An economic evaluation of chondroitin sulfate and non-steroidal anti-inflammatory drugs for the treatment of osteoarthritis. Data from the VECTRA study
Evaluación económica del uso de condroitín sulfato y antiinflamatorios no esteroideos en el tratamiento de la artrosis. Datos del estudio VECTRA
Health Value, Health Economics and Research Outcomes Consulting, Madrid, Spain
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Data from the VECTRA study" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "187" "paginaFinal" => "195" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Carlos Rubio-Terrés" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Carlos" "apellidos" => "Rubio-Terrés" "email" => array:1 [ 0 => "crubioterres@healthvalue.org" ] ] 1 => array:2 [ "colaborador" => "Grupo del estudio VECTRA" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">◊</span>" "identificador" => "fn0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Health Value, Health Economics and Research Outcomes Consulting, Madrid, Spain" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación económica del uso de condroitín sulfato y antiinflamatorios no esteroideos en el tratamiento de la artrosis. Datos del estudio VECTRA" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-05-21" "fechaAceptado" => "2009-12-02" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112482" "palabras" => array:7 [ 0 => "Chondroitin sulphate" 1 => "Non-steroidal antiinflammatory drugs" 2 => "Antirheumatic drugs" 3 => "Osteoarthritis" 4 => "Knee osteoarthritis" 5 => "Hip osteoarthritis" 6 => "Costs" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112483" "palabras" => array:7 [ 0 => "Condroitín sulfato" 1 => "Agentes antiinflamatorios no esteroideos" 2 => "Agentes antirreumáticos" 3 => "Artrosis" 4 => "Artrosis de rodilla" 5 => "Artrosis de cadera" 6 => "Costes" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Our aim was to investigate: 1) the average cost per patient with osteoarthritis treated with chondroitin sulfate compared with NSAIDs for 6 months and 2) the possible impact that the reduction NSAID use due to monotherapy with or combined administration of chondroitin sulfate treatment may have on the budget of the Spanish National Health System.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A cost-minimization model compared both treatments (efficacy equivalence assumption), used at the recommended doses and regimens during a 6-month period. Data used in the model was obtained from the VECTRA study, a retrospective study of 530 patients with osteoarthritis treated with chondroitin sulfate or NSAIDs that was conducted to determine the consumption of health care resources. The efficacy and incidence of adverse events was estimated from meta-analysis based on randomized clinical trials. Univariate sensitivity analysis was performed for the base case scenario.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The overall 6-month cost per patient given chondroitin sulfate was 141 € compared with 182 € when treated with NSAIDs. If during the forthcoming 3 years, 5%, 10%, and 15% of patients currently treated with NSAIDs would gradually be replaced by treatment with chondroitin sulfate, the expected savings for the Spanish National Health System during these 3 years would be over 38,700,000 €. In addition, 2,666 cases of gastrointestinal adverse events (including 90 serious adverse events) will have been avoided for every 10,000 patients treated with chondroitin sulfate instead of NSAID. Sensitivity analysis confirmed the strength of base-case in all scenarios.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">On the basis of these findings, chondroitin sulfate is a treatment for osteoarthritis with a lesser cost and better gastrointestinal tolerability compared with NSAIDs.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El presente estudio <span class="elsevierStyleItalic">a</span>) estima el coste medio de un paciente con artrosis tratado durante 6 meses con condroitín sulfato (CS) o antiinflamatorios no esteroideos (AINE), y <span class="elsevierStyleItalic">b</span>) evalúa el impacto presupuestario para el Sistema Nacional de Salud que causaría la disminución del consumo de AINE con la administración en monoterapia o conjunta de CS.