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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sj&#246;gren&#39;s syndrome &#40;SS&#41; is a chronic systemic disease of autoimmune origin of the exocrine glands&#44; manifested by symptoms that result from hyposecretion&#46; SS may occur alone &#40;primary SS &#91;pSS&#93;&#41; or associated with other autoimmune diseases &#40;secondary SS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The histopathology of the salivary glands as a part of diagnosis was proposed first in 1970 by Waterhouse&#44; Chisholm&#44; and Mason&#44; the latter established a score based on inflammatory<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> cell aggregates&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">According to the European-American<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> criteria for diagnosis of pSS&#44; the presence of a SGB compatible with the disease and&#47;or the presence of antibodies anti-Ro&#47;anti-La is needed&#46; The MSGB is also a method for diagnosing diseases such as infiltrative amiloidosis<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and sarcoidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Numerous surgical techniques have been described&#46; They vary according to size from 1&#46;5<span class="elsevierStyleHsp" style=""></span>mm to 30<span class="elsevierStyleHsp" style=""></span>mm&#44; the shape of the incision &#40;elliptical&#44; horizontal&#44; vertical&#44; and wedge&#41;&#44; and localization&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> While this is an invasive procedure&#44; it is easy to perform and has a low frequency complications&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Caporali et al&#46; 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MSGB is not incorporated in daily practice in all centers&#46; Although other authors have reported complication rates of the different techniques and usefulness of the procedure&#44; we consider important to evaluate the safety and yield &#40;obtaining suitable material for pathology&#41; of the method in our center&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In this paper we estimate the percentage of mediate and immediate complications of MSGB and frequency of obtaining suitable material for pathology&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Material and Methods</span><p id="par0045" class="elsevierStylePara elsevierViewall">We designed a prospective&#44; observational&#44; descriptive&#44; and longitudinal study&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We included patients referred with suspected SS and who underwent MSGB&#46; Patients should have no evidence of coagulation disorders and a platelet count within normal within 1 month before the procedure&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Exclusion criteria were&#58; use of aspirin or other NSAIDs 1 week before the study&#44; clinical signs of local infection&#44; patients on anticoagulants&#44; and those who refused inclusion in the protocol&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The study was approved by the Ethics Committee of the hospital&#46; All patients signed an informed consent&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">We prospectively studied MSGB conducted between October 2007 and May 2010&#44; at the Rheumatology Service of Hospital Bernardino Rivadavia City of Buenos Aires&#44; Argentina&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients underwent minor salivary gland biopsy with the surgical technique described by Caporali et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The material obtained was preserved in 10&#37; formalin and sent for analysis to pathology&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">We analyzed the characteristics of the incision and any complications during the procedure and after it&#46; The patient was followed up a week and a month after the procedure&#46; The yield was evaluated through the results of the pathology&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Measurements&#58; immediate complications&#58; bleeding that obstructs the proceedings&#44; fainting&#44; accidents due to health staff while performing the procedure&#46; Mediate complications&#58; surgical wound infection&#44; suture dehiscence&#44; sensory disturbances &#40;dysesthesia&#44; anesthesia&#44; paresthesia&#41;&#44; defective wound healing&#44; as defined by the presence of granuloma or keloid scarring at the site&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical Analysis</span><p id="par0090" class="elsevierStylePara elsevierViewall">Complications were studied with a frequency analysis and calculation of confidence intervals of 95&#37;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall">We included 186 procedures performed between October 2007 and May 2010&#44; of which 29 were performed to confirm the diagnosis of secondary SS and the rest of pSS&#46; Among patients with suspected secondary SS&#44; 21 had a diagnosis of rheumatoid arthritis &#40;RA&#41;&#44; 3 systemic lupus erythematosus &#40;SLE&#41;&#44; 3 primary biliary cirrhosis &#40;PBC&#41;&#44; 1 mixed connective tissue disease &#40;MCTD&#41; and 1 of cryoglobulinemic vasculitis&#46; The clinical and serological features are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Of the 14 &#40;7&#46;5&#37;&#41; patients receiving immunosuppressive therapy at the time of the procedure&#44; 11 received methotrexate &#40;9 of them had a diagnosis of RA&#41;&#44; 1 leflunomide and 1 azathioprine&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">All patients tolerated the procedure