was read the article
array:23 [ "pii" => "S2173574311700077" "issn" => "21735743" "doi" => "10.1016/S2173-5743(11)70007-7" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "70007" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Reumatol Clin. 2011;7:45-50" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2813 "formatos" => array:3 [ "EPUB" => 57 "HTML" => 1538 "PDF" => 1218 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173574311700089" "issn" => "21735743" "doi" => "10.1016/S2173-5743(11)70008-9" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "70008" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Reumatol Clin. 2011;7:51-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2424 "formatos" => array:3 [ "EPUB" => 50 "HTML" => 1558 "PDF" => 816 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Anti-TNFα therapy in ankylosing spondylitis: symptom control and structural damage modification" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "51" "paginaFinal" => "55" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Terapia anti-TNFα en espondilitis anquilosante: control sintomático y modificación del daño estructural" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Luis Andreu, Teresa Otón, Jesús Sanz" "autores" => array:3 [ 0 => array:2 [ "nombre" => "José Luis" "apellidos" => "Andreu" ] 1 => array:2 [ "nombre" => "Teresa" "apellidos" => "Otón" ] 2 => array:2 [ "nombre" => "Jesús" "apellidos" => "Sanz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700089?idApp=UINPBA00004M" "url" => "/21735743/0000000700000001/v1_201305061616/S2173574311700089/v1_201305061616/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173574311700065" "issn" => "21735743" "doi" => "10.1016/S2173-5743(11)70006-5" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "70006" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2011;7:30-44" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2650 "formatos" => array:3 [ "EPUB" => 56 "HTML" => 1829 "PDF" => 765 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Consensus on the use of Rituximab in Rheumatoid Arthritis. A document with evidence based recommendations" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "30" "paginaFinal" => "44" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Consenso de uso de rituximab en artritis reumatoide. Un documento con recomendaciones basadas en la evidencia" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Emilio Martín Mola, Blanca Hernández, Miriam García-Arias, José María Álvaro-Gracia, Alejandro Balsa, Juan Gómez-Reino, José L. Marenco de la Fuente, Víctor Martínez-Taboada, José Andrés Román Ivorra, Raimon Sanmartí" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Emilio" "apellidos" => "Martín Mola" ] 1 => array:2 [ "nombre" => "Blanca" "apellidos" => "Hernández" ] 2 => array:2 [ "nombre" => "Miriam" "apellidos" => "García-Arias" ] 3 => array:2 [ "nombre" => "José María" "apellidos" => "Álvaro-Gracia" ] 4 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Balsa" ] 5 => array:2 [ "nombre" => "Juan" "apellidos" => "Gómez-Reino" ] 6 => array:2 [ "nombre" => "José L." "apellidos" => "Marenco de la Fuente" ] 7 => array:2 [ "nombre" => "Víctor" "apellidos" => "Martínez-Taboada" ] 8 => array:2 [ "nombre" => "José Andrés Román" "apellidos" => "Ivorra" ] 9 => array:2 [ "nombre" => "Raimon" "apellidos" => "Sanmartí" ] 10 => array:1 [ "colaborador" => "Expert Group on Rituximab" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700065?idApp=UINPBA00004M" "url" => "/21735743/0000000700000001/v1_201305061616/S2173574311700065/v1_201305061616/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Hereditary systemic autoinflammatory diseases" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "45" "paginaFinal" => "50" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Juan I. Aróstegui" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Juan I." "apellidos" => "Aróstegui" "email" => array:1 [ 0 => "jiaroste@clinic.ub.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Enfermedades Autoinflamatorias, Servicio de Inmunología, Hospital Clínic, Villarroel, Barcelona, Spain" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedades autoinflamatorias sistémicas hereditarias" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-07" "fechaAceptado" => "2010-01-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112622" "palabras" => array:8 [ 0 => "Autoinflammatory diseases" 1 => "Hereditary periodic fever syndrome" 2 => "Innate immune response" 3 => "Inflammasome" 4 => "Nod-like receptor" 5 => "Pyrin" 6 => "Interleukin-1beta" 7 => "TNF" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112623" "palabras" => array:8 [ 0 => "Enfermedades autoinflamatorias" 1 => "Síndromes hereditarios de fiebre periódica" 2 => "Respuesta inmune innata" 3 => "Inflamasoma" 4 => "Nod-like receptor" 5 => "Pirina" 6 => "Interleucina-1beta" 7 => "TNF" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Systemic autoinflammatory diseases encompass different rare clinical entities characterized by recurrent acute inflammatory episodes secondary to a dysregulated inflammatory process. Since their first clinical descriptions, the Mendelian hereditary nature of some of them became evident, with their genetic and molecular basis being recently elucidated. There are disease-causing mutations in genes encoding for different proteins involved in the innate immune response and inflammation. Herein, we will introduce the reader to an updated review of the main clinical, physiopathological and therapeutic features of the different hereditary systemic autoinflammatory diseases.