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                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Collado Otero"
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                        "titulo" => "Patolog&#237;a infantil estructurada&#46; Bases fisiopatol&#243;gicas del diagn&#243;stico tratamiento"
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                        "editorial" => "Ediciones Norma"
                        "editorialLocalizacion" => "Madrid"
                      ]
                    ]
                  ]
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              ]
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                    0 => array:2 [
                      "titulo" => "Radiological diagnosis of the constitutional disorders of bone&#46; As easy as A&#44; B&#44; C&#63;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
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                        "paginaInicial" => "153"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12612812"
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                          "autores" => array:2 [
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                        "tituloSerie" => "Genet Med"
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                        "paginaFinal" => "341"
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                      "titulo" => "Osteochondral diseases and fibrodysplasia ossificans progressiva"
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                          "autores" => array:2 [
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                        "titulo" => "Rare diseases epidemiology"
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                        "serieFecha" => "2010"
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                    ]
                  ]
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              ]
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                    0 => array:2 [
                      "titulo" => "The classification and registration of bone displasias"
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                        "tituloSerie" => "Postgrad Med J"
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                        "paginaFinal" => "428"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/917955"
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                        "tituloSerie" => "J Bone Joint Surg &#40;Am&#41;"
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                        "paginaFinal" => "986"
                      ]
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                        "paginaFinal" => "616"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/702238"
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                        "tituloSerie" => "Ann Radiol &#40;Paris&#41;"
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                        "paginaInicial" => "457"
                        "paginaFinal" => "462"
                      ]
                    ]
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                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1992"
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                        "paginaInicial" => "223"
                        "paginaFinal" => "229"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1360767"
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                        "paginaFinal" => "382"
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                            0 => "C&#46; Hall"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ajmg.10828"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2002"
                        "volumen" => "113"
                        "paginaInicial" => "65"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12400068"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "and the Nosology Group of the International Skeletal Displasia Society&#46; Nosology and classification of genetic skeletal disorders&#58; 2006 revision"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Superti-Furga"
                            1 => "S&#46; Unger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2007"
                        "volumen" => "143A"
                        "paginaInicial" => "1"
                        "paginaFinal" => "18"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular defects in the condrodisplasias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;L&#46; Rimoin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1096-8628(19960503)63:1<106::AID-AJMG20>3.0.CO;2-R"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1996"
                        "volumen" => "63"
                        "paginaInicial" => "106"
                        "paginaFinal" => "110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8723095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagens and collagens related diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Myllyharju"
                            1 => "K&#46;I&#46; Kivirikko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Med"
                        "fecha" => "2001"
                        "volumen" => "33"
                        "paginaInicial" => "7"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11310942"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic heterogeneity in osteogenesis imperfecta"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;O&#46; Sillence"
                            1 => "A&#46; Senn"
                            2 => "D&#46;M&#46; Danks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "1979"
                        "volumen" => "16"
                        "paginaInicial" => "101"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/458828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brittle bones-fragile molecules&#58; disorders of collagen gene structure and expression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;H&#46; Byers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Trends Genet"
                        "fecha" => "1990"
                        "volumen" => "6"
                        "paginaInicial" => "293"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2238087"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular basis of ostogenesis imperfecta and related disorders of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;J&#46; Prockop"
                            1 => "H&#46; Kuivaniemi"
                            2 => "G&#46; Tromp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Plast Surg"
                        "fecha" => "1994"
                        "volumen" => "21"
                        "paginaInicial" => "407"
                        "paginaFinal" => "413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7924138"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COL2A1&#8211;related Skeletal Dysplasias with predominant Metaphyseal involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Walter"
                            1 => "M&#46; Tansek"
                            2 => "E&#46;S&#46; Tobias"
                            3 => "S&#46; Ikegawa"
                            4 => "P&#46; Coucke"
                            5 => "J&#46; Hyland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2007"
                        "volumen" => "143A"
                        "paginaInicial" => "161"
                        "paginaFinal" => "167"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Phenotypic Spectrum of COL2A1 Mutations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Nishimura"
                            1 => "N&#46; Haga"
                            2 => "H&#46; Kitoh"
                            3 => "Y&#46; Tanaka"
                            4 => "T&#46; Sonoda"
                            5 => "M&#46; Kitamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/humu.20179"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mutat"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "36"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15895462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations within the gene encoding the alpha 1 &#40;X&#41; chain of tipo X collagen &#40;COL10A1&#41; cause metaphyseal condroplasia tipo Schmid but not several other forms of metaphyseal condroplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Wallis"
                            1 => "B&#46; Rash"
                            2 => "B&#46; Sykes"
                            3 => "J&#46; Bonaventure"