and no serious adverse events were recorded&#46; 15 patients had postoperative complications &#40;8&#46;1&#37;&#44; 95&#37; CI&#44; 4&#46;7&#8211;13&#46;2&#41;&#46; Complications included&#58; bleeding 7&#46;5&#37;&#44; fainting 3&#46;2&#37;&#44; hematoma 2&#46;7&#37;&#46; There were no accidents &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">There were 164 patients who attended follow-up visits a week and a month after the procedure&#46; Mediate complications were found in 16 patients &#40;9&#46;75&#37;&#44; 95&#37; CI&#44; 5&#46;9&#8211;15&#46;6&#41;&#44; distributed as follows&#58; pain 7&#46;32&#37;&#44; inflammatory signs 3&#46;66&#37;&#44; sensory loss 3&#46;05&#37;&#44; and granuloma 1&#46;22&#37;&#46; Sensitivity disorders were transient&#46; No cases of infections or dehiscence of the suture were seen&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">At the time of analysis&#44; we had the pathology report of 154 biopsies and in 140 &#40;90&#46;9&#37;&#44; 95&#37; CI&#44; 85&#8211;95&#41; glandular material was obtained &#40;typically minor salivary glands&#44; lipomatosis&#44; chronic nonspecific sialadenitis&#44; grade III and IV infiltrates&#41;&#44; and in other cases fibromuscular tissue and fat or little material was obtained&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0120" class="elsevierStylePara elsevierViewall">Establishing the diagnosis of SS has some difficulty due to the low specificity and sensitivity of serological markers and the lack of specific symptoms of the syndrome&#46; To date&#44; different classification criteria have been proposed&#44; which are based on a combination of clinical&#44; serological&#44; and histologic data&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;9&#8211;13</span></a> There are some differences between the San Francisco<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> &#40;which is based on the histopathology&#41; and San Diego<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> criteria&#44; where the MSGB is essential to reach the diagnosis of SS&#44; as well as the Copenhague&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> the Greek&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Japanese&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> and European<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> community criteria&#44; which do not require MSGB or the presence of antibodies&#44; or the American-European criteria 2002&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> which require the presence of histological or serological criteria&#46; Minor salivary gland biopsy is therefore essential for diagnosis in patients with negative suspected SS autoantibodies&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The importance of MSGB is stressed for differential diagnosis with other pathologies and it is currently proposed that the lymphoid organization be a marker for the development of Hodgkin&#39;s<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> lymphoma&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">MSGB is a technically simple procedure and complications are rare&#46; Furthermore&#44; with the technique presented&#44; 90&#46;9&#37; of the material obtained was useful for pathology&#44; somewhat lower than that described by Caporali et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> &#40;99&#46;2&#37;&#41; and Teppo&#8211;Revonta<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> &#40;98&#46;4&#37;&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">This study describes a high prevalence of immediate complications of 8&#46;1&#37; and 9&#46;75&#37; mediate complications&#44; showing the reliability of both health personnel and patients&#44; since there were no serious or medium or long term complications during the procedure&#46; Within a week&#44; 12 patients reported pain and 6 had inflammatory signs during the first days&#44; 5 had mild sensory loss&#44; which disappeared within a month&#44; and in 2 of them we found the formation of granuloma&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Several observations analyzed MSGB with a technique similar to that used in this study and obtained comparable results&#59; the complications were uncommon&#44; and the most prevalent were paresthesias at the site of incision&#44; transient in nature&#44; in most the patients&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Richards et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> reported 2 cases of disorders of sensation at the incision site&#44; which persisted beyond 1 year&#44; with mild features and no objective evidence of neurological disease&#44; while Berquin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> described anesthesia in 1 case and Marx et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> reported 3 cases of which one was persistent after 2 years of follow-up&#46; Caporali et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> reported transient adverse events in 64 of the 502 patients&#44; of whom 57 had transient paresthesias&#44; 8 hematoma&#44; 27 local inflammatory signs&#44; and 5 had others &#40;granuloma&#44; bleeding&#44; and internal scar&#41;&#46; Pijpe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> reported 4 cases of hypoesthesia of the incision site&#44; 2 of which persisted for more than 12 months and 11 cases of pain lasting than 1 month&#46; Moreover&#44; Teppo and Revonta reported a case of pyogenic granuloma&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Patients who underwent MSGB were referred for the study of sicca syndrome by professionals of both our institution and other rheumatology departments who did not have the means for carrying it out&#46; This explains the lack of some data for analysis&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0160" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects</span>&#46; The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data</span>&#46; The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent</span>&#46; The authors have obtained the informed consent of the patients and &#47;or subjects mentioned in the article&#46; The author for correspondence is in possession of this document&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Disclosure</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no disclosures to make&#46;</p></span></span>"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2011-10-05"
