MCP-1 in urine as biomarker of renal lupus in absence of cytokines, interferon-γ and growth factors
MCP-1 en orina como biomarcador de lupus renal en ausencia de citoquinas, interferón-γ y factores de crecimiento
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Romanini, Antonio Catalan Pellet, Alejandro Berra" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Liliana" "apellidos" => "Villalon" ] 1 => array:2 [ "nombre" => "Marta" "apellidos" => "Mamani" ] 2 => array:2 [ "nombre" => "Felix E." "apellidos" => "Romanini" ] 3 => array:2 [ "nombre" => "Antonio" "apellidos" => "Catalan Pellet" ] 4 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Berra" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431070068X?idApp=UINPBA00004M" "url" => "/21735743/0000000600000006/v1_201305061614/S217357431070068X/v1_201305061614/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "titulo" => "MCP-1 in urine as biomarker of renal lupus in absence of cytokines, interferon-γ and growth factors" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "296" "paginaFinal" => "298" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Julia Barbado, Luisa Vega, Rocío González-Gallego, Antonio Jimeno, Raúl Ortiz De Lejarazu, Jesús F. Bermejo-Martin" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Julia" "apellidos" => "Barbado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Luisa" "apellidos" => "Vega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Rocío" "apellidos" => "González-Gallego" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Antonio" "apellidos" => "Jimeno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Raúl Ortiz" "apellidos" => "De Lejarazu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:4 [ "nombre" => "Jesús F." "apellidos" => "Bermejo-Martin" "email" => array:1 [ 0 => "jbermejo@hcuv.sacyl.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Enfermedades Autoinmunes, Servicio de Medicina Interna, Hospital Clínico Universitario, Valladolid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Investigación en Infección e Inmunidad, Servicio de Microbiología e Inmunología, Hospital Clínico Universitario, IECSCYL, Valladolid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "MCP-1 en orina como biomarcador de lupus renal en ausencia de citoquinas, interferón-γ y factores de crecimiento" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-07-15" "fechaAceptado" => "2009-09-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112563" "palabras" => array:3 [ 0 => "Renal lupus" 1 => "Urine" 2 => "Immune mediators" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112562" "palabras" => array:3 [ 0 => "Lupus renal" 1 => "Orina" 2 => "Mediadores inmunológicos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To characterize 17 immunological markers in the Urine of patients with SLE.</p> <span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lupus nephritis is an inflammatory disease affecting the renal parenchyma. Cytokines and chemokines are key immune mediators that have been related with the pathogenesis of the disease. Obtaining non invasive prognosis markers is a highly desirable objective in order to improve the clinical management of these patients.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In this study we profiled 17 immune mediators (Th1, Th2, Th17 cytokines, chemokines and growth factors) in the urine of 25 patients with systemic lupus erythematosus with active renal disease by using a Biorad<span class="elsevierStyleSup">©</span> 17-plex kit on a Luminex<span class="elsevierStyleSup">©</span> platform. A group of healthy volunteers of similar age and comparable sex distribution was recruited as control (n=10).