                            4 => "P&#46; Maroteaux"
                            5 => "B&#46; Zabel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "1996"
                        "volumen" => "33"
                        "paginaInicial" => "450"
                        "paginaFinal" => "457"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8782043"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pseudoacondroplasia and m&#250;ltiple epiphyseal displasia&#58; new etiologic developments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Unger"
                            1 => "J&#46;T&#46; Hecht"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "244"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11891674"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Brigss"
                            1 => "G&#46;R&#46; Mortier"
                            2 => "W&#46;G&#46; Cole"
                            3 => "L&#46;M&#46; King"
                            4 => "S&#46;S&#46; Golik"
                            5 => "J&#46; Bonaventure"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/301713"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "1998"
                        "volumen" => "62"
                        "paginaInicial" => "311"
                        "paginaFinal" => "319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9463320"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;L&#46; Chapman"
                            1 => "G&#46;R&#46; Mortier"
                            2 => "K&#46; Chapman"
                            3 => "J&#46; Loughlin"
                            4 => "M&#46;E&#46; Grant"
                            5 => "M&#46;D&#46; Briggs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng573"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2001"
                        "volumen" => "28"
                        "paginaInicial" => "393"
                        "paginaFinal" => "396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11479597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dyssegmental displasia&#46; Silverman-Handmaker tipo&#58; unexpected role of perlecan in cartilage development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Arikawa-Hirasawa"
                            1 => "W&#46;R&#46; Wilcox"
                            2 => "Y&#46; Yamada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "254"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11891676"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S030028960800015X"
                          "estado" => "S300"
                          "issn" => "03002896"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Mutation in the variable repeat region of the aggrecan gene &#40;AGC1&#41; causes a form of spondyloepiphyseal dysplasia associated with severe&#44; premature osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Gleghorn"
                            1 => "R&#46; Ramesar"
                            2 => "P&#46; Beighton"
                            3 => "G&#46; Wallis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/444401"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2005"
                        "volumen" => "77"
                        "paginaInicial" => "484"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16080123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A recessive skeletal dysplasia&#46; SEMD aggrecan type&#44; results from a missense mutation affecting the C-type lectin domain of aggrecan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;W&#46; Tompson"
                            1 => "B&#46; Merriman"
                            2 => "V&#46;A&#46; Funari"
                            3 => "M&#46; Fresquet"
                            4 => "R&#46;S&#46; Lachman"
                            5 => "D&#46;L&#46; Rimoin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajhg.2008.12.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2009"
                        "volumen" => "84"
                        "paginaInicial" => "72"
                        "paginaFinal" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19110214"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of fifteen novel mutations in the tissue-nonspecific alkaline phosphatase &#40;TNSALP&#41; gene in European patients with severe hypophosphatasia"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Mornet"
                            1 => "A&#46; Taillandier"
                            2 => "S&#46; Peyramaure"
                            3 => "F&#46; Kaper"
                            4 => "F&#46; Muller"
                            5 => "R&#46; Brenner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.ejhg.5200190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Hum Genet"
                        "fecha" => "1998"
                        "volumen" => "6"
                        "paginaInicial" => "308"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9781036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the a3 subunit of the vacuolar H&#40;&#43;&#41;-ATPase cause infantile malignant osteopetrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "A&#46; Schulz"
                            2 => "W&#46; Friedrich"
                            3 => "S&#46; Uhlhaas"
                            4 => "B&#46; Kremens"
                            5 => "T&#46; Voit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mol Genet"
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                        "volumen" => "9"
                        "paginaInicial" => "2059"
                        "paginaFinal" => "2063"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10942435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib29"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis"
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                        0 => array:2 [
                          "etal" => true
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                            1 => "P&#46;J&#46; Orchard"
                            2 => "C&#46; Sobacchi"
                            3 => "S&#46; Giliani"
                            4 => "M&#46; Abinun"
                            5 => "J&#46;P&#46; Mattson"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/76980"
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                        "tituloSerie" => "Nat Genet"
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                        "volumen" => "25"
                        "paginaInicial" => "246"
                        "paginaFinal" => "343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10888861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "U&#46; Kornak"
                            1 => "D&#46; Kasper"
                            2 => "M&#46;R&#46; B&#246;sl"
                            3 => "E&#46; Kaiser"
                            4 => "M&#46; Schweizer"
                            5 => "A&#46; Schulz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "2001"
                        "volumen" => "104"
                        "paginaInicial" => "205"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11207362"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue &#40;107 His&#8722;Tyr&#41;&#58; complete structure of the normal human CA II gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;J&#46; Venta"
                            1 => "R&#46;J&#46; Welty"
                            2 => "T&#46;M&#46; Johnson"
                            3 => "W&#46;S&#46; Sly"
                            4 => "R&#46;E&#46; Tashian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "1991"
                        "volumen" => "49"
                        "paginaInicial" => "1082"
                        "paginaFinal" => "1090"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1928091"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A condroplasia family produced by mutations in the diastrophic displasia sulfate transporter gene&#58; genotipo&#47;phenotipo correlations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Superti-Furga"
                            1 => "A&#46; Rossi"
                            2 => "B&#46; Steinmann"
                            3 => "R&#46; Gitzelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1096-8628(19960503)63:1<144::AID-AJMG25>3.0.CO;2-N"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1996"
                        "volumen" => "63"
                        "paginaInicial" => "144"
