descripción de 9 casos
Emma García-Melchor
, Sonia Mínguez Blasco, Anna Moltó Revilla, Lourdes Mateo Soria, Susana Holgado Pérez, Alejandro Olivé Marqués
Corresponding author
Sección de Reumatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Read
5788
Timeswas read the article
2756
Total PDF
3032
Total HTML
Share statistics
array:23 [ "pii" => "S2173574310700174" "issn" => "21735743" "doi" => "10.1016/S2173-5743(10)70017-4" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70017" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2010;6:76-81" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2320 "formatos" => array:3 [ "EPUB" => 47 "HTML" => 1453 "PDF" => 820 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173574310700186" "issn" => "21735743" "doi" => "10.1016/S2173-5743(10)70018-6" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70018" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2010;6:82-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2612 "formatos" => array:3 [ "EPUB" => 43 "HTML" => 1441 "PDF" => 1128 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Treatment with rituximab for thrombocytopenia due to systemic lupus erythematosus" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "82" "paginaFinal" => "85" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento con rituximab para la trombocitopenia secundaria a lupus eritematoso sistémico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rosa Elena Calderón Saldierna, María Azucena Ramos Sánchez, Yadhira Mejía Holguín, Laura Elena Aranda Baca, María Josefina Sauza del Pozo, Ariana Maia Becerra Márquez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Rosa Elena" "apellidos" => "Calderón Saldierna" ] 1 => array:2 [ "nombre" => "María Azucena" "apellidos" => "Ramos Sánchez" ] 2 => array:2 [ "nombre" => "Yadhira" "apellidos" => "Mejía Holguín" ] 3 => array:2 [ "nombre" => "Laura Elena" "apellidos" => "Aranda Baca" ] 4 => array:2 [ "nombre" => "María Josefina" "apellidos" => "Sauza del Pozo" ] 5 => array:2 [ "nombre" => "Ariana Maia" "apellidos" => "Becerra Márquez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700186?idApp=UINPBA00004M" "url" => "/21735743/0000000600000002/v1_201305061606/S2173574310700186/v1_201305061606/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173574310700162" "issn" => "21735743" "doi" => "10.1016/S2173-5743(10)70016-2" "estado" => "S300" "fechaPublicacion" => "2010-03-01" "aid" => "70016" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Reumatol Clin. 2010;6:73-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1998 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 1190 "PDF" => 764 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Deciphering the association of anti P ribosomal antibodies and neuropsychiatric affection in systemic lupus erythematosus" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "73" "paginaFinal" => "75" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Descifrando la asociación de los anticuerpos antiproteína P ribosomal y el cuadro neuropsiquiátrico del lupus eritematoso sistémico" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jozélio Freire de Carvalho, Vilma S. Trindade Viana, Eloísa Bonfá" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Jozélio Freire" "apellidos" => "de Carvalho" ] 1 => array:2 [ "nombre" => "Vilma S." "apellidos" => "Trindade Viana" ] 2 => array:2 [ "nombre" => "Eloísa" "apellidos" => "Bonfá" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700162?idApp=UINPBA00004M" "url" => "/21735743/0000000600000002/v1_201305061606/S2173574310700162/v1_201305061606/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Churg-Strauss Vasculitis. Description of 9 cases" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "76" "paginaFinal" => "81" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Emma García-Melchor, Sonia