Frequency of systemic manifestations in patients with primary Sjögren's syndrome in Argentina
Frecuencia de manifestaciones sistémicas en pacientes con síndrome de Sjögren primario en Argentina
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Hospital Británico de Buenos Aires, Buenos Aires, Argentina" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Frecuencia de manifestaciones sistémicas en pacientes con síndrome de Sjögren primario en Argentina" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-07-13" "fechaAceptado" => "2010-01-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112564" "palabras" => array:4 [ 0 => "Sjögren's Syndrome" 1 => "Autoimmunity" 2 => "Connective Tissue Diseases" 3 => "Xerostomia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112565" "palabras" => array:4 [ 0 => "Síndrome de Sjögren" 1 => "Autoinmunidad" 2 => "Enfermedades del tejido conectivo" 3 => "Xerostomía" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Twenty to 71% of patients with Sjögren's syndrome (SS) will develop systemic manifestations.</p> <span class="elsevierStyleSectionTitle">Objetive</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To characterize the clinical-serological presentation and the frequency of systemic manifestations in patients with primary SS.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Retrospective study including patients with SS visited in “Hospital Británico de Buenos Aires” during the period from January 2000 to August 2008.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Forty-one patients fulfilled the 2002 American-European classification criteria for SS. All patients were women. Mean age at enrollment was 57,85±12,42 years (range 26–79). Mean duration of the disease was 9,28 years (range 0,08–24). Thirty-three (80.49%) developed systemic manifestations. The most frequent were arthritis, cutaneous vasculitis and polyneuropathy. This group featured more frequently ANA titles ≥1/640 and hypocomplementemia; although no statistical significance was found. The frequency of systemic manifestations found was greater than reported in the literature.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A multidisciplinary approach focusing also on systemic manifestations should be the new standard for management of SS.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Del 20–71% de los pacientes con síndrome de Sjögren (SS) desarrolla manifestaciones sistémicas.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El objetivo fue evaluar las características clinicoserológicas y frecuencia de manifestaciones sistémicas en pacientes con SS primario.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0530" class="elsevierStyleSimplePara elsevierViewall">Material y métodos: Estudio retrospectivo con revisión de historias clínicas de pacientes con Sd de Sjögren primario visitados en el Hospital Británico de Buenos Aires en el período desde Enero de 2000 a Agosto de 2008.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 41 pacientes que cumplian criterios de clasificacion Europeoamericanos 2002 para SS, todos de sexo femenino. La edad media fue 57,85<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>12,42 anos (rango 26–79). El tiempo de evolucion fue de 9,28 anos (rango 0,08–24). Treinta y tres (80,49%) presentaron manifestaciones sistemicas. Las mas frecuentes fueron artritis, vasculitis cutanea y polineuropatia. Este grupo presento mas frecuentemente titulos de AAN ≥<span class="elsevierStyleHsp" style=""></span>1/640 e hipocomplementemia; aunque no estadisticamente significativas. La frecuencia de manifestaciones sistemicas halladas fue mayor a la reportada en otras series.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Un abordaje multidisciplinario enfocado en las manifestaciones sistémicas debería ser el nuevo estándar para el manejo del SS.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunopathogenesis of primary Sjögren's syndrome: implications for disease management and therapy (review)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Hansen" 1 => "P.E. Lipsky" 2 => "T. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 17 | 23 |
| 2024 October | 16 | 37 | 53 |
| 2024 September | 23 | 25 | 48 |