    "fechaAceptado" => "2012-03-22"
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          "clase" => "keyword"
          "titulo" => "Keywords"
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          "palabras" => array:3 [
            0 => "Sj&#246;gren syndrome"
            1 => "Minor salivary gland biopsy"
            2 => "Complications"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:3 [
            0 => "S&#237;ndrome de Sj&#246;gren"
            1 => "Biopsia de gl&#225;ndulas salivales menores"
            2 => "Complicaciones"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Findings of specific antibodies and histopathology data are essential for the diagnosis of Sj&#246;gren syndrome &#40;SS&#41;&#46; Although the minor salivary gland biopsy &#40;MSGB&#41; is technically simple&#44; it needs to be performed in a medical institution to avoid complications&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the frequency of complications and the usefulness of this technique&#46;</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Patients who underwent a minor salivary gland biopsy for a possible diagnosis of SS at Rivadavia Hospital between October 2007 and May 2010 where included&#46; The patients were seen a week and a month after the procedure for follow-up&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Frequency of acute complications &#40;n&#61;186&#41;&#58; 15 patients&#59; 8&#46;1&#37;&#44; 95&#37; CI&#58; 4&#46;7&#8211;13&#46;2 &#40;Bleeding 7&#46;5&#37;&#44; syncope 3&#46;2&#37;&#44; hematoma 2&#46;7&#37;&#46; No accidents occurred&#41;&#46; Medium term complications &#40;n&#61;164&#41;&#58; 16 patients&#58; 9&#46;75&#37;&#44; 95&#37; CI&#58; 5&#46;9&#8211;15&#46;6 &#40;pain 7&#46;32&#37;&#44; inflammation 3&#46;66&#37;&#44; sensitivity disorders 3&#46;05&#37;&#44; granuloma 1&#46;22&#37;&#41;&#46; No infections or suture dehiscence occurred&#46; Microscopic results&#58; 154 biopsy reports were received&#58; glandular 90&#46;9&#37;&#44; 95&#37; CI&#58; 85&#8211;95 &#40;typical&#44; sialadenitis&#44; grade III and IV infiltration&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">MSGB has very low frequency of medium term and acute complications and it has high usefulness&#46;</p>"
      ]
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        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El hallazgo de anticuerpos espec&#237;ficos y datos histopatol&#243;gicos son indispensables para llegar al diagn&#243;stico de s&#237;ndrome de Sj&#246;gren &#40;SS&#41;&#46; La biopsia de gl&#225;ndulas salivales menores &#40;BGSM&#41;&#44; si bien es un procedimiento sencillo&#44; debe ser realizada en una instituci&#243;n a fin de evitar complicaciones&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estimar la frecuencia de complicaciones mediatas e inmediatas y el r&#233;dito de la t&#233;cnica&#46;</p> <span class="elsevierStyleSectionTitle">Materiales y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron los pacientes derivados al Hospital Rivadavia para realizaci&#243;n de biopsia&#44; entre octubre del 2007 y mayo del 2010&#46; Los pacientes fueron citados a la semana y al mes del procedimiento para control de la lesi&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Frecuencia de complicaciones inmediatas &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>186&#41;&#58; 15 pacientes&#58; 8&#44;1&#37;&#44; IC del 95&#37;&#44; 4&#44;7&#8211;13&#44;2 &#40;sangrado 7&#44;5&#37;&#44; lipotimia 3&#44;2&#37;&#44; hematomas 2&#44;7&#37;&#59; no hubo accidentes&#41;&#46; Complicaciones mediatas &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>164&#41;&#58; 16 pacientes&#58; 9&#44;75&#37;&#44; IC del 95&#37;&#44; 5&#44;9&#8211;15&#44;6 &#40;dolor 7&#44;32&#37;&#44; signos inflamatorios 3&#44;66&#37;&#44; trastornos de sensibilidad 3&#44;05&#37;&#44; granuloma 1&#44;22&#37;&#41;&#46; No hubo casos de infecciones&#44; ni dehiscencia del punto de sutura&#46; R&#233;dito microsc&#243;pico&#58; total 154 biopsias&#58; se obtuvo tejido glandular en el 90&#44;9&#37;&#44; IC del 95&#37;&#44; 85&#8211;95 &#40;t&#237;pica&#44; sialoadenitis&#44; infiltrado grado III y IV&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La BGSM presenta una baja frecuencia de complicaciones mediatas e inmediatas y un alto r&#233;dito en el estudio anatomo-patol&#243;gico&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Lida Santiago M&#44; et al&#46; Frecuencia de complicaciones y r&#233;dito de la biopsia de gl&#225;ndula salival menor&#46; Reumatol Clin&#46; 2012&#46; <span class="elsevierStyleInterRef" href="doi:10.1016/j.reuma.2012.03.006">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;reuma&#46;2012&#46;03&#46;006</span>&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">IQR&#58; interquartile range&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Manifestations&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Absolute