                        "paginaFinal" => "147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8723100"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A cluster of sulfatase genes on Xp22&#46;3&#58; mutations in chondrodysplasia punctata &#40;CDPX&#41; and implications for warfarin embryopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Franco"
                            1 => "G&#46; Meroni"
                            2 => "G&#46; Parenti"
                            3 => "J&#46; Levilliers"
                            4 => "L&#46; Bernard"
                            5 => "M&#46; Gebbia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1995"
                        "volumen" => "81"
                        "paginaInicial" => "15"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7720070"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia&#46; Kozlowski type and metatropic dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Krakow"
                            1 => "J&#46; Vriens"
                            2 => "N&#46; Camacho"
                            3 => "P&#46; Luong"
                            4 => "H&#46; Deixler"
                            5 => "T&#46;L&#46; Funari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajhg.2009.01.021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2009"
                        "volumen" => "84"
                        "paginaInicial" => "307"
                        "paginaFinal" => "315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19232556"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;S&#46; Hou"
                            1 => "D&#46; Bromme"
                            2 => "Y&#46; Zhao"
                            3 => "E&#46; Mehler"
                            4 => "C&#46; Dushey"
                            5 => "H&#46; Weinstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI653"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1999"
                        "volumen" => "103"
                        "paginaInicial" => "731"
                        "paginaFinal" => "738"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10074491"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of the gene &#40;SEDL&#41; causing X-linked spondyloepiphyseal dysplasia tarda"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;K&#46; Gedeon"
                            1 => "A&#46; Colley"
                            2 => "R&#46; Jamieson"
                            3 => "E&#46;M&#46; Thompson"
                            4 => "J&#46; Rogers"
                            5 => "D&#46; Sillence"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/11976"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1999"
                        "volumen" => "22"
                        "paginaInicial" => "400"
                        "paginaFinal" => "404"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10431248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inactivating mutations in the 25-hydroxyvitamin D3 1&#945;-hydroxylase gene in patients with pseudovitamin D&#8211;deficiency rickets"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Kitanaka"
                            1 => "K&#46; Takeyama"
                            2 => "A&#46; Murayama"
                            3 => "T&#46; Sato"
                            4 => "H&#46; Okumura"
                            5 => "M&#46; Nogami"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199803053381004"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "338"
                        "paginaInicial" => "653"
                        "paginaFinal" => "661"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9486994"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;R&#46; Hughes"
                            1 => "P&#46;J&#46; Malloy"
                            2 => "D&#46;G&#46; Kieback"
                            3 => "R&#46;A&#46; Kesterson"
                            4 => "J&#46;W&#46; Pike"
                            5 => "D&#46; Feldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1988"
                        "volumen" => "242"
                        "paginaInicial" => "1702"
                        "paginaFinal" => "1705"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2849209"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright&#39;s hereditary osteodystrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Patten"
                            1 => "D&#46;R&#46; Johns"
                            2 => "D&#46; Valle"
                            3 => "C&#46; Eil"
                            4 => "P&#46;A&#46; Gruppuso"
                            5 => "G&#46; Steele"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199005173222002"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1990"
                        "volumen" => "322"
                        "paginaInicial" => "1412"
                        "paginaFinal" => "1419"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2109828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen&#39;s metaphyseal chondroplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Schipani"
                            1 => "C&#46;B&#46; Langman"
                            2 => "A&#46;M&#46; Parfitt"
                            3 => "G&#46;S&#46; Jansen"
                            4 => "S&#46; Kikuchi"
                            5 => "S&#46;W&#46; Kooh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199609053351004"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1996"
                        "volumen" => "335"
                        "paginaInicial" => "708"
                        "paginaFinal" => "714"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8703170"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A gene &#40;PEX&#41; with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "The HYP consortium 1995"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng1095-130"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1995"
                        "volumen" => "11"
                        "paginaInicial" => "130"
                        "paginaFinal" => "136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7550339"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PHEXdb&#44; a locus-specific database for mutations causing X-linked hypophosphatemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Sabbagh"
                            1 => "A&#46;O&#46; Jones"
                            2 => "H&#46;S&#46; Tenenhouse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1098-1004(200007)16:1<1::AID-HUMU1>3.0.CO;2-J"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mut"
                        "fecha" => "2000"
                        "volumen" => "16"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10874297"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "The ADHR Consortium"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2000"
                        "volumen" => "25-6"
                        "paginaInicial" => "345"
                        "paginaFinal" => "348"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical spectrum of fibroblast growth factor receptor mutations"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;R&#46; Passos-Bueno"
                            1 => "W&#46;R&#46; Wilcox"
                            2 => "E&#46;W&#46; Jabs"
                            3 => "A&#46;L&#46; Sertie"
                            4 => "L&#46;G&#46; Alonso"
                            5 => "H&#46; Kitoh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1098-1004(1999)14:2<115::AID-HUMU3>3.0.CO;2-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mutat"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "paginaInicial" => "115"
                        "paginaFinal" => "125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10425034"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Craniosynostosis&#58; genes and mechanisms"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;O&#46; Wilkie"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mol Genet"
                        "fecha" => "1997"
                        "volumen" => "6"
                        "paginaInicial" => "1647"
                        "paginaFinal" => "1656"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9300656"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A gene for acondroplasia-hypocondroplasia maps to chromosome 4p"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Le Merrer"
                            1 => "F&#46; Rousseau"
                            2 => "L&#46; Legeai-Mallet"
                            3 => "J&#46;-C&#46; Landais"
                            4 => "A&#46; Pelet"
