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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las enfermedades autoinflamatorias sist&#233;micas engloban un conjunto de enfermedades poco frecuentes caracterizadas todas ellas por la presencia de episodios inflamatorios agudos y recurrentes&#44; que son consecuencia de una disregulaci&#243;n del control del proceso inflamatorio&#46; Desde sus respectivas descripciones cl&#237;nicas&#44; se hab&#237;a observado un claro patr&#243;n hereditario mendeliano para algunas de ellas&#46; En fechas recientes se han identificado los defectos gen&#233;ticos y moleculares subyacentes al identificarse mutaciones responsables de enfermedad en diferentes genes relacionados con la respuesta inmune innata y con la inflamaci&#243;n&#46; A lo largo de la presente revisi&#243;n se abordar&#225;n de una manera actualizada los principales aspectos cl&#237;nicos&#44; fisiopatol&#243;gicos y terap&#233;uticos de las diferentes enfermedades autoinflamatorias hereditarias&#46;</p>"
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Review
Hereditary systemic autoinflammatory diseases
Enfermedades autoinflamatorias sistémicas hereditarias
Juan I. Aróstegui
Unidad de Enfermedades Autoinflamatorias, Servicio de Inmunología, Hospital Clínic, Villarroel, Barcelona, Spain
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    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Juan I&#46; Ar&#243;stegui"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "Juan I&#46;"
            "apellidos" => "Ar&#243;stegui"
            "email" => array:1 [
              0 => "jiaroste&#64;clinic&#46;ub&#46;es"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Unidad de Enfermedades Autoinflamatorias&#44; Servicio de Inmunolog&#237;a&#44; Hospital Cl&#237;nic&#44; Villarroel&#44; Barcelona&#44; Spain"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Enfermedades autoinflamatorias sist&#233;micas hereditarias"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-01-07"
    "fechaAceptado" => "2010-01-10"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec112622"
          "palabras" => array:8 [
            0 => "Autoinflammatory diseases"
            1 => "Hereditary periodic fever syndrome"
            2 => "Innate immune response"
            3 => "Inflammasome"
            4 => "Nod-like receptor"
            5 => "Pyrin"
            6 => "Interleukin-1beta"
            7 => "TNF"
          ]
        ]
      ]
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec112623"
          "palabras" => array:8 [
            0 => "Enfermedades autoinflamatorias"
            1 => "S&#237;ndromes hereditarios de fiebre peri&#243;dica"
            2 => "Respuesta inmune innata"
            3 => "Inflamasoma"
            4 => "Nod-like receptor"
            5 => "Pirina"
            6 => "Interleucina-1beta"
            7 => "TNF"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Systemic autoinflammatory diseases encompass different rare clinical entities characterized by recurrent acute inflammatory episodes secondary to a dysregulated inflammatory process&#46; Since their first clinical descriptions&#44; the Mendelian hereditary nature of some of them became evident&#44; with their genetic and molecular basis being recently elucidated&#46; There are disease-causing mutations in genes encoding for different proteins involved in the innate immune response and inflammation&#46; Herein&#44; we will introduce the reader to an updated review of the main clinical&#44; physiopathological and therapeutic features of the different hereditary systemic autoinflammatory diseases&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las enfermedades autoinflamatorias sist&#233;micas engloban un conjunto de enfermedades poco frecuentes caracterizadas todas ellas por la presencia de episodios inflamatorios agudos y recurrentes&#44; que son consecuencia de una disregulaci&#243;n del control del proceso inflamatorio&#46; Desde sus respectivas descripciones cl&#237;nicas&#44; se hab&#237;a observado un claro patr&#243;n hereditario mendeliano para algunas de ellas&#46; En fechas recientes se han identificado los defectos gen&#233;ticos y moleculares subyacentes al identificarse mutaciones responsables de enfermedad en diferentes genes relacionados con la respuesta inmune innata y con la inflamaci&#243;n&#46; A lo largo de la presente revisi&#243;n se abordar&#225;n de una manera actualizada los principales aspectos cl&#237;nicos&#44; fisiopatol&#243;gicos y terap&#233;uticos de las diferentes enfermedades autoinflamatorias hereditarias&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
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        0 => array:2 [
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Article information
ISSN: 21735743
Original language: English
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