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Relative With the Review “Understanding the Concept of Immunogenicity”" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "253" "paginaFinal" => "254" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Respuesta a Balsa et al. en relación con la revisión «Entendiendo el concepto de inmunogenicidad»" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lara Valor, Inmaculada de la Torre" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Lara" "apellidos" => "Valor" ] 1 => array:2 [ "nombre" => "Inmaculada" "apellidos" => "de la Torre" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X13000946" "doi" => "10.1016/j.reuma.2013.03.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13000946?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000786?idApp=UINPBA00004M" "url" => "/21735743/0000000900000004/v1_201307160008/S2173574313000786/v1_201307160008/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Do rheumatologists think about sex?" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>:" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "255" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Emily Pease, Benedict Pease, Colin Pease" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Emily" "apellidos" => "Pease" "email" => array:1 [ 0 => "emilypease@doctors.org.uk" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Benedict" "apellidos" => "Pease" ] 2 => array:2 [ "nombre" => "Colin" "apellidos" => "Pease" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Leeds Teaching Hospitals NHS Trust, Yorkshire, United Kingdom" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Piensan los reumatólogos en el sexo?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read in interest Espinoza and García-Valladares's article entitled ‘Of Bugs and Joints’.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> We agree that the epidemiology of reactive arthritis (ReA) is difficult to determine, especially in the absence of any internationally validated diagnostic criteria or guidelines. Whilst the clinical features of a ReA secondary to a sexually transmitted infection (STI) are indistinguishable from those caused by an enteric organism, the management could potentially be different. As was discussed, there is evidence that chlamydia induced ReA may benefit from a prolonged course of combination antibiotics.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We wondered how good clinicians were at identifying the responsible organism? Is sexually acquired ReA (SARA), an under-recognised diagnosis, perhaps due to a reluctance from the rheumatologist to discuss and investigate such matters?</p><p id="par0015" class="elsevierStylePara elsevierViewall">We conducted an audit to establish whether patients with suspected ReA were screened for STIs. The first clinic letter of all new referrals <30 years of age to both the general rheumatology and the early arthritis clinics in the preceding 6 months was reviewed. Out of 244 referrals, 42 patients were considered to potentially have ReA and of these only 24% (10/42) were screened for an STI (all negative).</p><p id="par0020" class="elsevierStylePara elsevierViewall">It is not reassuring that no STIs were detected because over three quarters of patients were not tested. STIs are common in the young sexually active population, with chlamydia affecting 5–10% of those under 24 years, and in females especially it can be completely asymptomatic.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> If a patient denies any ‘promiscuous activities’ or appears to be in a stable relationship should they still be screened? We suggest if a diagnosis of ReA is being considered all patients should be tested, regardless of the social circumstances that they chose to disclose in their rheumatology consultation. The initial screening for an STI need involve only a first pass urine sample in males and in females a self-taken vulvo-vaginal swab sent for nucleic acid amplification testing (NAAT).<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This is no more onerous than routinely testing the same people for rheumatoid factor, anti-CCP and HLA B27.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Our findings were presented both locally and at the 2012 Rheumatology conference in Glasgow, reiterating the importance of STI screening.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> A re-audit 1 year later found that STI screening had increased to 50% (13/26) and two chlamydia infections were identified. This increase indicates that with clear guidance, clinicians are more likely to carry out an STI screen, and supports the need for a national ReA guidance.</p><p id="par0030" class="elsevierStylePara elsevierViewall">As the authors described so well, the relationship between ‘bugs and joints’ is clear, however, the underlying STI may not be obvious. SARA may well be an under-recognised diagnosis due to the absence of testing, not the absence of infection. Clinicians must view STI screening as ‘routine’, if only those who are perceived to be high risk for infection are tested, then infection will be missed.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-01-05" "fechaAceptado" => "2013-03-06" "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Espinoza L, García-Valladares I. Review article of bugs and joints: the relationship between infection and joints. Reumatol Clin. In press 2012 [Epub ahead of print]. doi: http://www.elsevier.es/sites/default/files/elsevier/eop/dx.doi.org/10.1016/j.reuma.2012.06.008." ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reactive arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Hannu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.berh.2011.01.018" "Revista" => array:7 [ "tituloSerie" => "Best Pract Res Clin Rheumatol" "fecha" => "2011" "volumen" => "25" "paginaInicial" => "347" "paginaFinal" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22100285" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0300893212000140" "estado" => "S300" "issn" => "11313587" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Double-blind, placebo-controlled study of three-month treatment with lymecycline in reactive arthritis, with special reference to <span class="elsevierStyleItalic">Chlamydia arthritis</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Lauhio" 1 => "M. Leirisalo-Repo" 2 => "J. Lahdevirta" 3 => "P. Saikku" 4 => "H. Repo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1991" "volumen" => "34" "paginaInicial" => "6" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1670621" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2006 UK national guideline for the management of genital tract infection with Chlamydia trachomatis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "British Association of Sexual Health and HIV (BASHH)" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2006" "editorial" => "British Association of Sexual Health and HIV (BASHH)" "editorialLocalizacion" => "London (UK)" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Audit: are potential reactive arthritis patients screened for a sexual aetiology?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Pease" 1 => "C. Pease" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Rheumatology" "fecha" => "2012" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000900000004/v1_201307160008/S2173574313000531/v1_201307160008/en/main.assets" "Apartado" => array:4 [ "identificador" => "8400" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000900000004/v1_201307160008/S2173574313000531/v1_201307160008/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313000531?idApp=UINPBA00004M" ]
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