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Oxidative stress biomarkers as indicator of chronic inflammatory joint diseases stage
Biomarcadores de estrés oxidativo como indicadores de actividad en la enfermedad articular inflamatoria crónica
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Activity of the disease was assessed by: RA patients, Disease Activity Score (DAS 28) and AS patients by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Oxidative stress biomarkers were determined in plasma using spectrophotometrical techniques. The statistical analysis was carried out using the SSPS statistical package.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Active CIJD showed a high oxidative stress characterized by increases in oxidative damage markers and a reduction in antioxidative systems, together with a higher myeloperoxidase (MPO) concentration. Inactive CIJD only showed changes in oxidized glutathione (GSSG) and reduced glutathione (GSH)/GSSG ratio levels, without changes in oxidative damage parameters or in antioxidative systems.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Our data revealed that: i) CIJD presents with a high oxidative stress; ii) inactive CIJD shows a production of reactive species without triggering oxidative damage and maintaining red-ox homeostasis, and iii) the combination of oxidative stress biomarkers may be used as markers of active-inactive stages of CIJD.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Evaluar la participación del estrés oxidativo (EO) en la enfermedad articular inflamatoria crónica (EAIC), así como su posible uso como biomarcador diagnóstico.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 29 pacientes con EAIC: 18 con artritis reumatoide (AR): 13 activos/ 5 inactivos; y 11 con espondilitis anquilosante (EA): 7 activos/4 inactivos, y como grupo control, 13 sujetos sanos. Los pacientes fueron clasificados según los siguientes criterios de actividad: escala de actividad de la enfermedad (DAS-28) para AR, e índice de actividad de enfermedad (BASDAI) y la escala visual analógica (EVA) de dolor nocturno para EA. Las concentraciones plasmáticas de los biomarcadores de estrés oxidativo fueron cuantificadas mediante técnicas espectrofotométricas y el análisis estadístico realizado, mediante el programa estadístico SPSS.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con EAIC activa presentan un intenso EO, caracterizado por elevación de los parámetros indicadores de daño oxidativo y disminución de los sistemas antioxidantes, junto con una mayor cantidad de mieloperoxidasa. En los pacientes con EAIC inactiva sólo encontramos cambios en los niveles de glutatión oxidado (GSSG) y en el cociente glutatión reducido (GSH)/GSSG, y no en los indicadores de daño oxidativo ni en los sistemas antioxidantes.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Nuestros datos indican que: a) los pacientes con EAIC activa presentan un intenso EO; b) la EAIC inactiva cursa con producción de especies reactivas sin llegar a desencadenar daño oxidativo y manteniendo la homeostasis reducción-oxidación, y c) los biomarcadores de EO podrían ser utilizados como indicadores del estado de actividad-inactividad de la EAIC.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Martín" 5 => "M.A. González-Gay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.22884" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2007" "volumen" => "57" "paginaInicial" => "1074" "paginaFinal" => "1080" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17665475" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000600000002/v1_201305061606/S2173574310700204/v1_201305061606/en/main.assets" "Apartado" => array:4 [ "identificador" => "17338" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original Article" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000600000002/v1_201305061606/S2173574310700204/v1_201305061606/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700204?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 7 | 9 |
| 2024 October | 22 | 68 | 90 |
| 2024 September | 20 | 31 | 51 |
| 2024 August | 33 | 48 | 81 |
| 2024 July | 30 | 55 | 85 |
| 2024 June | 22 | 36 | 58 |
| 2024 May | 32 | 58 | 90 |
| 2024 April | 21 | 32 | 53 |