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Results evidenced that the only detectable mediators in urine were IL-8, MCP-1 and MIP-1b. When levels of these mediators were compared between patients and controls, significantly higher levels of MCP-1 were observed in the urine of the patients. MCP-1 levels in urine correlated positively with the SLEDAI score in a significant way and negatively with plasma levels of complement C4.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Our results reinforce the role of MCP-1 in urine as biomarker of disease activity in renal lupus, excluding the detection of other soluble immune mediators such as Th1, Th2, Th17 cytokines and growth factors as suitable markers in this non invasive sample.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Perfilar 17 medidores inmunológicos en la orina de pacientes con LES. Introducción: La nefritis lúpica es una enfermedad inflamatoria que afecta al parénquima renal. Citoquinas y quimiocinas son los mediadores inmunes dominantes relacionados con la patogénesis de la enfermedad. La obtención de marcadores de pronóstico no invasivos es un objetivo sumamente deseable para mejorar el manejo clínico de estos pacientes.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En este estudio nosotros perfilamos 17 mediadores inmunológicos (citoquinas Th1, Th2, Th17, quimiocinas y factores de crecimiento) en la orina de 25 pacientes con lupus y enfermedad renal activa usando un kit Biorad<span class="elsevierStyleSup">©</span> 17-plex en plataforma Luminex<span class="elsevierStyleSup">©</span>. Como grupo control se seleccionaron (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>10) voluntarios sanos con similar edad y sexo que los casos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los resultados evidenciaron que los únicos mediadores perceptibles en orina eran IL-8, MCP-1 y MIP-1b. Cuando los niveles de estos mediadores fueron comparados entre los pacientes y los controles, MCP-1 en la orina de los casos fue el único que aumentó de forma significativa (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05) con respecto a los controles. Estos niveles de MCP-1 en orina se correlacionaron de forma positiva con la puntuación de SLEDAI y de forma negativa con los niveles en plasma de la proteína C4 del sistema de complemento.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Nuestros resultados refuerzan el papel de MCP-1 en orina como biomarcador no invasivo de actividad de enfermedad en el lupus renal, no evidenciando la detección de otros mediadores inmunológicos solubles, como son las citoquinas Th1, Th2, Th17 y factores de crecimiento.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Urowitz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2002" "volumen" => "29" "paginaInicial" => "288" "paginaFinal" => "291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11838846" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000600000006/v1_201305061614/S2173574310700691/v1_201305061614/en/main.assets" "Apartado" => array:4 [ "identificador" => "8426" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Brief original" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000600000006/v1_201305061614/S2173574310700691/v1_201305061614/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700691?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 17 | 23 |
| 2024 October | 29 | 45 | 74 |
| 2024 September | 33 | 33 | 66 |
| 2024 August | 48 | 40 | 88 |
| 2024 July | 32 | 40 | 72 |
| 2024 June | 34 | 31 | 65 |
| 2024 May | 27 | 32 | 59 |
| 2024 April | 21 | 32 | 53 |
| 2024 March | 22 | 47 | 69 |
| 2024 February | 19 | 31 | 50 |
| 2024 January | 17 | 29 | 46 |
| 2023 December | 20 | 28 | 48 |
| 2023 November | 15 | 24 | 39 |
| 2023 October | 28 | 44 | 72 |
| 2023 September | 28 | 38 | 66 |
| 2023 August | 16 | 13 | 29 |
| 2023 July | 25 | 27 | 52 |
| 2023 June | 19 | 24 | 43 |
| 2023 May | 17 | 8 | 25 |
