Review
Anti-TNF therapy and cancer
Terapias anti-TNF y neoplasias
Loreto Carmona
Unidad de Investigación, Sociedad Española de Reumatología, Madrid, Spain
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Gonzalo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Raúl Javier" "apellidos" => "García Renedo" ] 1 => array:2 [ "nombre" => "Antonio" "apellidos" => "Ortiz Menéndez" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Giráldez Sánchez" ] 3 => array:2 [ "nombre" => "Juan" "apellidos" => "Ribera Zabalbeascoa" ] 4 => array:2 [ "nombre" => "David H." "apellidos" => "Gonzalo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700228?idApp=UINPBA00004M" "url" => "/21735743/0000000600000002/v1_201305061606/S2173574310700228/v1_201305061606/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Anti-TNF therapy and cancer" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "102" "paginaFinal" => "105" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Loreto Carmona" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Loreto" "apellidos" => "Carmona" "email" => array:1 [ 0 => "loreto.carmona@ser.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Investigación, Sociedad Española de Reumatología, Madrid, Spain" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Terapias anti-TNF y neoplasias" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-11-13" "fechaAceptado" => "2009-01-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112394" "palabras" => array:5 [ 0 => "Infliximab" 1 => "Etanercept" 2 => "Adalimumab" 3 => "Cancer" 4 => "Adverse event" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112395" "palabras" => array:5 [ 0 => "Infliximab" 1 => "Etanercept" 2 => "Adalimumab" 3 => "Cáncer" 4 => "Efecto adverso" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tumor necrosis factor (TNF) is implicated in the control of tumoral growth in addition to the systemic inflammatory response. TNF blockage produces a comprensible reservation in patients with risk factors for cancer. No clear evidence for this came out from pre-clinical or clinical trials. Biosafety registries established in the post-marketing phase have concluded that, in general, cancer cases have not increased over what is expected in a population with RA exposed to the prolongued use of anti-TNF drugs. A meta-analysis of clinical trials which used infliximab and adalimumab for RA treatment showed an increase of up to three times the risk of developing cancer, but this dissapeared after correcting for time. Biobadaser shows evidence that support long-term safety. In the long-term, and if the inflammatory disease activity is truly under control, the risk of developing cancer is the same as with any other patient.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El factor de necrosis tumoral (TNF) está implicado en el control del crecimiento de tumores además de en la respuesta inflamatoria sistémica. El bloqueo del TNF produce un recelo comprensible en pacientes con riesgo de cáncer. Ni en el desarrollo preclínico ni durante los ensayos clínicos de los anti-TNF se detectaron alarmas claras. Los registros de seguridad de biológicos establecidos en el período poscomercialización han concluido que el cáncer en general no está aumentado con respecto de lo esperado en una población de AR con el uso prolongado de anti-TNF. Un meta-análisis de ensayos clínicos de infliximab y adalimumab mostró un aumento de hasta tres veces el riesgo de cáncer, pero al corregir la exposición por el tiempo en los mismos no se encontró. En BIOBADASER tenemos evidencias que apoyan la seguridad a largo plazo. A largo plazo, y si realmente la actividad inflamatoria de la enfermedad subyacente está controlada, el riesgo de desarrollar un cáncer es igual que el de cualquier paciente.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:48 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.B. Aggarwal" 1 => "T.E. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 7 | 12 |
| 2024 October | 71 | 59 | 130 |
| 2024 September | 65 | 24 | 89 |
| 2024 August | 57 | 45 | 102 |
| 2024 July | 51 | 51 | 102 |
| 2024 June | 60 | 43 | 103 |
| 2024 May | 66 | 54 | 120 |
| 2024 April | 56 | 30 | 86 |
| 2024 March | 57 | 42 | 99 |
| 2024 February | 58 | 39 | 97 |
