Primary Sjögren's syndrome: Expression of NF-κB in minor salivary glands
Síndrome de Sjögren primario: expresión del factor NF-κB en glándula salival menor
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Romanini, Antonio Catalan Pellet, Alejandro Berra" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Liliana" "apellidos" => "Villalon" "email" => array:1 [ 0 => "lvillalon@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Marta" "apellidos" => "Mamani" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Felix E." "apellidos" => "Romanini" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Antonio" "apellidos" => "Catalan Pellet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Alejandro" "apellidos" => "Berra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Laboratorio de Investigaciones Oculares, Departamento de Patología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Bernardino Rivadavia, Buenos Aires, Argentina" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Sjögren primario: expresión del factor NF-κB en glándula salival menor" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-06-25" "fechaAceptado" => "2009-10-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112558" "palabras" => array:2 [ 0 => "Primary Sjögren's syndrome" 1 => "Expression of NF-κB in minor salivary glands" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112559" "palabras" => array:3 [ 0 => "Síndrome de Sjogren" 1 => "Autoinmunidad NF-κB en glándulas salivales" 2 => "menores" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Purpose</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate nuclear NF-κB translocation in minor salivary glands (mSG) of human primary Sjogren Syndrome (pSS).</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lip biopsies’ mSG were done in 24 female patients with pSS from the Rheumatology Service of Rivadavia Hospital. Glands were stained with H&E and immunostained for NF-κB. Specimens were classified according to the Chisholm and Masson score.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The biopsies (H&E staining) showed lymphoplasmocitic infiltrates, forming periacini and periductal focuses which number depending on the stage of the disease. In stages III and IV there was acini destruction and, in some cases, fibrosis. In the biopsies with a diagnosis of sialadenitis we observed interstitially-dispersed lymphoplasmocitic elements and also polimorphonuclear neutrophils. The lip biopsies’ mSG of patients with clinical-serological diagnosis of pSS showed nuclear translocation of NF-κB in lymphocytes of focal infiltrates and in the acini epithelium adjacent to the infiltrates. In distal acini and ductal structures from the infitrates we did not observe nuclear translocation. However, in SSp patients with sialadenitis interstitial lymphocytes with nuclear translocation were observed but neither in the acini or the ducts. SSp patients with normal glands did not show nuclear translocation of NF-κB factor either in the acini or in the ducts.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">These results allow us to infer the importance of lymphocyte-epithelium interaction on the activation of NF-κB in human pSS.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Evaluar la translocacion nuclear del factor NF-κB en las glandulas salivales menores de pacientes con sindrome de Sjogren primario (SSp).</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realizaron biopsias de glandulas salivares menores en 24 pacientes mujeres con diagnostico de SSp del Servicio de Reumatologia del Hospital Rivadavia. Las glandulas fueron tenidas con H&E y la inmunohistoquimica para NF-κB, fueron clasificados de acuerdo con la puntuacion de Chisholm y Masson.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Las biopsias de pacientes con SSp (H&E) mostraron infiltrados linfoplasmocitarios, formando focos periacinares y periductales cuyo numero depende del estadio de la enfermedad. En las fases III y IV se observa la destruccion de los acinos y, en algunos casos, fibrosis. En las biopsias con diagnostico de sialoadenitis observamos elementos linfoplasmocitarios intersticiales dispersos y tambien neutrofilos polimorfonucleares. Las biopsias de labio de pacientes con diagnostico clinico serologico de SSp mostraron la translocacion nuclear de NF-κB en los linfocitos de infiltracion focal y en el epitelio de los acinos adyacentes a los infiltrados. En acinos y en las estructuras ductales alejadas de los infiltrados, no observamos translocacion nuclear. Sin embargo, en pacientes con sialoadenitis se observaron linfocitos intersticiales con translocacion nuclear pero no en acinos y ductos. Los pacientes con SSp con glandula normal no mostraron translocacion nuclear del factor NF-κB, ni en acinos ni en el conducto.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estos resultados nos permiten inferir la importancia de la interaccion linfocitosepitelio y la activacion del factor NF-κB en pacientes con diagnostico de SSp.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 16 | 21 |