| 2024 August | 35 | 35 | 70 |
| 2024 July | 21 | 39 | 60 |
| 2024 June | 23 | 31 | 54 |
| 2024 May | 30 | 29 | 59 |
| 2024 April | 21 | 14 | 35 |
| 2024 March | 23 | 46 | 69 |
| 2024 February | 19 | 27 | 46 |
| 2024 January | 13 | 22 | 35 |
| 2023 December | 15 | 28 | 43 |
| 2023 November | 20 | 19 | 39 |
| 2023 October | 24 | 35 | 59 |
| 2023 September | 18 | 39 | 57 |
| 2023 August | 21 | 17 | 38 |
| 2023 July | 18 | 24 | 42 |
| 2023 June | 17 | 20 | 37 |
| 2023 May | 19 | 9 | 28 |
| 2023 April | 9 | 7 | 16 |
| 2023 March | 18 | 21 | 39 |
| 2023 February | 19 | 28 | 47 |
| 2023 January | 17 | 16 | 33 |
| 2022 December | 23 | 31 | 54 |
| 2022 November | 36 | 29 | 65 |
| 2022 October | 21 | 26 | 47 |
| 2022 September | 28 | 27 | 55 |
| 2022 August | 23 | 47 | 70 |
| 2022 July | 20 | 46 | 66 |
| 2022 June | 23 | 51 | 74 |
| 2022 May | 19 | 46 | 65 |
| 2022 April | 20 | 52 | 72 |
| 2022 March | 19 | 51 | 70 |
| 2022 February | 22 | 29 | 51 |
| 2022 January | 13 | 36 | 49 |
| 2021 December | 15 | 47 | 62 |
| 2021 November | 24 | 41 | 65 |
| 2021 October | 63 | 54 | 117 |
| 2021 September | 40 | 51 | 91 |
| 2021 August | 37 | 55 | 92 |
| 2021 July | 31 | 38 | 69 |
| 2021 June | 14 | 45 | 59 |
| 2021 May | 21 | 35 | 56 |
| 2021 April | 67 | 88 | 155 |
| 2021 March | 36 | 26 | 62 |
| 2021 February | 24 | 19 | 43 |
| 2021 January | 18 | 22 | 40 |
| 2020 December | 19 | 22 | 41 |
| 2020 November | 19 | 22 | 41 |
| 2020 October | 5 | 35 | 40 |
| 2020 September | 42 | 22 | 64 |
| 2020 August | 14 | 15 | 29 |
| 2020 July | 32 | 15 | 47 |
| 2020 June | 20 | 32 | 52 |
| 2020 May | 36 | 20 | 56 |
| 2020 April | 39 | 23 | 62 |
| 2020 March | 20 | 11 | 31 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 16 | 0 | 16 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 2 | 1 | 3 |
| 2018 April | 30 | 18 | 48 |
| 2018 March | 34 | 25 | 59 |
| 2018 February | 23 | 10 | 33 |
| 2018 January | 16 | 10 | 26 |
| 2017 December | 19 | 11 | 30 |
| 2017 November | 17 | 9 | 26 |
| 2017 October | 14 | 9 | 23 |
| 2017 September | 14 | 15 | 29 |
| 2017 August | 10 | 9 | 19 |
| 2017 July | 29 | 15 | 44 |
| 2017 June | 35 | 5 | 40 |
| 2017 May | 23 | 15 | 38 |
| 2017 April | 18 | 7 | 25 |
| 2017 March | 13 | 9 | 22 |
| 2017 February | 8 | 8 | 16 |
| 2017 January | 9 | 8 | 17 |
| 2016 December | 32 | 17 | 49 |
| 2016 November | 21 | 9 | 30 |
| 2016 October | 34 | 8 | 42 |
| 2016 September | 27 | 8 | 35 |
| 2016 August | 17 | 4 | 21 |
| 2016 July | 11 | 4 | 15 |
| 2016 February | 2 | 0 | 2 |
| 2016 January | 3 | 0 | 3 |
| 2015 December | 3 | 0 | 3 |
| 2015 November | 3 | 0 | 3 |
| 2015 October | 0 | 16 | 16 |
| 2015 September | 5 | 0 | 5 |
| 2015 August | 14 | 0 | 14 |
| 2015 July | 18 | 7 | 25 |
| 2015 June | 26 | 14 | 40 |
| 2015 May | 29 | 23 | 52 |
| 2015 April | 30 | 10 | 40 |
| 2015 March | 18 | 37 | 55 |
| 2015 February | 24 | 9 | 33 |
| 2015 January | 13 | 30 | 43 |
| 2014 December | 23 | 17 | 40 |
| 2014 November | 15 | 19 | 34 |
| 2014 October | 21 | 17 | 38 |
| 2014 September | 13 | 24 | 37 |
| 2014 August | 25 | 17 | 42 |
| 2014 July | 22 | 17 | 39 |
| 2014 June | 36 | 17 | 53 |
| 2014 May | 33 | 19 | 52 |
| 2014 April | 32 | 11 | 43 |
| 2014 March | 44 | 18 | 62 |
| 2014 February | 25 | 14 | 39 |
| 2014 January | 28 | 8 | 36 |
| 2013 December | 24 | 16 | 40 |
| 2013 November | 25 | 16 | 41 |
| 2013 October | 31 | 13 | 44 |
| 2013 September | 30 | 12 | 42 |
| 2013 August | 33 | 14 | 47 |
| 2013 July | 37 | 12 | 49 |
| 2013 June | 23 | 8 | 31 |
| 2013 May | 23 | 15 | 38 |
| 2013 April | 16 | 18 | 34 |
| 2013 March | 26 | 10 | 36 |
| 2013 February | 29 | 11 | 40 |
| 2013 January | 18 | 24 | 42 |
| 2012 December | 20 | 16 | 36 |
| 2012 November | 14 | 11 | 25 |
| 2012 October | 6 | 8 | 14 |
| 2012 September | 9 | 5 | 14 |
| 2012 June | 1 | 0 | 1 |
| 2012 May | 1 | 0 | 1 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 5 | 0 | 5 |
| 2012 January | 7 | 0 | 7 |
| 2011 December | 4 | 0 | 4 |
| 2011 November | 4 | 0 | 4 |
| 2011 October | 3 | 0 | 3 |
| 2011 June | 4 | 0 | 4 |
| 2011 May | 1 | 0 | 1 |
| 2011 April | 1 | 0 | 1 |
| 2011 March | 3 | 0 | 3 |
| 2011 February | 2 | 0 | 2 |
| 2011 January | 4 | 0 | 4 |
| 2010 December | 13 | 0 | 13 |
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