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las enfermedades autoinflamatorias sistémicas engloban un conjunto de enfermedades poco frecuentes caracterizadas todas ellas por la presencia de episodios inflamatorios agudos y recurrentes, que son consecuencia de una disregulación del control del proceso inflamatorio. Desde sus respectivas descripciones clínicas, se había observado un claro patrón hereditario mendeliano para algunas de ellas. En fechas recientes se han identificado los defectos genéticos y moleculares subyacentes al identificarse mutaciones responsables de enfermedad en diferentes genes relacionados con la respuesta inmune innata y con la inflamación. A lo largo de la presente revisión se abordarán de una manera actualizada los principales aspectos clínicos, fisiopatológicos y terapéuticos de las diferentes enfermedades autoinflamatorias hereditarias.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:73 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.F. McDermott" 1 => "I. Aksentijevich" 2 => "J. Galon" 3 => "E.M. McDermott" 4 => "B.W. Ogunkolade" 5 => "M. Centola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1999" "volumen" => "97" "paginaInicial" => "133" "paginaFinal" => "144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10199409" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chapter 27: Periodic fever syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.L. Kastner" 1 => "S. Brydges" 2 => "K.M. Hull" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Primary immunodeficiency diseases. A molecular and genetic approach" "paginaInicial" => "367" "paginaFinal" => "389" "edicion" => "Second edition" "serieFecha" => "2007" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The systemic autoinflammatory diseases: inborn errors of the innate immune system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Brydges" 1 => "D.L. Kastner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Top Microbiol Immunol." "fecha" => "2006" "volumen" => "305" "paginaInicial" => "127" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16724804" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hereditary periodic fever" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.P.H. Drenth" 1 => "J.W.M. Van Der Meer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra010200" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2001" "volumen" => "345" "paginaInicial" => "1748" "paginaFinal" => "1757" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11742050" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Samuels" 1 => "I. Aksentijevich" 2 => "Y. Torosyan" 3 => "M. Centola" 4 => "Z. Deng" 5 => "R. Sood" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicine (Baltimore)." "fecha" => "1998" "volumen" => "77" "paginaInicial" => "268" "paginaFinal" => "297" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9715731" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial Mediterranean fever" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Ben-Chetrit" 1 => "M. Levy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(97)09408-7" "Revista" => array:6 [ "tituloSerie" => "Lancet." "fecha" => "1998" "volumen" => "351" "paginaInicial" => "659" "paginaFinal" => "664" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9500348" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Natural History and outcome in systemic AA amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.J. Lachmann" 1 => "H.J.B. Goodman" 2 => "J.A. Gilbertson" 3 => "J.R. Galimore" 4 => "C.A. Sabin" 5 => "J.D. Gilmore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa070265" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "2007" "volumen" => "356" "paginaInicial" => "2361" "paginaFinal" => "2371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17554117" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prophylactic colchicine therapy in familial Mediterranean fever. A controlled, double-blind study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.C. Goldstein" 1 => "A.D. Schwabe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Intern Med." "fecha" => "1974" "volumen" => "81" "paginaInicial" => "792" "paginaFinal" => "794" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4611296" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109797003197" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Colchicine therapy for Familial Mediterranean Fever. A double-blind trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.A. Dinarello" 1 => "S.M. Wolff" 2 => "S.E. Goldfinger" 3 => "D.C. Dale" 4 => "D.W. Alling" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM197410312911804" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "1974" "volumen" => "291" "paginaInicial" => "934" "paginaFinal" => "937" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4606353" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A controlled trial of colchicine in preventing attacks of familial Mediterranean fever" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Zemer" 1 => "M. Revach" 2 => "M. Pras" 3 => "B. Modan" 4 => "S. Schor" 5 => "E. Sohar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM197410312911803" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "1974" "volumen" => "291" "paginaInicial" => "932" "paginaFinal" => "934" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4606109" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The International FMF Consortium" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1997" "volumen" => "90" "paginaInicial" => "797" "paginaFinal" => "807" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9288758" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A candidate gene for familial Mediterranean