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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Reactive arthritis is defined as an acute arthritis caused by enteric or genitourinary infection&#46; This infection usually precedes arthritis by a month&#46; The most frequent reactive arthritis due to <span class="elsevierStyleItalic">Salmonella</span>&#44; <span class="elsevierStyleItalic">Shigella</span>&#44; <span class="elsevierStyleItalic">Chlamydia</span>&#44; <span class="elsevierStyleItalic">Yersinia</span> and <span class="elsevierStyleItalic">Campylobacter</span>&#46; However&#44; there are cases described in the literature of reactive arthritis caused by other microorganisms&#44; such as protozoa&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Currently there are no validated criteria for the classification or for the diagnosis of reactive arthritis&#46; According to the working definitions of the Third International Workshop on Reactive Arthritis&#44; there are two clinical features that are considered very important<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0015" class="elsevierStylePara elsevierViewall">Acute inflammatory arthritis&#44; inflammatory back pain or enthesitis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Evidence of infection preceding the disease between 4 and 8 weeks&#46;</p></li></ul></p><p id="par0025" class="elsevierStylePara elsevierViewall">Here we report a case of reactive arthritis due to <span class="elsevierStyleItalic">Blastocystis hominis</span> in immunocompetent patients&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A 45-year-old Spanish woman&#44; with no toxic habits&#44; who had made multiple trips to places like India&#44; Nepal&#44; Kenya&#44; Tanzania and Burma was seen&#46; Her last trip to Egypt was made a year ago&#46; Among her medical history featured a recurring tapeworm infection and isolation of <span class="elsevierStyleItalic">Blastocystis hominis &#40;B&#46; hominis&#41;</span> in a control stool&#46; She consulted for malaise&#44; and joint and back pain accompanied by mild fever of 2 days duration&#46; The latency period from the isolation of <span class="elsevierStyleItalic">B&#46; hominis</span> to the onset of symptoms was 10 days&#46; Physical examination showed fever &#40;38<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; monoarthritis of the left knee&#44; heel pain and pain with redness of the eye&#46; The rest of the examination was normal&#44; including oral and genital mucosa&#46; The chest radiograph showed no abnormalities&#46; Chest and hand X-rays were normal&#46; Knee arthrocentesis was performed&#44; resulting in inflammatory synovial fluid&#58; 21<span class="elsevierStyleHsp" style=""></span>250&#47;mm<span class="elsevierStyleSup">3</span> leukocytes &#40;94&#37; polymorphonuclear&#41; and glucose&#58; 143&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; The examination of joint fluid under a polarized optical microscope showed no birefringent crystals&#46; Joint fluid and blood cultures&#44; urine cultures&#44; stool cultures were negative for bacteria and parasites&#46; ESR was 67<span class="elsevierStyleHsp" style=""></span>mm at 1<span class="elsevierStyleHsp" style=""></span>h&#44; she had 15&#46;8&#215;10<span class="elsevierStyleSup">9</span><span class="elsevierStyleHsp" style=""></span>leukocytes &#40;88&#37; neutrophils&#41;&#44; hemoglobin 12&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#44; hematocrit 35&#37;&#44; CRP&#58; 56<span class="elsevierStyleHsp" style=""></span>mg&#47;l and fibrinogen<span class="elsevierStyleHsp" style=""></span>601<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Liver and kidney functions were normal&#46; Serologic testing for hepatitis B and C&#44; HIV&#44; <span class="elsevierStyleItalic">Salmonella</span>&#44; <span class="elsevierStyleItalic">Brucella</span>&#44; and <span class="elsevierStyleItalic">Treponema pallidum</span> were negative&#46; Antinuclear antibodies and rheumatoid factor were negative&#46; HLA-B27 was positive&#46; Ophthalmologic examination revealed bilateral anterior uveitis&#44; predominantly on the right eye&#46; Reactive arthritis due to <span class="elsevierStyleItalic">B&#46; hominis</span> was diagnosed&#44; and treatment with metronidazole 250<span class="elsevierStyleHsp" style=""></span>mg every 8<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>was continued&#44; which she had begun beforehand&#46; In addition&#44; indomethacin was started 125<span class="elsevierStyleHsp" style=""></span>mg every 24<span class="elsevierStyleHsp" style=""></span>h&#44; with resolution of arthritis&#46; The patient was intolerant to metronidazole and tinidazole and was changed to 1000<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>h&#46;<span class="elsevierStyleHsp" style=""></span>Upon discharge&#44; the patient had resolution of arthritis and improvement of uveitis&#46; He continued with indomethacin and tinidazole&#46; Subsequently&#44; the patient came for a control visit&#44; with improvement of arthritis&#44; which allowed her to gradually reduce the anti-inflammatory dose&#46; Further episodes of uveitis was controlled with topical treatment&#46; Stool cultures were repeated at three weeks until deworming was positive&#46; Subsequently&#44; the