Resistant orbital pseudotumor treated with rituximab in a patient with systemic lupus erythematosus. A case presentation
Pseudotumor orbitario refractario tratado con rituximab en paciente con lupus eritematoso sistémico. A propósito de un caso
Carmen María Escudero González
, Sergio Rodríguez Montero, Rosalía Martínez Pérez, Carolina Pastor Mañosa, María Luisa Velloso Feijoo, José Luis Marenco de La Fuente
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Servicio de Reumatología, Hospital Universitario Virgen de Valme, Sevilla, Spain
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A case presentation" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "214" "paginaFinal" => "216" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carmen María Escudero González, Sergio Rodríguez Montero, Rosalía Martínez Pérez, Carolina Pastor Mañosa, María Luisa Velloso Feijoo, José Luis Marenco de La Fuente" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Carmen María" "apellidos" => "Escudero González" "email" => array:1 [ 0 => "carmenescu1@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Sergio" "apellidos" => "Rodríguez Montero" ] 2 => array:2 [ "nombre" => "Rosalía" "apellidos" => "Martínez Pérez" ] 3 => array:2 [ "nombre" => "Carolina" "apellidos" => "Pastor Mañosa" ] 4 => array:2 [ "nombre" => "María Luisa" "apellidos" => "Velloso Feijoo" ] 5 => array:2 [ "nombre" => "José Luis" "apellidos" => "Marenco de La Fuente" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Virgen de Valme, Sevilla, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pseudotumor orbitario refractario tratado con rituximab en paciente con lupus eritematoso sistémico. A propósito de un caso" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-04-27" "fechaAceptado" => "2009-07-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112494" "palabras" => array:4 [ 0 => "Exophthalmos" 1 => "Systemic lupus erythematosus" 2 => "Orbital pseudotumor" 3 => "Rituximab" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112495" "palabras" => array:4 [ 0 => "Exoftalmos" 1 => "Lupus eritematoso sistémico" 2 => "Pseudotumor orbitario" 3 => "Rituximab" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ocular manifestations in Systemic Lupus Erythematosus (SLE) are relatively frequent, with a major prevalence of the Keratoconjunctivitis sicca. Nevertheless, the appearance of unilateral exophthalmos secondary to orbital pseudotumor in patients with SLE is extremely rare,<span class="elsevierStyleSup">1–7</span> and on occasion it can be refractory to conventional pharmacological treatment (glucocorticoids and immunosuppressants). We present the case of a patient with SLE and orbital pseudotumor refractory to treatment with Cyclophosphamide (CF) and an excellent clinical response, with disappearance of theo phthalmological condition after the beginning of therapy with Rituximab (1<span class="elsevierStyleHsp" style=""></span>g×2), continuing after the infusion of two complete cycles without incidents.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las manifestaciones oculares en el lupus eritematoso sistémico (LES) son relativamente frecuentes, con mayor prevalencia de la queratoconjuntivitis seca. Sin embargo, la aparición de exoftalmos unilateral secundario a pseudotumor orbitario en pacientes con LES es extremadamente rara,<span class="elsevierStyleSup">1–7</span> y en ocasiones puede presentarse refractaria al tratamiento farmacológico convencional (glucocorticoides e inmunosupresores). A continuación presentamos el caso de una paciente con LES y pseudotumor orbitario refractario a tratamiento con ciclofosfamida y excelente respuesta clínica con desaparición de la clínica oftalmológica tras el inicio de la terapia con rituximab (1<span class="elsevierStyleHsp" style=""></span>g × 2), eficacia mantenida tras la infusión de dos ciclos completos sin incidencias.