Review
Anti-TNFα therapy in ankylosing spondylitis: symptom control and structural damage modification
Terapia anti-TNFα en espondilitis anquilosante: control sintomático y modificación del daño estructural
José Luis Andreu
, Teresa Otón, Jesús Sanz
Corresponding author
Servicio de Reumatología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
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Anti-TNFα antagonists have demonstrated efficacy and safety in the long-term but continuous therapy is needed for an adequate control of symptoms. After the failure to a first anti-TNFα agent, the use of a second TNFα antagonist seems to be effective and safe. Despite the fast and continuous suppression of bone inflammation, demonstrated by magnetic resonance imaging, the beneficial effect of treatment with TNFα antagonists on the radiological evolution has not been demonstrated to date in ankylosing spondylitis. It seems that insights into new therapeutic molecular targets implicated in the process of ossification are needed.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los agentes anti-TNFα han representado un notable avance en el control sintomático de los pacientes con espondilitis anquilosante y respuesta inadecuada a AINE. Los antagonistas del TNFα son eficaces y seguros a largo plazo pero es necesario su uso continuado para un adecuado control sintomático. Tras el fracaso a uno de ellos, el uso de un segundo agente anti-TNFα parece ser eficaz y seguro. Aún no se ha demostrado un efecto beneficioso del tratamiento con antagonistas del TNFα sobre la evolución radiológica en la espondilitis anquilosante, a pesar de la desaparición rápida y mantenida de la inflamación ósea, evidenciada mediante RM. Parece necesario explorar nuevas dianas moleculares implicadas en el proceso de osificación.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 19 | 22 |
| 2024 October | 30 | 55 | 85 |
| 2024 September | 31 | 31 | 62 |
| 2024 August | 56 | 44 | 100 |
| 2024 July | 50 | 42 | 92 |
| 2024 June | 35 | 34 | 69 |
| 2024 May | 35 | 31 | 66 |
| 2024 April | 29 | 21 | 50 |
| 2024 March | 33 | 39 | 72 |
| 2024 February | 23 | 37 | 60 |
| 2024 January | 19 | 24 | 43 |
| 2023 December | 17 | 31 | 48 |
| 2023 November | 17 | 23 | 40 |
| 2023 October | 24 | 31 | 55 |
| 2023 September | 33 | 44 | 77 |
| 2023 August | 26 | 19 | 45 |
| 2023 July | 27 | 25 | 52 |
| 2023 June | 29 | 25 | 54 |
| 2023 May | 23 | 13 | 36 |
| 2023 April | 14 | 9 | 23 |
| 2023 March | 24 | 34 | 58 |
| 2023 February | 22 | 35 | 57 |
| 2023 January | 13 | 19 | 32 |
| 2022 December | 25 | 44 | 69 |
| 2022 November | 19 | 28 | 47 |
| 2022 October | 22 | 37 | 59 |
| 2022 September | 31 | 40 | 71 |
| 2022 August | 14 | 54 | 68 |
| 2022 July | 26 | 46 | 72 |
| 2022 June | 22 | 33 | 55 |
| 2022 May | 25 | 50 | 75 |
| 2022 April | 25 | 43 | 68 |
| 2022 March | 28 | 70 | 98 |
| 2022 February | 24 | 32 | 56 |
| 2022 January | 22 | 48 | 70 |
| 2021 December | 17 | 49 | 66 |
| 2021 November | 28 | 50 | 78 |
| 2021 October | 38 | 54 | 92 |