fever" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The French FMF Consortium" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng0997-25" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "1997" "volumen" => "17" "paginaInicial" => "25" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9288094" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-b" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Martinon" 1 => "K. Burns" 2 => "J. Tschopp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mol Cell." "fecha" => "2002" "volumen" => "10" "paginaInicial" => "417" "paginaFinal" => "426" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12191486" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations in the MEFV gene in a large series of patients with a clinical diagnosis of familial Mediterranean fever" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Dode" 1 => "C. Pecheux" 2 => "C. Cazeneuve" 3 => "D. Cattan" 4 => "M. Dervichian" 5 => "M. Goossens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet." "fecha" => "2000" "volumen" => "92" "paginaInicial" => "241" "paginaFinal" => "246" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10842288" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial hibernian fever" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.M. Williamson" 1 => "D. Hull" 2 => "R. Mehta" 3 => "W.G. Reeves" 4 => "B.H. Robinson" 5 => "P.J. Toghill" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Quart J Med." "fecha" => "1982" "volumen" => "51" "paginaInicial" => "469" "paginaFinal" => "480" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7156325" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene localization for an autosomal dominant familial periodic fever to 12p13" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Mulley" 1 => "K. Saar" 2 => "G. Hewitt" 3 => "F. Rüschendorf" 4 => "H. Phillips" 5 => "A. Colley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/301793" "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet." "fecha" => "1998" "volumen" => "62" "paginaInicial" => "884" "paginaFinal" => "889" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9529351" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autosomal dominant “Mediterranean fever” in a Finnishf amily" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Karenko" 1 => "T. Pettersson" 2 => "P. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Int Med." "fecha" => "1992" "volumen" => "232" "paginaInicial" => "365" "paginaFinal" => "369" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.M. Hull" 1 => "E. Drewe" 2 => "I. Aksentijevich" 3 => "H.K. Singh" 4 => "K. Wong" 5 => "E.M. McDermott" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicine (Baltimore)." "fecha" => "2002" "volumen" => "81" "paginaInicial" => "349" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12352631" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "INFEVERS: an evolving mutation database for auto-inflammatory syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Touitou" 1 => "S. Lesage" 2 => "M.F. McDermott" 3 => "L. Cuisset" 4 => "H. Hoffman" 5 => "C. Dode" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/humu.20080" "Revista" => array:6 [ "tituloSerie" => "Hum Mut." "fecha" => "2004" "volumen" => "24" "paginaInicial" => "194" "paginaFinal" => "198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15300846" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective study of anti-tumour necrosis factor receptor superfamily 1B fusion protein, and case study of anti-tumour necrosis factor receptor superfamily 1A fusion protein, in tumour necrosis factor receptor associated periodic syndrome (TRAPS): clinical and laboratory findings in a series of seven patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Drewe" 1 => "E.M. McDermott" 2 => "P.T. Powell" 3 => "J.D. Isaacs" 4 => "R.J. Powell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheumatology." "fecha" => "2003" "volumen" => "42" "paginaInicial" => "235" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12595616" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hereditary periodic fever" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.M. Hull" 1 => "D.L. Kastner" 2 => "J.E. Balow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med." "fecha" => "2002" "volumen" => "346" "paginaInicial" => "1415" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11987326" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etanercept plus colchicine treatment in a child with tumour necrosis factor receptor-associated periodic syndrome abolishes auto-inflammatory episodes without normalising the subclinical acute phase response" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.I. Arostegui" 1 => "P. Solis" 2 => "A. Aldea" 3 => "T. Cantero" 4 => "J. Rius" 5 => "P. Bahillo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00431-004-1563-1" "Revista" => array:6 [ "tituloSerie" => "Eur J Pediatr." "fecha" => "2005" "volumen" => "164" "paginaInicial" => "13" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15549379" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beneficial response to interleukin 1 receptor antagonist in TRAPS" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Simon" 1 => "E.J. Bodar" 2 => "J.C.H. Vander Hilst" 3 => "J.V.M. Van der Meer" 4 => "T.J.W. Fiselier" 5 => "M.P.J. Cuppen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med." "fecha" => "2004" "volumen" => "117" "paginaInicial" => "208" "paginaFinal" => "210" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15300976" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistent efficacy of anakinra in patients with tumor