patient underwent another round of treatment&#44; repeated cultures after a month&#44; which were negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Protozoal reactive arthritis is rare&#46; The microorganisms most frequently implicated are <span class="elsevierStyleItalic">Giardia lamblia</span>&#44; <span class="elsevierStyleItalic">Entamoeba histolytica</span>&#44; <span class="elsevierStyleItalic">Trichomonas vaginalis</span>&#44; <span class="elsevierStyleItalic">Toxoplasma gondii</span>&#44; and rarely&#44; <span class="elsevierStyleItalic">B&#46; hominis</span>&#46; This is a protozoa that is transmitted between animals and humans by ingestion of cysts in water or food contaminated by a carrier&#46; Its pathogenic role is not universally accepted&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> but has been associated with episodes of diarrhea and extraintestinal<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> manifestations&#44; and its relationship with reactive arthritis is less common&#46; Different morphological and ameboid<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> vacuolar types have been described&#44; which could be related to its pathogenic capacity&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The mechanisms by which different parasites can cause joint disease are multiple&#46; For example&#44; local invasion from neighboring bones or muscles&#44; via the blood or lymphatic with the presence of adult individuals&#44; larvae or eggs in the joint cavity&#46; They could also trigger a reactive inflammatory reaction to the presence of the parasite in the surrounding tissue&#44; without an actual joint invasion<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; In our case&#44; we assume that the latter was the most likely mechanism of action of <span class="elsevierStyleItalic">B&#46; hominis</span>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">On the other hand&#44; some authors use the term &#8220;parasitic rheumatism&#8221; in the case of inflammatory conditions without the presence of the parasite in the joint or in its vicinity&#44; probably triggered by an immune mechanism&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In a 1990&#8211;2010 PUBMED literature review &#40;keywords&#58; <span class="elsevierStyleItalic">Blastocystis hominis</span> and arthritis&#41; we found 4 cases of arthritis associated with <span class="elsevierStyleItalic">B&#46; hominis</span>&#44; treated in 2 cases as infectious arthritis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The other 2 cases were reactive arthritis associated with <span class="elsevierStyleItalic">B&#46; hominis</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> This case would be the fifth related to this parasite and the third description of reactive arthritis due to this organism&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">As in other cases&#44; this was a middle-aged&#44; immunocompetent woman&#44; who had traveled to risk countries&#46; However&#44; unlike the cases described above&#44; this case provided had a positive HLA B-27&#46;</p></span>"
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                          "etal" => false
                          "autores" => array:1 [
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                        "tituloSerie" => "Presse Med"
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                            1 => "P&#46; Thim Fang"
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                            3 => "J&#46;G&#46; Esteban"
                            4 => "C&#46; Mu&#241;oz"
                            5 => "R&#46; Borr&#225;s"
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                      "titulo" => "Association of <span class="elsevierStyleItalic">Blastocystis hominis</span> with symptoms of human disease"
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                          "autores" => array:3 [
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                            2 => "J&#46;C&#46; Mckitrick"
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                        ]
                      ]
                    ]
                  ]
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                        0 => array:2 [
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                          "autores" => array:1 [
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                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Seminn Fund Esp Reumatol"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "28"
                        "paginaFinal" => "36"
                      ]
                    ]
                  ]
                ]
              ]
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            5 => array:3 [
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              "etiqueta" => "6"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Blastocystis hominis</span> as a rare arthritogenic pathogen&#46; A case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Kr&#252;ger"
                            1 => "I&#46; Kamilli"
                            2 => "M&#46; Schattenkirchner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Z Rheumatol"