| 2024 March | 29 | 46 | 75 |
| 2024 February | 22 | 28 | 50 |
| 2024 January | 17 | 30 | 47 |
| 2023 December | 17 | 40 | 57 |
| 2023 November | 28 | 45 | 73 |
| 2023 October | 17 | 34 | 51 |
| 2023 September | 28 | 44 | 72 |
| 2023 August | 17 | 26 | 43 |
| 2023 July | 21 | 27 | 48 |
| 2023 June | 19 | 21 | 40 |
| 2023 May | 20 | 11 | 31 |
| 2023 April | 11 | 22 | 33 |
| 2023 March | 24 | 21 | 45 |
| 2023 February | 18 | 36 | 54 |
| 2023 January | 13 | 27 | 40 |
| 2022 December | 26 | 39 | 65 |
| 2022 November | 25 | 17 | 42 |
| 2022 October | 18 | 38 | 56 |
| 2022 September | 19 | 42 | 61 |
| 2022 August | 25 | 46 | 71 |
| 2022 July | 20 | 56 | 76 |
| 2022 June | 14 | 42 | 56 |
| 2022 May | 20 | 49 | 69 |
| 2022 April | 20 | 65 | 85 |
| 2022 March | 26 | 42 | 68 |
| 2022 February | 27 | 76 | 103 |
| 2022 January | 20 | 39 | 59 |
| 2021 December | 24 | 50 | 74 |
| 2021 November | 25 | 49 | 74 |
| 2021 October | 28 | 49 | 77 |
| 2021 September | 24 | 54 | 78 |
| 2021 August | 22 | 37 | 59 |
| 2021 July | 39 | 47 | 86 |
| 2021 June | 18 | 42 | 60 |
| 2021 May | 22 | 44 | 66 |
| 2021 April | 50 | 113 | 163 |
| 2021 March | 31 | 29 | 60 |
| 2021 February | 32 | 25 | 57 |
| 2021 January | 24 | 22 | 46 |
| 2020 December | 22 | 13 | 35 |
| 2020 November | 32 | 19 | 51 |
| 2020 October | 25 | 21 | 46 |
| 2020 September | 33 | 20 | 53 |
| 2020 August | 20 | 23 | 43 |
| 2020 July | 20 | 23 | 43 |
| 2020 June | 33 | 29 | 62 |
| 2020 May | 20 | 25 | 45 |
| 2020 April | 29 | 17 | 46 |
| 2020 March | 28 | 6 | 34 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 December | 2 | 0 | 2 |
| 2018 May | 2 | 1 | 3 |
| 2018 April | 24 | 16 | 40 |
| 2018 March | 17 | 14 | 31 |
| 2018 February | 8 | 5 | 13 |
| 2018 January | 14 | 5 | 19 |
| 2017 December | 10 | 9 | 19 |
| 2017 November | 13 | 9 | 22 |
| 2017 October | 12 | 10 | 22 |
| 2017 September | 10 | 10 | 20 |
| 2017 August | 10 | 14 | 24 |
| 2017 July | 13 | 10 | 23 |
| 2017 June | 21 | 12 | 33 |
| 2017 May | 20 | 14 | 34 |
| 2017 April | 10 | 7 | 17 |
| 2017 March | 10 | 15 | 25 |
| 2017 February | 7 | 8 | 15 |
| 2017 January | 11 | 5 | 16 |
| 2016 December | 34 | 13 | 47 |
| 2016 November | 17 | 9 | 26 |
| 2016 October | 24 | 12 | 36 |
| 2016 September | 24 | 7 | 31 |
| 2016 August | 40 | 15 | 55 |
| 2016 July | 18 | 10 | 28 |
| 2016 June | 0 | 13 | 13 |
| 2016 May | 0 | 17 | 17 |
| 2016 April | 0 | 23 | 23 |
| 2016 March | 0 | 17 | 17 |
| 2016 February | 3 | 27 | 30 |
| 2016 January | 0 | 20 | 20 |
| 2015 December | 4 | 0 | 4 |
| 2015 October | 3 | 15 | 18 |
| 2015 August | 1 | 23 | 24 |
| 2015 July | 16 | 4 | 20 |
| 2015 June | 16 | 20 | 36 |
| 2015 May | 34 | 12 | 46 |
| 2015 April | 21 | 16 | 37 |
| 2015 March | 19 | 14 | 33 |
| 2015 February | 29 | 16 | 45 |
| 2015 January | 18 | 20 | 38 |
| 2014 December | 20 | 25 | 45 |
| 2014 November | 15 | 31 | 46 |
| 2014 October | 16 | 22 | 38 |
| 2014 September | 16 | 20 | 36 |
| 2014 August | 17 | 22 | 39 |
| 2014 July | 25 | 26 | 51 |
| 2014 June | 36 | 20 | 56 |
| 2014 May | 33 | 23 | 56 |
| 2014 April | 30 | 21 | 51 |
| 2014 March | 47 | 24 | 71 |
| 2014 February | 34 | 16 | 50 |
| 2014 January | 23 | 21 | 44 |
| 2013 December | 24 | 6 | 30 |
| 2013 November | 23 | 9 | 32 |
| 2013 October | 31 | 20 | 51 |
| 2013 September | 33 | 19 | 52 |
| 2013 August | 21 | 13 | 34 |
| 2013 July | 24 | 23 | 47 |
| 2013 June | 29 | 22 | 51 |
| 2013 May | 29 | 16 | 45 |
| 2013 April | 23 | 20 | 43 |
| 2013 March | 18 | 19 | 37 |
| 2013 February | 18 | 10 | 28 |
| 2013 January | 15 | 18 | 33 |
| 2012 December | 12 | 5 | 17 |
| 2012 November | 13 | 11 | 24 |
| 2012 October | 3 | 7 | 10 |
| 2012 September | 8 | 4 | 12 |
| 2012 June | 2 | 0 | 2 |
| 2012 April | 5 | 0 | 5 |
| 2012 March | 5 | 0 | 5 |
| 2012 February | 1 | 0 | 1 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 7 | 0 | 7 |
| 2011 November | 1 | 0 | 1 |
| 2011 October | 3 | 0 | 3 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 2 | 0 | 2 |
| 2011 April | 1 | 0 | 1 |
| 2011 March | 6 | 0 | 6 |
| 2011 February | 7 | 0 | 7 |
| 2011 January | 4 | 0 | 4 |
| 2010 December | 7 | 0 | 7 |
| 2010 November | 4 | 0 | 4 |
| 2010 October | 4 | 0 | 4 |
| 2010 September | 14 | 0 | 14 |
| 2010 August | 23 | 0 | 23 |
| 2010 July | 11 | 0 | 11 |
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