Value&#47;Percentage&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Male&#47;female gender&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#47;177 &#40;4&#46;8&#47;95&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; median &#40;year&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;IQR 45&#8211;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time since onset of symptoms&#44; median &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;IQR 0&#46;64&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xerostomy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">155 &#40;83&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xerophtalmia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">168 &#40;90&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Positive syalometry &#40;n&#61;170&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;36&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Anti-Ro positive &#40;n&#61;122&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;32&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-La positive &#40;n&#61;115&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;17&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">ANA&#8805;1&#58;80 &#40;n&#61;138&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">91 &#40;65&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Rheumatoid factor&#8805;30 &#40;n&#61;109&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">42 &#40;38&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Pylocarpin &#40;n&#61;177&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;2&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Glucocorticoids&#60;20<span class="elsevierStyleHsp" style=""></span>mg prednisone &#40;n&#61;179&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">25 &#40;13&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Hydroxicloroquine&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">27 &#40;14&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Immunosuppressants&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;7&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">15 &#40;8&#46;1&#37;&#44; 95&#37; CI&#44; 4&#46;7&#8211;13&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;3&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Accident&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;9&#46;75&#37;&#44; 95&#37; CI&#44; 5&#46;9&#8211;15&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Pain&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">12 &#40;7&#46;32&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Inflammation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;3&#46;66&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5 &#40;3&#46;05&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2 &#40;1&#46;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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            0 => array:3 [
              "identificador" => "bib0005"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The management of Sj&#246;gren&#39;s syndrome"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;P&#46; Mavragani"
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                            2 => "H&#46;M&#46; Moutsopoulos"
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                      "doi" => "10.1038/ncprheum0165"
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                      "titulo" => "Labial salivary gland biopsy in Sjogren&#39;s syndrome"
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                          "etal" => false
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                    0 => array:2 [
                      "titulo" => "Classification criteria for Sj&#246;gren&#39;s syndrome&#58; a revised version of the European criteria proposed by the American-European Consensus Group"
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                        0 => array:2 [
                          "etal" => true
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                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
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                      "titulo" => "The value of labial biopsy in the differentiation of sarcoidosis from tuberculosis sarcoidosis"
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                            4 => "U&#46; G&#252;&#231;"
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                      "Revista" => array:5 [
                        "tituloSerie" => "Vasc Diffuse Lung Dis"
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                        "volumen" => "18"
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                      "titulo" => "Salivary gland biopsy&#58; a comprehensive review of techniques and related complications"
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                        0 => array:2 [
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                          "autores" => array:4 [
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                            1 => "R&#46; Cannavale"
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                      "doi" => "10.1093/rheumatology/keq225"
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Original article
Frequency of Complications and Usefulness of the Minor Salivary Gland Biopsy
Frecuencia de complicaciones y rédito de la biopsia de glándula salival menor
María Lida Santiago, María Renata Seisdedos
Corresponding author
mrseisdedos@intramed.net

Corresponding author.
