Adverse effects of bisphosphonates | Reumatología Clínica

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"autores" => array:3 [ 0 => array:4 [ "nombre" => "Luis" "apellidos" => "Arboleya" "email" => array:1 [ 0 => "arboleya@ser.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "¿" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Mercedes" "apellidos" => "Alperi" ] 2 => array:2 [ "nombre" => "Sara" "apellidos" => "Alonso" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Central de Asturias, Oviedo, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos adversos de los bisfosfonatos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-07-05" "fechaAceptado" => "2010-10-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112743" "palabras" => array:3 [ 0 => "Osteoporosis" 1 => "Aminobisphosphonates" 2 => "Adverse effects" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112744" "palabras" => array:3 [ 0 => "Osteoporosis" 1 => "Bisfosfonatos" 2 => "Efectos adversos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Aminobisphosphonates are drugs that have been used successfully in the treatment of osteoporosis for more than 20 years. Although main registry studies found a scarcity of relevant adverse events, in recent years and as a result of pharmacovigilance, different complications have been reported, some potentially serious. This has raised questions on the safety of these drugs, especially in high doses, like those used in oncology and long-term treatment, as needed in patients with osteoporosis. In this review, based on the analysis of relevant scientific evidence from clinical trials, case series, cohort studies and databases published to date, we summarize the clinical and epidemiological characteristics of the adverse effects of these drugs." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Los aminobisfosfonatos son fármacos que han sido utilizados con éxito en el tratamiento de la osteoporosis desde hace más de 20 años. Aunque en los estudios principales realizados para obtener la aprobación de su comercialización no se registraron efectos adversos relevantes, en los últimos años, y como resultado de la farmacovigilancia, se ha comunicado de manera irregular una serie de complicaciones, algunas potencialmente graves, que han puesto en duda la seguridad de estos fármacos, sobre todo en dosis elevadas como las que se utilizan en oncología y en tratamientos de larga duración, como los que se emplean en la osteoporosis. En la presente revisión, basada en el análisis de las pruebas científicas más relevantes procedentes de los ensayos clínicos, series de casos, estudios de cohortes y bases de datos publicados hasta el momento, se resumen las características clínicas y epidemiológicas de los efectos adversos de los bisfosfonatos." ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:113 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Adverse effects of bisphosphonates

Efectos adversos de los bisfosfonatos

Luis Arboleya

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arboleya@ser.es

Corresponding author.

, Mercedes Alperi, Sara Alonso

Servicio de Reumatología, Hospital Universitario Central de Asturias, Oviedo, Spain

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      "es" => array:1 [
        "titulo" => "Efectos adversos de los bisfosfonatos"
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    "fechaRecibido" => "2010-07-05"
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          "clase" => "keyword"
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            0 => "Osteoporosis"
            1 => "Aminobisphosphonates"
            2 => "Adverse effects"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Aminobisphosphonates are drugs that have been used successfully in the treatment of osteoporosis for more than 20 years&#46; Although main registry studies found a scarcity of relevant adverse events&#44; in recent years and as a result of pharmacovigilance&#44; different complications have been reported&#44; some potentially serious&#46; This has raised questions on the safety of these drugs&#44; especially in high doses&#44; like those used in oncology and long-term treatment&#44; as needed in patients with osteoporosis&#46; In this review&#44; based on the analysis of relevant scientific evidence from clinical trials&#44; case series&#44; cohort studies and databases published to date&#44; we summarize the clinical and epidemiological characteristics of the adverse effects of these drugs&#46;</p>"
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      "es" => array:2 [
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los aminobisfosfonatos son f&#225;rmacos que han sido utilizados con &#233;xito en el tratamiento de la osteoporosis desde hace m&#225;s de 20 a&#241;os&#46; Aunque en los estudios principales realizados para obtener la aprobaci&#243;n de su comercializaci&#243;n no se registraron efectos adversos relevantes&#44; en los &#250;ltimos a&#241;os&#44; y como resultado de la farmacovigilancia&#44; se ha comunicado de manera irregular una serie de complicaciones&#44; algunas potencialmente graves&#44; que han puesto en duda la seguridad de estos f&#225;rmacos&#44; sobre todo en dosis elevadas como las que se utilizan en oncolog&#237;a y en tratamientos de larga duraci&#243;n&#44; como los que se emplean en la osteoporosis&#46; En la presente revisi&#243;n&#44; basada en el an&#225;lisis de las pruebas cient&#237;ficas m&#225;s relevantes procedentes de los ensayos cl&#237;nicos&#44; series de casos&#44; estudios de cohortes y bases de datos publicados hasta el momento&#44; se resumen las caracter&#237;sticas cl&#237;nicas y epidemiol&#243;gicas de los efectos adversos de los bisfosfonatos&#46;</p>"
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                      "titulo" => "Bisfosfonatos"
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                        0 => array:2 [
                          "etal" => false
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                        ]
                      ]
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Article information