| 2021 September | 25 | 50 | 75 |
| 2021 August | 30 | 47 | 77 |
| 2021 July | 16 | 34 | 50 |
| 2021 June | 29 | 60 | 89 |
| 2021 May | 36 | 65 | 101 |
| 2021 April | 53 | 78 | 131 |
| 2021 March | 41 | 32 | 73 |
| 2021 February | 26 | 22 | 48 |
| 2021 January | 26 | 13 | 39 |
| 2020 December | 24 | 31 | 55 |
| 2020 November | 26 | 21 | 47 |
| 2020 October | 8 | 14 | 22 |
| 2020 September | 34 | 21 | 55 |
| 2020 August | 26 | 16 | 42 |
| 2020 July | 20 | 21 | 41 |
| 2020 June | 36 | 16 | 52 |
| 2020 May | 24 | 18 | 42 |
| 2020 April | 29 | 17 | 46 |
| 2020 March | 20 | 10 | 30 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 19 | 15 | 34 |
| 2018 March | 25 | 20 | 45 |
| 2018 February | 19 | 12 | 31 |
| 2018 January | 8 | 5 | 13 |
| 2017 December | 15 | 8 | 23 |
| 2017 November | 17 | 6 | 23 |
| 2017 October | 21 | 10 | 31 |
| 2017 September | 20 | 9 | 29 |
| 2017 August | 16 | 10 | 26 |
| 2017 July | 14 | 10 | 24 |
| 2017 June | 44 | 14 | 58 |
| 2017 May | 30 | 12 | 42 |
| 2017 April | 35 | 11 | 46 |
| 2017 March | 34 | 6 | 40 |
| 2017 February | 15 | 8 | 23 |
| 2017 January | 29 | 5 | 34 |
| 2016 December | 43 | 14 | 57 |
| 2016 November | 27 | 9 | 36 |
| 2016 October | 51 | 10 | 61 |
| 2016 September | 30 | 5 | 35 |
| 2016 August | 19 | 6 | 25 |
| 2016 July | 10 | 5 | 15 |
| 2016 June | 0 | 5 | 5 |
| 2016 May | 0 | 10 | 10 |
| 2016 April | 0 | 4 | 4 |
| 2016 March | 0 | 8 | 8 |
| 2016 February | 3 | 6 | 9 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 9 | 0 | 9 |
| 2015 September | 2 | 0 | 2 |
| 2015 August | 1 | 0 | 1 |
| 2015 July | 12 | 6 | 18 |
| 2015 June | 20 | 8 | 28 |
| 2015 May | 39 | 12 | 51 |
| 2015 April | 31 | 11 | 42 |
| 2015 March | 26 | 11 | 37 |
| 2015 February | 23 | 10 | 33 |
| 2015 January | 12 | 11 | 23 |
| 2014 December | 26 | 12 | 38 |
| 2014 November | 19 | 19 | 38 |
| 2014 October | 21 | 14 | 35 |
| 2014 September | 17 | 17 | 34 |
| 2014 August | 25 | 22 | 47 |
| 2014 July | 26 | 15 | 41 |
| 2014 June | 52 | 16 | 68 |
| 2014 May | 70 | 17 | 87 |
| 2014 April | 49 | 13 | 62 |
| 2014 March | 36 | 17 | 53 |
| 2014 February | 19 | 16 | 35 |
| 2014 January | 27 | 28 | 55 |
| 2013 December | 28 | 7 | 35 |
| 2013 November | 27 | 17 | 44 |
| 2013 October | 42 | 25 | 67 |
| 2013 September | 28 | 13 | 41 |
| 2013 August | 27 | 13 | 40 |
| 2013 July | 29 | 15 | 44 |
| 2013 June | 25 | 19 | 44 |
| 2013 May | 28 | 18 | 46 |
| 2013 April | 22 | 27 | 49 |
| 2013 March | 29 | 40 | 69 |
| 2013 February | 23 | 23 | 46 |
| 2013 January | 20 | 25 | 45 |
| 2012 December | 26 | 19 | 45 |
| 2012 November | 9 | 23 | 32 |
| 2012 October | 10 | 10 | 20 |
| 2012 September | 8 | 3 | 11 |
| 2012 July | 2 | 0 | 2 |
| 2012 June | 3 | 0 | 3 |
| 2012 April | 2 | 0 | 2 |
| 2012 March | 4 | 0 | 4 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 6 | 0 | 6 |
| 2011 November | 2 | 0 | 2 |
| 2011 October | 3 | 0 | 3 |
| 2011 September | 2 | 0 | 2 |
| 2011 August | 1 | 0 | 1 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 2 | 0 | 2 |
| 2011 February | 1 | 0 | 1 |
| 2011 January | 12 | 0 | 12 |
Show all