, Rodrigo Nicolás García Salinas, Anastasia Secco, Lucila Marino Claverie, Lorena Techera, Lorena Takashima, Pedro Aicardi, Marco Antonio Sandi Rosales, Elizabeth Knobel, Sebastián Juan Magri, Antonio Carlos Catalán Pellet
Servicio de Reumatología, Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sj&#246;gren&#39;s syndrome &#40;SS&#41; is a chronic systemic disease of autoimmune origin of the exocrine glands&#44; manifested by symptoms that result from hyposecretion&#46; SS may occur alone &#40;primary SS &#91;pSS&#93;&#41; or associated with other autoimmune diseases &#40;secondary SS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The histopathology of the salivary glands as a part of diagnosis was proposed first in 1970 by Waterhouse&#44; Chisholm&#44; and Mason&#44; the latter established a score based on inflammatory<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> cell aggregates&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">According to the European-American<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> criteria for diagnosis of pSS&#44; the presence of a SGB compatible with the disease and&#47;or the presence of antibodies anti-Ro&#47;anti-La is needed&#46; The MSGB is also a method for diagnosing diseases such as infiltrative amiloidosis<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and sarcoidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Numerous surgical techniques have been described&#46; They vary according to size from 1&#46;5<span class="elsevierStyleHsp" style=""></span>mm to 30<span class="elsevierStyleHsp" style=""></span>mm&#44; the shape of the incision &#40;elliptical&#44; horizontal&#44; vertical&#44; and wedge&#41;&#44; and localization&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> While this is an invasive procedure&#44; it is easy to perform and has a low frequency complications&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Caporali et al&#46; described transient adverse effects in 64 &#40;12&#46;7&#37;&#41; cases in their series of 502 procedures&#58; paresthesias &#40;57&#41;&#44; hematoma &#40;8&#41;&#44; local swelling &#40;27&#41;&#44; and others &#40;5&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> In other studies sensory disturbances &#40;anesthesia&#44; paresthesia&#41; are described as the complications encountered with greater frequency&#44; being transient in most cases&#46; However&#44; other authors have reported no complications&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">As for the sample collected&#44; 99&#37; is needed to be considered as the material is useful for study&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Despite the simplicity of the technique&#44; MSGB is not incorporated in daily practice in all centers&#46; Although other authors have reported complication rates of the different techniques and usefulness of the procedure&#44; we consider important to evaluate the safety and yield &#40;obtaining suitable material for pathology&#41; of the method in our center&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In this paper we estimate the percentage of mediate and immediate complications of MSGB and frequency of obtaining suitable material for pathology&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Material and Methods</span><p id="par0045" class="elsevierStylePara elsevierViewall">We designed a prospective&#44; observational&#44; descriptive&#44; and longitudinal study&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">We included patients referred with suspected SS and who underwent MSGB&#46; Patients should have no evidence of coagulation disorders and a platelet count within normal within 1 month before the procedure&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Exclusion criteria were&#58; use of aspirin or other NSAIDs 1 week before the study&#44; clinical signs of local infection&#44; patients on anticoagulants&#44; and those who refused inclusion in the protocol&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The study was approved by the Ethics Committee of the hospital&#46; All patients signed an informed consent&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">We prospectively studied MSGB conducted between October 2007 and May 2010&#44; at the Rheumatology Service of Hospital Bernardino Rivadavia City of Buenos Aires&#44; Argentina&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients underwent minor salivary gland biopsy with the surgical technique described by Caporali et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The material obtained was preserved in 10&#37; formalin and sent for analysis to pathology&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">We analyzed the characteristics of the incision and any complications during the procedure and after it&#46; The patient was followed up a week and a month after the procedure&#46; The yield was evaluated through the results of the pathology&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Measurements&#58; immediate complications&#58; bleeding that obstructs the proceedings&#44; fainting&#44; accidents due to health staff while performing the procedure&#46; Mediate complications&#58; surgical wound infection&#44; suture dehiscence&#44; sensory disturbances &#40;dysesthesia&#44; anesthesia&#44; paresthesia&#41;&#44; defective wound healing&#44; as defined by the presence of granuloma or keloid scarring at the site&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical Analysis</span><p id="par0090" class="elsevierStylePara elsevierViewall">Complications were studied with a frequency analysis and calculation of confidence intervals of 95&#37;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall">We included 186 procedures performed between October 2007 and May 2010&#44; of which 29 were performed to confirm the diagnosis of secondary SS and the rest of pSS&#46; Among patients with suspected secondary SS&#44; 21 had a diagnosis