                        "fecha" => "1994"
                        "volumen" => "53"
                        "paginaInicial" => "83"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8023590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infective arthritis due to <span class="elsevierStyleItalic">Blastocystis hominis</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;G&#46; Lee"
                            1 => "S&#46;C&#46; Rawlins"
                            2 => "M&#46; Didier"
                            3 => "K&#46; DeCeulaer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "1990"
                        "volumen" => "49"
                        "paginaInicial" => "192"
                        "paginaFinal" => "193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2322029"
                            "web" => "Medline"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reactive arthritis from <span class="elsevierStyleItalic">Blastocystis hominis</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "R&#46;M&#46; Fleischmann"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1991"
                        "volumen" => "34"
                        "paginaInicial" => "251"
                        "paginaFinal" => "253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1994931"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
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              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Artritis reactivas y <span class="elsevierStyleItalic">Blastocystis hominis&#58;</span> &#191;una asociaci&#243;n casual&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "M&#46; Pons"
                            2 => "I&#46; Carrasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Esp Reumatol"
                        "fecha" => "2000"
                        "volumen" => "27"
                        "paginaInicial" => "74"
                        "paginaFinal" => "75"
                      ]
                    ]
                  ]
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Letter to the Editor
Reactive Arthritis Caused by Blastocistys hominis
Artritis reactiva por Blastocistys hominis
Beatriz Tejeraa,
Corresponding author
bea_buchi@hotmail.com

Corresponding author.
, Dolors Gradosa, Melania Martinez-Morilloa, Silvia Roureb
a Sección de Reumatología, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain
b Sección de Medicina Interna, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Reactive arthritis is defined as an acute arthritis caused by enteric or genitourinary infection&#46; This infection usually precedes arthritis by a month&#46; The most frequent reactive arthritis due to <span class="elsevierStyleItalic">Salmonella</span>&#44; <span class="elsevierStyleItalic">Shigella</span>&#44; <span class="elsevierStyleItalic">Chlamydia</span>&#44; <span class="elsevierStyleItalic">Yersinia</span> and <span class="elsevierStyleItalic">Campylobacter</span>&#46; However&#44; there are cases described in the literature of reactive arthritis caused by other microorganisms&#44; such as protozoa&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Currently there are no validated criteria for the classification or for the diagnosis of reactive arthritis&#46; According to the working definitions of the Third International Workshop on Reactive Arthritis&#44; there are two clinical features that are considered very important<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0015" class="elsevierStylePara elsevierViewall">Acute inflammatory arthritis&#44; inflammatory back pain or enthesitis&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Evidence of infection preceding the disease between 4 and 8 weeks&#46;</p></li></ul></p><p id="par0025" class="elsevierStylePara elsevierViewall">Here we report a case of reactive arthritis due to <span class="elsevierStyleItalic">Blastocystis hominis</span> in immunocompetent patients&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A 45-year-old Spanish woman&#44; with no toxic habits&#44; who had made multiple trips to places like India&#44; Nepal&#44; Kenya&#44; Tanzania and Burma was seen&#46; Her last trip to Egypt was made a year ago&#46; Among her medical history featured a recurring tapeworm infection and isolation of <span class="elsevierStyleItalic">Blastocystis hominis &#40;B&#46; hominis&#41;</span> in a control stool&#46; She consulted for malaise&#44; and joint and back pain accompanied by mild fever of 2 days duration&#46; The latency period from the isolation of <span class="elsevierStyleItalic">B&#46; hominis</span> to the onset of symptoms was 10 days&#46; Physical examination showed fever &#40;38<span class="elsevierStyleHsp" style=""></span>&#176;C&#41;&#44; monoarthritis of the left knee&#44; heel pain and pain with redness of the eye&#46; The rest of the examination was normal&#44; including oral and genital mucosa&#46; The chest radiograph showed no abnormalities&#46; Chest and hand X-rays were normal&#46; Knee arthrocentesis was performed&#44; resulting in inflammatory synovial fluid&#58; 21<span class="elsevierStyleHsp" style=""></span>250&#47;mm<span class="elsevierStyleSup">3</span> leukocytes &#40;94&#37; polymorphonuclear&#41; and glucose&#58; 143&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; The