                            5 => "J&#46; Bonaventure"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng0394-318"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1994"
                        "volumen" => "6"
                        "paginaInicial" => "318"
                        "paginaFinal" => "321"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8012398"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The gene for acondroplasia maps to the telomeric region of chromosome 4p"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Velinov"
                            1 => "S&#46;A&#46; Slaugenhaupt"
                            2 => "I&#46; Stoilov"
                            3 => "C&#46;I&#46; Scott"
                            4 => "J&#46;F&#46; Gusella"
                            5 => "P&#46; Tsipouras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng0394-314"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1994"
                        "volumen" => "6"
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                        "paginaFinal" => "359"
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                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                  "contribucion" => array:1 [
                    0 => array:2 [
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                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "258"
                        "paginaFinal" => "271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11891677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "J&#46; Wirth"
                            2 => "J&#46; Meyer"
                            3 => "B&#46; Zabel"
                            4 => "M&#46; Held"
                            5 => "J&#46; Zimmer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
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                        "volumen" => "79"
                        "paginaInicial" => "1111"
                        "paginaFinal" => "1220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8001137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib52"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of CANT1 mutations in desbuquois dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Huber"
                            1 => "B&#46; Oule&#39;s"
                            2 => "M&#46; Bertoli"
                            3 => "M&#46; Chami"
                            4 => "M&#46; Fradin"
                            5 => "Y&#46; Alanay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajhg.2009.10.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2009"
                        "volumen" => "85"
                        "paginaInicial" => "706"
                        "paginaFinal" => "710"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19853239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "The link between heparan sulfate and hereditary bone disease&#58; finding a function for the EXT family of putative tumor suppressor proteins"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1172/JCI13737"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
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                        "volumen" => "108"
                        "paginaInicial" => "511"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11518722"
                            "web" => "Medline"
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                ]
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                    0 => array:2 [
                      "titulo" => "Mutations in the RNA component of RNase MRP cause a pleiotropic human disease&#44; cartilage-hair hypoplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "K&#46; Pelin"
                            3 => "R&#46; Chadwick"
                            4 => "C&#46; Johnson"
                            5 => "B&#46; Yuan"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "195"
                        "paginaFinal" => "203"
                        "link" => array:1 [
                          0 => array:2 [
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Implications of the new etiophatogenic approach in the classification of constitutional and genetic bone diseases
Implicaciones del nuevo enfoque etiopatogénico en la clasificación de las enfermedades constitucionales y genéticas del hueso
Antonio Morales Piga
Corresponding author
amorales@isciii.es

Corresponding author.
, Verónica Alonso Ferreira, Ana Villaverde-Hueso
Instituto de Investigación de Enfermedades Raras, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El avance en el conocimiento de las alteraciones bioqu&#237;micas que causan las enfermedades constitucionales &#243;seas no tiene precedentes&#46; La constataci&#243;n de que su caracter&#237;stica esencial es el trasfondo gen&#233;tico com&#250;n a todas ellas ha dado lugar a una propuesta de alcance&#58; sustituir el t&#233;rmino &#171;constitucionales&#187; por &#171;gen&#233;ticas&#187; para referirse a estas entidades&#46; La comprensi&#243;n de los mecanismos fisiopatol&#243;gicos implicados&#44; identificando el punto exacto de la v&#237;a metab&#243;lica alterada y sus sistemas de regulaci&#243;n y control&#44; facilita realizar un diagn&#243;stico preciso&#44; basado en la colaboraci&#243;n interdisciplinar&#44; en un tiempo muy inferior del que requer&#237;a el enfoque tradicional&#46; Adem&#225;s&#44; aunque la correcta valoraci&#243;n de las manifestaciones cl&#237;nicas y radiol&#243;gicas sigue siendo crucial&#44; el diagn&#243;stico de certeza se basa cada vez con mayor frecuencia en la aplicaci&#243;n de las nuevas t&#233;cnicas de an&#225;lisis gen&#233;tico y molecular&#46; Por &#250;ltimo&#44; el esclarecimiento de las complejas alteraciones subyacentes a estos trastornos descubre unas dianas moleculares de gran utilidad potencial en la investigaci&#243;n terap&#233;utica de unas enfermedades que a menudo limitan de manera notable la calidad de vida y que&#44; casi sin excepciones&#44; todav&#237;a carecen de un tratamiento eficaz&#46;</p>"
      ]
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:54 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Displasias &#243;seas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Collado Otero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Patolog&#237;a infantil estructurada&#46; Bases fisiopatol&#243;gicas del diagn&#243;stico tratamiento"
                        "fecha" => "1974"
                        "editorial" => "Ediciones Norma"
                        "editorialLocalizacion" => "Madrid"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiological diagnosis of the constitutional disorders of bone&#46; As easy as A&#44; B&#44; C&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;C&#46; Offiah"
                            1 => "C&#46;M&#46; Hall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00247-002-0855-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Radiol"
                        "fecha" => "2003"
                        "volumen" => "33"
                        "paginaInicial" => "153"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12612812"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The skeletal dysplasias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Krakow"
                            1 => "D&#46;L&#46; Rimoin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/GIM.0b013e3181daae9b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Genet Med"
                        "fecha" => "2010"
                        "volumen" => "12"
                        "paginaInicial" => "327"
                        "paginaFinal" => "341"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20556869"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteochondral diseases and fibrodysplasia ossificans progressiva"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Morales-Piga"
                            1 => "F&#46;S&#46; Kaplan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Rare diseases epidemiology"
                        "paginaInicial" => "335"
                        "paginaFinal" => "348"
                        "serieFecha" => "2010"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The classification and registration of bone displasias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46;R&#46; Butler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Postgrad Med J"
                        "fecha" => "1977"
                        "volumen" => "53"
                        "paginaInicial" => "427"
                        "paginaFinal" => "428"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/917955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A nomenclature for constitutional disorders of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;A&#46; McKusick"