necrosis factor receptor- associated periodic syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Gattorno" 1 => "M.A. Pelagatti" 2 => "A. Meini" 3 => "L. Obici" 4 => "R. Barcellona" 5 => "S. Federici" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.23475" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2008" "volumen" => "58" "paginaInicial" => "1516" "paginaFinal" => "1529" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18438813" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyperimmunoglobulinaemia D and periodic fever: a new syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.W. Van der Meer" 1 => "J.M. Vossen" 2 => "J. Radl" 3 => "J.A. Van Nieuwkoop" 4 => "C.J. Meyer" 5 => "S. Lobatto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet." "fecha" => "1984" "volumen" => "1" "paginaInicial" => "1087" "paginaFinal" => "1090" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2566041" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrumina series of 50 patients" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "International Hyper-IgD study group" "etal" => false "autores" => array:3 [ 0 => "J.P.H. Drenth" 1 => "C.J. Haagsma" 2 => "J.W. Van der Meer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicine (Baltimore)." "fecha" => "1994" "volumen" => "73" "paginaInicial" => "133" "paginaFinal" => "144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8190036" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term follow-up, linical features, and quality of lifeina series of 103 patients with hyperimmunoglobulinemia D syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.C.H. Van der Hilst" 1 => "E.J. Bodar" 2 => "K.S. Barron" 3 => "J. Frenkel" 4 => "J.P.H. Drenth" 5 => "J.W.M. Van der Meer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MD.0b013e318190cfb7" "Revista" => array:6 [ "tituloSerie" => "Medicine (Baltimore)." "fecha" => "2008" "volumen" => "87" "paginaInicial" => "301" "paginaFinal" => "310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19011501" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First report of systemic reactive (AA) amyloidosis in a patient with the hyperimmunoglobulinemia D with periodic fever syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Obici" 1 => "C. Manno" 2 => "A.O. Muda" 3 => "P. Picco" 4 => "A. D’Osualdo" 5 => "G. Palladini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.20490" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2004" "volumen" => "50" "paginaInicial" => "2966" "paginaFinal" => "2969" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15457465" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "AA amyloidosis complicating hyperimmunoglobulinemia D with periodic fever syndrome: are port of two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.J. Lachmann" 1 => "H.J. Goodman" 2 => "P.A. Andrews" 3 => "H. Gallagher" 4 => "J. Marsh" 5 => "S. Breuer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.21901" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2006" "volumen" => "54" "paginaInicial" => "2010" "paginaFinal" => "2014" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16732551" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.M. Houten" 1 => "W. Kuis" 2 => "M. Duran" 3 => "T.J. De Koning" 4 => "A. Van Royen-Kerkhof" 5 => "G.J. Romeijn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/9691" "Revista" => array:6 [ "tituloSerie" => "Nat Genet." "fecha" => "1999" "volumen" => "22" "paginaInicial" => "175" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10369261" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "International Hyper-IgD Study Group" "etal" => true "autores" => array:6 [ 0 => "J.P. Drenth" 1 => "L. Cuisset" 2 => "G. Grateau" 3 => "C. Vasseur" 4 => "S.D. Van de Velde-Visser" 5 => "J.G. DeJong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/9696" "Revista" => array:6 [ "tituloSerie" => "Nat Genet." "fecha" => "1999" "volumen" => "22" "paginaInicial" => "178" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10369262" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mevalonic aciduria: an inborn error of cholesterol and nonsterol isoprene biosynthesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.F. Hoffmann" 1 => "K.M. Gibson" 2 => "I.K. Brandt" 3 => "P.I. Bader" 4 => "R.S. Wappner" 5 => "L. Sweetman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198606193142504" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "1986" "volumen" => "314" "paginaInicial" => "1610" "paginaFinal" => "1614" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3012338" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mevalonate kinase deficiency: evidence for a phenotypic continuum" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Simon" 1 => "H.P.H. Kremer" 2 => "R.A. Wevers" 3 => "H. Scheffer" 4 => "J.G. De Jong" 5 => "J.W.M. Van der Meer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology." "fecha" => "2004" "volumen" => "62" "paginaInicial" => "994" "paginaFinal" => "997" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15037710" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Cuisset" 1 => "J.P.H. Drenth" 2 => "A. Simon" 3 => "M.F. Vincent" 4 => "S. Van der Velde Visser" 5 => "J.W.M. Van der Meer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ejhg.5200614" "Revista" => array:6 [ "tituloSerie" => "Eur J Hum Genet." "fecha" => "2001" "volumen" => "9" "paginaInicial" => "260" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11313769" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-steroidal anti-inflammatory drugs in the treatment of hyper-IgD syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Picco" 1 => "M. Gattorno" 