Influence of gender on treatment response in a cohort of patients with early rheumatoid arthritis in the area 2 of Madrid
Influencia del género en la respuesta al tratamiento en una cohorte de pacientes con artritis reumatoide precoz del área 2 de la Comunidad de Madrid
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Martínez-López, Ana M. Ortiz García, Loreto Carmona Ortells, Rosario García-Vicuña, Isidoro González-Álvaro" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Isabel" "apellidos" => "Castrejón Fernández" "email" => array:2 [ 0 => "isabelcastrejon@ser.es" 1 => "isonci@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Juan A." "apellidos" => "Martínez-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ana M." "apellidos" => "Ortiz García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Loreto" "apellidos" => "Carmona Ortells" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Rosario" "apellidos" => "García-Vicuña" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Isidoro" "apellidos" => "González-Álvaro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario “La Princesa”, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Investigación, Fundación Española de Reumatología, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Influencia del género en la respuesta al tratamiento en una cohorte de pacientes con artritis reumatoide precoz del área 2 de la Comunidad de Madrid" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-04-19" "fechaAceptado" => "2009-09-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112429" "palabras" => array:6 [ 0 => "Rheumatoid artritis" 1 => "Gender" 2 => "Disease Activity Indices" 3 => "DAS28" 4 => "ESR" 5 => "CRP" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112428" "palabras" => array:6 [ 0 => "Artritis reumatoide" 1 => "Género" 2 => "Índices de actividad" 3 => "DAS28" 4 => "Velocidad de sedimentación globular" 5 => "Proteína C reactiva" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate the differences between the responses to treatment using DAS28 based on erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in male and female patients. We then analyzed the individual behaviour of each component in a cohort of early arthritis patients in zone 2 of Madrid.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We studied a total of 134 patients (77.6% women) who met the American College of Rheumatology (ACR) criteria for the diagnosis of rheumatoid arthritis (RA) belonging to an early arthritis register of the Hospital de La Princesa. We performed 4 visits following a standardized protocol which included necessary variables to calculate the DAS28 with ESR and CRP as well as determining the treatment received by the patients. We analyzed the differences in responses to treatment in males and females using both indexes, as well as their component and the assessment of the disease by the physician.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Women had higher disease activity and disability at baseline. Although they received more intensive treatment, their average value of DAS28 remained significantly higher compared to men during the followup. By contrast, the global disease assessment evaluated by the patient and by the physician remained similar in both gender. When we analyze the DAS28 components separately, it was observed that this discrepancy was due mainly to the tender joints count and the ESR.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Women with early RA have higher DAS28ESR scores as a result of higher tender joint counts and ESR. This may represent bias when assessing the response to treatment using the DAS28ESR.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Valorar las diferencias de respuesta al tratamiento mediante DAS28 calculado mediante velocidad de sedimentación globular (VSG) y proteína C reactiva teniendo en cuenta el género del paciente y analizar el comportamiento individual de cada uno de sus componentes en una cohorte de pacientes de artritis precoz en el área 2 de la Comunidad de Madrid.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron un total de 134 pacientes (77,6% mujeres) que cumplían criterios del Colegio Americano de Reumatología para el diagnóstico de artritis reumatoide del registro de artritis precoz del Hospital de La Princesa. En dicho registro se realizaron 4 visitas protocolizadas en las que se recogen de forma sistemática los datos necesarios para calcular el DAS28 con VSG y proteína C reactiva, así como el tratamiento prescrito a los pacientes. Se analizaron las diferencias por género en la respuesta al tratamiento mediante ambos índices compuestos, así como de las variables que los componen y la valoración de la enfermedad por el médico.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Las mujeres presentaron mayor actividad de la enfermedad y discapacidad al inicio del seguimiento. A pesar de que éstas recibieron un tratamiento más intenso, su valor promedio de DAS28 no llegó a igualarse con el de los hombres a lo largo del seguimiento. Por el contrario, la valoración de la enfermedad por parte del paciente y del médico sí llegó a igualarse. Al analizar los componentes del DAS28 por separado, se observó que esta discordancia era debida principalmente a las variables VSG y recuento de articulaciones dolorosas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La VSG y el recuento de articulaciones dolorosas causan un sesgo en la evaluación de la actividad de la artritis reumatoide con el DAS28 que puede afectar a la evaluación de la respuesta al tratamiento.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 1 | 5 | 6 |