                            1 => "C&#46;I&#46; Scott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Bone Joint Surg &#40;Am&#41;"
                        "fecha" => "1971"
                        "volumen" => "53"
                        "paginaInicial" => "978"
                        "paginaFinal" => "986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International nomenclature of constitutional disorders of bone&#46; Revision&#44; May 1977"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "International Working Group on Constitutional Diseases of Bone"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediat"
                        "fecha" => "1978"
                        "volumen" => "93"
                        "paginaInicial" => "614"
                        "paginaFinal" => "616"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/702238"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International nomenclature of constitutional diseases of bone&#46; Revision&#44; May 1983"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "International Working Group on Constitutional Diseases of Bone"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Radiol &#40;Paris&#41;"
                        "fecha" => "1983"
                        "volumen" => "26"
                        "paginaInicial" => "457"
                        "paginaFinal" => "462"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International classification of osteocondrodisplasias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "International Working Group on Constitutional Diseases of Bone"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ajmg.1320440220"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1992"
                        "volumen" => "44"
                        "paginaInicial" => "223"
                        "paginaFinal" => "229"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1360767"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International nomenclature and classification of osteocondrodisplasias &#40;1997&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "International Working Group on Constitutional Diseases of Bone"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1998"
                        "volumen" => "79"
                        "paginaInicial" => "376"
                        "paginaFinal" => "382"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9779805"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International Nosology and Classification of Constitutional Disorders of Bone &#40;2001&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Hall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ajmg.10828"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2002"
                        "volumen" => "113"
                        "paginaInicial" => "65"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12400068"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "and the Nosology Group of the International Skeletal Displasia Society&#46; Nosology and classification of genetic skeletal disorders&#58; 2006 revision"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Superti-Furga"
                            1 => "S&#46; Unger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2007"
                        "volumen" => "143A"
                        "paginaInicial" => "1"
                        "paginaFinal" => "18"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular defects in the condrodisplasias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;L&#46; Rimoin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1096-8628(19960503)63:1<106::AID-AJMG20>3.0.CO;2-R"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1996"
                        "volumen" => "63"
                        "paginaInicial" => "106"
                        "paginaFinal" => "110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8723095"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagens and collagens related diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Myllyharju"
                            1 => "K&#46;I&#46; Kivirikko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Med"
                        "fecha" => "2001"
                        "volumen" => "33"
                        "paginaInicial" => "7"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11310942"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic heterogeneity in osteogenesis imperfecta"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;O&#46; Sillence"
                            1 => "A&#46; Senn"
                            2 => "D&#46;M&#46; Danks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "1979"
                        "volumen" => "16"
                        "paginaInicial" => "101"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/458828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brittle bones-fragile molecules&#58; disorders of collagen gene structure and expression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;H&#46; Byers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Trends Genet"
                        "fecha" => "1990"
                        "volumen" => "6"
                        "paginaInicial" => "293"
                        "paginaFinal" => "300"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2238087"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular basis of ostogenesis imperfecta and related disorders of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;J&#46; Prockop"
                            1 => "H&#46; Kuivaniemi"
                            2 => "G&#46; Tromp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Plast Surg"
                        "fecha" => "1994"
                        "volumen" => "21"
                        "paginaInicial" => "407"
                        "paginaFinal" => "413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7924138"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COL2A1&#8211;related Skeletal Dysplasias with predominant Metaphyseal involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Walter"
                            1 => "M&#46; Tansek"
                            2 => "E&#46;S&#46; Tobias"
                            3 => "S&#46; Ikegawa"
                            4 => "P&#46; Coucke"
                            5 => "J&#46; Hyland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2007"
                        "volumen" => "143A"
                        "paginaInicial" => "161"
                        "paginaFinal" => "167"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Phenotypic Spectrum of COL2A1 Mutations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Nishimura"
                            1 => "N&#46; Haga"
                            2 => "H&#46; Kitoh"
                            3 => "Y&#46; Tanaka"
                            4 => "T&#46; Sonoda"
                            5 => "M&#46; Kitamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/humu.20179"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mutat"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "36"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15895462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations within the gene encoding the alpha 1 &#40;X&#41; chain of tipo X collagen &#40;COL10A1&#41; cause metaphyseal condroplasia tipo Schmid but not several other forms of metaphyseal condroplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Wallis"
                            1 => "B&#46; Rash"
                            2 => "B&#46; Sykes"
                            3 => "J&#46; Bonaventure"
                            4 => "P&#46; Maroteaux"
                            5 => "B&#46; Zabel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "1996"
                        "volumen" => "33"
                        "paginaInicial" => "450"
                        "paginaFinal" => "457"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8782043"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pseudoacondroplasia and m&#250;ltiple epiphyseal displasia&#58; new etiologic developments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Unger"
                            1 => "J&#46;T&#46; Hecht"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "244"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11891674"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Brigss"
                            1 => "G&#46;R&#46; Mortier"
                            2 => "W&#46;G&#46; Cole"