Mínguez Blasco, Anna Moltó Revilla, Lourdes Mateo Soria, Susana Holgado Pérez, Alejandro Olivé Marqués" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Emma" "apellidos" => "García-Melchor" "email" => array:1 [ 0 => "emmitagm@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Sonia" "apellidos" => "Mínguez Blasco" ] 2 => array:2 [ "nombre" => "Anna" "apellidos" => "Moltó Revilla" ] 3 => array:2 [ "nombre" => "Lourdes" "apellidos" => "Mateo Soria" ] 4 => array:2 [ "nombre" => "Susana" "apellidos" => "Holgado Pérez" ] 5 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Olivé Marqués" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Sección de Reumatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vasculitis de Jacob Churg y Lotte Strauss. Descripción de 9 casos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-09-25" "fechaAceptado" => "2009-02-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112363" "palabras" => array:2 [ 0 => "Vasculitis" 1 => "Churg-Strauss syndrome" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112364" "palabras" => array:3 [ 0 => "Vasculitis" 1 => "Síndrome Churg-Strauss" 2 => "Anticuerpos anticitoplasma de neutrófilo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Churg-Strauss Syndrome (CSS) is a necrotizing vasculitis affecting small to medium-sized vessels, characterized by lung involvement, asthma and peripheral blood eosinophilia, and pathologically by the presence of granulomas and eosinophilic infiltrates.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This report analizes the characteristics of 9 patients with SCS diagnosed in an university referral center.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Retrospective study. Between 1984 and 2007 nine patients with SCS were diagnosed in our center. Epidemiological, clinical, laboratory test as well as pathologic studies and treatment required were retrospectively analyzed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nine patients (7 males). The mean age at the time of diagnosis was 51 years (range 23–76 years). Eight of these patients had history of asthma. The more frequent organs involved were the skin (66%), musculoesqueletical system (66%), peripheral nervous system (55%) and the lung (55%). All patients presented peripheral eosinophilia. ANCA positivity was demonstrated in 6 patients (66%), most of the patients with the p-ANCA pattern. All patients were treated with corticosteroids, and in 8 immunosupressant treatment was required, mainly cyclophosphamide.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In this report, 9 patients with SCS are presented. Clinical characteristics are similar with the observed in other reports. We observed a major positivity of ANCA. Most of the patients were treated with corticosteroids and inmunosupresants, but the treatment should be tailored depending on the involvement of the patient.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El síndrome de Churg-Strauss (SCS) es una vasculitis que afecta a vasos de pequeño y mediano calibre, caracterizándose clínicamente por afectación predominante del aparato respiratorio, asma y eosinofilia periférica y anatomopatológicamente por la presencia de granulomas y la infiltración tisular por eosinófilos.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En el presente trabajo se detallan las características de una serie de 9 pacientes con SCS diagnosticados en un centro universitario de referencia. Pacientes y métodos: Estudio retrospectivo: entre 1984 y 2007 se diagnosticaron 9 pacientes con SCS en nuestro centro. De todos ellos se obtuvieron de forma retrospectiva datos epidemiológicos, clínicos, analíticos, estudios anatomopatológicos y tratamiento recibido.