| 2024 October | 19 | 64 | 83 |
| 2024 September | 20 | 46 | 66 |
| 2024 August | 34 | 50 | 84 |
| 2024 July | 23 | 49 | 72 |
| 2024 June | 23 | 33 | 56 |
| 2024 May | 39 | 49 | 88 |
| 2024 April | 27 | 32 | 59 |
| 2024 March | 31 | 57 | 88 |
| 2024 February | 24 | 52 | 76 |
| 2024 January | 18 | 41 | 59 |
| 2023 December | 18 | 47 | 65 |
| 2023 November | 23 | 40 | 63 |
| 2023 October | 21 | 42 | 63 |
| 2023 September | 34 | 50 | 84 |
| 2023 August | 23 | 27 | 50 |
| 2023 July | 17 | 29 | 46 |
| 2023 June | 20 | 32 | 52 |
| 2023 May | 20 | 37 | 57 |
| 2023 April | 12 | 24 | 36 |
| 2023 March | 24 | 37 | 61 |
| 2023 February | 21 | 35 | 56 |
| 2023 January | 21 | 26 | 47 |
| 2022 December | 28 | 57 | 85 |
| 2022 November | 32 | 53 | 85 |
| 2022 October | 24 | 40 | 64 |
| 2022 September | 21 | 40 | 61 |
| 2022 August | 22 | 42 | 64 |
| 2022 July | 18 | 52 | 70 |
| 2022 June | 17 | 46 | 63 |
| 2022 May | 25 | 42 | 67 |
| 2022 April | 32 | 61 | 93 |
| 2022 March | 30 | 59 | 89 |
| 2022 February | 28 | 53 | 81 |
| 2022 January | 22 | 44 | 66 |
| 2021 December | 18 | 43 | 61 |
| 2021 November | 26 | 47 | 73 |
| 2021 October | 27 | 50 | 77 |
| 2021 September | 25 | 45 | 70 |
| 2021 August | 15 | 44 | 59 |
| 2021 July | 19 | 32 | 51 |
| 2021 June | 17 | 43 | 60 |
| 2021 May | 25 | 30 | 55 |
| 2021 April | 56 | 75 | 131 |
| 2021 March | 32 | 24 | 56 |
| 2021 February | 19 | 16 | 35 |
| 2021 January | 17 | 15 | 32 |
| 2020 December | 16 | 11 | 27 |
| 2020 November | 20 | 13 | 33 |
| 2020 October | 9 | 11 | 20 |
| 2020 September | 27 | 15 | 42 |
| 2020 August | 12 | 19 | 31 |
| 2020 July | 11 | 20 | 31 |
| 2020 June | 34 | 17 | 51 |
| 2020 May | 32 | 14 | 46 |
| 2020 April | 20 | 14 | 34 |
| 2020 March | 15 | 12 | 27 |
| 2020 January | 7 | 0 | 7 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 3 | 0 | 3 |
| 2018 May | 3 | 3 | 6 |
| 2018 April | 26 | 9 | 35 |
| 2018 March | 21 | 10 | 31 |
| 2018 February | 11 | 6 | 17 |
| 2018 January | 15 | 6 | 21 |
| 2017 December | 17 | 7 | 24 |
| 2017 November | 11 | 4 | 15 |
| 2017 October | 19 | 3 | 22 |
| 2017 September | 15 | 4 | 19 |
| 2017 August | 12 | 6 | 18 |
| 2017 July | 15 | 8 | 23 |
| 2017 June | 38 | 7 | 45 |
| 2017 May | 22 | 9 | 31 |
| 2017 April | 19 | 14 | 33 |
| 2017 March | 27 | 4 | 31 |
| 2017 February | 18 | 2 | 20 |
| 2017 January | 16 | 2 | 18 |
| 2016 December | 70 | 13 | 83 |
| 2016 November | 45 | 2 | 47 |
| 2016 October | 68 | 6 | 74 |
| 2016 September | 51 | 5 | 56 |
| 2016 August | 37 | 5 | 42 |
| 2016 July | 24 | 3 | 27 |
| 2016 June | 0 | 5 | 5 |
| 2016 April | 3 | 0 | 3 |
| 2016 March | 0 | 15 | 15 |
| 2016 February | 2 | 0 | 2 |
| 2016 January | 5 | 0 | 5 |
| 2015 December | 3 | 0 | 3 |
| 2015 November | 0 | 12 | 12 |
| 2015 October | 1 | 7 | 8 |
| 2015 September | 2 | 0 | 2 |
| 2015 August | 2 | 0 | 2 |
| 2015 July | 14 | 4 | 18 |
| 2015 June | 27 | 6 | 33 |
| 2015 May | 26 | 15 | 41 |
| 2015 April | 26 | 12 | 38 |
| 2015 March | 23 | 10 | 33 |
| 2015 February | 33 | 7 | 40 |
| 2015 January | 36 | 10 | 46 |
| 2014 December | 29 | 21 | 50 |
| 2014 November | 20 | 12 | 32 |
| 2014 October | 17 | 14 | 31 |
| 2014 September | 11 | 8 | 19 |
| 2014 August | 25 | 11 | 36 |
| 2014 July | 16 | 13 | 29 |
| 2014 June | 46 | 14 | 60 |
| 2014 May | 38 | 16 | 54 |
| 2014 April | 32 | 7 | 39 |
| 2014 March | 38 | 15 | 53 |
| 2014 February | 41 | 9 | 50 |
| 2014 January | 30 | 11 | 41 |
| 2013 December | 25 | 4 | 29 |
| 2013 November | 22 | 3 | 25 |
| 2013 October | 41 | 8 | 49 |
| 2013 September | 27 | 8 | 35 |
| 2013 August | 28 | 6 | 34 |
| 2013 July | 26 | 14 | 40 |
| 2013 June | 22 | 9 | 31 |
| 2013 May | 19 | 5 | 24 |
| 2013 April | 21 | 8 | 29 |
| 2013 March | 26 | 9 | 35 |
| 2013 February | 21 | 7 | 28 |
| 2013 January | 22 | 5 | 27 |
| 2012 December | 17 | 6 | 23 |
| 2012 November | 7 | 9 | 16 |
| 2012 October | 9 | 4 | 13 |
| 2012 September | 6 | 3 | 9 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 1 | 0 | 1 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 2 | 0 | 2 |
| 2011 December | 6 | 0 | 6 |
| 2011 November | 2 | 0 | 2 |
| 2011 October | 3 | 0 | 3 |
| 2011 August | 2 | 0 | 2 |
| 2011 July | 3 | 0 | 3 |
| 2011 June | 4 | 0 | 4 |
| 2011 April | 1 | 0 | 1 |
| 2011 March | 2 | 0 | 2 |
| 2011 February | 4 | 0 | 4 |
| 2011 January | 9 | 0 | 9 |
| 2010 December | 10 | 0 | 10 |
| 2010 November | 6 | 0 | 6 |
| 2010 October | 11 | 0 | 11 |
| 2010 September | 4 | 0 | 4 |
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