of rheumatoid arthritis &#40;RA&#41;&#44; 3 systemic lupus erythematosus &#40;SLE&#41;&#44; 3 primary biliary cirrhosis &#40;PBC&#41;&#44; 1 mixed connective tissue disease &#40;MCTD&#41; and 1 of cryoglobulinemic vasculitis&#46; The clinical and serological features are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Of the 14 &#40;7&#46;5&#37;&#41; patients receiving immunosuppressive therapy at the time of the procedure&#44; 11 received methotrexate &#40;9 of them had a diagnosis of RA&#41;&#44; 1 leflunomide and 1 azathioprine&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">All patients tolerated the procedure and no serious adverse events were recorded&#46; 15 patients had postoperative complications &#40;8&#46;1&#37;&#44; 95&#37; CI&#44; 4&#46;7&#8211;13&#46;2&#41;&#46; Complications included&#58; bleeding 7&#46;5&#37;&#44; fainting 3&#46;2&#37;&#44; hematoma 2&#46;7&#37;&#46; There were no accidents &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">There were 164 patients who attended follow-up visits a week and a month after the procedure&#46; Mediate complications were found in 16 patients &#40;9&#46;75&#37;&#44; 95&#37; CI&#44; 5&#46;9&#8211;15&#46;6&#41;&#44; distributed as follows&#58; pain 7&#46;32&#37;&#44; inflammatory signs 3&#46;66&#37;&#44; sensory loss 3&#46;05&#37;&#44; and granuloma 1&#46;22&#37;&#46; Sensitivity disorders were transient&#46; No cases of infections or dehiscence of the suture were seen&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">At the time of analysis&#44; we had the pathology report of 154 biopsies and in 140 &#40;90&#46;9&#37;&#44; 95&#37; CI&#44; 85&#8211;95&#41; glandular material was obtained &#40;typically minor salivary glands&#44; lipomatosis&#44; chronic nonspecific sialadenitis&#44; grade III and IV infiltrates&#41;&#44; and in other cases fibromuscular tissue and fat or little material was obtained&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0120" class="elsevierStylePara elsevierViewall">Establishing the diagnosis of SS has some difficulty due to the low specificity and sensitivity of serological markers and the lack of specific symptoms of the syndrome&#46; To date&#44; different classification criteria have been proposed&#44; which are based on a combination of clinical&#44; serological&#44; and histologic data&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;9&#8211;13</span></a> There are some differences between the San Francisco<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> &#40;which is based on the histopathology&#41; and San Diego<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> criteria&#44; where the MSGB is essential to reach the diagnosis of SS&#44; as well as the Copenhague&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> the Greek&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Japanese&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> and European<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> community criteria&#44; which do not require MSGB or the presence of antibodies&#44; or the American-European criteria 2002&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> which require the presence of histological or serological criteria&#46; Minor salivary gland biopsy is therefore essential for diagnosis in patients with negative suspected SS autoantibodies&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The importance of MSGB is stressed for differential diagnosis with other pathologies and it is currently proposed that the lymphoid organization be a marker for the development of Hodgkin&#39;s<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> lymphoma&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">MSGB is a technically simple procedure and complications are rare&#46; Furthermore&#44; with the technique presented&#44; 90&#46;9&#37; of the material obtained was useful for pathology&#44; somewhat lower than that described by Caporali et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> &#40;99&#46;2&#37;&#41; and Teppo&#8211;Revonta<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> &#40;98&#46;4&#37;&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">This study describes a high prevalence of immediate complications of 8&#46;1&#37; and 9&#46;75&#37; mediate complications&#44; showing the reliability of both health personnel and patients&#44; since there were no serious or medium or long term complications during the procedure&#46; Within a week&#44; 12 patients reported pain and 6 had inflammatory signs during the first days&#44; 5 had mild sensory loss&#44; which disappeared within a month&#44; and in 2 of them we found the formation of granuloma&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Several observations analyzed MSGB with a technique similar to that used in this study and obtained comparable results&#59; the complications were uncommon&#44; and the most prevalent were paresthesias at the site of incision&#44; transient in nature&#44; in most the patients&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Richards et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> reported 2 cases of disorders of sensation at the incision site&#44; which persisted beyond 1 year&#44; with mild features and no objective evidence of neurological disease&#44; while Berquin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> described anesthesia in 1 case and Marx et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> reported 3 cases of which one was persistent after 2 years of follow-up&#46; Caporali et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> reported transient adverse events in 64 of the 502 patients&#44; of whom 57 had transient paresthesias&#44; 8 hematoma&#44; 27 local inflammatory signs&#44; and 5 had others &#40;granuloma&#44; bleeding&#44; and internal scar&#41;&#46; Pijpe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> reported 4 cases of hypoesthesia of the incision site&#44; 