One year clinical and ultrasonographic follow up of the Pilot Study for the Referral of Patients with Early Spondyloarthritis (ESPIDEP)
Seguimiento clínico y ecográfico a 1 año del EStudio PIloto de Derivación de pacientes con Espondiloartritis Precoz (ESPIDEP)
Tatiana Cobo-Ibáñeza,
, Santiago Muñoz-Fernándeza, Eugenio De Miguelb, Jesús Díez Sebastiánc, Martina Steinera, Emilio Martín-Molab
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mtatiana.cobo@salud.madrid.org
Corresponding author. Sección de Reumatología, Hospital Infanta Sofía, Paseo de Europa, 34, San Sebastián de los Reyes, 28702 Madrid, Spain.
Corresponding author. Sección de Reumatología, Hospital Infanta Sofía, Paseo de Europa, 34, San Sebastián de los Reyes, 28702 Madrid, Spain.
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Sección de Reumatología, Hospital Infanta Sofía, Paseo de Europa, 34, San Sebastián de los Reyes, 28702 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Seguimiento clínico y ecográfico a 1 año del EStudio PIloto de Derivación de pacientes con Espondiloartritis Precoz (ESPIDEP)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-09-05" "fechaAceptado" => "2010-09-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112778" "palabras" => array:5 [ 0 => "Spondylarthritis" 1 => "Ultrasonography" 2 => "Doppler ultrasonography" 3 => "Enthesopathy" 4 => "Statistical models" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112777" "palabras" => array:5 [ 0 => "Espondiloartritis" 1 => "Ecografía" 2 => "Ecografía Doppler" 3 => "Entesopatía" 4 => "Modelos estadísticos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">T</span>o characterize a cohort of early spondyloarthritis (SpA) patients, to demonstrate the usefulness of enthesis ultrasonography for the diagnosis and follow up, and to develop a statistical model to predict persitent activity.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A 1 year prospective study with clinical, radiological and ultrasonographic evaluations was performed in patients with SpA from the Pilot Study for the Referral of Patients with Early SpA (ESPIDEP). Enthesis ultrasonography was explored by the MAdrid Sonographic Enthesis Index (MASEI), and its diagnostic utility was determined to be a cutoff score of ≥18 points. The clinical, radiological and MASEI scores were studied. Finally, a statistical model from factors predicting persitent activity was developed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A 1 year follow-up of 32 patients was carried out. The baseline MASEI reached a sensitivity and specificity of 78.12% and 84.37% respectively, positive and negative predictive value was 83.3% and 79.41% respectively, and positive and negative likelihood ratios were 5 and 0.26, respectively. The improvement of BASMI and the MASEI scores were significant (P=.001 and P=.007, respectively). From the beginning, women had more peripheral affectation, and men had higher axial radiological progression and higher CRP (P<.05). The statistical model that best predicted persitent activity was constituted by nocturnal back pain, BASDAI and CRP.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Enthesis ultrasonography can be useful when begining the evaluation and follow-up of early SpA. Disease patterns are different according to sex. The ability to predict persitent activity in early stages supports the use of more intensive treatments</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Caracterizar a una cohorte de pacientes con espondiloartritis (SpA) precoz, demostrar la utilidad de la ecografía de entesis en el diagnóstico y seguimiento, y desarrollar un modelo para predecir actividad persistente.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo a 1 año de los pacientes con SpA del EStudio PIloto de Derivación de pacientes con Espondiloartritis Precoz (ESPIDEP). Se llevó a cabo una evaluación clínica, radiológica y ecográfica. La ecográfica de entesis se realizó con el MAdrid Sonographic Enthesis Index (MASEI), y su utilidad diagnóstica se determinó con el punto de corte ≥ 18. Se examinó la evolución clínica, radiológica y del MASEI. Finalmente se desarrolló un modelo a partir de los factores que predicen actividad persistente.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se realizó el seguimiento durante 1 año a 32 pacientes. El MASEI basal alcanzó una sensibilidad y especificidad de 78,12% y 83,37%, un valor predictivo positivo y negativo del 83,3% y el 79,41%, y una razón de verosimilitud positiva y negativa de 5 y 0,26, respectivamente. La mejoría del BASMI y el MASEI fue significativa (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001 y p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,007, respectivamente). Las mujeres tuvieron más afectación periférica desde el inicio y los hombres mayor progresión radiológica axial y PCR más elevada (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05). El modelo que mejor predijo actividad persistente estaba formado por dolor axial nocturno, BASDAI y PCR.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La ecografía de entesis puede ser útil en la evaluación inicial y el seguimiento de las SpA precoces. El patrón de enfermedad difiere según el sexo. Predecir actividad persistente en estadios precoces apoya la utilización de tratamientos más intensivos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 16 | 21 |