                            3 => "L&#46;M&#46; King"
                            4 => "S&#46;S&#46; Golik"
                            5 => "J&#46; Bonaventure"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/301713"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "1998"
                        "volumen" => "62"
                        "paginaInicial" => "311"
                        "paginaFinal" => "319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9463320"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;L&#46; Chapman"
                            1 => "G&#46;R&#46; Mortier"
                            2 => "K&#46; Chapman"
                            3 => "J&#46; Loughlin"
                            4 => "M&#46;E&#46; Grant"
                            5 => "M&#46;D&#46; Briggs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng573"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2001"
                        "volumen" => "28"
                        "paginaInicial" => "393"
                        "paginaFinal" => "396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11479597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dyssegmental displasia&#46; Silverman-Handmaker tipo&#58; unexpected role of perlecan in cartilage development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Arikawa-Hirasawa"
                            1 => "W&#46;R&#46; Wilcox"
                            2 => "Y&#46; Yamada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "254"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11891676"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S030028960800015X"
                          "estado" => "S300"
                          "issn" => "03002896"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Mutation in the variable repeat region of the aggrecan gene &#40;AGC1&#41; causes a form of spondyloepiphyseal dysplasia associated with severe&#44; premature osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Gleghorn"
                            1 => "R&#46; Ramesar"
                            2 => "P&#46; Beighton"
                            3 => "G&#46; Wallis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/444401"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2005"
                        "volumen" => "77"
                        "paginaInicial" => "484"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16080123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A recessive skeletal dysplasia&#46; SEMD aggrecan type&#44; results from a missense mutation affecting the C-type lectin domain of aggrecan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;W&#46; Tompson"
                            1 => "B&#46; Merriman"
                            2 => "V&#46;A&#46; Funari"
                            3 => "M&#46; Fresquet"
                            4 => "R&#46;S&#46; Lachman"
                            5 => "D&#46;L&#46; Rimoin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajhg.2008.12.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2009"
                        "volumen" => "84"
                        "paginaInicial" => "72"
                        "paginaFinal" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19110214"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of fifteen novel mutations in the tissue-nonspecific alkaline phosphatase &#40;TNSALP&#41; gene in European patients with severe hypophosphatasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Mornet"
                            1 => "A&#46; Taillandier"
                            2 => "S&#46; Peyramaure"
                            3 => "F&#46; Kaper"
                            4 => "F&#46; Muller"
                            5 => "R&#46; Brenner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.ejhg.5200190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Hum Genet"
                        "fecha" => "1998"
                        "volumen" => "6"
                        "paginaInicial" => "308"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9781036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the a3 subunit of the vacuolar H&#40;&#43;&#41;-ATPase cause infantile malignant osteopetrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "U&#46; Kornak"
                            1 => "A&#46; Schulz"
                            2 => "W&#46; Friedrich"
                            3 => "S&#46; Uhlhaas"
                            4 => "B&#46; Kremens"
                            5 => "T&#46; Voit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mol Genet"
                        "fecha" => "2000"
                        "volumen" => "9"
                        "paginaInicial" => "2059"
                        "paginaFinal" => "2063"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10942435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Frattini"
                            1 => "P&#46;J&#46; Orchard"
                            2 => "C&#46; Sobacchi"
                            3 => "S&#46; Giliani"
                            4 => "M&#46; Abinun"
                            5 => "J&#46;P&#46; Mattson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/76980"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2000"
                        "volumen" => "25"
                        "paginaInicial" => "246"
                        "paginaFinal" => "343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10888861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "U&#46; Kornak"
                            1 => "D&#46; Kasper"
                            2 => "M&#46;R&#46; B&#246;sl"
                            3 => "E&#46; Kaiser"
                            4 => "M&#46; Schweizer"
                            5 => "A&#46; Schulz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "2001"
                        "volumen" => "104"
                        "paginaInicial" => "205"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11207362"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue &#40;107 His&#8722;Tyr&#41;&#58; complete structure of the normal human CA II gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;J&#46; Venta"
                            1 => "R&#46;J&#46; Welty"
                            2 => "T&#46;M&#46; Johnson"
                            3 => "W&#46;S&#46; Sly"
                            4 => "R&#46;E&#46; Tashian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "1991"
                        "volumen" => "49"
                        "paginaInicial" => "1082"
                        "paginaFinal" => "1090"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1928091"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A condroplasia family produced by mutations in the diastrophic displasia sulfate transporter gene&#58; genotipo&#47;phenotipo correlations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Superti-Furga"
                            1 => "A&#46; Rossi"
                            2 => "B&#46; Steinmann"
                            3 => "R&#46; Gitzelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1096-8628(19960503)63:1<144::AID-AJMG25>3.0.CO;2-N"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1996"
                        "volumen" => "63"
                        "paginaInicial" => "144"
                        "paginaFinal" => "147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8723100"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A cluster of sulfatase genes on Xp22&#46;3&#58; mutations in chondrodysplasia punctata &#40;CDPX&#41; and implications for warfarin embryopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Franco"
                            1 => "G&#46; Meroni"
                            2 => "G&#46; Parenti"
                            3 => "J&#46; Levilliers"
                            4 => "L&#46; Bernard"
                            5 => "M&#46; Gebbia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
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                        "paginaInicial" => "15"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7720070"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia&#46; Kozlowski type and metatropic dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            0 => "D&#46; Krakow"
                            1 => "J&#46; Vriens"
                            2 => "N&#46; Camacho"
                            3 => "P&#46; Luong"
                            4 => "H&#46; Deixler"
                            5 => "T&#46;L&#46; Funari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajhg.2009.01.021"
