Diffuse alveolar hemorrhage: Causes and outcomes in a referral center
Hemorragia alveolar difusa: causas y desenlaces en un instituto de tercer nivel
a Instituto Nacional de Enfermedades Respiratorias Dr. Ismael Cosio Villegas, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico
b Servicio Clínico de Enfermedades Intersticiales del Pulmón, Instituto Nacional de Enfermedades Respiratorias Dr. Ismael Cosio Villegas, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico
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In 35% of the cases, there was a failure in identifying an etiology. Six patients died (35%), the only factor associated with mortality was male gender 5/6 vs 3/11, <span class="elsevierStyleItalic">P</span>=.05.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The most frequent cause of alveolar hemorrhage was ANCA associated vasculitis. The mortality in DAH is about 35%, males seem to have a worse prognosis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Identificar las causas más frecuentes de hemorragia alveolar difusa (HAD) y conocer la evolución de los casos durante su hospitalización.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Revisión de expedientes con diagnóstico de HAD. Se clasificaron los diagnósticos de acuerdo con los criterios vigentes y se determinó la evolución.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se identificaron 17 casos de HAD, la principal causa fueron las vasculitis asociadas a ANCA (el 41% de los casos) seguida de las secundarias a drogas (el 18% de los casos). En un 35% no se logró identificar una etiología. Seis pacientes fallecieron (35%), el único factor asociado a mortalidad fue el sexo masculino (5/6 vs.− 3/11; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,05).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La causa más frecuente de hemorragia alveolar son las vasculitis asociadas a ANCA, la mortalidad de la HAD es del 35% y los hombres parecen tener peor pronóstico.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse alveolar hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.R. Collard" 1 => "I.S. 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| 2018 May | 1 | 5 | 6 |
| 2018 April | 24 | 19 | 43 |
| 2018 March | 41 | 23 | 64 |
| 2018 February | 14 | 13 | 27 |
| 2018 January | 15 | 10 | 25 |
| 2017 December | 19 | 17 | 36 |
| 2017 November | 12 | 17 | 29 |
| 2017 October | 11 | 18 | 29 |
| 2017 September | 10 | 15 | 25 |
| 2017 August | 11 | 22 | 33 |
| 2017 July | 13 | 28 | 41 |
| 2017 June | 25 | 14 | 39 |
| 2017 May | 23 | 25 | 48 |
| 2017 April | 26 | 20 | 46 |
| 2017 March | 15 | 27 | 42 |
| 2017 February | 11 | 16 | 27 |
| 2017 January | 7 | 11 | 18 |
| 2016 December | 38 | 17 | 55 |
| 2016 November | 34 | 11 | 45 |
| 2016 October | 37 | 15 | 52 |
| 2016 September | 29 | 13 | 42 |
| 2016 August | 27 | 16 | 43 |
| 2016 July | 13 | 7 | 20 |
| 2016 June | 0 | 12 | 12 |
| 2016 May | 0 | 12 | 12 |
| 2016 April | 0 | 32 | 32 |
| 2016 March | 1 | 25 | 26 |
| 2016 February | 5 | 28 | 33 |
| 2016 January | 2 | 22 | 24 |
| 2015 December | 3 | 23 | 26 |
| 2015 November | 3 | 20 | 23 |
| 2015 October | 3 | 22 | 25 |
| 2015 September | 3 | 0 | 3 |
| 2015 August | 2 | 12 | 14 |
| 2015 July | 14 | 5 | 19 |
| 2015 June | 21 | 23 | 44 |
| 2015 May | 33 | 21 | 54 |
| 2015 April | 22 | 28 | 50 |
| 2015 March | 17 | 32 | 49 |
| 2015 February | 33 | 22 | 55 |
| 2015 January | 18 | 33 | 51 |
| 2014 December | 33 | 27 | 60 |
| 2014 November | 21 | 31 | 52 |
| 2014 October | 25 | 23 | 48 |
| 2014 September | 22 | 19 | 41 |
| 2014 August | 26 | 39 | 65 |
| 2014 July | 23 | 37 | 60 |
| 2014 June | 40 | 26 | 66 |
| 2014 May | 40 | 31 | 71 |
| 2014 April | 35 | 19 | 54 |
| 2014 March | 38 | 32 | 70 |
| 2014 February | 28 | 19 | 47 |
| 2014 January | 28 | 20 | 48 |
| 2013 December | 28 | 22 | 50 |
| 2013 November | 19 | 18 | 37 |
| 2013 October | 36 | 32 | 68 |
| 2013 September | 47 | 29 | 76 |
| 2013 August | 45 | 36 | 81 |
| 2013 July | 32 | 31 | 63 |
| 2013 June | 36 | 26 | 62 |
| 2013 May | 28 | 24 | 52 |
| 2013 April | 27 | 17 | 44 |
| 2013 March | 20 | 24 | 44 |
| 2013 February | 23 | 13 | 36 |
| 2013 January | 15 | 17 | 32 |
| 2012 December | 20 | 10 | 30 |
| 2012 November | 11 | 18 | 29 |
| 2012 October | 5 | 9 | 14 |
| 2012 September | 10 | 3 | 13 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 3 | 0 | 3 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 2 | 0 | 2 |
| 2012 February | 3 | 0 | 3 |
| 2012 January | 2 | 0 | 2 |
| 2011 December | 5 | 0 | 5 |
| 2011 November | 4 | 0 | 4 |
| 2011 July | 1 | 0 | 1 |
| 2011 May | 2 | 0 | 2 |
| 2011 April | 2 | 0 | 2 |
| 2011 March | 4 | 0 | 4 |
| 2011 February | 3 | 0 | 3 |
| 2011 January | 8 | 0 | 8 |
| 2010 December | 7 | 0 | 7 |
| 2010 November | 15 | 0 | 15 |
| 2010 October | 11 | 0 | 11 |
Show all