2 => "M. Di Rocco" 3 => "A. Buoncompagni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Rheum Dis." "fecha" => "2001" "volumen" => "60" "paginaInicial" => "904" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11534513" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.P.H. Drenth" 1 => "A.G. Vonk" 2 => "A. Simon" 3 => "R. Powell" 4 => "J.W.M. Van der Meer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pharmacol Exp Ther." "fecha" => "2001" "volumen" => "298" "paginaInicial" => "1221" "paginaFinal" => "1226" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11504824" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Favorable preliminary experience with etanercept in two patients with the hyperimmunoglobulinemia D and periodic fever syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Takada" 1 => "I. Aksentijevich" 2 => "V. Mahadevan" 3 => "J.A. Dean" 4 => "R.I. Kelley" 5 => "D.L. Kastner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.11218" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2003" "volumen" => "48" "paginaInicial" => "2645" "paginaFinal" => "2651" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13130485" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Simon" 1 => "E. Drewe" 2 => "J.W. Van der Meer" 3 => "R.J. Powell" 4 => "R.I. Kelley" 5 => "A.F.H. Stalenhoef" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clpt.2004.01.012" "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacol Ther." "fecha" => "2004" "volumen" => "75" "paginaInicial" => "476" "paginaFinal" => "483" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15116060" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of etanercept and anakinra on inflammatory attacks in the hyper-IgD syndrome: introducing a vaccination provocation model" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.J. Bodar" 1 => "J.C.H. Van der Hilst" 2 => "J.P.H. Drenth" 3 => "J.W.M. Van der Meer" 4 => "A. Simon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neth J Med." "fecha" => "2005" "volumen" => "63" "paginaInicial" => "260" "paginaFinal" => "264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16093577" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Cailliez" 1 => "F. Garaix" 2 => "C. Rousset-Rouviere" 3 => "D. Bruno" 4 => "I. Kone-Paut" 5 => "J. Sarles" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10545-006-0408-7" "Revista" => array:5 [ "tituloSerie" => "J Inherit Metab Dis." "fecha" => "2006" "volumen" => "29" "paginaInicial" => "763" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17103011" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of coldurticaria with an unusual family history" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.L. Kile" 1 => "H.A. Rusk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Med Assoc." "fecha" => "1940" "volumen" => "114" "paginaInicial" => "1067" "paginaFinal" => "1068" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial urticarial due to cold" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F.G. Witherspoon" 1 => "C.B. White" 2 => "H. Hailey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Dermatol Syphilol." "fecha" => "1948" "volumen" => "58" "paginaInicial" => "52" "paginaFinal" => "55" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urticaria, deafness, and amyloidosis: a new heredo-familial syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.J. Muckle" 1 => "M. Wells" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "QJM" "fecha" => "1962" "volumen" => "31" "paginaInicial" => "235" "paginaFinal" => "248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14476827" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arthropathy with rash, chronic meningitis, eye lesions, and mental retardation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Prieur" 1 => "C. Griscelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "1981" "volumen" => "99" "paginaInicial" => "79" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7252669" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A chronic, infantile, neurological, cutaneous and articular (CINCA) syndrome. A specific entity analysed in 30 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.M. Prieur" 1 => "C. Griscelli" 2 => "F. Lampert" 3 => "H. Truckenbrodt" 4 => "M.A. Guggenheim" 5 => "D.J. Lovell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatology." "fecha" => "1987" "volumen" => "66" "numero" => "Suppl" "paginaInicial" => "57" "paginaFinal" => "68" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations of a new gene encoding a putative pyrin-like protein causes familial cold autoinflamatory syndrome and Muckle-Wells syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.M. Hoffman" 1 => "J.L. Mueller" 2 => "D.H. Broide" 3 => "A.A. Wanderer" 4 => "R.D. Kolodner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng756" "Revista" => array:6 [ "tituloSerie" => "Nature Genet." "fecha" => "2001" "volumen" => "29" "paginaInicial" => "301" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11687797" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic Infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Feldman" 1 => "A.M. Prieur" 2 => "P. Quartier" 3 => "P. Berquin" 4 => "S. Certain" 5 => "E. Cortis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet." "fecha" => "2002" "volumen" => "71" "paginaInicial" => "198" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12032915" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CATERPILLERs, pyrin and hereditary immunological disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.P.Y. Ting" 1 => "D.L. Kastner" 2 => "H.M. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nri1788" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Immunol." "fecha" => "2006" "volumen" => "6" "paginaInicial" => "183" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16498449" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-1-receptor antagonist in the Muckle-Wells syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.N. Hawkins" 1 => "H.J. Lachmann" 2 => "M.F. McDermott" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM200306193482523" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "2003" "volumen" => "348" "paginaInicial" => "2583" "paginaFinal" => "2584" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12815153" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.M. Hoffman" 1 => "S. Rosengren" 2 => "D.L. Boyle" 3 => "J.Y. Cho" 4 => "J. Nayar" 5 => "J.L. Mueller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(04)17401-1" "Revista" => array:6 [ "tituloSerie" => "Lancet." "fecha" => "2004" "volumen" => "364" "paginaInicial" => "1779" "paginaFinal" => "1785" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15541451" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Positive clinical and biochemical responses to anakinraina 3-yr-old patient with cryopyrin-associated periodic syndrome (CAPS)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Ramos" 1 => "J.I. Arostegui" 2 => "S. Campuzano" 3 => "J. Rius" 4 => "C. Bousoño" 5 => "J. Yague" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/keh652" "Revista" => array:6 [ "tituloSerie" => "Rheumatology." "fecha" => "2005" "volumen" => "44" "paginaInicial" => "1072" "paginaFinal" => "1073" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15840596" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal-onset multisystem inflammatory disease responsive to interleukin-1b inhibition" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Goldbach-Mansky" 1 => "N.J. Dailey" 2 => "S.W. Canna" 3 => "A. Gelabert" 4 => "J. Jones" 5 => "B.I. Rubin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa055137" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "2006" "volumen" => "355" "paginaInicial" => "581" "paginaFinal" => "592" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16899778" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.M. Hoffman" 1 => "M.L. Throne" 2 => "N.J. Amar" 3 => "M. Sebai" 4 => "A.J. Kivitz" 5 => "A. Kavanaugh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.23687" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2008" "volumen" => "58" "paginaInicial" => "2443" "paginaFinal" => "2452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18668535" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Goldbach-Mansky" 1 => "S.D. Shroff" 2 => "M. Wilson" 3 => "C. Snyder" 4 => "S. Plenh" 5 => "B. Barham" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.23620" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2008" "volumen" => "58" "paginaInicial" => "2432" "paginaFinal" => "2442" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18668591" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoid arthritis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.F. North Jr." 1 => "C.W. Fink" 2 => "W.M. Gibson" 3 => "J.E. Levinson" 4 => "S.L. Schuchter" 5 => "W.K. Howard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med." "fecha" => "1970" "volumen" => "48" "paginaInicial" => "449" "paginaFinal" => "455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5444300" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis in a young child" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Gluck" 1 => "J.J. Miller 3rd" 2 => "W.T. Summerlin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "1972" "volumen" => "81" "paginaInicial" => "354" "paginaFinal" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5042499" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial granulomatous arthritis, iritis, and rash" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.B. Blau" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "1985" "volumen" => "107" "paginaInicial" => "689" "paginaFinal" => "693" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4056967" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial granulomatous synovitis, uveitis, and cranial neuropathies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.A. Jabs" 1 => "J.L. Houk" 2 => "W.B. Bias" 3 => "F.C. Arnett" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med." "fecha" => "1985" "volumen" => "78" "paginaInicial" => "801" "paginaFinal" => "804" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3993660" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early-onset “sarcoidosis” and “familial granulomatous arthritis (arteritis)”: the same disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.J. Miller 3rd." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "1986" "volumen" => "109" "paginaInicial" => "387" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3734978" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Earlyonset sarcoidosis and CARD15 mutations with constitutive enuclear factor-kappaB activation: common genetic etiology with Blau syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Kanazawa" 1 => "I. Okafuji" 2 => "N. Kambe" 3 => "R. Nishikomori" 4 => "M. Nakata-Hizume" 5 => "S. Nagai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2004-07-2972" "Revista" => array:6 [ "tituloSerie" => "Blood." "fecha" => "2005" "volumen" => "105" "paginaInicial" => "1195" "paginaFinal" => "1197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15459013" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pediatric granulomatous arthritis. An international registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.D. Rose" 1 => "C.H. Wouters" 2 => "S. Meiorin" 3 => "T.M. Doyle" 4 => "M.P. Davey" 5 => "J.T. Rosenbaum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.22122" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2006" "volumen" => "54" "paginaInicial" => "3337" "paginaFinal" => "3344" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17009307" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "NOD2 gene-associated Pediatric granulomatous arthritis. Clinical diversity, novel and recurrent mutations and evidence of clinical improvement with interleukin-1 blockade in a Spanish cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.I. Aróstegui" 1 => "C. Arnal" 2 => "R. Merino" 3 => "C. Modesto" 4 => "M.A. Carballo" 5 => "P. Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.22966" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2007" "volumen" => "56" "paginaInicial" => "3805" "paginaFinal" => "3813" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17968944" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CARD15 mutations in Blau syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Miceli-Richard" 1 => "S. Lesage" 2 => "M. Rybojad" 3 => "A.M. Prieur" 4 => "S. Manouvrier-Hanu" 5 => "R. Hafner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng720" "Revista" => array:7 [ "tituloSerie" => "Nat Genet." "fecha" => "2001" "volumen" => "29" "paginaInicial" => "19" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11528384" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109798003106" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib64" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "NODs: intracellular proteins involved in inflammation and apoptosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Inohara" 1 => "G. Nunez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nature Rev Immunol." "fecha" => "2003" "volumen" => "3" "paginaInicial" => "371" "paginaFinal" => "382" ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib65" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sporadic Blau syndrome with a double CARD15 mutation. Report of a case with lifelong follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Priori" 1 => "M. Bombardieri" 2 => "F.R. Spinelli" 3 => "F. Merlin" 4 => "C. Miceli-Richard" 5 => "M. La Cava" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sarcoidosis Vasc Diffuse Lung Dis." "fecha" => "2004" "volumen" => "21" "paginaInicial" => "228" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15554080" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib66" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blau syndrome mutation of CARD15/NOD2 in sporadic early onset granulomatous arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.D. Rose" 1 => "T.M. Doyle" 2 => "G. McIlvain-Simpson" 3 => "J.E. Coffman" 4 => "J.T. Rosenbaum" 5 => "M.P. Davey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol." "fecha" => "2005" "volumen" => "32" "paginaInicial" => "335" "paginaFinal" => "373" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15693096" "web" => "Medline" ] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib67" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.M. Lindor" 1 => "T.M. Arsenault" 2 => "H. Solomon" 3 => "C.E. Seidman" 4 => "M.T. McEvoy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0025-6196(11)63565-9" "Revista" => array:6 [ "tituloSerie" => "Mayo Clin Proc." "fecha" => "1997" "volumen" => "72" "paginaInicial" => "611" "paginaFinal" => "615" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9212761" "web" => "Medline" ] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib68" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Localization of a gene for familial recurrent arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.A. Wise" 1 => "L.B. Bennett" 2 => "V. Pascual" 3 => "J.D. Gillum" 4 => "A.M. Bowcock" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(200009)43:9<2041::AID-ANR15>3.0.CO;2-G" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum." "fecha" => "2000" "volumen" => "43" "paginaInicial" => "2041" "paginaFinal" => "2045" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11014354" "web" => "Medline" ] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib69" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.A. Wise" 1 => "J.D. Gillum" 2 => "C.E. Seidman" 3 => "N.M. Lindor" 4 => "R. Veile" 5 => "S. Bashiardes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Mol Genet." "fecha" => "2002" "volumen" => "11" "paginaInicial" => "961" "paginaFinal" => "969" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11971877" "web" => "Medline" ] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib70" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pyrin binds the PSTPIP1-CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.G. Shoham" 1 => "M. Centola" 2 => "E. Mansfield" 3 => "K.M. Hull" 4 => "G. Word" 5 => "C.A. Wise" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.2135380100" "Revista" => array:6 [ "tituloSerie" => "PNAS." "fecha" => "2003" "volumen" => "100" "paginaInicial" => "13501" "paginaFinal" => "13506" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14595024" "web" => "Medline" ] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib71" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anakinra for flares of pyogenic arthritis in PAPA syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.P. Dierselhuis" 1 => "J. Frenkel" 2 => "N.M. Wullfraat" 3 => "J.J. Boelens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/keh470" "Revista" => array:6 [ "tituloSerie" => "Rheumatology." "fecha" => "2005" "volumen" => "44" "paginaInicial" => "406" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15637037" "web" => "Medline" ] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib72" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.S. Stichweh" 1 => "M. Punaro" 2 => "V. Pascual" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1525-1470.2005.22320.x" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol." "fecha" => "2005" "volumen" => "22" "paginaInicial" => "262" "paginaFinal" => "265" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15916580" "web" => "Medline" ] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib73" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abnormal production of tumor necrosis factor (TNF)−alpha and clinical efficacy of the TNF inhibitor etanercept in a patient with PAPA syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Cortis" 1 => "F. De Benedetti" 2 => "A. Insalaco" 3 => "S. Cioschi" 4 => "F. Muratori" 5 => "L.E. D’Urbano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jpeds.2004.08.001" "Revista" => array:6 [ "tituloSerie" => "J Pediatr." "fecha" => "2004" "volumen" => "145" "paginaInicial" => "851" "paginaFinal" => "855" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15580218" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000700000001/v1_201305061616/S2173574311700077/v1_201305061616/en/main.assets" "Apartado" => array:4 [ "identificador" => "8381" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Review" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000700000001/v1_201305061616/S2173574311700077/v1_201305061616/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700077?idApp=UINPBA00004M" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 7 | 19 | 26 |
2024 October | 31 | 38 | 69 |
2024 September | 40 | 20 | 60 |
2024 August | 50 | 38 | 88 |
2024 July | 34 | 37 | 71 |
2024 June | 31 | 31 | 62 |
2024 May | 39 | 28 | 67 |
2024 April | 33 | 34 | 67 |
2024 March | 26 | 27 | 53 |
2024 February | 31 | 26 | 57 |
2024 January | 19 | 28 | 47 |
2023 December | 26 | 31 | 57 |
2023 November | 19 | 28 | 47 |
2023 October | 25 | 36 | 61 |
2023 September | 32 | 40 | 72 |
2023 August | 18 | 18 | 36 |
2023 July | 25 | 29 | 54 |
2023 June | 23 | 26 | 49 |
2023 May | 28 | 20 | 48 |
2023 April | 26 | 20 | 46 |
2023 March | 23 | 35 | 58 |
2023 February | 27 | 36 | 63 |
2023 January | 19 | 34 | 53 |
2022 December | 29 | 40 | 69 |
2022 November | 29 | 31 | 60 |
2022 October | 19 | 30 | 49 |
2022 September | 29 | 33 | 62 |
2022 August | 48 | 48 | 96 |
2022 July | 37 | 34 | 71 |
2022 June | 26 | 50 | 76 |
2022 May | 32 | 49 | 81 |
2022 April | 32 | 56 | 88 |
2022 March | 28 | 50 | 78 |
2022 February | 23 | 39 | 62 |
2022 January | 23 | 37 | 60 |
2021 December | 19 | 46 | 65 |
2021 November | 36 | 59 | 95 |
2021 October | 25 | 50 | 75 |
2021 September | 29 | 42 | 71 |
2021 August | 21 | 34 | 55 |
2021 July | 14 | 36 | 50 |
2021 June | 30 | 38 | 68 |
2021 May | 24 | 40 | 64 |
2021 April | 34 | 97 | 131 |
2021 March | 28 | 27 | 55 |
2021 February | 24 | 21 | 45 |
2021 January | 17 | 19 | 36 |
2020 December | 34 | 22 | 56 |
2020 November | 15 | 22 | 37 |
2020 October | 13 | 17 | 30 |
2020 September | 33 | 21 | 54 |
2020 August | 23 | 22 | 45 |
2020 July | 17 | 22 | 39 |
2020 June | 25 | 22 | 47 |
2020 May | 21 | 12 | 33 |
2020 April | 24 | 20 | 44 |
2020 March | 16 | 17 | 33 |
2020 January | 13 | 0 | 13 |
2019 September | 4 | 0 | 4 |
2019 June | 2 | 0 | 2 |
2019 March | 2 | 0 | 2 |
2019 January | 1 | 0 | 1 |
2018 May | 1 | 1 | 2 |
2018 April | 24 | 17 | 41 |
2018 March | 21 | 24 | 45 |
2018 February | 11 | 12 | 23 |
2018 January | 5 | 10 | 15 |
2017 December | 17 | 12 | 29 |
2017 November | 12 | 15 | 27 |
2017 October | 11 | 15 | 26 |
2017 September | 13 | 19 | 32 |
2017 August | 10 | 16 | 26 |
2017 July | 12 | 17 | 29 |
2017 June | 24 | 39 | 63 |
2017 May | 24 | 35 | 59 |
2017 April | 23 | 18 | 41 |
2017 March | 19 | 51 | 70 |
2017 February | 10 | 18 | 28 |
2017 January | 15 | 12 | 27 |
2016 December | 32 | 35 | 67 |
2016 November | 27 | 24 | 51 |
2016 October | 48 | 21 | 69 |
2016 September | 33 | 14 | 47 |
2016 August | 20 | 10 | 30 |
2016 July | 18 | 7 | 25 |
2016 June | 0 | 11 | 11 |
2016 May | 1 | 7 | 8 |
2016 April | 0 | 12 | 12 |
2016 February | 0 | 18 | 18 |
2015 December | 9 | 0 | 9 |
2015 November | 1 | 12 | 13 |
2015 September | 9 | 0 | 9 |
2015 August | 0 | 10 | 10 |
2015 July | 10 | 5 | 15 |
2015 June | 33 | 12 | 45 |
2015 May | 42 | 34 | 76 |
2015 April | 27 | 25 | 52 |
2015 March | 18 | 12 | 30 |
2015 February | 26 | 26 | 52 |
2015 January | 24 | 30 | 54 |
2014 December | 30 | 23 | 53 |
2014 November | 23 | 19 | 42 |
2014 October | 26 | 25 | 51 |
2014 September | 30 | 10 | 40 |
2014 August | 23 | 24 | 47 |
2014 July | 20 | 27 | 47 |
2014 June | 44 | 19 | 63 |
2014 May | 43 | 20 | 63 |
2014 April | 35 | 12 | 47 |
2014 March | 48 | 30 | 78 |
2014 February | 33 | 22 | 55 |
2014 January | 33 | 22 | 55 |
2013 December | 32 | 8 | 40 |
2013 November | 29 | 22 | 51 |
2013 October | 46 | 23 | 69 |
2013 September | 38 | 19 | 57 |
2013 August | 36 | 28 | 64 |
2013 July | 32 | 20 | 52 |
2013 June | 29 | 22 | 51 |
2013 May | 37 | 19 | 56 |
2013 April | 29 | 28 | 57 |
2013 March | 21 | 25 | 46 |
2013 February | 35 | 20 | 55 |
2013 January | 22 | 21 | 43 |
2012 December | 25 | 18 | 43 |
2012 November | 18 | 16 | 34 |
2012 October | 11 | 13 | 24 |
2012 September | 7 | 7 | 14 |
2012 July | 3 | 0 | 3 |
2012 June | 3 | 0 | 3 |
2012 April | 4 | 0 | 4 |
2012 March | 2 | 0 | 2 |
2012 February | 2 | 0 | 2 |
2012 January | 4 | 0 | 4 |
2011 December | 10 | 0 | 10 |
2011 November | 2 | 0 | 2 |
2011 October | 4 | 0 | 4 |
2011 July | 1 | 0 | 1 |
2011 June | 2 | 0 | 2 |
2011 May | 2 | 0 | 2 |
2011 January | 12 | 0 | 12 |