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Orbital myositis secondary to systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Serop" 1 => "R.N. Vianna" 2 => "M. Claeys" 3 => "J.J. De Laey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Ophthalmol (Copenh)" "fecha" => "1994" "volumen" => "72" "paginaInicial" => "520" "paginaFinal" => "523" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exophthalmos in systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.D. Bankhurst" 1 => "T.J. Carlow" 2 => "R.W. Reidy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Ophthalmol" "fecha" => "1984" "volumen" => "6" "paginaInicial" => "669" "paginaFinal" => "671" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4526486" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proptosis can be the presenting feature of systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Siebert" 1 => "U. Srinivasan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2004.020602" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2004" "volumen" => "63" "paginaInicial" => "908" "paginaFinal" => "909" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15249316" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Orbital panniculitis as the initial manifestation of systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.R. Jordan" 1 => "H. McDonald" 2 => "B. Olberg" 3 => "D. McKim" 4 => "R. McKendy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthal Plast Reconstr Surg" "fecha" => "1993" "volumen" => "9" "paginaInicial" => "71" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8443118" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Orbital inflammation, myositis, and systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B.S. Grimson" 1 => "K.B. Simons" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Ophthalmol" "fecha" => "1983" "volumen" => "101" "paginaInicial" => "736" "paginaFinal" => "738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6847461" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Orbital inflammatory disease associated with systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.E. Feinfield" 1 => "R.J. Hesse" 2 => "S.A. Rosenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "South Med J" "fecha" => "1991" "volumen" => "84" "paginaInicial" => "98" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1986438" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exophthalmos associated with systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.S. Wildinson" 1 => "R.S. Panush" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1975" "volumen" => "18" "paginaInicial" => "188" "paginaFinal" => "189" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1131286" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Orbytal pseudotumor syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.G. Snebold" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Ophthalmol" "fecha" => "1997" "volumen" => "8" "paginaInicial" => "41" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10176102" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic dilemmas in orbital inflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.K. Gordon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ocul Immunol Inflamm" "fecha" => "2003" "volumen" => "11" "paginaInicial" => "3" "paginaFinal" => "15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12854023" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrent acute proptosis in atypical systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.E. Gray" 1 => "E.A. Jenkins" 2 => "M.A. Hall" 3 => "J.J. Kanski" 4 => "B.M. Ansell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "1989" "volumen" => "8" "paginaInicial" => "528" "paginaFinal" => "532" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2612122" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of idiopathic orbital inflammation with infliximab: an alternative to conventional steroid-sparing agents" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Miquel" 1 => "S. Abad" 2 => "I. Badelon" 3 => "C. Vignal" 4 => "U. Warzocha" 5 => "C. Larroche" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/IOP.0b013e318182a522" "Revista" => array:6 [ "tituloSerie" => "Ophthal Plast Reconstr