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            2 => "Systemic lupus erythematosus"
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            0 => "Rituximab"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Some patients with thrombocytopenia due SLE fail to respond to conventional therapies&#46; Rituximab has been reported to be an alternative for patient treatment&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the response of thrombocytopenia due to Systemic Lupus Erythematosus to the use of Rituximab and patient relapse time at our hospital&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We analyzed patients with SLE than received a 2 gram rituximab treatment for thrombocytopenia&#46; We analyzed the rate of patients that achieved complete remission &#40;CR&#41;&#44; defined as a platelet count over 100 mil&#47;mm3&#44; partial remission &#40;PR&#41; described as platelets within 50&#8211;100 mil&#47;mm3 and no response &#40;NR&#41; if platelets remained unchanged and the time the remission was sustained&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Sixteen treatments were applied to 13 patients&#44; aged 28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years of age and SLE mean duration time of 68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44 months with a mean platelet count of 38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29 mil&#46; In 14 treatments &#40;87&#37;&#41; remission was achieved after 5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2 weeks where 2 patients &#40;12&#46;5&#37;&#41; were non respondent&#46; One of them died due to a massive hemorrhage&#46; The mean response time without relapse was 15&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6 months&#46; Follow up of three patients was not possible and 3 other died due to infections&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Rituximab is an alternative for treatment of thrombocytopenia due to Systemic Lupus Erythematosus&#46;</p>"
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        "titulo" => "Resumen"
        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En algunos casos la trombocitopenia secundaria a lupus eritematoso sist&#233;mico &#40;LES&#41; no responde al tratamiento convencional&#46; En los &#250;ltimos a&#241;os se ha reportado que el rituximab es una alternativa para estos pacientes&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar la respuesta de la trombocitopenia &#40;T&#41; secundaria a LES con el uso de rituximab y determinar el tiempo que se mantiene el efecto libre de reca&#237;da&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se revisaron los expedientes de los pacientes con diagn&#243;stico de LES con T que recibieron tratamiento con rituximab &#40;2<span class="elsevierStyleHsp" style=""></span>g&#41; para conocer la proporci&#243;n de pacientes que lograron remisi&#243;n completa &#40;RC&#41;&#58; definida como una cuenta plaquetaria &#62;<span class="elsevierStyleHsp" style=""></span>100&#46;000&#47;mm3&#59; remisi&#243;n parcial &#40;RP&#41;&#58; cuenta plaquetaria entre 50&#46;000 y 100&#46;000&#47;mm3 y los no respondedores &#40;NR&#41;&#59; as&#237; como el tiempo que se mantiene el paciente sin reca&#237;da&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se aplicaron 16 tratamientos en 13 pacientes&#44; en una paciente 3 y en otra 2 ciclos&#46; Fueron 12 mujeres y 1 hombre con edad media de 28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 a&#241;os y tiempo medio de duraci&#243;n del LES de 68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>44 meses&#44; con una cuenta media plaquetaria de 38&#46;000<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;000&#46; En 14 tratamientos &#40;87&#37;&#41; se logr&#243; RC despu&#233;s de 5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2 semanas y 2 pacientes &#40;12&#46;5&#37;&#41; fueron NR&#46; Una de ellas muri&#243; por hemorragia masiva&#46; El tiempo medio de respuesta sin reca&#237;da fue de 15&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6 meses&#46; Tres pacientes perdieron el seguimiento y 3 murieron de infecciones&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El rituximab es una alternativa de tratamiento en pacientes con T secundaria a LES&#46;</p>"
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                            3 => "G&#46;D&#46; Sebastiani"
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                      "titulo" => "The 1982 revised criteria for the classification of systemic lupus erythematosus"
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                            0 => "E&#46;M&#46; Tan"
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                            2 => "J&#46;F&#46; Fries"
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                            0 => "K&#46; Moss"
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                          ]
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                      "titulo" => "Mortality risks associated with specific clinical manifestations of systemic lupus erythematosus"
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                            0 => "M&#46;M&#46; Ward"
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                      "titulo" => "Treatment of refractory systemic lupus erythematosusassociated thrombocytopenia with intermittent low-dose intravenous cyclophosphamide"
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                          "etal" => false
                          "autores" => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1993"
                        "volumen" => "36"
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