ISSN: 21735743
Original language: English

DOI:10.1016/S2173-5743(11)70039-9

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Year/Month	Html	Pdf	Total

2024 November	9	18	27
2024 October	30	59	89
2024 September	37	47	84
2024 August	48	59	107
2024 July	35	47	82
2024 June	53	65	118
2024 May	39	56	95
2024 April	37	40	77
2024 March	28	41	69
2024 February	29	35	64
2024 January	23	30	53
2023 December	14	32	46
2023 November	26	34	60
2023 October	28	45	73
2023 September	24	50	74
2023 August	24	21	45
2023 July	11	23	34
2023 June	53	34	87
2023 May	29	24	53
2023 April	17	25	42
2023 March	33	40	73
2023 February	18	31	49
2023 January	22	30	52
2022 December	37	41	78
2022 November	42	31	73
2022 October	29	20	49
2022 September	34	47	81
2022 August	28	48	76
2022 July	22	61	83
2022 June	35	48	83
2022 May	40	57	97
2022 April	66	66	132
2022 March	41	49	90
2022 February	28	44	72
2022 January	23	28	51
2021 December	22	56	78
2021 November	35	70	105
2021 October	85	74	159
2021 September	64	54	118
2021 August	60	50	110
2021 July	21	34	55
2021 June	28	52	80
2021 May	38	41	79
2021 April	154	113	267
2021 March	93	34	127
2021 February	55	29	84
2021 January	34	20	54
2020 December	35	31	66
2020 November	33	25	58
2020 October	17	16	33
2020 September	19	21	40
2020 August	17	25	42
2020 July	19	16	35
2020 June	32	24	56
2020 May	23	19	42
2020 April	24	18	42
2020 March	17	11	28
2020 January	4	0	4
2019 September	4	0	4
2019 June	2	0	2
2019 March	2	0	2
2019 January	1	0	1
2018 May	7	1	8
2018 April	29	15	44
2018 March	27	21	48
2018 February	17	10	27
2018 January	11	8	19
2017 December	20	10	30
2017 November	20	8	28
2017 October	29	5	34
2017 September	14	10	24
2017 August	19	8	27
2017 July	18	15	33
2017 June	33	26	59
2017 May	38	11	49
2017 April	26	9	35
2017 March	23	29	52
2017 February	18	4	22
2017 January	15	5	20
2016 December	53	16	69
2016 November	47	6	53
2016 October	70	12	82
2016 September	49	1	50
2016 August	23	1	24
2016 July	12	4	16
2016 June	0	3	3
2016 May	0	3	3
2016 March	4	3	7
2016 February	6	0	6
2015 December	5	0	5
2015 November	1	0	1
2015 September	2	14	16
2015 August	3	0	3
2015 July	20	9	29
2015 June	38	11	49
2015 May	47	25	72
2015 April	35	16	51
2015 March	48	12	60
2015 February	50	17	67
2015 January	41	35	76
2014 December	27	22	49
2014 November	37	21	58
2014 October	30	17	47
2014 September	30	18	48
2014 August	31	26	57
2014 July	32	21	53
2014 June	53	13	66
2014 May	41	22	63
2014 April	43	14	57
2014 March	57	18	75
2014 February	50	18	68
2014 January	44	19	63
2013 December	38	9	47
2013 November	52	35	87
2013 October	64	23	87
2013 September	47	15	62
2013 August	47	18	65
2013 July	42	14	56
2013 June	28	13	41
2013 May	23	14	37
2013 April	39	16	55
2013 March	26	25	51
2013 February	22	19	41
2013 January	50	12	62
2012 December	60	16	76
2012 November	37	11	48
2012 October	10	5	15
2012 September	25	8	33
2012 July	1	0	1
2012 June	3	0	3
2012 May	2	0	2
2012 April	4	0	4
2012 February	2	0	2
2012 January	3	0	3
2011 December	4	0	4
2011 November	2	0	2
2011 October	4	0	4
2011 September	6	0	6
2011 August	4	0	4
2011 July	2	0	2
2011 June	11	0	11
2011 May	2	0	2

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