Surg" "fecha" => "2008" "volumen" => "24" "paginaInicial" => "415" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18806671" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The emerging use of TNF-alpha inhibitors in orbital inflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.K. Kapadia" 1 => "P.A. Rubin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Ophthalmol Clin" "fecha" => "2006" "volumen" => "46" "paginaInicial" => "165" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16770161" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic orbital inflammatory disease successfully treated with Rituximab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.D. Schafranski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-008-1040-8" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2009" "volumen" => "28" "paginaInicial" => "225" "paginaFinal" => "226" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19015801" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of Graves’ disease and associated ophthalmopathy with the anti-CD20 monoclonal antibody rituximab: An open study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Salvi" 1 => "G. Vannucchi" 2 => "I. Campi" 3 => "N. Currò" 4 => "D. Dazzi" 5 => "S. Simonetta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1530/eje.1.02325" "Revista" => array:6 [ "tituloSerie" => "Eur J Endocrinol" "fecha" => "2007" "volumen" => "156" "paginaInicial" => "33" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17218723" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New immunomodulators in the treatment of Graves’ ophthalmopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Salvi" 1 => "G. Vannucchi" 2 => "I. Campi" 3 => "N. Currò" 4 => "P. Beck-Peccoz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Endocrinol (Paris)" "fecha" => "2008" "volumen" => "69" "paginaInicial" => "153" "paginaFinal" => "156" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.P. Sfikakis" 1 => "J.N. Boletis" 2 => "G.C. Tsokos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Rheumatol" "fecha" => "2005" "volumen" => "17" "paginaInicial" => "550" "paginaFinal" => "557" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16093832" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab in severe lupus nephritis: early B-cell depletion affects long-term renal outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Melander" 1 => "M. Sallée" 2 => "P. Trolliet" 3 => "S. Candon" 4 => "X. Belenfant" 5 => "E. Daugas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2215/CJN.04030808" "Revista" => array:6 [ "tituloSerie" => "Clin J Am Soc Nephrol" "fecha" => "2009" "volumen" => "4" "paginaInicial" => "579" "paginaFinal" => "587" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19261822" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The differentiation of idiopathic inflammatory pseudotumor from lymphoid tumors of orbit: analysis of 319 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Yan" 1 => "Z. Wu" 2 => "Y. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/01676830490487980" "Revista" => array:6 [ "tituloSerie" => "Orbit" "fecha" => "2004" "volumen" => "23" "paginaInicial" => "245" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15590527" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000600000004/v1_201305061610/S2173574310700472/v1_201305061610/en/main.assets" "Apartado" => array:4 [ "identificador" => "17376" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Case Report" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000600000004/v1_201305061610/S2173574310700472/v1_201305061610/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700472?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 3 | 5 |
| 2024 October | 29 | 51 | 80 |
| 2024 September | 34 | 26 | 60 |
| 2024 August | 50 | 59 | 109 |
| 2024 July | 30 | 40 | 70 |
| 2024 June | 33 | 37 | 70 |
| 2024 May | 33 | 44 | 77 |
| 2024 April | 46 | 23 | 69 |
| 2024 March | 43 | 26 | 69 |
| 2024 February | 40 | 23 | 63 |
| 2024 January | 38 | 37 | 75 |
| 2023 December | 38 | 28 | 66 |
| 2023 November | 19 | 19 | 38 |
| 2023 October | 24 | 27 | 51 |