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                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2009"
                        "volumen" => "84"
                        "paginaInicial" => "307"
                        "paginaFinal" => "315"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19232556"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib35"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "Y&#46; Zhao"
                            3 => "E&#46; Mehler"
                            4 => "C&#46; Dushey"
                            5 => "H&#46; Weinstein"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI653"
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                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1999"
                        "volumen" => "103"
                        "paginaInicial" => "731"
                        "paginaFinal" => "738"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10074491"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib36"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of the gene &#40;SEDL&#41; causing X-linked spondyloepiphyseal dysplasia tarda"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "R&#46; Jamieson"
                            3 => "E&#46;M&#46; Thompson"
                            4 => "J&#46; Rogers"
                            5 => "D&#46; Sillence"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/11976"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1999"
                        "volumen" => "22"
                        "paginaInicial" => "400"
                        "paginaFinal" => "404"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10431248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inactivating mutations in the 25-hydroxyvitamin D3 1&#945;-hydroxylase gene in patients with pseudovitamin D&#8211;deficiency rickets"
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                        0 => array:2 [
                          "etal" => true
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                            1 => "K&#46; Takeyama"
                            2 => "A&#46; Murayama"
                            3 => "T&#46; Sato"
                            4 => "H&#46; Okumura"
                            5 => "M&#46; Nogami"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199803053381004"
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1998"
                        "volumen" => "338"
                        "paginaInicial" => "653"
                        "paginaFinal" => "661"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9486994"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                    0 => array:2 [
                      "titulo" => "Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;R&#46; Hughes"
                            1 => "P&#46;J&#46; Malloy"
                            2 => "D&#46;G&#46; Kieback"
                            3 => "R&#46;A&#46; Kesterson"
                            4 => "J&#46;W&#46; Pike"
                            5 => "D&#46; Feldman"
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                    0 => array:1 [
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                        "tituloSerie" => "Science"
                        "fecha" => "1988"
                        "volumen" => "242"
                        "paginaInicial" => "1702"
                        "paginaFinal" => "1705"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2849209"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright&#39;s hereditary osteodystrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Patten"
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                            2 => "D&#46; Valle"
                            3 => "C&#46; Eil"
                            4 => "P&#46;A&#46; Gruppuso"
                            5 => "G&#46; Steele"
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1990"
                        "volumen" => "322"
                        "paginaInicial" => "1412"
                        "paginaFinal" => "1419"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2109828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib40"
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                    0 => array:2 [
                      "titulo" => "Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen&#39;s metaphyseal chondroplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            1 => "C&#46;B&#46; Langman"
                            2 => "A&#46;M&#46; Parfitt"
                            3 => "G&#46;S&#46; Jansen"
                            4 => "S&#46; Kikuchi"
                            5 => "S&#46;W&#46; Kooh"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199609053351004"
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1996"
                        "volumen" => "335"
                        "paginaInicial" => "708"
                        "paginaFinal" => "714"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8703170"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib41"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A gene &#40;PEX&#41; with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets"
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                        0 => array:2 [
                          "colaboracion" => "The HYP consortium 1995"
                          "etal" => false
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng1095-130"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1995"
                        "volumen" => "11"
                        "paginaInicial" => "130"
                        "paginaFinal" => "136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7550339"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "PHEXdb&#44; a locus-specific database for mutations causing X-linked hypophosphatemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Sabbagh"
                            1 => "A&#46;O&#46; Jones"
                            2 => "H&#46;S&#46; Tenenhouse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1098-1004(200007)16:1<1::AID-HUMU1>3.0.CO;2-J"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mut"
                        "fecha" => "2000"
                        "volumen" => "16"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10874297"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "The ADHR Consortium"
                          "etal" => false
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nat Genet"
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                        "volumen" => "25-6"
                        "paginaInicial" => "345"
                        "paginaFinal" => "348"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib44"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical spectrum of fibroblast growth factor receptor mutations"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;R&#46; Passos-Bueno"
                            1 => "W&#46;R&#46; Wilcox"
                            2 => "E&#46;W&#46; Jabs"
                            3 => "A&#46;L&#46; Sertie"
                            4 => "L&#46;G&#46; Alonso"
                            5 => "H&#46; Kitoh"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1098-1004(1999)14:2<115::AID-HUMU3>3.0.CO;2-2"
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                        "tituloSerie" => "Hum Mutat"
                        "fecha" => "1999"
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                        "paginaFinal" => "125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10425034"
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                    ]
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                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Craniosynostosis&#58; genes and mechanisms"
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;O&#46; Wilkie"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mol Genet"
                        "fecha" => "1997"
                        "volumen" => "6"
                        "paginaInicial" => "1647"
                        "paginaFinal" => "1656"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9300656"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A gene for acondroplasia-hypocondroplasia maps to chromosome 4p"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Le Merrer"
                            1 => "F&#46; Rousseau"
                            2 => "L&#46; Legeai-Mallet"
                            3 => "J&#46;-C&#46; Landais"
                            4 => "A&#46; Pelet"