| 2023 April | 13 | 12 | 25 |
| 2023 March | 22 | 32 | 54 |
| 2023 February | 21 | 29 | 50 |
| 2023 January | 13 | 19 | 32 |
| 2022 December | 30 | 35 | 65 |
| 2022 November | 25 | 24 | 49 |
| 2022 October | 17 | 32 | 49 |
| 2022 September | 28 | 40 | 68 |
| 2022 August | 32 | 42 | 74 |
| 2022 July | 21 | 55 | 76 |
| 2022 June | 24 | 48 | 72 |
| 2022 May | 28 | 62 | 90 |
| 2022 April | 27 | 57 | 84 |
| 2022 March | 24 | 49 | 73 |
| 2022 February | 23 | 35 | 58 |
| 2022 January | 22 | 43 | 65 |
| 2021 December | 25 | 44 | 69 |
| 2021 November | 19 | 47 | 66 |
| 2021 October | 30 | 49 | 79 |
| 2021 September | 35 | 52 | 87 |
| 2021 August | 23 | 49 | 72 |
| 2021 July | 21 | 44 | 65 |
| 2021 June | 28 | 55 | 83 |
| 2021 May | 19 | 36 | 55 |
| 2021 April | 64 | 87 | 151 |
| 2021 March | 30 | 36 | 66 |
| 2021 February | 32 | 28 | 60 |
| 2021 January | 27 | 24 | 51 |
| 2020 December | 25 | 17 | 42 |
| 2020 November | 22 | 18 | 40 |
| 2020 October | 15 | 14 | 29 |
| 2020 September | 30 | 25 | 55 |
| 2020 August | 18 | 16 | 34 |
| 2020 July | 22 | 16 | 38 |
| 2020 June | 35 | 19 | 54 |
| 2020 May | 21 | 18 | 39 |
| 2020 April | 26 | 18 | 44 |
| 2020 March | 15 | 10 | 25 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 1 | 1 | 2 |
| 2018 April | 34 | 16 | 50 |
| 2018 March | 25 | 22 | 47 |
| 2018 February | 27 | 5 | 32 |
| 2018 January | 12 | 6 | 18 |
| 2017 December | 21 | 9 | 30 |
| 2017 November | 13 | 11 | 24 |
| 2017 October | 15 | 6 | 21 |
| 2017 September | 8 | 6 | 14 |
| 2017 August | 8 | 7 | 15 |
| 2017 July | 12 | 13 | 25 |
| 2017 June | 19 | 9 | 28 |
| 2017 May | 25 | 14 | 39 |
| 2017 April | 21 | 6 | 27 |
| 2017 March | 19 | 8 | 27 |
| 2017 February | 6 | 4 | 10 |
| 2017 January | 14 | 7 | 21 |
| 2016 December | 31 | 16 | 47 |
| 2016 November | 19 | 6 | 25 |
| 2016 October | 25 | 11 | 36 |
| 2016 September | 29 | 11 | 40 |
| 2016 August | 15 | 3 | 18 |
| 2016 July | 10 | 5 | 15 |
| 2016 June | 0 | 9 | 9 |
| 2016 May | 0 | 6 | 6 |
| 2016 April | 0 | 7 | 7 |
| 2016 March | 0 | 13 | 13 |
| 2016 February | 2 | 16 | 18 |
| 2016 January | 6 | 19 | 25 |
| 2015 December | 2 | 0 | 2 |
| 2015 November | 3 | 0 | 3 |
| 2015 October | 1 | 17 | 18 |
| 2015 September | 1 | 0 | 1 |
| 2015 July | 13 | 6 | 19 |
| 2015 June | 21 | 18 | 39 |
| 2015 May | 54 | 15 | 69 |
| 2015 April | 30 | 17 | 47 |
| 2015 March | 20 | 18 | 38 |
| 2015 February | 14 | 21 | 35 |
| 2015 January | 10 | 17 | 27 |
| 2014 December | 21 | 15 | 36 |
| 2014 November | 16 | 33 | 49 |
| 2014 October | 22 | 22 | 44 |
| 2014 September | 15 | 29 | 44 |
| 2014 August | 24 | 31 | 55 |
| 2014 July | 27 | 32 | 59 |
| 2014 June | 33 | 39 | 72 |
| 2014 May | 28 | 26 | 54 |
| 2014 April | 25 | 22 | 47 |
| 2014 March | 35 | 45 | 80 |
| 2014 February | 28 | 29 | 57 |
| 2014 January | 28 | 51 | 79 |
| 2013 December | 24 | 69 | 93 |
| 2013 November | 20 | 34 | 54 |
| 2013 October | 30 | 18 | 48 |
| 2013 September | 31 | 26 | 57 |
| 2013 August | 33 | 27 | 60 |
| 2013 July | 28 | 22 | 50 |
| 2013 June | 23 | 20 | 43 |
| 2013 May | 28 | 28 | 56 |
| 2013 April | 29 | 20 | 49 |
| 2013 March | 22 | 21 | 43 |
| 2013 February | 37 | 23 | 60 |
| 2013 January | 20 | 31 | 51 |
| 2012 December | 29 | 23 | 52 |
| 2012 November | 11 | 17 | 28 |
| 2012 October | 10 | 11 | 21 |
| 2012 September | 8 | 3 | 11 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 3 | 0 | 3 |
| 2012 May | 7 | 0 | 7 |
| 2012 April | 8 | 0 | 8 |
| 2012 March | 5 | 0 | 5 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 5 | 0 | 5 |
| 2011 November | 6 | 0 | 6 |
| 2011 October | 4 | 0 | 4 |
| 2011 September | 3 | 0 | 3 |
| 2011 August | 2 | 0 | 2 |
| 2011 July | 2 | 0 | 2 |
| 2011 June | 5 | 0 | 5 |
| 2011 May | 1 | 0 | 1 |
| 2011 April | 1 | 0 | 1 |
| 2011 March | 4 | 0 | 4 |
| 2011 February | 7 | 0 | 7 |
| 2011 January | 16 | 0 | 16 |
| 2010 December | 15 | 0 | 15 |
Show all