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Modelo de minimización de costes que comparó ambos tratamientos (asumiendo igualdad de eficacia), a las dosis y las pautas recomendadas, durante un período de seis meses. Los datos utilizados en el modelo se obtuvieron del estudio VECTRA, un estudio retrospectivo en el que se recogió el consumo de recursos sanitarios de 530 pacientes con artrosis tratados con CS o AINE. La eficacia y la incidencia de efectos adversos se estimaron a partir del metaanálisis de ensayos clínicos aleatorizados. Se hicieron análisis de sensibilidad simples univariantes del caso básico.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El coste semestral por paciente tratado con CS fue de 141 €, y de 182 € en el caso de los AINE. Esto significa que, si durante los 3 próximos años el 5, el 10 y el 15% de los pacientes con artrosis tratados actualmente con AINE fueran tratados con CS, se generarían ahorros para el Sistema Nacional de Salud de más de 38,7 millones de euros durante este período. Además, por cada 10.000 pacientes tratados con CS en lugar de AINE se evitarían 2.666 efectos adversos gastrointestinales, de los que 90 serían graves. Los análisis de sensibilidad confirmaron la estabilidad del caso básico en todos los supuestos considerados.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Comparado con los AINE, el CS es un tratamiento con menores costes y con mejor tolerancia gastrointestinal en el manejo de la artrosis.</p>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "◊" "nota" => "<p class="elsevierStyleNotepara">The list of the VECTRA study researchers is shown in Annex I.</p>" ] 1 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">VECTRA is the acronym for the “Economic and Health Evaluation of Chondroitin Sulphate for the Treatment of Osteoarthritis”.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2018 February | 23 | 5 | 28 |
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| 2017 June | 31 | 9 | 40 |
| 2017 May | 39 | 10 | 49 |
| 2017 April | 27 | 4 | 31 |
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| 2016 July | 26 | 6 | 32 |
| 2016 June | 0 | 5 | 5 |
| 2016 May | 0 | 6 | 6 |
| 2016 April | 2 | 12 | 14 |
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| 2016 February | 3 | 13 | 16 |
| 2016 January | 3 | 23 | 26 |
| 2015 December | 2 | 22 | 24 |
| 2015 November | 4 | 15 | 19 |
| 2015 October | 4 | 21 | 25 |
| 2015 September | 3 | 0 | 3 |
| 2015 August | 4 | 8 | 12 |
| 2015 July | 21 | 5 | 26 |
| 2015 June | 17 | 14 | 31 |
| 2015 May | 36 | 23 | 59 |
| 2015 April | 20 | 18 | 38 |
| 2015 March | 15 | 8 | 23 |
| 2015 February | 20 | 29 | 49 |
| 2015 January | 25 | 20 | 45 |
| 2014 December | 24 | 13 | 37 |
| 2014 November | 13 | 19 | 32 |
| 2014 October | 22 | 18 | 40 |
| 2014 September | 23 | 17 | 40 |
| 2014 August | 21 | 19 | 40 |
| 2014 July | 21 | 14 | 35 |
| 2014 June | 45 | 19 | 64 |
| 2014 May | 38 | 16 | 54 |
| 2014 April | 35 | 14 | 49 |
| 2014 March | 36 | 20 | 56 |
| 2014 February | 32 | 17 | 49 |
| 2014 January | 22 | 19 | 41 |
| 2013 December | 40 | 11 | 51 |
| 2013 November | 19 | 24 | 43 |
| 2013 October | 31 | 22 | 53 |
| 2013 September | 29 | 24 | 53 |
| 2013 August | 22 | 20 | 42 |
| 2013 July | 22 | 13 | 35 |
| 2013 June | 27 | 19 | 46 |
| 2013 May | 24 | 14 | 38 |
| 2013 April | 18 | 17 | 35 |
| 2013 March | 29 | 17 | 46 |
| 2013 February | 29 | 10 | 39 |
| 2013 January | 20 | 12 | 32 |
| 2012 December | 20 | 7 | 27 |
| 2012 November | 12 | 13 | 25 |
| 2012 October | 7 | 2 | 9 |
| 2012 September | 7 | 4 | 11 |
| 2012 June | 3 | 0 | 3 |
| 2012 April | 3 | 0 | 3 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 6 | 0 | 6 |
| 2011 December | 5 | 0 | 5 |
| 2011 November | 5 | 0 | 5 |
| 2011 October | 6 | 0 | 6 |
| 2011 September | 2 | 0 | 2 |
| 2011 August | 4 | 0 | 4 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 1 | 0 | 1 |
| 2011 April | 2 | 0 | 2 |
| 2011 March | 1 | 0 | 1 |
| 2011 February | 8 | 0 | 8 |
| 2011 January | 13 | 0 | 13 |
| 2010 December | 12 | 0 | 12 |
| 2010 November | 14 | 0 | 14 |
| 2010 October | 12 | 0 | 12 |
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