                            5 => "J&#46; Bonaventure"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng0394-318"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1994"
                        "volumen" => "6"
                        "paginaInicial" => "318"
                        "paginaFinal" => "321"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8012398"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The gene for acondroplasia maps to the telomeric region of chromosome 4p"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Velinov"
                            1 => "S&#46;A&#46; Slaugenhaupt"
                            2 => "I&#46; Stoilov"
                            3 => "C&#46;I&#46; Scott"
                            4 => "J&#46;F&#46; Gusella"
                            5 => "P&#46; Tsipouras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng0394-314"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1994"
                        "volumen" => "6"
                        "paginaInicial" => "314"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8012397"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypocondroplasia"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            3 => "A&#46;S&#46; Aylsworth"
                            4 => "I&#46; Kaitila"
                            5 => "W&#46;A&#46; Horton"
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                    0 => array:2 [
                      "doi" => "10.1038/ng0795-357"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1995"
                        "volumen" => "10"
                        "paginaInicial" => "357"
                        "paginaFinal" => "359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7670477"
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                    0 => array:2 [
                      "titulo" => "Mutations in TNFRSF11A&#44; affecting the signal peptide of RANK&#44; cause familial expansile osteolysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            1 => "S&#46;H&#46; Ralston"
                            2 => "J&#46; Marken"
                            3 => "C&#46; Bell"
                            4 => "H&#46; MacPherson"
                            5 => "R&#46;G&#46; Wallace"
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                    0 => array:2 [
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                        "tituloSerie" => "Nat Genet"
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                        "volumen" => "24"
                        "paginaInicial" => "45"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10615125"
                            "web" => "Medline"
                          ]
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                    ]
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              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Transcriptional dysregulation in skeletal malformation syndromes"
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                          "autores" => array:2 [
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "258"
                        "paginaFinal" => "271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11891677"
                            "web" => "Medline"
                          ]
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                  ]
                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "J&#46; Meyer"
                            3 => "B&#46; Zabel"
                            4 => "M&#46; Held"
                            5 => "J&#46; Zimmer"
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                    ]
                  ]
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                    0 => array:1 [
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                        "tituloSerie" => "Cell"
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                        "paginaInicial" => "1111"
                        "paginaFinal" => "1220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8001137"
                            "web" => "Medline"
                          ]
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                ]
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                    0 => array:2 [
                      "titulo" => "Identification of CANT1 mutations in desbuquois dysplasia"
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                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2009"
                        "volumen" => "85"
                        "paginaInicial" => "706"
                        "paginaFinal" => "710"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19853239"
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                          ]
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                ]
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                      "titulo" => "The link between heparan sulfate and hereditary bone disease&#58; finding a function for the EXT family of putative tumor suppressor proteins"
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                          "etal" => false
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                        "tituloSerie" => "J Clin Invest"
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                        "volumen" => "108"
                        "paginaInicial" => "511"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11518722"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
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                    0 => array:2 [
                      "titulo" => "Mutations in the RNA component of RNase MRP cause a pleiotropic human disease&#44; cartilage-hair hypoplasia"
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                        0 => array:2 [
                          "etal" => true
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                            5 => "B&#46; Yuan"
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ISSN: 21735743
Original language: English
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2023 March 16 21 37
2023 February 17 24 41
2023 January 16 14 30
2022 December 24 32 56
2022 November 17 24 41
2022 October 20 30 50
2022 September 17 36 53
2022 August 17 42 59
2022 July 17 42 59
2022 June 17 46 63
2022 May 26 51 77
2022 April 17 48 65
2022 March 27 62 89
2022 February 17 46 63
2022 January 17 47 64
2021 December 15 42 57
2021 November 21 57 78
2021 October 71 48 119
2021 September 27 42 69
2021 August 25 56 81
2021 July 17 47 64
2021 June 15 39 54
2021 May 29 49 78
2021 April 56 133 189
2021 March 27 46 73
2021 February 29 33 62
2021 January 23 29 52
2020 December 15 18 33
2020 November 23 17 40
2020 October 13 19 32
2020 September 16 22 38
2020 August 18 22 40
2020 July 13 18 31
2020 June 20 23 43
2020 May 26 14 40
2020 April 15 10 25
2020 March 9 9 18
2020 February 1 0 1
2020 January 4 0 4
2019 September 4 0 4
2019 June 2 0 2
2019 March 2 0 2
2019 January 1 0 1
2018 May 4 3 7
2018 April 11 17 28
2018 March 31 23 54
2018 February 12 9 21
2018 January 12 7 19
2017 December 8 11 19
2017 November 11 6 17
2017 October 19 9 28
2017 September 17 6 23
2017 August 9 7 16
2017 July 12 12 24
2017 June 24 16 40
2017 May 31 15 46
2017 April 27 11 38
2017 March 27 11 38
2017 February 9 5 14
2017 January 16 7 23
2016 December 43 11 54
2016 November 29 6 35
2016 October 39 12 51
2016 September 30 3 33
2016 August 23 6 29
2016 July 16 8 24
2016 June 2 5 7
2016 May 0 6 6
2016 April 2 15 17
2016 March 0 12 12
2016 February 3 7 10
2015 December 7 0 7
2015 October 1 16 17
2015 September 1 0 1
2015 August 1 0 1
2015 July 18 7 25
2015 June 29 28 57
2015 May 53 34 87
2015 April 46 11 57
2015 March 35 10 45
2015 February 39 9 48
2015 January 21 11 32
2014 December 30 13 43
2014 November 18 16 34
2014 October 20 14 34
2014 September 14 30 44
2014 August 14 47 61
2014 July 24 19 43
2014 June 38 20 58
2014 May 40 41 81
2014 April 43 26 69
2014 March 45 24 69
2014 February 63 22 85
2014 January 38 21 59
2013 December 25 9 34
2013 November 24 16 40
2013 October 37 22 59
2013 September 38 13 51
2013 August 52 19 71
2013 July 34 7 41
2013 June 33 14 47
2013 May 29 12 41
2013 April 31 25 56
2013 March 31 22 53
2013 February 37 13 50
2013 January 26 12 38
2012 December 21 16 37
2012 November 19 13 32
2012 October 11 6 17
2012 September 9 5 14
2012 June 3 0 3
2012 April 5 0 5
2012 March 5 0 5
2012 February 5 0 5
2012 January 2 0 2
2011 December 5 0 5
2011 November 4 0 4
2011 October 1 0 1
2011 September 1 0 1
2011 July 5 0 5
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