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">De estos 9 pacientes, 7 eran hombres. La edad media en el momento del diagnóstico fue de 51 años (rango 23–76 años). Ocho de los pacientes tenían antecedente de asma bronquial. Las manifestaciones clínicas más frecuentes fueron las cutáneas (66%), musculoesqueléticas (66%), del sistema nervioso periférico (55%) y las pulmonares (55%). Todos presentaban eosinofilia periférica. Los anticuerpos anticito-plasma de neutrófilo (ANCA) fueron positivos en 6 pacientes (66%), la mayor parte de ellos con patrón perinuclear en inmunofluorescencia (p-ANCA). Todos los pacientes recibieron tratamiento con glucocorticoides y 8 de ellos requirieron, además, tratamiento inmunosupresor, principalmente ciclofosfamida.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">En este trabajo se presentan 9 pacientes diagnosticados de SCS. Las manifestaciones clínicas no difieren de las observadas en el resto de series publicadas. Sin embargo, en esta serie se observa una mayor positividad de ANCA. La mayoría de los pacientes fueron tratados con glucocorticoides e inmunosupresores, debiéndose individualizar el tratamiento de cada paciente según el grado de afectación.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Churg-Strauss syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "U. Specks" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Vasculitis" "serieFecha" => "2008" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic granulomatosis, allergic angiitis, and periarteritis nodosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Churg" 1 => "L. Strauss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Pathol" "fecha" => "1951" "volumen" => "27" "paginaInicial" => "277" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14819261" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Periarteritis nodosa and asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.M. Rackemann" 1 => "E.J. Greene" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Trans Assoc Am Phys" "fecha" => "1939" "volumen" => "54" "paginaInicial" => "112" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic granulomatosis and angiitis (Churg-Strauss Syndrome). Report and analysis of 30 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.C. Chumbley" 1 => "E.G. Harriso" 2 => "R.A. DeRemee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mayo Clin Proc" "fecha" => "1977" "volumen" => "52" "paginaInicial" => "477" "paginaFinal" => "484" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18640" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic vasculitis with asthma an eosinophilia: A clinical approach to the Churg-Strauss syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.G. Lanham" 1 => "K.B. Elkon" 2 => "C.D. Pusey" 3 => "G.R. Hughes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "1984" "volumen" => "63" "paginaInicial" => "65" "paginaFinal" => "81" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.T. Masi" 1 => "G.G. Hunder" 2 => "J.T. Lie" 3 => "B.A. Michel" 4 => "D.A. Bloch" 5 => "W.P. Arend" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1990" "volumen" => "33" "paginaInicial" => "1094" "paginaFinal" => "1100" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2202307" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nomenclature of systemic vasculitis Proposal of an international consensus conference" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.C. Jennette" 1 => "R.J. Falk" 2 => "K. Andrassy" 3 => "P.A. Bacon" 4 => "J. Churg" 5 => "W.L. Gross" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "1994" "volumen" => "37" "paginaInicial" => "187" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8129773" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Churg-Strauss syndrome Clinical study and long-term follow-up of 96 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Guillevin" 1 => "P. Cohen" 2 => "M. Gayraud" 3 => "F. Lhote" 4 => "B. Jarrousse" 5 => "P. Casassus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "1999" "volumen" => "78" "paginaInicial" => "26" "paginaFinal" => "37" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Churg- Strauss syndrome: outcome and long-term follow-up of 32 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Solans" 1 => "J.A. Bosch" 2 => "C. Pérez-Bocanegra" 3 => "A. Selva" 4 => "P. Huguet" 5 => "J. Alijotas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2001" "volumen" => "40" "paginaInicial" => "763" "paginaFinal" => "771" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Churg- Strauss síndrome: clinical and serological features of 19 patients from a single Italian center" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Della Rosa" 1 => "C. Baldini" 2 => "A. Tavoni" 3 => "A. Tognetti" 4 => "D. Neglia" 5 => "G. Sambuceti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2002" "volumen" => "41" "paginaInicial" => "1286" "paginaFinal" => "1293" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Churg-Strauss syndrome: the clinical features and long-term follow-up of 17 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.J. Oh" 1 => "J.Y. Lee" 2 => "N.H. Kwon" 3 => "D.C. Choi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3346/jkms.2006.21.2.265" "Revista" => array:6 [ "tituloSerie" => "J Korean Med Sci" "fecha" => "2006" "volumen" => "21" "paginaInicial" => "265" "paginaFinal" => "271" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16614512" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Churg-Strauss syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.A. DeRemee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Vasculitis" "serieFecha" => "2002" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasculitis asociada con anticuerpos contra el citoplasma de los neutrófilos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:2 [ 0 => "L.H. Calabrese" 1 => "G. Duna" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "Kelley Tratado de reumatología." "edicion" => "7th ed" "serieFecha" => "2005" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Sablé-Fortassou" 1 => "P. Cohen" 2 => "A. Mahr" 3 => "C. Pagnoux" 4 => "L. Mouthon" 5 => "D. Jayne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Int Med" "fecha" => "2005" "volumen" => "143" "paginaInicial" => "632" "paginaFinal" => "638" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16263885" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study of 342 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Guillevin" 1 => "F. Lhote" 2 => "M. Gayraud" 3 => "P. Cohen" 4 => "B. Jarrousse" 5 => "O. Lortholary" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "1992" "volumen" => "75" "paginaInicial" => "17" "paginaFinal" => "28" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000600000002/v1_201305061606/S2173574310700174/v1_201305061606/en/main.assets" "Apartado" => array:4 [ "identificador" => "17338" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original Article" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000600000002/v1_201305061606/S2173574310700174/v1_201305061606/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700174?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 2 | 7 |
| 2024 October | 33 | 51 | 84 |
| 2024 September | 26 | 39 | 65 |
| 2024 August | 46 | 58 | 104 |
| 2024 July | 38 | 54 | 92 |
| 2024 June | 40 | 46 | 86 |
| 2024 May | 42 | 39 | 81 |
| 2024 April | 19 | 38 | 57 |
| 2024 March | 33 | 38 | 71 |
| 2024 February | 28 | 30 | 58 |
| 2024 January | 20 | 26 | 46 |
| 2023 December | 18 | 25 | 43 |
| 2023 November | 25 | 34 | 59 |
| 2023 October | 30 | 58 | 88 |
| 2023 September | 26 | 51 | 77 |
| 2023 August | 24 | 26 | 50 |
| 2023 July | 22 | 41 | 63 |
| 2023 June | 22 | 26 | 48 |
| 2023 May | 24 | 13 | 37 |
| 2023 April | 29 | 26 | 55 |
| 2023 March | 27 | 31 | 58 |
| 2023 February | 23 | 33 | 56 |
