Continuing medical education
Predictors of response to biologic therapies in rheumatoid arthritis
Factores predictores de respuesta a terapias biológicas en la artritis reumatoide
Lara M. Chaves Chaparro
, Juan Salvatierra Ossorio, Enrique Raya Álvarez
Corresponding author
Servicio de Reumatología, Hospital Clínico San Cecilio, Granada, Spain
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Chaves Chaparro, Juan Salvatierra Ossorio, Enrique Raya Álvarez" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Lara M." "apellidos" => "Chaves Chaparro" "email" => array:1 [ 0 => "chch@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Juan" "apellidos" => "Salvatierra Ossorio" ] 2 => array:2 [ "nombre" => "Enrique" "apellidos" => "Raya Álvarez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Reumatología, Hospital Clínico San Cecilio, Granada, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Factores predictores de respuesta a terapias biológicas en la artritis reumatoide" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-11-15" "fechaAceptado" => "2010-11-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112696" "palabras" => array:3 [ 0 => "Biologic therapies" 1 => "Rheumatoid arthritis" 2 => "Response predictors" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112697" "palabras" => array:3 [ 0 => "Terapias biológicas" 1 => "Artritis reumatoide" 2 => "Predictores de respuesta" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The advent of biological therapies has revolutionized the management of rheumatoid arthritis, demonstrating effectiveness in controlling clinical and radiological damage. However, 20% to 40% of the patients will not respond to these therapies, which are associated to a very high cost. In addition, non-responder patients are exposed to possible adverse effects. For these reasons, we need to identify predictors of response to these treatments. These predictors are reviewed in this evidence-based paper and classified into genetic and nongenetic. Despite extensive search, nowadays there are no predictors powerful enough to be used in regular clinical practice. Serum factors, the presence of rheumatoid factor and anti-cyclic citrullinated peptide antibodies, are the only factors currently being used to predict the response to specific biological therapy. In the future, probably thanks to new technologies based on genomics, transcriptomics and proteomics, it will be possible to identify genetic predictors of response to biological drugs that will allow us to select suitable patients for a specific biological therapy.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El desarrollo de las terapias biológicas ha supuesto un gran avance en el manejo de la artritis reumatoide (AR) al haber demostrado efectividad en el control de la clínica y daño radiológico. Sin embargo, entre un 20–40% de los pacientes no van a responder a estas terapias, lo que determina un alto coste económico a la vez que los expone a posibles efectos adversos, por lo que se precisa de la identificación de factores predictores de respuesta a ellos. Estos se revisan en el actual trabajo en función de su evidencia científica y se clasifican en genéticos y no genéticos. A pesar de su extensa búsqueda, en la actualidad no disponemos de potentes predictores que puedan ser utilizados en la práctica clínica diaria. Posiblemente a día de hoy sólo los factores séricos, positividad del factor reumatoide (FR) y anticuerpos antipéptido citrulinado (anti-CCP) permiten predecir la respuesta a determinados biológicos. En un futuro, probablemente gracias a las nuevas tecnologías basadas en la genómica, transcriptómica y proteómica se identificarán predictores genéticos que permita seleccionar pacientes idóneos para una determinada terapia biológica.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Can rheumatoid arthritis responsiveness to methotrexate and biologics be predicted?" 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| 2024 September | 45 | 15 | 60 |
| 2024 August | 43 | 34 | 77 |
| 2024 July | 32 | 35 | 67 |
| 2024 June | 47 | 39 | 86 |