| 2024 January | 56 | 40 | 96 |
| 2023 December | 39 | 33 | 72 |
| 2023 November | 48 | 36 | 84 |
| 2023 October | 61 | 49 | 110 |
| 2023 September | 60 | 48 | 108 |
| 2023 August | 60 | 16 | 76 |
| 2023 July | 41 | 33 | 74 |
| 2023 June | 42 | 20 | 62 |
| 2023 May | 59 | 21 | 80 |
| 2023 April | 41 | 17 | 58 |
| 2023 March | 68 | 33 | 101 |
| 2023 February | 38 | 33 | 71 |
| 2023 January | 43 | 24 | 67 |
| 2022 December | 38 | 38 | 76 |
| 2022 November | 57 | 33 | 90 |
| 2022 October | 43 | 41 | 84 |
| 2022 September | 50 | 40 | 90 |
| 2022 August | 50 | 59 | 109 |
| 2022 July | 70 | 53 | 123 |
| 2022 June | 38 | 48 | 86 |
| 2022 May | 44 | 45 | 89 |
| 2022 April | 49 | 48 | 97 |
| 2022 March | 44 | 47 | 91 |
| 2022 February | 52 | 53 | 105 |
| 2022 January | 37 | 45 | 82 |
| 2021 December | 16 | 44 | 60 |
| 2021 November | 28 | 55 | 83 |
| 2021 October | 33 | 62 | 95 |
| 2021 September | 37 | 48 | 85 |
| 2021 August | 39 | 36 | 75 |
| 2021 July | 35 | 42 | 77 |
| 2021 June | 26 | 41 | 67 |
| 2021 May | 37 | 42 | 79 |
| 2021 April | 30 | 47 | 77 |
| 2021 March | 35 | 53 | 88 |
| 2021 February | 30 | 24 | 54 |
| 2021 January | 20 | 23 | 43 |
| 2020 December | 10 | 18 | 28 |
| 2020 November | 21 | 35 | 56 |
| 2020 October | 13 | 29 | 42 |
| 2020 September | 12 | 18 | 30 |
| 2020 August | 15 | 21 | 36 |
| 2020 July | 17 | 18 | 35 |
| 2020 June | 13 | 25 | 38 |
| 2020 May | 23 | 16 | 39 |
| 2020 April | 17 | 16 | 33 |
| 2020 March | 22 | 11 | 33 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 18 | 15 | 33 |
| 2018 March | 23 | 26 | 49 |
| 2018 February | 16 | 17 | 33 |
| 2018 January | 10 | 15 | 25 |
| 2017 December | 13 | 18 | 31 |
| 2017 November | 6 | 21 | 27 |
| 2017 October | 17 | 14 | 31 |
| 2017 September | 11 | 14 | 25 |
| 2017 August | 14 | 21 | 35 |
| 2017 July | 18 | 21 | 39 |
| 2017 June | 41 | 49 | 90 |
| 2017 May | 37 | 23 | 60 |
| 2017 April | 28 | 18 | 46 |
| 2017 March | 17 | 25 | 42 |
| 2017 February | 15 | 22 | 37 |
| 2017 January | 18 | 23 | 41 |
| 2016 December | 37 | 22 | 59 |
| 2016 November | 28 | 11 | 39 |
| 2016 October | 38 | 13 | 51 |
| 2016 September | 37 | 19 | 56 |
| 2016 August | 25 | 11 | 36 |
| 2016 July | 12 | 9 | 21 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 2 | 0 | 2 |
| 2016 February | 4 | 0 | 4 |
| 2016 January | 2 | 13 | 15 |
| 2015 December | 5 | 0 | 5 |
| 2015 October | 2 | 14 | 16 |
| 2015 September | 2 | 0 | 2 |
| 2015 August | 3 | 0 | 3 |
| 2015 July | 12 | 5 | 17 |
| 2015 June | 22 | 22 | 44 |
| 2015 May | 40 | 40 | 80 |
| 2015 April | 23 | 59 | 82 |
| 2015 March | 20 | 56 | 76 |
| 2015 February | 27 | 48 | 75 |
| 2015 January | 8 | 38 | 46 |
| 2014 December | 25 | 35 | 60 |
| 2014 November | 12 | 50 | 62 |
| 2014 October | 21 | 28 | 49 |
| 2014 September | 9 | 20 | 29 |
| 2014 August | 19 | 25 | 44 |
| 2014 July | 12 | 22 | 34 |
| 2014 June | 32 | 19 | 51 |
| 2014 May | 23 | 27 | 50 |
| 2014 April | 24 | 15 | 39 |
| 2014 March | 36 | 25 | 61 |
| 2014 February | 26 | 20 | 46 |
| 2014 January | 25 | 19 | 44 |
| 2013 December | 20 | 18 | 38 |
| 2013 November | 20 | 17 | 37 |
| 2013 October | 24 | 18 | 42 |
| 2013 September | 31 | 20 | 51 |
| 2013 August | 24 | 25 | 49 |
| 2013 July | 34 | 21 | 55 |
| 2013 June | 23 | 18 | 41 |
| 2013 May | 28 | 15 | 43 |
| 2013 April | 27 | 20 | 47 |
| 2013 March | 21 | 14 | 35 |
| 2013 February | 27 | 22 | 49 |
| 2013 January | 23 | 15 | 38 |
| 2012 December | 21 | 9 | 30 |
| 2012 November | 20 | 14 | 34 |
| 2012 October | 12 | 7 | 19 |
| 2012 September | 9 | 4 | 13 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 2 | 0 | 2 |
| 2012 April | 5 | 0 | 5 |
| 2012 March | 1 | 0 | 1 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 6 | 0 | 6 |
| 2011 December | 2 | 0 | 2 |
| 2011 November | 2 | 0 | 2 |
| 2011 October | 5 | 0 | 5 |
| 2011 September | 2 | 0 | 2 |
| 2011 August | 2 | 0 | 2 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 1 | 0 | 1 |
| 2011 April | 1 | 0 | 1 |
| 2011 March | 4 | 0 | 4 |
| 2011 February | 8 | 0 | 8 |
| 2011 January | 16 | 0 | 16 |
| 2010 December | 4 | 0 | 4 |
| 2010 November | 3 | 0 | 3 |
| 2010 October | 4 | 0 | 4 |
| 2010 September | 15 | 0 | 15 |
| 2010 August | 13 | 0 | 13 |
| 2010 July | 12 | 0 | 12 |
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