| 2023 January | 19 | 38 | 57 |
| 2022 December | 34 | 30 | 64 |
| 2022 November | 29 | 26 | 55 |
| 2022 October | 26 | 34 | 60 |
| 2022 September | 34 | 44 | 78 |
| 2022 August | 33 | 46 | 79 |
| 2022 July | 28 | 55 | 83 |
| 2022 June | 31 | 38 | 69 |
| 2022 May | 29 | 43 | 72 |
| 2022 April | 40 | 46 | 86 |
| 2022 March | 47 | 52 | 99 |
| 2022 February | 27 | 32 | 59 |
| 2022 January | 28 | 30 | 58 |
| 2021 December | 30 | 41 | 71 |
| 2021 November | 29 | 50 | 79 |
| 2021 October | 36 | 51 | 87 |
| 2021 September | 23 | 50 | 73 |
| 2021 August | 21 | 42 | 63 |
| 2021 July | 16 | 42 | 58 |
| 2021 June | 20 | 39 | 59 |
| 2021 May | 34 | 46 | 80 |
| 2021 April | 52 | 59 | 111 |
| 2021 March | 28 | 23 | 51 |
| 2021 February | 34 | 20 | 54 |
| 2021 January | 23 | 13 | 36 |
| 2020 December | 22 | 15 | 37 |
| 2020 November | 26 | 26 | 52 |
| 2020 October | 25 | 19 | 44 |
| 2020 September | 30 | 15 | 45 |
| 2020 August | 17 | 13 | 30 |
| 2020 July | 11 | 15 | 26 |
| 2020 June | 27 | 19 | 46 |
| 2020 May | 26 | 13 | 39 |
| 2020 April | 25 | 15 | 40 |
| 2020 March | 18 | 11 | 29 |
| 2020 February | 2 | 0 | 2 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 3 | 2 | 5 |
| 2018 April | 27 | 10 | 37 |
| 2018 March | 15 | 11 | 26 |
| 2018 February | 7 | 4 | 11 |
| 2018 January | 9 | 5 | 14 |
| 2017 December | 10 | 7 | 17 |
| 2017 November | 9 | 5 | 14 |
| 2017 October | 14 | 6 | 20 |
| 2017 September | 10 | 4 | 14 |
| 2017 August | 9 | 9 | 18 |
| 2017 July | 8 | 8 | 16 |
| 2017 June | 19 | 14 | 33 |
| 2017 May | 16 | 8 | 24 |
| 2017 April | 19 | 2 | 21 |
| 2017 March | 11 | 6 | 17 |
| 2017 February | 4 | 2 | 6 |
| 2017 January | 9 | 4 | 13 |
| 2016 December | 29 | 7 | 36 |
| 2016 November | 17 | 3 | 20 |
| 2016 October | 28 | 7 | 35 |
| 2016 September | 34 | 8 | 42 |
| 2016 August | 12 | 3 | 15 |
| 2016 July | 12 | 3 | 15 |
| 2016 May | 1 | 0 | 1 |
| 2016 February | 1 | 12 | 13 |
| 2016 January | 2 | 16 | 18 |
| 2015 December | 2 | 0 | 2 |
| 2015 November | 0 | 6 | 6 |
| 2015 October | 1 | 0 | 1 |
| 2015 September | 2 | 0 | 2 |
| 2015 August | 3 | 0 | 3 |
| 2015 July | 19 | 4 | 23 |
| 2015 June | 28 | 23 | 51 |
| 2015 May | 34 | 24 | 58 |
| 2015 April | 30 | 33 | 63 |
| 2015 March | 25 | 17 | 42 |
| 2015 February | 26 | 22 | 48 |
| 2015 January | 22 | 26 | 48 |
| 2014 December | 34 | 27 | 61 |
| 2014 November | 20 | 23 | 43 |
| 2014 October | 23 | 22 | 45 |
| 2014 September | 20 | 17 | 37 |
| 2014 August | 27 | 24 | 51 |
| 2014 July | 22 | 22 | 44 |
| 2014 June | 33 | 24 | 57 |
| 2014 May | 34 | 19 | 53 |
| 2014 April | 30 | 14 | 44 |
| 2014 March | 37 | 22 | 59 |
| 2014 February | 35 | 28 | 63 |
| 2014 January | 16 | 23 | 39 |
| 2013 December | 38 | 7 | 45 |
| 2013 November | 20 | 15 | 35 |
| 2013 October | 47 | 29 | 76 |
| 2013 September | 45 | 21 | 66 |
| 2013 August | 36 | 16 | 52 |
| 2013 July | 30 | 17 | 47 |
| 2013 June | 40 | 21 | 61 |
| 2013 May | 44 | 25 | 69 |
| 2013 April | 34 | 26 | 60 |
| 2013 March | 24 | 15 | 39 |
| 2013 February | 27 | 11 | 38 |
| 2013 January | 22 | 5 | 27 |
| 2012 December | 18 | 14 | 32 |
| 2012 November | 8 | 3 | 11 |
| 2012 October | 8 | 6 | 14 |
| 2012 September | 4 | 3 | 7 |
| 2012 June | 2 | 0 | 2 |
| 2012 May | 2 | 0 | 2 |
| 2012 April | 5 | 0 | 5 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 1 | 0 | 1 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 4 | 0 | 4 |
| 2011 November | 2 | 0 | 2 |
| 2011 October | 3 | 0 | 3 |
| 2011 September | 4 | 0 | 4 |
| 2011 August | 3 | 0 | 3 |
| 2011 July | 2 | 0 | 2 |
| 2011 June | 4 | 0 | 4 |
| 2011 May | 2 | 0 | 2 |
| 2011 April | 2 | 0 | 2 |
| 2011 March | 7 | 0 | 7 |
| 2011 February | 5 | 0 | 5 |
| 2011 January | 9 | 0 | 9 |
| 2010 December | 6 | 0 | 6 |
| 2010 November | 4 | 0 | 4 |
| 2010 October | 9 | 0 | 9 |
| 2010 September | 18 | 0 | 18 |
| 2010 August | 16 | 0 | 16 |
| 2010 July | 17 | 0 | 17 |
Show all