| 2024 May | 23 | 26 | 49 |
| 2024 April | 29 | 19 | 48 |
| 2024 March | 28 | 33 | 61 |
| 2024 February | 25 | 22 | 47 |
| 2024 January | 20 | 19 | 39 |
| 2023 December | 20 | 27 | 47 |
| 2023 November | 27 | 23 | 50 |
| 2023 October | 38 | 39 | 77 |
| 2023 September | 42 | 41 | 83 |
| 2023 August | 23 | 21 | 44 |
| 2023 July | 23 | 26 | 49 |
| 2023 June | 25 | 22 | 47 |
| 2023 May | 20 | 15 | 35 |
| 2023 April | 15 | 13 | 28 |
| 2023 March | 26 | 20 | 46 |
| 2023 February | 19 | 40 | 59 |
| 2023 January | 16 | 22 | 38 |
| 2022 December | 26 | 36 | 62 |
| 2022 November | 36 | 36 | 72 |
| 2022 October | 26 | 16 | 42 |
| 2022 September | 22 | 29 | 51 |
| 2022 August | 20 | 47 | 67 |
| 2022 July | 21 | 41 | 62 |
| 2022 June | 22 | 37 | 59 |
| 2022 May | 20 | 50 | 70 |
| 2022 April | 22 | 39 | 61 |
| 2022 March | 30 | 48 | 78 |
| 2022 February | 20 | 35 | 55 |
| 2022 January | 23 | 36 | 59 |
| 2021 December | 15 | 36 | 51 |
| 2021 November | 30 | 52 | 82 |
| 2021 October | 28 | 51 | 79 |
| 2021 September | 26 | 38 | 64 |
| 2021 August | 15 | 51 | 66 |
| 2021 July | 13 | 34 | 47 |
| 2021 June | 27 | 53 | 80 |
| 2021 May | 20 | 28 | 48 |
| 2021 April | 49 | 62 | 111 |
| 2021 March | 39 | 17 | 56 |
| 2021 February | 37 | 25 | 62 |
| 2021 January | 19 | 21 | 40 |
| 2020 December | 21 | 14 | 35 |
| 2020 November | 20 | 13 | 33 |
| 2020 October | 12 | 15 | 27 |
| 2020 September | 19 | 18 | 37 |
| 2020 August | 17 | 20 | 37 |
| 2020 July | 10 | 16 | 26 |
| 2020 June | 27 | 17 | 44 |
| 2020 May | 23 | 15 | 38 |
| 2020 April | 13 | 15 | 28 |
| 2020 March | 16 | 5 | 21 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 2 | 1 | 3 |
| 2018 April | 14 | 14 | 28 |
| 2018 March | 23 | 20 | 43 |
| 2018 February | 19 | 12 | 31 |
| 2018 January | 8 | 4 | 12 |
| 2017 December | 12 | 10 | 22 |
| 2017 November | 8 | 9 | 17 |
| 2017 October | 12 | 6 | 18 |
| 2017 September | 10 | 11 | 21 |
| 2017 August | 14 | 21 | 35 |
| 2017 July | 15 | 17 | 32 |
| 2017 June | 28 | 8 | 36 |
| 2017 May | 27 | 9 | 36 |
| 2017 April | 19 | 10 | 29 |
| 2017 March | 14 | 11 | 25 |
| 2017 February | 8 | 9 | 17 |
| 2017 January | 11 | 7 | 18 |
| 2016 December | 26 | 14 | 40 |
| 2016 November | 28 | 7 | 35 |
| 2016 October | 28 | 5 | 33 |
| 2016 September | 22 | 8 | 30 |
| 2016 August | 24 | 7 | 31 |
| 2016 July | 15 | 8 | 23 |
| 2016 May | 1 | 16 | 17 |
| 2016 April | 1 | 0 | 1 |
| 2016 February | 5 | 10 | 15 |
| 2015 December | 4 | 0 | 4 |
| 2015 October | 0 | 13 | 13 |
| 2015 September | 7 | 0 | 7 |
| 2015 August | 3 | 0 | 3 |
| 2015 July | 13 | 5 | 18 |
| 2015 June | 20 | 20 | 40 |
| 2015 May | 51 | 36 | 87 |
| 2015 April | 19 | 36 | 55 |
| 2015 March | 26 | 41 | 67 |
| 2015 February | 10 | 49 | 59 |
| 2015 January | 16 | 25 | 41 |
| 2014 December | 20 | 27 | 47 |
| 2014 November | 12 | 36 | 48 |
| 2014 October | 19 | 32 | 51 |
| 2014 September | 13 | 33 | 46 |
| 2014 August | 18 | 35 | 53 |
| 2014 July | 21 | 40 | 61 |
| 2014 June | 34 | 35 | 69 |
| 2014 May | 38 | 50 | 88 |
| 2014 April | 36 | 31 | 67 |
| 2014 March | 37 | 26 | 63 |
| 2014 February | 33 | 26 | 59 |
| 2014 January | 36 | 33 | 69 |
| 2013 December | 21 | 17 | 38 |
| 2013 November | 22 | 14 | 36 |
| 2013 October | 31 | 21 | 52 |
| 2013 September | 28 | 23 | 51 |
| 2013 August | 38 | 32 | 70 |
| 2013 July | 25 | 22 | 47 |
| 2013 June | 21 | 26 | 47 |
| 2013 May | 20 | 28 | 48 |
| 2013 April | 24 | 26 | 50 |
| 2013 March | 26 | 25 | 51 |
| 2013 February | 32 | 16 | 48 |
| 2013 January | 22 | 17 | 39 |
| 2012 December | 12 | 12 | 24 |
| 2012 November | 15 | 25 | 40 |
| 2012 October | 8 | 11 | 19 |
| 2012 September | 8 | 3 | 11 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 2 | 0 | 2 |
| 2012 May | 3 | 0 | 3 |
| 2012 April | 3 | 0 | 3 |
| 2012 March | 4 | 0 | 4 |
| 2012 February | 3 | 0 | 3 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 4 | 0 | 4 |
| 2011 November | 3 | 0 | 3 |
| 2011 October | 6 | 0 | 6 |
| 2011 September | 3 | 0 | 3 |
| 2011 August | 3 | 0 | 3 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 3 | 0 | 3 |
| 2011 May | 2 | 0 | 2 |
| 2011 April | 12 | 0 | 12 |
Show all