| 2024 October | 35 | 41 | 76 |
| 2024 September | 38 | 17 | 55 |
| 2024 August | 57 | 50 | 107 |
| 2024 July | 19 | 38 | 57 |
| 2024 June | 20 | 23 | 43 |
| 2024 May | 31 | 38 | 69 |
| 2024 April | 18 | 25 | 43 |
| 2024 March | 27 | 41 | 68 |
| 2024 February | 15 | 23 | 38 |
| 2024 January | 14 | 20 | 34 |
| 2023 December | 19 | 34 | 53 |
| 2023 November | 14 | 20 | 34 |
| 2023 October | 20 | 43 | 63 |
| 2023 September | 29 | 46 | 75 |
| 2023 August | 14 | 14 | 28 |
| 2023 July | 21 | 20 | 41 |
| 2023 June | 11 | 25 | 36 |
| 2023 May | 16 | 8 | 24 |
| 2023 April | 10 | 8 | 18 |
| 2023 March | 17 | 32 | 49 |
| 2023 February | 16 | 30 | 46 |
| 2023 January | 17 | 20 | 37 |
| 2022 December | 23 | 35 | 58 |
| 2022 November | 22 | 23 | 45 |
| 2022 October | 17 | 34 | 51 |
| 2022 September | 15 | 32 | 47 |
| 2022 August | 21 | 50 | 71 |
| 2022 July | 17 | 50 | 67 |
| 2022 June | 12 | 43 | 55 |
| 2022 May | 24 | 51 | 75 |
| 2022 April | 13 | 65 | 78 |
| 2022 March | 19 | 48 | 67 |
| 2022 February | 16 | 42 | 58 |
| 2022 January | 11 | 44 | 55 |
| 2021 December | 22 | 46 | 68 |
| 2021 November | 15 | 48 | 63 |
| 2021 October | 26 | 61 | 87 |
| 2021 September | 19 | 49 | 68 |
| 2021 August | 16 | 44 | 60 |
| 2021 July | 20 | 38 | 58 |
| 2021 June | 24 | 38 | 62 |
| 2021 May | 15 | 39 | 54 |
| 2021 April | 79 | 86 | 165 |
| 2021 March | 36 | 31 | 67 |
| 2021 February | 24 | 25 | 49 |
| 2021 January | 19 | 20 | 39 |
| 2020 December | 11 | 29 | 40 |
| 2020 November | 22 | 17 | 39 |
| 2020 October | 13 | 7 | 20 |
| 2020 September | 18 | 30 | 48 |
| 2020 August | 15 | 18 | 33 |
| 2020 July | 30 | 18 | 48 |
| 2020 June | 32 | 16 | 48 |
| 2020 May | 21 | 28 | 49 |
| 2020 April | 34 | 17 | 51 |
| 2020 March | 21 | 7 | 28 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 2 | 1 | 3 |
| 2018 April | 26 | 15 | 41 |
| 2018 March | 31 | 13 | 44 |
| 2018 February | 24 | 8 | 32 |
| 2018 January | 8 | 3 | 11 |
| 2017 December | 15 | 8 | 23 |
| 2017 November | 14 | 7 | 21 |
| 2017 October | 15 | 9 | 24 |
| 2017 September | 11 | 5 | 16 |
| 2017 August | 9 | 7 | 16 |
| 2017 July | 8 | 11 | 19 |
| 2017 June | 28 | 10 | 38 |
| 2017 May | 22 | 11 | 33 |
| 2017 April | 11 | 6 | 17 |
| 2017 March | 9 | 6 | 15 |
| 2017 February | 8 | 5 | 13 |
| 2017 January | 18 | 3 | 21 |
| 2016 December | 38 | 12 | 50 |
| 2016 November | 19 | 1 | 20 |
| 2016 October | 31 | 11 | 42 |
| 2016 September | 27 | 7 | 34 |
| 2016 August | 20 | 6 | 26 |
| 2016 July | 17 | 3 | 20 |
| 2016 February | 5 | 7 | 12 |
| 2015 December | 4 | 0 | 4 |
| 2015 November | 1 | 0 | 1 |
| 2015 October | 1 | 13 | 14 |
| 2015 September | 1 | 0 | 1 |
| 2015 August | 3 | 0 | 3 |
| 2015 July | 19 | 4 | 23 |
| 2015 June | 19 | 17 | 36 |
| 2015 May | 46 | 21 | 67 |
| 2015 April | 28 | 24 | 52 |
| 2015 March | 28 | 8 | 36 |
| 2015 February | 24 | 11 | 35 |
| 2015 January | 26 | 16 | 42 |
| 2014 December | 29 | 18 | 47 |
| 2014 November | 20 | 21 | 41 |
| 2014 October | 24 | 16 | 40 |
| 2014 September | 14 | 11 | 25 |
| 2014 August | 17 | 23 | 40 |
| 2014 July | 19 | 18 | 37 |
| 2014 June | 42 | 20 | 62 |
| 2014 May | 29 | 17 | 46 |
| 2014 April | 32 | 7 | 39 |
| 2014 March | 33 | 21 | 54 |
| 2014 February | 34 | 18 | 52 |
| 2014 January | 23 | 12 | 35 |
| 2013 December | 19 | 12 | 31 |
| 2013 November | 15 | 16 | 31 |
| 2013 October | 35 | 13 | 48 |
| 2013 September | 33 | 20 | 53 |
| 2013 August | 30 | 14 | 44 |
| 2013 July | 34 | 23 | 57 |
| 2013 June | 54 | 10 | 64 |
| 2013 May | 57 | 10 | 67 |
| 2013 April | 39 | 15 | 54 |
| 2013 March | 34 | 22 | 56 |
| 2013 February | 42 | 19 | 61 |
| 2013 January | 61 | 23 | 84 |
| 2012 December | 343 | 19 | 362 |
| 2012 November | 54 | 17 | 71 |
| 2012 October | 8 | 7 | 15 |
| 2012 September | 7 | 5 | 12 |
| 2012 May | 1 | 0 | 1 |
| 2012 April | 5 | 0 | 5 |
| 2012 March | 2 | 0 | 2 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 4 | 0 | 4 |
| 2011 November | 9 | 0 | 9 |
| 2011 October | 4 | 0 | 4 |
| 2011 September | 4 | 0 | 4 |
| 2011 August | 3 | 0 | 3 |
| 2011 July | 3 | 0 | 3 |
| 2011 June | 3 | 0 | 3 |
| 2011 April | 2 | 0 | 2 |
| 2011 March | 1 | 0 | 1 |
| 2011 February | 4 | 0 | 4 |
| 2011 January | 5 | 0 | 5 |
| 2010 December | 12 | 0 | 12 |
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