examination of joint fluid under a polarized optical microscope showed no birefringent crystals&#46; Joint fluid and blood cultures&#44; urine cultures&#44; stool cultures were negative for bacteria and parasites&#46; ESR was 67<span class="elsevierStyleHsp" style=""></span>mm at 1<span class="elsevierStyleHsp" style=""></span>h&#44; she had 15&#46;8&#215;10<span class="elsevierStyleSup">9</span><span class="elsevierStyleHsp" style=""></span>leukocytes &#40;88&#37; neutrophils&#41;&#44; hemoglobin 12&#46;2<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#44; hematocrit 35&#37;&#44; CRP&#58; 56<span class="elsevierStyleHsp" style=""></span>mg&#47;l and fibrinogen<span class="elsevierStyleHsp" style=""></span>601<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Liver and kidney functions were normal&#46; Serologic testing for hepatitis B and C&#44; HIV&#44; <span class="elsevierStyleItalic">Salmonella</span>&#44; <span class="elsevierStyleItalic">Brucella</span>&#44; and <span class="elsevierStyleItalic">Treponema pallidum</span> were negative&#46; Antinuclear antibodies and rheumatoid factor were negative&#46; HLA-B27 was positive&#46; Ophthalmologic examination revealed bilateral anterior uveitis&#44; predominantly on the right eye&#46; Reactive arthritis due to <span class="elsevierStyleItalic">B&#46; hominis</span> was diagnosed&#44; and treatment with metronidazole 250<span class="elsevierStyleHsp" style=""></span>mg every 8<span class="elsevierStyleHsp" style=""></span>h<span class="elsevierStyleHsp" style=""></span>was continued&#44; which she had begun beforehand&#46; In addition&#44; indomethacin was started 125<span class="elsevierStyleHsp" style=""></span>mg every 24<span class="elsevierStyleHsp" style=""></span>h&#44; with resolution of arthritis&#46; The patient was intolerant to metronidazole and tinidazole and was changed to 1000<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>h&#46;<span class="elsevierStyleHsp" style=""></span>Upon discharge&#44; the patient had resolution of arthritis and improvement of uveitis&#46; He continued with indomethacin and tinidazole&#46; Subsequently&#44; the patient came for a control visit&#44; with improvement of arthritis&#44; which allowed her to gradually reduce the anti-inflammatory dose&#46; Further episodes of uveitis was controlled with topical treatment&#46; Stool cultures were repeated at three weeks until deworming was positive&#46; Subsequently&#44; the patient underwent another round of treatment&#44; repeated cultures after a month&#44; which were negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Protozoal reactive arthritis is rare&#46; The microorganisms most frequently implicated are <span class="elsevierStyleItalic">Giardia lamblia</span>&#44; <span class="elsevierStyleItalic">Entamoeba histolytica</span>&#44; <span class="elsevierStyleItalic">Trichomonas vaginalis</span>&#44; <span class="elsevierStyleItalic">Toxoplasma gondii</span>&#44; and rarely&#44; <span class="elsevierStyleItalic">B&#46; hominis</span>&#46; This is a protozoa that is transmitted between animals and humans by ingestion of cysts in water or food contaminated by a carrier&#46; Its pathogenic role is not universally accepted&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> but has been associated with episodes of diarrhea and extraintestinal<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> manifestations&#44; and its relationship with reactive arthritis is less common&#46; Different morphological and ameboid<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> vacuolar types have been described&#44; which could be related to its pathogenic capacity&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The mechanisms by which different parasites can cause joint disease are multiple&#46; For example&#44; local invasion from neighboring bones or muscles&#44; via the blood or lymphatic with the presence of adult individuals&#44; larvae or eggs in the joint cavity&#46; They could also trigger a reactive inflammatory reaction to the presence of the parasite in the surrounding tissue&#44; without an actual joint invasion<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; In our case&#44; we assume that the latter was the most likely mechanism of action of <span class="elsevierStyleItalic">B&#46; hominis</span>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">On the other hand&#44; some authors use the term &#8220;parasitic rheumatism&#8221; in the case of inflammatory conditions without the presence of the parasite in the joint or in its vicinity&#44; probably triggered by an immune mechanism&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In a 1990&#8211;2010 PUBMED literature review &#40;keywords&#58; <span class="elsevierStyleItalic">Blastocystis hominis</span> and arthritis&#41; we found 4 cases of arthritis associated with <span class="elsevierStyleItalic">B&#46; hominis</span>&#44; treated in 2 cases as infectious arthritis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> The other 2 cases were reactive arthritis associated with <span class="elsevierStyleItalic">B&#46; hominis</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> This case would be the fifth related to this parasite and the third description of reactive arthritis due to this organism&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">As in other cases&#44; this was a middle-aged&#44; immunocompetent woman&#44; who had traveled to risk countries&#46; However&#44; unlike the cases described above&#44; this case provided had a positive HLA B-27&#46;</p></span>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arthrites parasitaires&#44; rhumatismes parasitaires et arthrites reactionnelles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Doury"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Presse Med"