| 2024 October | 18 | 27 | 45 |
| 2024 September | 17 | 19 | 36 |
| 2024 August | 32 | 32 | 64 |
| 2024 July | 31 | 43 | 74 |
| 2024 June | 27 | 25 | 52 |
| 2024 May | 25 | 33 | 58 |
| 2024 April | 22 | 23 | 45 |
| 2024 March | 23 | 40 | 63 |
| 2024 February | 34 | 25 | 59 |
| 2024 January | 27 | 20 | 47 |
| 2023 December | 20 | 34 | 54 |
| 2023 November | 22 | 29 | 51 |
| 2023 October | 22 | 35 | 57 |
| 2023 September | 21 | 44 | 65 |
| 2023 August | 21 | 21 | 42 |
| 2023 July | 18 | 23 | 41 |
| 2023 June | 11 | 23 | 34 |
| 2023 May | 15 | 16 | 31 |
| 2023 April | 12 | 14 | 26 |
| 2023 March | 18 | 22 | 40 |
| 2023 February | 23 | 30 | 53 |
| 2023 January | 15 | 24 | 39 |
| 2022 December | 32 | 33 | 65 |
| 2022 November | 39 | 23 | 62 |
| 2022 October | 41 | 26 | 67 |
| 2022 September | 33 | 41 | 74 |
| 2022 August | 54 | 46 | 100 |
| 2022 July | 56 | 50 | 106 |
| 2022 June | 59 | 40 | 99 |
| 2022 May | 46 | 46 | 92 |
| 2022 April | 44 | 58 | 102 |
| 2022 March | 34 | 49 | 83 |
| 2022 February | 19 | 65 | 84 |
| 2022 January | 16 | 35 | 51 |
| 2021 December | 19 | 40 | 59 |
| 2021 November | 18 | 46 | 64 |
| 2021 October | 26 | 46 | 72 |
| 2021 September | 18 | 49 | 67 |
| 2021 August | 22 | 58 | 80 |
| 2021 July | 16 | 36 | 52 |
| 2021 June | 19 | 43 | 62 |
| 2021 May | 26 | 44 | 70 |
| 2021 April | 69 | 110 | 179 |
| 2021 March | 36 | 34 | 70 |
| 2021 February | 49 | 33 | 82 |
| 2021 January | 32 | 20 | 52 |
| 2020 December | 24 | 21 | 45 |
| 2020 November | 23 | 19 | 42 |
| 2020 October | 12 | 19 | 31 |
| 2020 September | 18 | 28 | 46 |
| 2020 August | 20 | 27 | 47 |
| 2020 July | 15 | 14 | 29 |
| 2020 June | 28 | 31 | 59 |
| 2020 May | 20 | 27 | 47 |
| 2020 April | 15 | 23 | 38 |
| 2020 March | 20 | 10 | 30 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 15 | 11 | 26 |
| 2018 March | 36 | 11 | 47 |
| 2018 February | 18 | 5 | 23 |
| 2018 January | 14 | 5 | 19 |
| 2017 December | 11 | 5 | 16 |
| 2017 November | 7 | 4 | 11 |
| 2017 October | 13 | 4 | 17 |
| 2017 September | 17 | 5 | 22 |
| 2017 August | 19 | 5 | 24 |
| 2017 July | 16 | 6 | 22 |
| 2017 June | 39 | 8 | 47 |
| 2017 May | 24 | 7 | 31 |
| 2017 April | 16 | 9 | 25 |
| 2017 March | 9 | 3 | 12 |
| 2017 February | 4 | 3 | 7 |
| 2017 January | 13 | 5 | 18 |
| 2016 December | 39 | 8 | 47 |
| 2016 November | 25 | 2 | 27 |
| 2016 October | 26 | 9 | 35 |
| 2016 September | 19 | 5 | 24 |
| 2016 August | 15 | 8 | 23 |
| 2016 July | 17 | 7 | 24 |
| 2016 June | 1 | 0 | 1 |
| 2016 May | 0 | 8 | 8 |
| 2016 March | 2 | 0 | 2 |
| 2016 February | 2 | 10 | 12 |
| 2015 December | 4 | 0 | 4 |
| 2015 November | 1 | 0 | 1 |
| 2015 October | 0 | 25 | 25 |
| 2015 September | 2 | 0 | 2 |
| 2015 August | 2 | 0 | 2 |
| 2015 July | 13 | 5 | 18 |
| 2015 June | 31 | 10 | 41 |
| 2015 May | 30 | 14 | 44 |
| 2015 April | 31 | 12 | 43 |
| 2015 March | 17 | 8 | 25 |
| 2015 February | 33 | 16 | 49 |
| 2015 January | 37 | 16 | 53 |
| 2014 December | 24 | 11 | 35 |
| 2014 November | 16 | 12 | 28 |
| 2014 October | 17 | 19 | 36 |
| 2014 September | 16 | 14 | 30 |
| 2014 August | 22 | 21 | 43 |
| 2014 July | 20 | 18 | 38 |
| 2014 June | 44 | 16 | 60 |
| 2014 May | 40 | 14 | 54 |
| 2014 April | 40 | 16 | 56 |
| 2014 March | 38 | 24 | 62 |
| 2014 February | 33 | 22 | 55 |
| 2014 January | 29 | 16 | 45 |
| 2013 December | 26 | 16 | 42 |
| 2013 November | 30 | 9 | 39 |
| 2013 October | 29 | 14 | 43 |
| 2013 September | 35 | 12 | 47 |
| 2013 August | 27 | 7 | 34 |
| 2013 July | 33 | 9 | 42 |
| 2013 June | 27 | 16 | 43 |
| 2013 May | 24 | 8 | 32 |
| 2013 April | 24 | 14 | 38 |
| 2013 March | 23 | 9 | 32 |
| 2013 February | 19 | 8 | 27 |
| 2013 January | 23 | 7 | 30 |
| 2012 December | 20 | 5 | 25 |
| 2012 November | 11 | 4 | 15 |
| 2012 October | 8 | 9 | 17 |
| 2012 September | 14 | 4 | 18 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 1 | 0 | 1 |
| 2012 April | 4 | 0 | 4 |
| 2012 February | 9 | 0 | 9 |
| 2012 January | 2 | 0 | 2 |
| 2011 December | 9 | 0 | 9 |
| 2011 November | 5 | 0 | 5 |
| 2011 October | 4 | 0 | 4 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 1 | 0 | 1 |
| 2011 July | 5 | 0 | 5 |
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