| 2023 September | 30 | 47 | 77 |
| 2023 August | 14 | 14 | 28 |
| 2023 July | 20 | 28 | 48 |
| 2023 June | 21 | 30 | 51 |
| 2023 May | 12 | 15 | 27 |
| 2023 April | 22 | 12 | 34 |
| 2023 March | 34 | 32 | 66 |
| 2023 February | 24 | 32 | 56 |
| 2023 January | 42 | 24 | 66 |
| 2022 December | 26 | 33 | 59 |
| 2022 November | 34 | 29 | 63 |
| 2022 October | 31 | 30 | 61 |
| 2022 September | 32 | 32 | 64 |
| 2022 August | 33 | 44 | 77 |
| 2022 July | 27 | 49 | 76 |
| 2022 June | 31 | 31 | 62 |
| 2022 May | 36 | 44 | 80 |
| 2022 April | 27 | 58 | 85 |
| 2022 March | 29 | 48 | 77 |
| 2022 February | 41 | 20 | 61 |
| 2022 January | 45 | 40 | 85 |
| 2021 December | 33 | 52 | 85 |
| 2021 November | 31 | 52 | 83 |
| 2021 October | 56 | 66 | 122 |
| 2021 September | 36 | 46 | 82 |
| 2021 August | 35 | 49 | 84 |
| 2021 July | 38 | 45 | 83 |
| 2021 June | 35 | 56 | 91 |
| 2021 May | 29 | 57 | 86 |
| 2021 April | 70 | 80 | 150 |
| 2021 March | 44 | 40 | 84 |
| 2021 February | 39 | 42 | 81 |
| 2021 January | 36 | 21 | 57 |
| 2020 December | 29 | 24 | 53 |
| 2020 November | 37 | 18 | 55 |
| 2020 October | 18 | 22 | 40 |
| 2020 September | 27 | 36 | 63 |
| 2020 August | 30 | 19 | 49 |
| 2020 July | 19 | 23 | 42 |
| 2020 June | 29 | 30 | 59 |
| 2020 May | 20 | 15 | 35 |
| 2020 April | 16 | 14 | 30 |
| 2020 March | 20 | 9 | 29 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 2 | 2 | 4 |
| 2018 April | 14 | 10 | 24 |
| 2018 March | 34 | 16 | 50 |
| 2018 February | 14 | 6 | 20 |
| 2018 January | 11 | 4 | 15 |
| 2017 December | 13 | 11 | 24 |
| 2017 November | 13 | 5 | 18 |
| 2017 October | 9 | 6 | 15 |
| 2017 September | 10 | 9 | 19 |
| 2017 August | 16 | 12 | 28 |
| 2017 July | 8 | 15 | 23 |
| 2017 June | 23 | 25 | 48 |
| 2017 May | 18 | 16 | 34 |
| 2017 April | 12 | 24 | 36 |
| 2017 March | 14 | 9 | 23 |
| 2017 February | 11 | 15 | 26 |
| 2017 January | 21 | 5 | 26 |
| 2016 December | 31 | 16 | 47 |
| 2016 November | 18 | 5 | 23 |
| 2016 October | 29 | 12 | 41 |
| 2016 September | 23 | 11 | 34 |
| 2016 August | 27 | 6 | 33 |
| 2016 July | 16 | 10 | 26 |
| 2016 June | 0 | 19 | 19 |
| 2016 May | 0 | 10 | 10 |
| 2016 April | 2 | 8 | 10 |
| 2016 March | 1 | 8 | 9 |
| 2016 February | 2 | 14 | 16 |
| 2016 January | 4 | 12 | 16 |
| 2015 December | 2 | 9 | 11 |
| 2015 November | 4 | 7 | 11 |
| 2015 October | 3 | 16 | 19 |
| 2015 September | 1 | 0 | 1 |
| 2015 August | 4 | 13 | 17 |
| 2015 July | 11 | 5 | 16 |
| 2015 June | 15 | 16 | 31 |
| 2015 May | 38 | 28 | 66 |
| 2015 April | 28 | 18 | 46 |
| 2015 March | 22 | 16 | 38 |
| 2015 February | 26 | 17 | 43 |
| 2015 January | 17 | 19 | 36 |
| 2014 December | 25 | 15 | 40 |
| 2014 November | 11 | 21 | 32 |
| 2014 October | 15 | 20 | 35 |
| 2014 September | 13 | 11 | 24 |
| 2014 August | 16 | 19 | 35 |
| 2014 July | 14 | 17 | 31 |
| 2014 June | 37 | 21 | 58 |
| 2014 May | 40 | 22 | 62 |
| 2014 April | 34 | 19 | 53 |
| 2014 March | 35 | 18 | 53 |
| 2014 February | 26 | 13 | 39 |
| 2014 January | 28 | 22 | 50 |
| 2013 December | 22 | 25 | 47 |
| 2013 November | 20 | 15 | 35 |
| 2013 October | 36 | 25 | 61 |
| 2013 September | 25 | 19 | 44 |
| 2013 August | 44 | 27 | 71 |
| 2013 July | 25 | 12 | 37 |
| 2013 June | 32 | 15 | 47 |
| 2013 May | 20 | 20 | 40 |
| 2013 April | 26 | 19 | 45 |
| 2013 March | 24 | 17 | 41 |
| 2013 February | 29 | 9 | 38 |
| 2013 January | 17 | 20 | 37 |
| 2012 December | 22 | 11 | 33 |
| 2012 November | 12 | 25 | 37 |
| 2012 October | 6 | 19 | 25 |
| 2012 September | 6 | 4 | 10 |
| 2012 July | 2 | 0 | 2 |
| 2012 June | 2 | 0 | 2 |
| 2012 May | 3 | 0 | 3 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 2 | 0 | 2 |
| 2011 December | 2 | 0 | 2 |
| 2011 November | 5 | 0 | 5 |
| 2011 October | 3 | 0 | 3 |
| 2011 September | 2 | 0 | 2 |
| 2011 August | 2 | 0 | 2 |
| 2011 July | 2 | 0 | 2 |
| 2011 June | 3 | 0 | 3 |
| 2011 May | 1 | 0 | 1 |
| 2011 April | 1 | 0 | 1 |
| 2011 March | 4 | 0 | 4 |
| 2011 February | 7 | 0 | 7 |
| 2011 January | 6 | 0 | 6 |
| 2010 December | 6 | 0 | 6 |
| 2010 November | 21 | 0 | 21 |
| 2010 October | 17 | 0 | 17 |
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