                        "fecha" => "1988"
                        "volumen" => "17"
                        "paginaInicial" => "373"
                        "paginaFinal" => "374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2966367"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S&#237;ndrome de Reiter&#44; espondiloartropat&#237;as indiferenciadas y artritis reactiva"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Tank Yan Yu"
                            1 => "P&#46; Thim Fang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Tratado de reumatolog&#237;a &#40;1175&#8211;1153&#41;"
                        "serieFecha" => "2006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Significaci&#243;n cl&#237;nica de la infecci&#243;n por <span class="elsevierStyleItalic">Blastocystis hominis</span>&#58; estudio epidemiol&#243;gico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Carbajal"
                            1 => "J&#46; Villar"
                            2 => "M&#46;D&#46; Lanuza"
                            3 => "J&#46;G&#46; Esteban"
                            4 => "C&#46; Mu&#241;oz"
                            5 => "R&#46; Borr&#225;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1997"
                        "volumen" => "108"
                        "paginaInicial" => "608"
                        "paginaFinal" => "612"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of <span class="elsevierStyleItalic">Blastocystis hominis</span> with symptoms of human disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;J&#46; Sheehan"
                            1 => "B&#46;G&#46; Rancher"
                            2 => "J&#46;C&#46; Mckitrick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Microbiol"
                        "fecha" => "1986"
                        "volumen" => "24"
                        "paginaInicial" => "548"
                        "paginaFinal" => "550"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3771743"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Revisi&#243;n&#44; patolog&#237;a reumatol&#243;gica importada"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Richi Alberti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Seminn Fund Esp Reumatol"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "28"
                        "paginaFinal" => "36"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Blastocystis hominis</span> as a rare arthritogenic pathogen&#46; A case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Kr&#252;ger"
                            1 => "I&#46; Kamilli"
                            2 => "M&#46; Schattenkirchner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Z Rheumatol"
                        "fecha" => "1994"
                        "volumen" => "53"
                        "paginaInicial" => "83"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8023590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infective arthritis due to <span class="elsevierStyleItalic">Blastocystis hominis</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;G&#46; Lee"
                            1 => "S&#46;C&#46; Rawlins"
                            2 => "M&#46; Didier"
                            3 => "K&#46; DeCeulaer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "1990"
                        "volumen" => "49"
                        "paginaInicial" => "192"
                        "paginaFinal" => "193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2322029"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reactive arthritis from <span class="elsevierStyleItalic">Blastocystis hominis</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Lakhanpal"
                            1 => "S&#46;B&#46; Cohen"
                            2 => "R&#46;M&#46; Fleischmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1991"
                        "volumen" => "34"
                        "paginaInicial" => "251"
                        "paginaFinal" => "253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1994931"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Artritis reactivas y <span class="elsevierStyleItalic">Blastocystis hominis&#58;</span> &#191;una asociaci&#243;n casual&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "I&#46; Gonz&#225;lez"
                            1 => "M&#46; Pons"
                            2 => "I&#46; Carrasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Esp Reumatol"
                        "fecha" => "2000"
                        "volumen" => "27"
                        "paginaInicial" => "74"
                        "paginaFinal" => "75"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
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