2 of which persisted for more than 12 months and 11 cases of pain lasting than 1 month&#46; Moreover&#44; Teppo and Revonta reported a case of pyogenic granuloma&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Patients who underwent MSGB were referred for the study of sicca syndrome by professionals of both our institution and other rheumatology departments who did not have the means for carrying it out&#46; This explains the lack of some data for analysis&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><p id="par0160" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects</span>&#46; The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of Data</span>&#46; The authors declare that they have followed the protocols of their work centre on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent</span>&#46; The authors have obtained the informed consent of the patients and &#47;or subjects mentioned in the article&#46; The author for correspondence is in possession of this document&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Disclosure</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no disclosures to make&#46;</p></span></span>"
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          "identificador" => "xres125924"
          "titulo" => array:5 [
            0 => "Abstract"
            1 => "Objective"
            2 => "Materials and methods"
            3 => "Results"
            4 => "Conclusions"
          ]
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        1 => array:2 [
          "identificador" => "xpalclavsec113219"
          "titulo" => "Keywords"
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        2 => array:2 [
          "identificador" => "xres125923"
          "titulo" => array:5 [
            0 => "Resumen"
            1 => "Objetivo"
            2 => "Materiales y m&#233;todos"
            3 => "Resultados"
            4 => "Conclusiones"
          ]
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        3 => array:2 [
          "identificador" => "xpalclavsec113218"
          "titulo" => "Palabras clave"
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        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
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        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Material and Methods"
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        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Statistical Analysis"
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        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Results"
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        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Discussion"
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        9 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Ethical disclosures"
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        10 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Disclosure"
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        11 => array:2 [
          "identificador" => "xack38126"
          "titulo" => "Acknowledgment"
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        12 => array:1 [
          "titulo" => "References"
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      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2011-10-05"
    "fechaAceptado" => "2012-03-22"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec113219"
          "palabras" => array:3 [
            0 => "Sj&#246;gren syndrome"
            1 => "Minor salivary gland biopsy"
            2 => "Complications"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec113218"
          "palabras" => array:3 [
            0 => "S&#237;ndrome de Sj&#246;gren"
            1 => "Biopsia de gl&#225;ndulas salivales menores"
            2 => "Complicaciones"
          ]
        ]
      ]
    ]
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Findings of specific antibodies and histopathology data are essential for the diagnosis of Sj&#246;gren syndrome &#40;SS&#41;&#46; Although the minor salivary gland biopsy &#40;MSGB&#41; is technically simple&#44; it needs to be performed in a medical institution to avoid complications&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the frequency of complications and the usefulness of this technique&#46;</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Patients who underwent a minor salivary gland biopsy for a possible diagnosis of SS at Rivadavia Hospital between October 2007 and May 2010 where included&#46; The patients were seen a week and a month after the procedure for follow-up&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Frequency of acute complications &#40;n&#61;186&#41;&#58; 15 patients&#59; 8&#46;1&#37;&#44; 95&#37; CI&#58; 4&#46;7&#8211;13&#46;2 &#40;Bleeding 7&#46;5&#37;&#44; syncope 3&#46;2&#37;&#44; hematoma 2&#46;7&#37;&#46; No accidents occurred&#41;&#46; Medium term complications &#40;n&#61;164&#41;&#58; 16 patients&#58; 9&#46;75&#37;&#44; 95&#37; CI&#58; 5&#46;9&#8211;15&#46;6 &#40;pain 7&#46;32&#37;&#44; inflammation 3&#46;66&#37;&#44; sensitivity disorders 3&#46;05&#37;&#44; granuloma 1&#46;22&#37;&#41;&#46; No infections or suture dehiscence occurred&#46; Microscopic results&#58; 154 biopsy reports were received&#58; glandular 90&#46;9&#37;&#44; 95&#37; CI&#58; 85&#8211;95 &#40;typical&#44; sialadenitis&#44; grade III and IV infiltration&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">MSGB has very low frequency of medium term and acute complications and it has high usefulness&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El hallazgo de anticuerpos espec&#237;ficos y datos histopatol&#243;gicos son indispensables para llegar al diagn&#243;stico de s&#237;ndrome de Sj&#246;gren &#40;SS&#41;&#46; La biopsia de gl&#225;ndulas salivales menores &#40;BGSM&#41;&#44; si bien es un procedimiento sencillo&#44; debe ser realizada en una instituci&#243;n a fin de evitar complicaciones&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estimar la frecuencia de complicaciones mediatas e inmediatas y el r&#233;dito de la t&#233;cnica&#46;</p> <span class="elsevierStyleSectionTitle">Materiales y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron los pacientes derivados al Hospital Rivadavia para realizaci&#243;n de biopsia&#44; entre octubre del 2007 y mayo del 2010&#46; Los pacientes fueron citados a la semana y al mes del procedimiento para control de la lesi&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Frecuencia de complicaciones inmediatas &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>186&#41;&#58; 15 pacientes&#58; 8&#44;1&#37;&#44; IC del 95&#37;&#44; 4&#44;7&#8211;13&#44;2 &#40;sangrado 7&#44;5&#37;&#44; lipotimia 3&#44;2&#37;&#44; hematomas 2&#44;7&#37;&#59; no hubo accidentes&#41;&#46; Complicaciones mediatas &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>164&#41;&#58; 16 pacientes&#58; 9&#44;75&#37;&#44; IC del 95&#37;&#44; 5&#44;9&#8211;15&#44;6 &#40;dolor 7&#44;32&#37;&#44; signos inflamatorios 3&#44;66&#37;&#44; trastornos de sensibilidad 3&#44;05&#37;&#44; granuloma 1&#44;22&#37;&#41;&#46; No hubo casos de infecciones&#44; ni dehiscencia del punto de sutura&#46; R&#233;dito microsc&#243;pico&#58; total 154 biopsias&#58; se obtuvo tejido glandular en el 90&#44;9&#37;&#44; IC del 95&#37;&#44; 85&#8211;95 &#40;t&#237;pica&#44; sialoadenitis&#44; infiltrado grado III y IV&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La BGSM presenta una baja frecuencia de complicaciones mediatas e inmediatas y un alto r&#233;dito en el estudio anatomo-patol&#243;gico&#46;</p>"
      ]
    ]
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Lida Santiago M&#44; et al&#46; Frecuencia de complicaciones y r&#233;dito de la biopsia de gl&#225;ndula salival menor&#46; Reumatol Clin&#46; 2012&#46; <span class="elsevierStyleInterRef" href="doi:10.1016/j.reuma.2012.03.006">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;reuma&#46;2012&#46;03&#46;006</span>&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">IQR&#58; interquartile range&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Manifestations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Absolute Value&#47;Percentage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&#47;female gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#47;177 &#40;4&#46;8&#47;95&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; median &#40;year&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;IQR 45&#8211;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time since onset of symptoms&#44; median &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;IQR 0&#46;64&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xerostomy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">155 &#40;83&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xerophtalmia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">168 &#40;90&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Positive syalometry &#40;n&#61;170&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;36&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-Ro positive &#40;n&#61;122&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;32&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anti-La positive &#40;n&#61;115&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;17&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA&#8805;1&#58;80 &#40;n&#61;138&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91 &#40;65&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rheumatoid factor&#8805;30 &#40;n&#61;109&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;38&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pylocarpin &#40;n&#61;177&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;2&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glucocorticoids&#60;20<span class="elsevierStyleHsp" style=""></span>mg prednisone &#40;n&#61;179&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;13&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hydroxicloroquine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;14&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Immunosuppressants&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;7&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Clinical and Serologic Characteristics of Patients Evaluated&#46;</p>"
        ]
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        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Immediate complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">15 &#40;8&#46;1&#37;&#44; 95&#37; CI&#44; 4&#46;7&#8211;13&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bleeding&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">14 &#40;7&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fainting&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">6 &#40;3&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hematoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5 &#40;2&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Accident&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Mediate complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">16 &#40;9&#46;75&#37;&#44; 95&#37; CI&#44; 5&#46;9&#8211;15&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">12 &#40;7&#46;32&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inflammation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">6 &#40;3&#46;66&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5 &#40;3&#46;05&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Granuloma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2 &#40;1&#46;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  """
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Article information
ISSN: 21735743
Original language: English
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